BR9810955A - "4-5-diaril imidazóis 2-substituìdo" - Google Patents

"4-5-diaril imidazóis 2-substituìdo"

Info

Publication number
BR9810955A
BR9810955A BR9810955-3A BR9810955A BR9810955A BR 9810955 A BR9810955 A BR 9810955A BR 9810955 A BR9810955 A BR 9810955A BR 9810955 A BR9810955 A BR 9810955A
Authority
BR
Brazil
Prior art keywords
replaced
substituent
ring
diseases
compounds
Prior art date
Application number
BR9810955-3A
Other languages
English (en)
Inventor
Laszlo Revesz
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR9810955A publication Critical patent/BR9810955A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Abstract

Patente de Invenção: <B>"4,5-DIARIL IMIDAZóIS 2-SUBSTITUìDO"<D>. Novos 4,5-diarilimidazóis 2-substituído em que: i) o átomo de nitrogênio na posição 1 é substituído por um substituente contendo trialquilsilila, ou ii) o substituente na posição 2 é arilalquila, arilsulfonila, arilseleno de ariltio, arilteluro, cicloalquila, cicloalquenila, alquilcicloalquila, alquilcicloalquenila, amino ou hidrazino, ou N-heterociclila mono ou bicíclica em que o anel contendo N tenha seis membros no anel, são fornecidos, em particular compostos da fórmula I onde R~ 1~,R~ 2~, R~ 3~, e R~ 4~ são conforme definidos, em forma de sal ácido de adição farmaceuticamente aceitável ou de éster fisiologicamente clivável, que têm atividade inibidora da quinase p38 MAP (Quinase de Proteína Ativada por Mitógeno). Os compostos são usados como remédios para o tramento de doenças mediadas or TNF<244> e IL-1, como atrite reumatóide e doenças do metabolismo ósseo, por exemplo, osteoporose.
BR9810955-3A 1997-06-30 1998-06-26 "4-5-diaril imidazóis 2-substituìdo" BR9810955A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9713726.9A GB9713726D0 (en) 1997-06-30 1997-06-30 Organic compounds
PCT/EP1998/003930 WO1999001449A1 (en) 1997-06-30 1998-06-26 2-substituted 4,5-diaryl imidazoles

Publications (1)

Publication Number Publication Date
BR9810955A true BR9810955A (pt) 2000-09-26

Family

ID=10815101

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9810955-3A BR9810955A (pt) 1997-06-30 1998-06-26 "4-5-diaril imidazóis 2-substituìdo"

Country Status (28)

