ZA909141B - Therapeutically active chloro substituted benzimidazoles,processes for their preparation as well as their use - Google Patents
Therapeutically active chloro substituted benzimidazoles,processes for their preparation as well as their useInfo
- Publication number
- ZA909141B ZA909141B ZA909141A ZA909141A ZA909141B ZA 909141 B ZA909141 B ZA 909141B ZA 909141 A ZA909141 A ZA 909141A ZA 909141 A ZA909141 A ZA 909141A ZA 909141 B ZA909141 B ZA 909141B
- Authority
- ZA
- South Africa
- Prior art keywords
- processes
- preparation
- well
- therapeutically active
- substituted benzimidazoles
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/454,049 US4965269A (en) | 1989-12-20 | 1989-12-20 | Therapeutically active chloro substituted benzimidazoles |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA909141B true ZA909141B (en) | 1991-08-28 |
Family
ID=23803085
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA909141A ZA909141B (en) | 1989-12-20 | 1990-11-14 | Therapeutically active chloro substituted benzimidazoles,processes for their preparation as well as their use |
Country Status (10)
Country | Link |
---|---|
US (1) | US4965269A (xx) |
CN (1) | CN1052671A (xx) |
AU (1) | AU6973991A (xx) |
IE (1) | IE904249A1 (xx) |
IL (1) | IL96398A0 (xx) |
IS (1) | IS3660A7 (xx) |
PL (1) | PL288336A1 (xx) |
PT (1) | PT96257A (xx) |
WO (1) | WO1991009029A1 (xx) |
ZA (1) | ZA909141B (xx) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5274099A (en) * | 1989-12-20 | 1993-12-28 | Aktiebolaget Hassle | Therapeutically active fluoro substituted benzimidazoles |
ATE184602T1 (de) * | 1990-06-20 | 1999-10-15 | Astra Ab | Dialkoxypyridinylbenzimidazolderivate, verfahren zur herstellung und ihre pharmazeutische verwendung |
US6274591B1 (en) * | 1997-11-03 | 2001-08-14 | Joseph F. Foss | Use of methylnaltrexone and related compounds |
US20030158220A1 (en) * | 1997-11-03 | 2003-08-21 | Foss Joseph F. | Use of methylnaltrexone and related compounds to treat chronic opioid use side effects |
KR100472126B1 (ko) * | 1998-08-10 | 2005-03-08 | 더 리전츠 오브 더 유니버시티 오브 캘리포니아 | 양성자 펌프 억제제의 프로드러그 |
US6093734A (en) * | 1998-08-10 | 2000-07-25 | Partnership Of Michael E. Garst, George Sachs, And Jai Moo Shin | Prodrugs of proton pump inhibitors |
WO2003027098A1 (fr) * | 2001-09-25 | 2003-04-03 | Takeda Chemical Industries, Ltd. | Compose de benzymidazole, procede de production et d'utilisation de celui-ci |
ATE437642T1 (de) * | 2002-06-14 | 2009-08-15 | Takeda Pharmaceutical | Prodrugs von imidazol-derivaten, zur verwendung als protonenpumpen-hemmer zur behandlung von z.b. peptischen magengeschwüren |
DK1556371T3 (da) * | 2002-07-19 | 2006-08-21 | Winston Pharmaceuticals Llc | Benzimidazol-derivater og deres anvendelse som prodrugs for protonpumpe-inhibitorer |
MY148805A (en) | 2002-10-16 | 2013-05-31 | Takeda Pharmaceutical | Controlled release preparation |
PT2368553E (pt) | 2003-04-08 | 2015-03-03 | Progenics Pharm Inc | Formulações farmacêuticas contendo metilnaltrexona |
WO2004091665A1 (en) * | 2003-04-08 | 2004-10-28 | Progenics Pharmaceuticals, Inc. | Combination therapy for constipation comprising a laxative and a peripheral opioid antagonist |
US20050004155A1 (en) * | 2003-04-08 | 2005-01-06 | Boyd Thomas A. | Use of methylnaltrexone to treat irritable bowel syndrome |
WO2004112756A1 (en) * | 2003-06-26 | 2004-12-29 | Isa Odidi | Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient |
