HUP0402270A2 - [1,2,4]Triazolo[1,5-c]pirimidin-5-il-aminok mint adenozin A2a receptor antagonisták és az ezeket tartalmazó gyógyszerkészítmények - Google Patents
[1,2,4]Triazolo[1,5-c]pirimidin-5-il-aminok mint adenozin A2a receptor antagonisták és az ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0402270A2 HUP0402270A2 HU0402270A HUP0402270A HUP0402270A2 HU P0402270 A2 HUP0402270 A2 HU P0402270A2 HU 0402270 A HU0402270 A HU 0402270A HU P0402270 A HUP0402270 A HU P0402270A HU P0402270 A2 HUP0402270 A2 HU P0402270A2
- Authority
- HU
- Hungary
- Prior art keywords
- triazolo
- pyrimidin
- adenosine
- amines
- pharmaceutical compositions
- Prior art date
Links
- 229940123702 Adenosine A2a receptor antagonist Drugs 0.000 title 1
- WLMIXIOSYFFELW-UHFFFAOYSA-N [1,2,4]triazolo[1,5-c]pyrimidin-5-amine Chemical class NC1=NC=CC2=NC=NN12 WLMIXIOSYFFELW-UHFFFAOYSA-N 0.000 title 1
- 239000002467 adenosine A2a receptor antagonist Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 208000023516 stroke disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A jelen találmány (I) általános képletű vegyületekre vagy ezekgyógyászatilag elfogadható sóira vagy szolvátjaira vonatkozik, melyképletben R, R2 és R3 jelentése a leírásban megadott. A találmánytovábbá ezeket a vegyületeket tartalmazó és stroke vagy központiidegrendszeri betegségek kezelésére szolgáló gyógyszerkészítményekreis vonatkozik. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33429301P | 2001-11-30 | 2001-11-30 | |
PCT/US2002/038134 WO2003048164A2 (en) | 2001-11-30 | 2002-11-26 | Adenosine a2a receptor antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0402270A2 true HUP0402270A2 (hu) | 2005-02-28 |
HUP0402270A3 HUP0402270A3 (en) | 2008-09-29 |
Family
ID=23306533
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0402270A HUP0402270A3 (en) | 2001-11-30 | 2002-11-26 | [1,2,4]triazolo[1,5-c]pyrimidin-5-yl-amines as adenosine a2a receptor antagonists and pharmaceutical compositions containing them |
Country Status (19)
Country | Link |
---|---|
US (1) | US7041666B2 (hu) |
EP (1) | EP1453835B1 (hu) |
JP (2) | JP4284181B2 (hu) |
KR (1) | KR20050044607A (hu) |
CN (1) | CN1596258A (hu) |
AR (1) | AR038366A1 (hu) |
AT (1) | ATE317844T1 (hu) |
AU (1) | AU2002346572A1 (hu) |
CA (1) | CA2468681C (hu) |
DE (1) | DE60209251T2 (hu) |
ES (1) | ES2258164T3 (hu) |
HK (1) | HK1064100A1 (hu) |
HU (1) | HUP0402270A3 (hu) |
IL (1) | IL161572A0 (hu) |
MX (1) | MXPA04005156A (hu) |
PE (1) | PE20030739A1 (hu) |
TW (1) | TW200300686A (hu) |
WO (1) | WO2003048164A2 (hu) |
ZA (1) | ZA200404160B (hu) |
Families Citing this family (29)
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EP1544200A1 (en) * | 2002-09-24 | 2005-06-22 | Kyowa Hakko Kogyo Co., Ltd. | 1,2,4 -TRIAZOLO 1,5-c PYRIMIDINE DERIVATIVE |
CN100415217C (zh) | 2002-12-19 | 2008-09-03 | 先灵公司 | 腺苷A2a受体拮抗剂的应用 |
US20060106040A1 (en) | 2002-12-19 | 2006-05-18 | Michael Grzelak | Adenosine A2a receptor antagonists for the treatment of extra-pyramidal syndrome and other movement disorders |
EP1618109A2 (en) * | 2003-04-09 | 2006-01-25 | Biogen Idec MA Inc. | Triazolo[1,5-c]pyrimidines and pyrazolo[1,5-c]pyrimidines useful as a2a adenosine receptor antagonists |
AU2004283751B2 (en) * | 2003-10-24 | 2011-05-19 | Exelixis, Inc. | p70S6 kinase modulators and method of use |
AR050926A1 (es) * | 2004-09-03 | 2006-12-06 | Astrazeneca Ab | Derivados de benzamida como inhibidores de la histonadesacetilasa(hdac) |