Country Link
US (1) US6300347B1 (pt)
EP (2) EP1396491A3 (pt)
JP (1) JP3704362B2 (pt)
KR (1) KR20010013215A (pt)
CN (1) CN1261885A (pt)
AR (1) AR014886A1 (pt)
AT (1) ATE275557T1 (pt)
AU (1) AU744411B2 (pt)
BR (1) BR9810955A (pt)
CA (1) CA2291758A1 (pt)
CO (1) CO4940462A1 (pt)
DE (1) DE69826127T2 (pt)
ES (1) ES2226164T3 (pt)
GB (1) GB9713726D0 (pt)
HU (1) HUP0003351A3 (pt)
ID (1) ID23385A (pt)
IL (1) IL133034A0 (pt)
NO (1) NO996429L (pt)
NZ (1) NZ501275A (pt)
PE (1) PE99999A1 (pt)
PL (1) PL337057A1 (pt)
PT (1) PT993456E (pt)
RU (1) RU2214408C2 (pt)
SK (1) SK186599A3 (pt)
TR (1) TR199903278T2 (pt)
TW (1) TW429258B (pt)
WO (1) WO1999001449A1 (pt)
ZA (1) ZA985656B (pt)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998007425A1 (en) 1996-08-21 1998-02-26 Smithkline Beecham Corporation Imidazole compounds, compositions and use
US7301021B2 (en) 1997-07-02 2007-11-27 Smithkline Beecham Corporation Substituted imidazole compounds
EP1119254A4 (en) 1998-10-07 2004-05-12 Smithkline Beecham Corp STROKE TREATMENT
EP1143957A3 (en) * 1998-12-16 2002-02-27 Warner-Lambert Company Treatment of arthritis with mek inhibitors
DE60033028T2 (de) * 1999-04-23 2007-11-15 Takeda Pharmaceutical Co. Ltd. 5-pyridyl-1,3-azol-derivate, verfahren zu ihrer herstellung und ihre verwendung
WO2000064872A1 (en) * 1999-04-23 2000-11-02 Vertex Pharmaceuticals Incorporated INHIBITORS OF c-JUN N-TERMINAL KINASES (JNK)
US6291457B1 (en) * 1999-07-01 2001-09-18 Merck & Co., Inc. Compounds having cytokine inhibitory activity
US7122666B2 (en) 1999-07-21 2006-10-17 Sankyo Company, Limited Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses
DE60024480T2 (de) * 1999-10-27 2006-07-27 Novartis Ag Thiazol und imidazo[4,5-b]pyridin verbindungen und ihre verwendung als pharmazeutika
JP2003513977A (ja) 1999-11-10 2003-04-15 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド 置換２−アリール−３−（ヘテロアリール）−イミダゾ［１，２−α］ピリミジン類および関連薬剤組成物および方法
US6808902B1 (en) 1999-11-12 2004-10-26 Amgen Inc. Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
US7026336B1 (en) * 1999-11-22 2006-04-11 Smithkline Beecham P.L.C. Compounds
US7053099B1 (en) 1999-11-23 2006-05-30 Smithkline Beecham Corporation 3,4-dihydro-(1H)quinazolin-2-one compounds as CSBP/p38 kinase inhibitors
US7612065B2 (en) 2000-04-21 2009-11-03 Vertex Pharmaceuticals Incorporated Inhibitors of c-JUN N-terminal kinases (JNK)
OA12552A (en) 2001-03-09 2006-06-06 Pfizer Prod Inc Triazolopyridines as anti-inflammatory agents.
CA2440211A1 (en) 2001-03-09 2002-09-19 Pfizer Products Inc. Benzimidazole anti-inflammatory compounds
ATE304009T1 (de) 2001-04-04 2005-09-15 Pfizer Prod Inc Neue benzotriazole mit entzündungshemmender wirkung
ES2907826T3 (es) 2001-06-26 2022-04-26 Amgen Inc Anticuerpos para OPGL
EP1439174B1 (en) * 2001-10-22 2012-03-21 Mitsubishi Tanabe Pharma Corporation 4-IMIDAZOLIN-2-ONE COMPOUNDS AS p38 MAP KINASE INHIBITORS
AR039241A1 (es) 2002-04-04 2005-02-16 Biogen Inc Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos
DE10222103A1 (de) * 2002-05-17 2003-11-27 Merckle Gmbh Chem Pharm Fabrik 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie
ATE349210T1 (de) 2002-07-09 2007-01-15 Boehringer Ingelheim Pharma Pharazeutische zusammensetzungen aus anticholinergica und p38 kinase hemmern zur behandlung von erkrankungen der atemwege
US7037923B2 (en) 2002-08-30 2006-05-02 Pfizer, Inc. Alkyl-[4-(trifluorophenyl)-oxazol-5-yl]-triazolo-pyridines
US6949652B2 (en) 2002-08-30 2005-09-27 Pfizer, Inc. Crystalline forms of 3-isopropyl-6-[4-(2,5-difluoro-phenyl)-oxazol-5-yl]-[1,2,4]triazolo-[4,3-A]pyridine
US7012143B2 (en) 2002-08-30 2006-03-14 Dombroski Mark A Cycloalkyl-[4-(difluorophenyl)-oxazol-5-yl]-triazolo-pyridines
US7005523B2 (en) 2002-08-30 2006-02-28 Pfizer Inc. Cycloalkyl-[4-(trifluorophenyl)-oxazol-5yl]-triazolo-pyridines