WO2005039640A1 (en) * | 2003-10-03 | 2005-05-06 | Allergan Inc. | Compositions comprising trefoil factor family peptides and/or mucoadhesives and proton pump inhibitor prodrugs |
US20050075371A1 (en) * | 2003-10-03 | 2005-04-07 | Allergan, Inc. | Methods and compositions for the oral administration of prodrugs of proton pump inhibitors |
CA2557471A1 (en) * | 2004-02-18 | 2005-09-09 | Allergan, Inc. | Methods and compositions for the intravenous administration of compounds related to proton pump inhibitors |
BRPI0507784A (pt) * | 2004-02-18 | 2007-07-17 | Allergan Inc | métodos e composições para a administração de pró-fármacos de inibidores da bomba de prótons |
EP1742630A4 (en) * | 2004-04-16 | 2010-01-20 | Santarus Inc | COMBINATION OF INHIBITOR OF PROTON PUMP, BUFFER AND PROKINETIC AGENT |
US8394409B2 (en) | 2004-07-01 | 2013-03-12 | Intellipharmaceutics Corp. | Controlled extended drug release technology |
US10624858B2 (en) | 2004-08-23 | 2020-04-21 | Intellipharmaceutics Corp | Controlled release composition using transition coating, and method of preparing same |
JP2008528497A (ja) * | 2005-01-20 | 2008-07-31 | プロジェニックス ファーマシューティカルズ,インコーポレーテッド | メチルナルトレキソンおよび関連化合物の術後性胃腸障害のための使用 |
US9662325B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
US8518962B2 (en) | 2005-03-07 | 2013-08-27 | The University Of Chicago | Use of opioid antagonists |
CN104248763A (zh) | 2005-03-07 | 2014-12-31 | 芝加哥大学 | 阿片样物质拮抗剂用于减少内皮细胞增殖和迁移的用途 |
US8524731B2 (en) | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
AR057035A1 (es) * | 2005-05-25 | 2007-11-14 | Progenics Pharm Inc | SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS |
AR057325A1 (es) | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos |
US20080194611A1 (en) * | 2005-06-03 | 2008-08-14 | Alverdy John C | Modulation of Cell Barrier Dysfunction |
US10064828B1 (en) | 2005-12-23 | 2018-09-04 | Intellipharmaceutics Corp. | Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems |
EP2007360B1 (en) | 2006-04-03 | 2014-11-26 | Isa Odidi | Controlled release delivery device comprising an organosol coat |
US10960077B2 (en) | 2006-05-12 | 2021-03-30 | Intellipharmaceutics Corp. | Abuse and alcohol resistant drug composition |
US20100317689A1 (en) * | 2006-09-19 | 2010-12-16 | Garst Michael E | Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety |
EP2086543A2 (en) | 2006-10-27 | 2009-08-12 | The Curators of the University of Missouri | Compositions comprising at least one acid labile proton pump inhibiting agents, optionally other pharmaceutically active agents and methods of using same |
US20080194307A1 (en) * | 2007-02-13 | 2008-08-14 | Jeff Sanger | Sports-based game of chance |
CA2865389A1 (en) | 2007-03-29 | 2008-10-09 | Progenics Pharmaceuticals, Inc. | Crystal forms and uses thereof |
EP2139890B1 (en) | 2007-03-29 | 2014-06-25 | Wyeth LLC | Peripheral opioid receptor antagonists and uses thereof |
PE20090700A1 (es) | 2007-03-29 | 2009-07-13 | Progenics Pharm Inc | Compuestos heterociclicos como antagonistas del receptor opioide periferico |
CN101959892B (zh) | 2008-02-06 | 2014-01-08 | 普罗热尼奇制药公司 | (r),(r)-2,2’-二-甲基纳曲酮的制备和用途 |
WO2009105568A1 (en) | 2008-02-20 | 2009-08-27 | The Curators Of The University Of Missouri | Composition comprising a combination of omeprazole and lansoprazole, and a buffering agent, and methods of using same |
