HUP0303329A2 - Új fenil-piperazinok - Google Patents
Új fenil-piperazinokInfo
- Publication number
- HUP0303329A2 HUP0303329A2 HU0303329A HUP0303329A HUP0303329A2 HU P0303329 A2 HUP0303329 A2 HU P0303329A2 HU 0303329 A HU0303329 A HU 0303329A HU P0303329 A HUP0303329 A HU P0303329A HU P0303329 A2 HUP0303329 A2 HU P0303329A2
- Authority
- HU
- Hungary
- Prior art keywords
- new
- phenylpiperzines
- formula
- disease
- partial
- Prior art date
Links
- 101150049660 DRD2 gene Proteins 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000004885 piperazines Chemical class 0.000 abstract 1
- 239000000018 receptor agonist Substances 0.000 abstract 1
- 229940044601 receptor agonist Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
A találmány tárgyát az (1) általános képletű új piperazinszármazékokképezik, ahol a képletben szereplő -R jelentése a leírásban megadott(a) vagy (b) képletű csoport vagy azok gyógyszerészetileg elfogadhatósói. A jelen találmány szerinti vegyületek (részleges) D2 receptoragonisták és alkalmasak központi idegrendszeri betegségek, különösen aParkinson-kór kezelésére. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01200609 | 2001-02-21 | ||
| PCT/EP2002/001793 WO2002066472A1 (en) | 2001-02-21 | 2002-02-19 | New phenylpiperazines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0303329A2 true HUP0303329A2 (hu) | 2004-01-28 |
| HUP0303329A3 HUP0303329A3 (en) | 2008-12-29 |
Family
ID=8179908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0303329A HUP0303329A3 (en) | 2001-02-21 | 2002-02-19 | New phenylpiperzines |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US6828325B2 (hu) |
| EP (1) | EP1395583B1 (hu) |
| JP (1) | JP4178033B2 (hu) |
| KR (1) | KR100848482B1 (hu) |
| CN (1) | CN1190433C (hu) |
| AR (1) | AR032711A1 (hu) |
| AT (1) | ATE289604T1 (hu) |
| AU (1) | AU2002253043B2 (hu) |
| BR (1) | BR0205220A (hu) |
| CA (1) | CA2411973A1 (hu) |
| CZ (1) | CZ299487B6 (hu) |
| DE (1) | DE60203042T2 (hu) |
| DK (1) | DK1395583T3 (hu) |
| DZ (1) | DZ3441A1 (hu) |
| ES (1) | ES2235029T3 (hu) |
| HK (1) | HK1059781A1 (hu) |
| HU (1) | HUP0303329A3 (hu) |
| IL (1) | IL153176A (hu) |
| MX (1) | MXPA03004242A (hu) |
| NO (1) | NO323781B1 (hu) |
| NZ (1) | NZ523135A (hu) |
| PL (1) | PL359650A1 (hu) |
| PT (1) | PT1395583E (hu) |
| RU (1) | RU2279431C2 (hu) |
| SI (1) | SI1395583T1 (hu) |
| SK (1) | SK286064B6 (hu) |
| UA (1) | UA74426C2 (hu) |
| WO (1) | WO2002066472A1 (hu) |
| ZA (1) | ZA200209897B (hu) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2246494C2 (ru) | 1999-08-23 | 2005-02-20 | Солвей Фармасьютикалс Б.В. | Новые фенилпиперазины |
| AR032712A1 (es) | 2001-02-21 | 2003-11-19 | Solvay Pharm Bv | Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen |
| US7504395B2 (en) * | 2001-07-20 | 2009-03-17 | Psychogenics, Inc. | Treatment for attention-deficit hyperactivity disorder |
| EP1683790A1 (en) * | 2005-01-24 | 2006-07-26 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | 3,4-dihydro-2-naphthamide derivatives as selective dopamine D3 ligands |
| GB0708818D0 (en) | 2007-05-08 | 2007-06-13 | Portela & Ca Sa | Compounds |