PA8579601A1 (es) 2002-08-30 2004-05-07 Pfizer Prod Inc Compuestos antiinflamatorios de di y trifloruro-triazolo-piridinas
UA80295C2 (en) 2002-09-06 2007-09-10 Biogen Inc Pyrazolopyridines and using the same
WO2004053107A2 (en) * 2002-12-06 2004-06-24 Scios Inc. Methods for treating diabetes
JP2006516548A (ja) 2002-12-30 2006-07-06 アンジオテック インターナショナル アクツィエン ゲゼルシャフト 迅速ゲル化ポリマー組成物からの薬物送達法
CN100422175C (zh) * 2003-04-03 2008-10-01 麦克公司 作为代谢型谷氨酸受体-5调制剂的四环咪唑衍生物
US20040229878A1 (en) * 2003-05-13 2004-11-18 Depuy Spine, Inc. Transdiscal administration of specific inhibitors of P38 kinase
US8273347B2 (en) * 2003-05-13 2012-09-25 Depuy Spine, Inc. Autologous treatment of degenerated disc with cells
US7553827B2 (en) * 2003-08-13 2009-06-30 Depuy Spine, Inc. Transdiscal administration of cycline compounds
US7344716B2 (en) * 2003-05-13 2008-03-18 Depuy Spine, Inc. Transdiscal administration of specific inhibitors of pro-inflammatory cytokines
US8361467B2 (en) 2003-07-30 2013-01-29 Depuy Spine, Inc. Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints
MXPA06001081A (es) * 2003-07-31 2006-04-24 Irm Llc Compuestos biciclicos y composiciones como inhibidores de pdf.
CN100455579C (zh) * 2003-10-02 2009-01-28 Irm责任有限公司 作为蛋白激酶抑制剂的化合物和组合物
US8895540B2 (en) * 2003-11-26 2014-11-25 DePuy Synthes Products, LLC Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor
WO2005063716A1 (en) 2003-12-22 2005-07-14 Janssen Pharmaceutica, N.V. Imidazoles and their use cck-1 receptor modulators
US20060035893A1 (en) 2004-08-07 2006-02-16 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
US7713998B2 (en) 2004-11-10 2010-05-11 Ono Pharmaceutical Co., Ltd. Nitrogenous heterocyclic compound and pharmaceutical use thereof
PE20060777A1 (es) 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
ES2351308T3 (es) * 2005-02-28 2011-02-02 Merckle Gmbh Derivados de imidazol 2-sulfinil- y 2-sulfonil-sustituidos y su uso como inhibidores de citocina.
BRPI0616655A2 (pt) * 2005-10-03 2011-06-28 Ono Pharmaceutical Co composto heterocìclico contendo nitrogênio e aplicação farmacêutica do mesmo
ES2380236T3 (es) 2005-10-28 2012-05-09 Takeda Pharmaceutical Company Limited Compuesto de amida heterocíclica y uso del mismo
ES2301380B1 (es) 2006-08-09 2009-06-08 Laboratorios Almirall S.A. Nuevos derivados de 1,7-naftiridina.
ES2320955B1 (es) 2007-03-02 2010-03-16 Laboratorios Almirall S.A. Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida.
ES2329639B1 (es) 2007-04-26 2010-09-23 Laboratorios Almirall S.A. Nuevos derivados de 4,8-difenilpoliazanaftaleno.
EP1992344A1 (en) 2007-05-18 2008-11-19 Institut Curie P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation
US20100168210A1 (en) * 2007-06-05 2010-07-01 Edwards Iii Carl Keith T-Cell Cytokine-Inducing Surface Molecules and Methods of Use
US20090162351A1 (en) * 2007-12-21 2009-06-25 Depuy Spine, Inc. Transdiscal administration of inhibitors of p38 MAP kinase
US8986696B2 (en) * 2007-12-21 2015-03-24 Depuy Mitek, Inc. Trans-capsular administration of p38 map kinase inhibitors into orthopedic joints
EP2108641A1 (en) 2008-04-11 2009-10-14 Laboratorios Almirall, S.A. New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors
EP2113503A1 (en) 2008-04-28 2009-11-04 Laboratorios Almirall, S.A. New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors
TWI435874B (zh) 2008-10-31 2014-05-01 Toray Industries 環己烷衍生物及其醫藥用途
EP2322176A1 (en) 2009-11-11 2011-05-18 Almirall, S.A. New 7-phenyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives
EP2516668B1 (en) * 2009-12-22 2016-04-06 Csir Inhibition of the activity of kinase and synthetase enzymes
JP2013523766A (ja) * 2010-03-31 2013-06-17 グラクソ グループ リミテッド キナーゼ阻害剤としてのイミダゾリル‐イミダゾール
WO2017151409A1 (en) 2016-02-29 2017-09-08 University Of Florida Research Foundation, Incorporated Chemotherapeutic methods

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69322254T2 (de) * 1992-01-13 1999-04-29 Smithkline Beecham Corp Pyridyl-substituierte imidazole
MX9300141A (es) * 1992-01-13 1994-07-29 Smithkline Beecham Corp Compuestos de imidazol novedosos, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
US5916891A (en) 1992-01-13 1999-06-29 Smithkline Beecham Corporation Pyrimidinyl imidazoles
ZA945363B (en) * 1993-07-21 1995-03-14 Smithkline Beecham Corp Novel compounds
US5620999A (en) * 1994-07-28 1997-04-15 Weier; Richard M. Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation
US5717100A (en) * 1995-10-06 1998-02-10 Merck & Co., Inc. Substituted imidazoles having anti-cancer and cytokine inhibitory activity
IL123950A (en) * 1995-10-06 2001-04-30 Merck & Co Inc Transformed imidazoles with anti-cancer and cytokine-inhibiting activity and pharmaceutical preparations containing them
DE69816109T2 (de) 1997-04-24 2004-04-22 Ortho-Mcneil Pharmaceutical, Inc. Substituierte imidazole zur behandlung von entzündlichen krankheiten
AU742293B2 (en) 1997-06-12 2001-12-20 Aventis Pharma Limited Imidazolyl-cyclic acetals
CA2294137A1 (en) 1997-06-19 1998-12-23 Smithkline Beecham Corporation Novel aryloxy substituted pyrimidine imidazole compounds
IL133766A0 (en) 1997-06-30 2001-04-30 Ortho Mcneil Pharm Inc 2-substituted imidazoles useful in the treatment of inflammatory diseases
TW517055B (en) 1997-07-02 2003-01-11 Smithkline Beecham Corp Novel substituted imidazole compounds
WO1999001452A1 (en) 1997-07-02 1999-01-14 Smithkline Beecham Corporation Novel cycloalkyl substituted imidazoles
AR016294A1 (es) 1997-07-02 2001-07-04 Smithkline Beecham Corp Compuesto de imidazol sustituido, composicion farmaceutica que la contiene, su uso en la fabricacion de un medicamento y procedimiento para supreparacion
FR2772377B1 (fr) 1997-12-12 2000-01-07 Synthelabo Derives de 1-(1-h-imidazol-2-yl)pyrrolidines et 1-(1-h-imidazol-2-ylpiperidines), leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
EP0993456B1 (en) 2004-09-08
JP2001506280A (ja) 2001-05-15
HUP0003351A2 (hu) 2001-06-28
PE99999A1 (es) 1999-11-01
SK186599A3 (en) 2000-06-12
NO996429D0 (no) 1999-12-23
DE69826127T2 (de) 2005-09-29
EP1396491A2 (en) 2004-03-10
CN1261885A (zh) 2000-08-02
AU8801598A (en) 1999-01-25
ID23385A (id) 2000-04-20
RU2214408C2 (ru) 2003-10-20
ATE275557T1 (de) 2004-09-15
PL337057A1 (en) 2000-07-31
AU744411B2 (en) 2002-02-21
KR20010013215A (ko) 2001-02-26
EP1396491A3 (en) 2004-06-30
JP3704362B2 (ja) 2005-10-12
TR199903278T2 (en) 2000-07-21
CO4940462A1 (es) 2000-07-24
HUP0003351A3 (en) 2002-01-28
US6300347B1 (en) 2001-10-09
PT993456E (pt) 2005-01-31
IL133034A0 (en) 2001-03-19
AR014886A1 (es) 2001-04-11
GB9713726D0 (en) 1997-09-03
NO996429L (no) 1999-12-23
ZA985656B (en) 1998-12-30
NZ501275A (en) 2002-04-26
CA2291758A1 (en) 1999-01-14
ES2226164T3 (es) 2005-03-16
DE69826127D1 (de) 2004-10-14
WO1999001449A1 (en) 1999-01-14
EP0993456A1 (en) 2000-04-19
TW429258B (en) 2001-04-11