JP5647098B2 (ja) | 2008-03-21 | 2014-12-24 | ザ ユニヴァーシティー オヴ シカゴ | オピオイド拮抗薬とmTOR阻害薬を用いた治療 |
CA2676881C (en) | 2008-09-30 | 2017-04-25 | Wyeth | Peripheral opioid receptor antagonists and uses thereof |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE418966B (sv) * | 1974-02-18 | 1981-07-06 | Haessle Ab | Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan |
SE416649B (sv) * | 1974-05-16 | 1981-01-26 | Haessle Ab | Forfarande for framstellning av foreningar som paverkar magsyrasekretionen |
IN148930B (xx) * | 1977-09-19 | 1981-07-25 | Hoffmann La Roche | |
SE7804231L (sv) * | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
US4359465A (en) * | 1980-07-28 | 1982-11-16 | The Upjohn Company | Methods for treating gastrointestinal inflammation |
CH644116A5 (de) * | 1980-08-21 | 1984-07-13 | Hoffmann La Roche | Imidazolderivate. |
SE8204879D0 (sv) * | 1982-08-26 | 1982-08-26 | Haessle Ab | Novel chemical intermediates |
SE8300736D0 (sv) * | 1983-02-11 | 1983-02-11 | Haessle Ab | Novel pharmacologically active compounds |
SE8301182D0 (sv) * | 1983-03-04 | 1983-03-04 | Haessle Ab | Novel compounds |
HU195220B (en) * | 1983-05-03 | 1988-04-28 | Byk Gulden Lomberg Chem Fqb | Process for production of new fluor-alkoxi-benzimidasole-derivatives and medical compositions containig them |
US4575554A (en) * | 1983-12-05 | 1986-03-11 | The Upjohn Company | Substituted 2-pyridylmethylthio- and sulfinyl-benzimidazoles as gastric antisecretory agents |
GB2161160B (en) * | 1984-07-06 | 1989-05-24 | Fisons Plc | Heterocyclic sulphinyl compounds |
SE8404065D0 (sv) * | 1984-08-10 | 1984-08-10 | Haessle Ab | Novel biologically active compounds |
JPS6150979A (ja) * | 1984-08-16 | 1986-03-13 | Takeda Chem Ind Ltd | ピリジン誘導体およびその製造法 |
JPS6150978A (ja) * | 1984-08-16 | 1986-03-13 | Takeda Chem Ind Ltd | ピリジン誘導体およびその製造法 |
AU568441B2 (en) * | 1984-09-24 | 1987-12-24 | Upjohn Company, The | 2-(pyridylalkenesulfinyl) benzimidazole derivatives |
US4738975A (en) * | 1985-07-02 | 1988-04-19 | Takeda Chemical Industries, Ltd. | Pyridine derivatives, and use as anti-ulcer agents |
SE8505112D0 (sv) * | 1985-10-29 | 1985-10-29 | Haessle Ab | Novel pharmacological compounds |
JPS62201884A (ja) * | 1986-02-28 | 1987-09-05 | Tokyo Tanabe Co Ltd | ベンズイミダゾール誘導体及びその製造法 |
FI90544C (fi) * | 1986-11-13 | 1994-02-25 | Eisai Co Ltd | Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi |
NZ234564A (en) * | 1986-11-21 | 1991-04-26 | Haessle Ab | 1-substituted benzimidazoles and pharmaceutical compositions |
JPS63183577A (ja) * | 1987-01-23 | 1988-07-28 | Grelan Pharmaceut Co Ltd | ベンズイミダゾ−ル誘導体 |
US4839365A (en) * | 1987-05-19 | 1989-06-13 | Shinogi & Co., Ltd. | Thienopyridine derivatives useful in treating gastric ulcers |
FI96860C (fi) * | 1987-06-17 | 1996-09-10 | Eisai Co Ltd | Analogiamenetelmä lääkeaineena käytettävän pyridiinijohdannaisen valmistamiseksi |
WO1989005299A1 (en) * | 1987-12-11 | 1989-06-15 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Novel benzimidazole derivatives |
-
1989
- 1989-12-20 US US07/454,049 patent/US4965269A/en not_active Expired - Fee Related
-
1990
- 1990-11-14 ZA ZA909141A patent/ZA909141B/xx unknown
- 1990-11-19 IL IL96398A patent/IL96398A0/xx unknown
- 1990-11-26 IE IE424990A patent/IE904249A1/en unknown
- 1990-12-17 AU AU69739/91A patent/AU6973991A/en not_active Abandoned
- 1990-12-17 IS IS3660A patent/IS3660A7/is unknown