| WO2011082266A2 (en) | 2009-12-30 | 2011-07-07 | Arqule, Inc. | Substituted heterocyclic compounds |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0900792B1 (en) | 1997-09-02 | 2003-10-29 | Duphar International Research B.V | Piperazine and piperidine derivatives as 5-HT1A and dopamine D2-receptor (ant)agonists |
| AU765317C (en) * | 1998-06-19 | 2004-05-20 | H. Lundbeck A/S | 4,5,6 and 7-indole and indoline derivatives, their preparation and use |
| AR020773A1 (es) * | 1998-10-16 | 2002-05-29 | Duphar Int Res | Compuesto derivados de 3-(tetrahidropiridin-4-il)indol, metodo para prepararlo, una composicion farmaceutica que los contiene, metodo para preparar dicha composicion y uso del compuesto |
| RU2246494C2 (ru) | 1999-08-23 | 2005-02-20 | Солвей Фармасьютикалс Б.В. | Новые фенилпиперазины |
| EP1336406A1 (en) | 2002-02-14 | 2003-08-20 | Solvay Pharmaceuticals B.V. | Partial dopamine-D2 receptor agonist plus serotonin and/or noradrenaline inhibitory activity |
-
2002
- 2002-02-18 AR ARP020100547A patent/AR032711A1/es active IP Right Grant
- 2002-02-19 SK SK1805-2002A patent/SK286064B6/sk not_active IP Right Cessation
- 2002-02-19 DK DK02722107T patent/DK1395583T3/da active
- 2002-02-19 KR KR1020027016845A patent/KR100848482B1/ko not_active IP Right Cessation
- 2002-02-19 ES ES02722107T patent/ES2235029T3/es not_active Expired - Lifetime
- 2002-02-19 CN CNB02801684XA patent/CN1190433C/zh not_active Expired - Fee Related
- 2002-02-19 CZ CZ20023933A patent/CZ299487B6/cs not_active IP Right Cessation
- 2002-02-19 PL PL02359650A patent/PL359650A1/xx not_active IP Right Cessation
- 2002-02-19 CA CA002411973A patent/CA2411973A1/en not_active Abandoned
- 2002-02-19 HU HU0303329A patent/HUP0303329A3/hu unknown
- 2002-02-19 SI SI200230087T patent/SI1395583T1/xx unknown
- 2002-02-19 PT PT02722107T patent/PT1395583E/pt unknown
- 2002-02-19 WO PCT/EP2002/001793 patent/WO2002066472A1/en active IP Right Grant
- 2002-02-19 AT AT02722107T patent/ATE289604T1/de active
- 2002-02-19 MX MXPA03004242A patent/MXPA03004242A/es active IP Right Grant
- 2002-02-19 IL IL153176A patent/IL153176A/en not_active IP Right Cessation
- 2002-02-19 NZ NZ523135A patent/NZ523135A/en unknown
- 2002-02-19 US US10/343,232 patent/US6828325B2/en not_active Expired - Fee Related
- 2002-02-19 EP EP02722107A patent/EP1395583B1/en not_active Expired - Lifetime
- 2002-02-19 RU RU2003106194/04A patent/RU2279431C2/ru not_active IP Right Cessation
- 2002-02-19 DZ DZ023441A patent/DZ3441A1/fr active
- 2002-02-19 UA UA2003098663A patent/UA74426C2/uk unknown
- 2002-02-19 DE DE60203042T patent/DE60203042T2/de not_active Expired - Lifetime
- 2002-02-19 JP JP2002565986A patent/JP4178033B2/ja not_active Expired - Fee Related
- 2002-02-19 AU AU2002253043A patent/AU2002253043B2/en not_active Ceased
- 2002-02-19 BR BR0205220-2A patent/BR0205220A/pt not_active Application Discontinuation
- 2002-12-05 ZA ZA200209897A patent/ZA200209897B/en unknown
- 2002-12-09 NO NO20025902A patent/NO323781B1/no not_active IP Right Cessation
-
2004
- 2004-04-15 HK HK04102632A patent/HK1059781A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |