ZA902871B - 3-substituted-2-oxindole derivatives - Google Patents

3-substituted-2-oxindole derivatives

Info

Publication number
ZA902871B
ZA902871B ZA902871A ZA902871A ZA902871B ZA 902871 B ZA902871 B ZA 902871B ZA 902871 A ZA902871 A ZA 902871A ZA 902871 A ZA902871 A ZA 902871A ZA 902871 B ZA902871 B ZA 902871B
Authority
ZA
South Africa
Prior art keywords
substituted
oxindole derivatives
oxindole
derivatives
Prior art date
Application number
ZA902871A
Other languages
English (en)
Inventor
Frederick Jacob Ehrgott
Jacob Ehrgott Frederick
Carl Joseph Goddard
Joseph Goddard Carl
Gary Richard Schulte
Richard Schulte Gary
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ZA902871B publication Critical patent/ZA902871B/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
ZA902871A 1989-04-18 1990-04-17 3-substituted-2-oxindole derivatives ZA902871B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34011389A 1989-04-18 1989-04-18

Publications (1)

Publication Number Publication Date
ZA902871B true ZA902871B (en) 1991-11-27

Family

ID=23331948

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA902871A ZA902871B (en) 1989-04-18 1990-04-17 3-substituted-2-oxindole derivatives

Country Status (33)

Country Link
US (4) US5047554A (sv)
EP (1) EP0393936B1 (sv)
JP (2) JP2506478B2 (sv)
KR (1) KR920006394B1 (sv)
CN (1) CN1022832C (sv)
AP (1) AP142A (sv)
AT (1) ATE118767T1 (sv)
AU (1) AU633767B2 (sv)
BG (1) BG60646B1 (sv)
CA (1) CA2014467C (sv)
CZ (1) CZ284340B6 (sv)
DD (1) DD293822A5 (sv)
DE (1) DE69017066T2 (sv)
DK (1) DK0393936T3 (sv)
EG (1) EG19122A (sv)
ES (1) ES2068334T3 (sv)
FI (1) FI106378B (sv)
GR (1) GR3015811T3 (sv)
HU (2) HUT58314A (sv)
IE (1) IE65091B1 (sv)
IL (3) IL94047A (sv)
IS (1) IS1636B (sv)
MA (1) MA21808A1 (sv)
MX (1) MX20359A (sv)
NO (1) NO176759C (sv)
NZ (1) NZ233320A (sv)
OA (1) OA09205A (sv)
PL (2) PL163951B1 (sv)
PT (1) PT93785B (sv)
RO (1) RO106402B1 (sv)
RU (2) RU2039042C1 (sv)
YU (1) YU47588B (sv)
ZA (1) ZA902871B (sv)

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BR0309412A (pt) 2002-04-22 2005-02-01 Pfizer Prod Inc Indol-2-onas como inibidores seletivos da ciclooxigenase-2
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Also Published As

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KR920006394B1 (ko) 1992-08-06
BG60646B1 (bg) 1995-11-30
DE69017066D1 (de) 1995-03-30
DK0393936T3 (da) 1995-06-26
NO901684L (no) 1990-10-19
HU902462D0 (en) 1990-08-28
IE65091B1 (en) 1995-10-04
US5919809A (en) 1999-07-06
IL110173A0 (en) 1994-10-07
MX20359A (es) 1994-02-28
US5290802A (en) 1994-03-01
AP142A (en) 1991-09-26
RO106402B1 (ro) 1993-04-30
OA09205A (en) 1992-06-30
KR900016189A (ko) 1990-11-12
US5047554A (en) 1991-09-10
AP9000175A0 (en) 1990-04-30
RU2039042C1 (ru) 1995-07-09
EG19122A (en) 1994-07-30
YU47588B (sh) 1995-10-24
YU75590A (sh) 1992-07-20
NO901684D0 (no) 1990-04-17
IS1636B (is) 1996-09-20
ES2068334T3 (es) 1995-04-16
PL287812A1 (en) 1991-07-15
NO176759C (no) 1995-05-24
PL284817A1 (en) 1991-03-25
HUT58314A (en) 1992-02-28
ATE118767T1 (de) 1995-03-15
AU633767B2 (en) 1993-02-04
CA2014467A1 (en) 1990-10-18
NZ233320A (en) 1991-09-25
IL110173A (en) 1997-06-10
CZ184890A3 (cs) 1998-07-15
NO176759B (no) 1995-02-13
AU621477B2 (en) 1992-03-12
PL163941B1 (pl) 1994-05-31
CA2014467C (en) 2000-02-08
BG91773A (bg) 1993-12-24
AU1051092A (en) 1992-04-09
EP0393936B1 (en) 1995-02-22
CN1046525A (zh) 1990-10-31
PL163951B1 (pl) 1994-05-31
PT93785A (pt) 1990-11-20
PT93785B (pt) 1996-09-30
US6174883B1 (en) 2001-01-16
DD293822A5 (de) 1991-09-12
MA21808A1 (fr) 1990-12-31
CZ284340B6 (cs) 1998-10-14
FI106378B (sv) 2001-01-31
IS3570A7 (is) 1990-10-19
IL94047A (en) 1995-10-31
IE901360L (en) 1990-10-18
RU2073671C1 (ru) 1997-02-20
JPH02292258A (ja) 1990-12-03
JP2581525B2 (ja) 1997-02-12
GR3015811T3 (en) 1995-07-31
FI901915A0 (fi) 1990-04-17
JPH07118261A (ja) 1995-05-09
CN1022832C (zh) 1993-11-24
EP0393936A1 (en) 1990-10-24
HU211150A9 (en) 1995-10-30
DE69017066T2 (de) 1995-06-14
JP2506478B2 (ja) 1996-06-12
AU5362690A (en) 1990-11-22
IL94047A0 (en) 1991-01-31

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