- 1990-12-17 WO PCT/SE1990/000840 patent/WO1991009029A1/en unknown
- 1990-12-19 PT PT96257A patent/PT96257A/pt unknown
- 1990-12-19 CN CN90110080A patent/CN1052671A/zh active Pending
- 1990-12-19 PL PL28833690A patent/PL288336A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
PL288336A1 (en) | 1991-12-02 |
US4965269A (en) | 1990-10-23 |
IL96398A0 (en) | 1991-08-16 |
PT96257A (pt) | 1991-09-30 |
IE904249A1 (en) | 1991-07-03 |
IS3660A7 (is) | 1991-06-21 |
WO1991009029A1 (en) | 1991-06-27 |
CN1052671A (zh) | 1991-07-03 |
AU6973991A (en) | 1991-07-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA909141B (en) | Therapeutically active chloro substituted benzimidazoles,processes for their preparation as well as their use | |
IT8847956A0 (it) | Benzo-b-pirani e piranopiridone, loro preparazione e loro impiego come medicamenti | |
NO179639C (no) | Analogifremgangsmåte for fremstilling av terapeutisk aktive, substituerte piperidinforbindelser | |
EP0412350A3 (en) | Renininhibitors, procedure for their preparation and use as medicaments | |
LTIP1712A (en) | Substituted benzimidazoles, process for their preparation and their pharmaceutical use | |
ITRM920412A1 (it) | Eteroprostanoidi, procedimento per la loro preparazione e loro impiego terapeutico. | |
NO900032D0 (no) | Fremgangsmaate for fremstilling av terapeutisk aktive tiazol-forbindelser. | |
DE3377795D1 (en) | Spergualin-related compounds, processes for the preparation thereof and their use as medicaments | |
NO177096C (no) | Analogifremgangsmåte for fremstilling av terapeutisk aktive, substituerte isokinoliner | |
ZA907637B (en) | Anthelmintics | |
IT1146940B (it) | Composti 2,4-diamminopirido (2,3-d) pirimidinici dotati di attivita' farmacologica e procedimento per la loro preparazione | |
AP9200463A0 (en) | Substituted benzimidazoles,process for their preparation as well as their use | |
FI901883A0 (fi) | Menetelmä terapeuttisesti vaikuttavien 2-substituoitujen N,N'-ditrimetoksibentsoyylipiperatsiinien valmistamiseksi | |
AU1630188A (en) | Substituted compounds, processes for their preparation and their use as medicaments | |
ZA883068B (en) | Substituted tetrahydrophthalimides,processes for their preparation and their use as herbicides | |
ZA902245B (en) | Azolylethylcyclopropanes,the preparation thereof and the use thereof as crop protection agents | |
ZA905932B (en) | 14,17alpha-etheno-and-ethanoestratrienes,processes for the preparation of these compounds,as well as their use for the production of medicinal agents | |
ZA909142B (en) | Therapeutically active fluoro substituted benzimidazoles,processes for their preparation as well as their use | |
EP0533056A3 (en) | Substituted aminopropanes, process for their preparation and their use as antimycotic agents | |
FI940607A0 (fi) | Imidatso(5,1-C)(1,4)bentsoksatsin-1-onijohdannaiset 5HT3-antagonisteina | |
IL89204A0 (en) | Veterinary composition,especially suitable for the treatment of mastitis | |
ZA909630B (en) | Anthelmintics | |
NO175746C (no) | Analogifremgangsmåte for fremstilling av terapeutisk aktivt 1-etyl-fenoksatiin-10,10-dioksyd | |
ZA902695B (en) | Benzimidazoles,medicaments containing these compounds and processes for their preparation | |
NO174393C (no) | Analogifremgangsmåte for fremstilling av terapeutisk aktive 6-metyl-19-nor-pregna-4,6-diener som er 17 eventuelt 21-alkylert |