JPWO2006129626A1 (ja) * | 2005-05-30 | 2009-01-08 | 協和醗酵工業株式会社 | [1,2,4]トリアゾロ[1,5−c]ピリミジン誘導体の製造法 |
ES2273599B1 (es) | 2005-10-14 | 2008-06-01 | Universidad De Barcelona | Compuestos para el tratamiento de la fibrilacion auricular. |
US8835631B2 (en) | 2007-05-24 | 2014-09-16 | Mitsubishi Tanabe Pharma Corporation | Therapeutic agent for cerebral infarction |
US20110002855A1 (en) * | 2007-06-25 | 2011-01-06 | Neurogen Corporation | Piperazinyl oxoalkyl tetrahydro-beta-carbolines and related analogues |
US20100093764A1 (en) * | 2008-10-13 | 2010-04-15 | Devraj Chakravarty | AMINES AND SULFOXIDES OF THIENO[2,3-d]PYRIMIDINE AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS |
US20100093756A1 (en) * | 2008-10-13 | 2010-04-15 | Berbay J Kent | HETEROARYL SUBSTITUTED THIENO[2,3-d]PYRIMIDINE AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS |
CN102224550B (zh) | 2008-11-25 | 2013-01-16 | 日产自动车株式会社 | 导电构件及使用其的固体高分子型燃料电池 |
JP5807971B2 (ja) * | 2009-04-27 | 2015-11-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Cxcr3受容体アンタゴニスト |
US8952004B2 (en) | 2010-01-07 | 2015-02-10 | Boehringer Ingelheim International Gmbh | CXCR3 receptor antagonists |
JP5843869B2 (ja) * | 2010-09-24 | 2016-01-13 | アドヴィナス・セラピューティックス・リミテッド | アデノシン受容体拮抗薬としての縮合三環化合物 |
WO2012127472A1 (en) * | 2011-03-22 | 2012-09-27 | Mapi Pharma Ltd. | Process and intermediates for the preparation of preladenant and related compounds |
US11117899B2 (en) * | 2017-04-07 | 2021-09-14 | Medshine Discovery Inc. | [1,2,4]triazolo[1,5-c]pyrimidine derivative as A2A receptor inhibitor |
AU2019227607C1 (en) * | 2018-02-27 | 2023-07-20 | Incyte Corporation | Imidazopyrimidines and triazolopyrimidines as A2A / A2B inhibitors |
EP3766884B1 (en) * | 2018-04-28 | 2022-02-09 | Medshine Discovery Inc. | Crystal form and salt type of triazolopyrimidine compound and preparation method therefor |
CA3100731A1 (en) | 2018-05-18 | 2019-11-21 | Incyte Corporation | Fused pyrimidine derivatives as a2a / a2b inhibitors |
WO2020010197A1 (en) | 2018-07-05 | 2020-01-09 | Incyte Corporation | Fused pyrazine derivatives as a2a / a2b inhibitors |
AR116315A1 (es) * | 2018-09-12 | 2021-04-21 | Dizal Jiangsu Pharmaceutical Co Ltd | Compuestos de triazolo-pirimidina y usos de los mismos |
EP3883576A4 (en) * | 2018-11-20 | 2022-06-22 | Merck Sharp & Dohme Corp. | SUBSTITUTED AMINOTRIAZOLOPYRIMIDINES AND AMINO-TRIAZOLOPYRAZINE ADENOSINE RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS AND THEIR USE |
CN113015530A (zh) | 2018-11-20 | 2021-06-22 | 默沙东公司 | 取代的氨基三唑并嘧啶和氨基三唑并吡嗪腺苷受体拮抗剂、药物组合物及其用途 |
JOP20210117A1 (ar) | 2018-11-30 | 2023-01-30 | Merck Sharp & Dohme | مشتقات أمينو ترايازولو كوينازولين بها استبدال في الموضع-9 كمضادات مستقبل أدينوزين، تركيبات صيدلانية واستخدامها |
PE20220277A1 (es) | 2018-12-20 | 2022-02-25 | Incyte Corp | Compuestos de imidazopiridazina e imidazopiridina como inhibidores de quinasa-2 de tipo receptor de activina |
WO2020128036A1 (en) * | 2018-12-21 | 2020-06-25 | Ryvu Therapeutics S.A. | Modulators of the adenosine a2a receptor |
TWI829857B (zh) * | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU622330B2 (en) | 1989-06-23 | 1992-04-02 | Takeda Chemical Industries Ltd. | Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides |
IT1264901B1 (it) | 1993-06-29 | 1996-10-17 | Schering Plough S P A | Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina |
AU7237294A (en) | 1993-07-27 | 1995-02-28 | Kyowa Hakko Kogyo Co. Ltd. | Remedy for parkinson's disease |