Similar Documents

Publication Publication Date Title
BR9810955A (pt) &#34;4-5-diaril imidazóis 2-substituìdo&#34;
BR0314372A (pt) Compostos imidazol como inibidores do fator de crescimento tranformador (tgf)
BR9911488A (pt) Composto, uso do mesmo, composição farmacêutica, e, processos para tratamento ou de profilaxia de doenças inflamatórias, e para a preparação de um composto
NO20042298L (no) Farmasoytiske preparater og deres anvendelser
BR9911482A (pt) Composto, composição farmacêutica, uso do composto, e, processos para o tratamento ou profilaxia de doenças inflamatórias, e para a preparação de um composto
BR9907270A (pt) Composto, composição farmacêutica, uso de um composto, e, processos para tratamento ou profilaxia de doenças inflamatórias, por exemplo, asma ou copd, e para a preparação de um composto
DK1427708T3 (da) Amino-phthalazinon-derivater som kinase-inhibitorer, fremgangsmåde til deres fremstilling og farmaceutiske sammensætninger der indeholder det samme
LU91145I9 (pt)
WO2001042231A3 (en) Polyhydroxystilbenes and stilbene oxides as antisoriatic agents and protein kinase inhibitors
BR0316234A (pt) Hidroxiindóis, seu uso como inibidores de fosfodiesterase 4 e processos para a preparação dos mesmos
AP2004003069A0 (en) 3-beta-d-ribofuranosynthiazolo [4-5-d] pyridimine nucleosides and uses thereof.
SE9701398D0 (sv) Novel compounds
ATE388951T1 (de) Dpp-iv-inhibierende purin-derivative zur behandlung von diabetes
BR0312464A (pt) Inibidores de tirosina quinases
MXPA02012272A (es) Compuestos heterociclicos que son inhibidores de la enzima dipeptidilpeptidasa-iv.
ATE267200T1 (de) Bicyclische kinase inhibitoren
HUP0402270A2 (hu) [1,2,4]Triazolo[1,5-c]pirimidin-5-il-aminok mint adenozin A2a receptor antagonisták és az ezeket tartalmazó gyógyszerkészítmények
BR9811093A (pt) Piridinas substituìdas com 2-amino-6-(4-fenóxi 2-substituìdo)
KR870700599A (ko) 카르복실산유도체, 그의 제조방법, 이화합물을 함유한 약제조성물 및 그의 용도
BR0113590A (pt) 7-oxo-piridopirimidinas
BR0012610A (pt) Novo derivado de difenilpiperidina
NO178261C (no) Substituerte diaminoftalimider og analoger, farmasöytiske preparater inneholdende dem samt deres anvendelse i medikamenter
WO2001092218A3 (en) Polyamine analogues as therapeutic and diagnostic agents
BR9809234A (pt) Composto, composição farmacêutica, uso de um composto, processos para tratar ou prevenir doenças do sistema endocrinológico, para fabricar um medicamento, para preparar um composto e um conjunto, conjunto, e, uso do mesmo.
AU2003260436A1 (en) Pyrimidine compounds

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A,8A E 9A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1909 DE 07/08/2007.