BR0309412A - Indol-2-onas como inibidores seletivos da ciclooxigenase-2 - Google Patents

Indol-2-onas como inibidores seletivos da ciclooxigenase-2

Info

Publication number
BR0309412A
BR0309412A BR0309412-0A BR0309412A BR0309412A BR 0309412 A BR0309412 A BR 0309412A BR 0309412 A BR0309412 A BR 0309412A BR 0309412 A BR0309412 A BR 0309412A
Authority
BR
Brazil
Prior art keywords
inhibitors
selective cyclooxygenase
indol
ones
inflammation
Prior art date
Application number
BR0309412-0A
Other languages
English (en)
Inventor
Kristin Lundy Demello
Brian Scott Bronk
Rhonda Marie Crosson
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29251180&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0309412(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BR0309412A publication Critical patent/BR0309412A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"INDOL-2-ONAS COMO INIBIDORES SELETIVOS DA CICLOOXIGENASE-2". A presente invenção refere-se a inibidores seletivos da ciclooxigenase-2 (COX-2) de fórmula 1: composições farmacêuticas que os contenham, o seu uso medicinal, e as suas preparações. Os compostos da invenção são particularmente úteis no tratamento ou no alívio da inflamação e de distúrbios associados à inflamação, tais como, por exemplo, artrite reumatóide e osteoartrite, e no alívio da dor, tal como, por exemplo, a dor associada à cirurgia ou à trauma, em mamiferos, preferivelmente felinos e caninos.
BR0309412-0A 2002-04-22 2003-04-10 Indol-2-onas como inibidores seletivos da ciclooxigenase-2 BR0309412A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37437202P 2002-04-22 2002-04-22
PCT/IB2003/001339 WO2003089427A1 (en) 2002-04-22 2003-04-10 Indol-2-ones as selective inhibitors of cyclooxygenase-2

Publications (1)

Publication Number Publication Date
BR0309412A true BR0309412A (pt) 2005-02-01

Family

ID=29251180

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0309412-0A BR0309412A (pt) 2002-04-22 2003-04-10 Indol-2-onas como inibidores seletivos da ciclooxigenase-2

Country Status (13)

Country Link
US (1) US6846818B2 (pt)
EP (1) EP1497280A1 (pt)
JP (1) JP2005535576A (pt)
AR (1) AR039320A1 (pt)
AU (1) AU2003215867A1 (pt)
BR (1) BR0309412A (pt)
CA (1) CA2484017A1 (pt)
GT (1) GT200300083A (pt)
MX (1) MXPA04010397A (pt)
PA (1) PA8571601A1 (pt)
PL (1) PL373523A1 (pt)
TW (1) TW200406405A (pt)
WO (1) WO2003089427A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040220155A1 (en) * 2003-03-28 2004-11-04 Pharmacia Corporation Method of providing a steroid-sparing benefit with a cyclooxygenase-2 inhibitor and compositions therewith
WO2005009342A2 (en) * 2003-07-16 2005-02-03 Pharmacia Corporation Method for the treatment or prevention of dermatological disorders with a cyclooxygenase-2 inhibitor alone and in combination with a dermatological treatment agent and compositions therewith
US20050119262A1 (en) * 2003-08-21 2005-06-02 Pharmacia Corporation Method for preventing or treating an optic neuropathy with a cox-2 inhibitor and an intraocular pressure reducing agent
US20050107350A1 (en) * 2003-08-22 2005-05-19 Pharmacia Corporation Method for the treatment or prevention of bone disorders with a cyclooxygenase-2 inhibitor alone and in combination with a bone disorder treatment agent and compositions therewith
WO2005023189A2 (en) * 2003-09-03 2005-03-17 Pharmacia Corporation Method of cox-2 selective inhibitor and nitric oxide-donating agent
US8034796B2 (en) * 2004-04-07 2011-10-11 The University Of Georgia Research Foundation, Inc. Glucosamine and glucosamine/anti-inflammatory mutual prodrugs, compositions, and methods
JP2007532562A (ja) 2004-04-07 2007-11-15 ザ ユニバーシティ オブ ジョージア リサーチファウンデーション，インコーポレイティド グルコサミン、及びグルコサミン／抗炎症薬の相互プロドラッグ、組成物、及び方法
US8354434B2 (en) 2006-01-30 2013-01-15 Purdue Pharma L.P. Cyclourea compounds as calcium channel blockers
US20080161324A1 (en) * 2006-09-14 2008-07-03 Johansen Lisa M Compositions and methods for treatment of viral diseases
RU2582278C2 (ru) * 2013-04-25 2016-04-20 Закрытое Акционерное Общество "Фармфирма "Сотекс" Трансдермальное средство для лечения и профилактики болезней суставов и мягких тканей, способ его получения и комбинированный трансдермальный препарат для лечения и профилактики болезней суставов и мягких тканей

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4160032A (en) * 1973-11-21 1979-07-03 Sandoz, Inc. Oxindoles as sleep-inducers
US4006161A (en) * 1973-12-26 1977-02-01 Eli Lilly And Company Thio-substituted 2-oxo-indolines
US3882236A (en) * 1973-12-26 1975-05-06 Lilly Co Eli Pharmaceutical compositions containing substituted 2-oxo-indolines and the use thereof to treat anxiety and tension
US4569942A (en) * 1984-05-04 1986-02-11 Pfizer Inc. N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents
US5047554A (en) * 1989-04-18 1991-09-10 Pfizer Inc. 3-substituted-2-oxindole derivatives
US6048850A (en) * 1992-09-22 2000-04-11 Young; Donald A. Method of inhibiting prostaglandin synthesis in a human host
US5604260A (en) * 1992-12-11 1997-02-18 Merck Frosst Canada Inc. 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2
US5380738A (en) * 1993-05-21 1995-01-10 Monsanto Company 2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
US5344991A (en) * 1993-10-29 1994-09-06 G.D. Searle & Co. 1,2 diarylcyclopentenyl compounds for the treatment of inflammation
US5434178A (en) * 1993-11-30 1995-07-18 G.D. Searle & Co. 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation
US5466823A (en) * 1993-11-30 1995-11-14 G.D. Searle & Co. Substituted pyrazolyl benzenesulfonamides
US5510368A (en) * 1995-05-22 1996-04-23 Merck Frosst Canada, Inc. N-benzyl-3-indoleacetic acids as antiinflammatory drugs
EP0826685A1 (en) 1996-08-21 1998-03-04 Pfizer Inc. Stable, long acting salts of carboxamides for the treatment of joint disease

Also Published As

Publication number Publication date
AU2003215867A1 (en) 2003-11-03
AR039320A1 (es) 2005-02-16
WO2003089427A1 (en) 2003-10-30
PL373523A1 (en) 2005-09-05
EP1497280A1 (en) 2005-01-19
US6846818B2 (en) 2005-01-25
PA8571601A1 (es) 2003-12-10
GT200300083A (es) 2004-03-29
TW200406405A (en) 2004-05-01
JP2005535576A (ja) 2005-11-24
US20030207897A1 (en) 2003-11-06
CA2484017A1 (en) 2003-10-30
MXPA04010397A (es) 2005-02-17

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]