IT1277392B1 (it) | 1995-07-28 | 1997-11-10 | Schering Plough S P A | Analoghi eterociclici di 1,2,4-triazolo(1,5-c]pirimidine ad attivita' antagonista per il recettore a2a dell'adenosina |
ATE257156T1 (de) * | 1997-03-24 | 2004-01-15 | Kyowa Hakko Kogyo Kk | (1,2,4)triazolo(1,5-c)pyrimidin-derivate |
IT1291372B1 (it) | 1997-05-21 | 1999-01-07 | Schering Plough S P A | Uso di analoghi eterociclici di 1,2,4-triazolo (1,5-c) pirimidine per la preparazione di medicamenti utili per il trattamento delle malattie |
CN1328560A (zh) * | 1998-09-22 | 2001-12-26 | 协和发酵工业株式会社 | [1,2,4]三唑并[1,5-c]嘧啶衍生物 |
MY132006A (en) | 2000-05-26 | 2007-09-28 | Schering Corp | ADENOSINE A2a RECEPTOR ANTAGONISTS |
WO2002079204A1 (fr) * | 2001-03-28 | 2002-10-10 | Kyowa Hakko Kogyo Co., Ltd. | Derive 8-thiazolyl[1,2,4]triazolo[1,5-c]pyrimidine |
ES2283625T3 (es) | 2001-11-30 | 2007-11-01 | Schering Corporation | Antagonistas del receptopr a2a de adenosina de (1,2,4)-triazol biciclicos. |
-
2002
- 2002-11-25 PE PE2002001128A patent/PE20030739A1/es not_active Application Discontinuation
- 2002-11-25 TW TW091134178A patent/TW200300686A/zh unknown
- 2002-11-25 AR ARP020104528A patent/AR038366A1/es unknown
- 2002-11-26 CN CNA028239229A patent/CN1596258A/zh active Pending
- 2002-11-26 AU AU2002346572A patent/AU2002346572A1/en not_active Abandoned
- 2002-11-26 WO PCT/US2002/038134 patent/WO2003048164A2/en active IP Right Grant
- 2002-11-26 KR KR1020047008031A patent/KR20050044607A/ko not_active Application Discontinuation
- 2002-11-26 JP JP2003549354A patent/JP4284181B2/ja not_active Expired - Fee Related
- 2002-11-26 EP EP02784641A patent/EP1453835B1/en not_active Expired - Lifetime
- 2002-11-26 US US10/304,504 patent/US7041666B2/en not_active Expired - Lifetime
- 2002-11-26 AT AT02784641T patent/ATE317844T1/de not_active IP Right Cessation
- 2002-11-26 DE DE60209251T patent/DE60209251T2/de not_active Expired - Lifetime
- 2002-11-26 HU HU0402270A patent/HUP0402270A3/hu unknown
- 2002-11-26 MX MXPA04005156A patent/MXPA04005156A/es active IP Right Grant
- 2002-11-26 ES ES02784641T patent/ES2258164T3/es not_active Expired - Lifetime
- 2002-11-26 IL IL16157202A patent/IL161572A0/xx unknown
- 2002-11-26 CA CA2468681A patent/CA2468681C/en not_active Expired - Fee Related
-
2004
- 2004-05-27 ZA ZA200404160A patent/ZA200404160B/en unknown
- 2004-09-11 HK HK04106913A patent/HK1064100A1/xx not_active IP Right Cessation
-
2008
- 2008-06-04 JP JP2008147394A patent/JP2008303217A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AR038366A1 (es) | 2005-01-12 |
HK1064100A1 (en) | 2005-01-21 |
MXPA04005156A (es) | 2004-08-11 |
KR20050044607A (ko) | 2005-05-12 |
US7041666B2 (en) | 2006-05-09 |
EP1453835A2 (en) | 2004-09-08 |
EP1453835B1 (en) | 2006-02-15 |
CA2468681C (en) | 2011-01-25 |
CA2468681A1 (en) | 2003-06-12 |
WO2003048164A3 (en) | 2003-10-16 |
US20030212080A1 (en) | 2003-11-13 |
IL161572A0 (en) | 2004-09-27 |
DE60209251D1 (de) | 2006-04-20 |
ES2258164T3 (es) | 2006-08-16 |
ATE317844T1 (de) | 2006-03-15 |
CN1596258A (zh) | 2005-03-16 |
TW200300686A (en) | 2003-06-16 |
JP2008303217A (ja) | 2008-12-18 |
PE20030739A1 (es) | 2003-08-28 |
JP4284181B2 (ja) | 2009-06-24 |
HUP0402270A3 (en) | 2008-09-29 |
WO2003048164A2 (en) | 2003-06-12 |
DE60209251T2 (de) | 2006-11-09 |
JP2005511698A (ja) | 2005-04-28 |
ZA200404160B (en) | 2005-04-08 |
AU2002346572A1 (en) | 2003-06-17 |
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Legal Events
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FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |