BR0205220A - Derivados de fenilpiperazina, método para a preparação de um composto, composição farmacêutica, e, métodos de tratamento do mal de parkinson, e de distúrbios de cns tais como esquizofrenia, ansiedade e depressão - Google Patents

Derivados de fenilpiperazina, método para a preparação de um composto, composição farmacêutica, e, métodos de tratamento do mal de parkinson, e de distúrbios de cns tais como esquizofrenia, ansiedade e depressão

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Publication number
BR0205220A
BR0205220A BR0205220-2A BR0205220A BR0205220A BR 0205220 A BR0205220 A BR 0205220A BR 0205220 A BR0205220 A BR 0205220A BR 0205220 A BR0205220 A BR 0205220A
Authority
BR
Brazil
Prior art keywords
schizophrenia
anxiety
depression
disease
compound
Prior art date
Application number
BR0205220-2A
Other languages
English (en)
Inventor
Roelof W Feenstra
Eric Ronken
Cornelis G Kruse
Andrew C Mccreary
Gustaaf J M Van Scharrenburg
Original Assignee
Solvay Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv
Publication of BR0205220A publication Critical patent/BR0205220A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06Peri-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"DERIVADOS DE FENILPIPERAZINA, MéTODO PARA A PREPARAçãO DE UM COMPOSTO, COMPOSIçãO FARMACêUTICA, E, MéTODOS DE TRATAMENTO DO MAL DE PARKINSON, E DE DISTúRBIOS DE CNS TAIS COMO ESQUIZOFRENIA, ANSIEDADE E DEPRESSãO". A invenção diz respeito a novos derivados de fenilpiperazina da fórmula em que:- R representa o grupo (a) ou (b) conforme indicado no relatório. Esses compostos são agonistas (parciais) de receptores D2 e são úteis para o tratamento de distúrbios do CNS, em particular o mal de Parkinson.
BR0205220-2A 2001-02-21 2002-02-19 Derivados de fenilpiperazina, método para a preparação de um composto, composição farmacêutica, e, métodos de tratamento do mal de parkinson, e de distúrbios de cns tais como esquizofrenia, ansiedade e depressão BR0205220A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01200609 2001-02-21
PCT/EP2002/001793 WO2002066472A1 (en) 2001-02-21 2002-02-19 New phenylpiperazines

Publications (1)

Publication Number Publication Date
BR0205220A true BR0205220A (pt) 2003-06-24

Family

ID=8179908

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0205220-2A BR0205220A (pt) 2001-02-21 2002-02-19 Derivados de fenilpiperazina, método para a preparação de um composto, composição farmacêutica, e, métodos de tratamento do mal de parkinson, e de distúrbios de cns tais como esquizofrenia, ansiedade e depressão

Country Status (29)

Country Link
US (1) US6828325B2 (pt)
EP (1) EP1395583B1 (pt)
JP (1) JP4178033B2 (pt)
KR (1) KR100848482B1 (pt)
CN (1) CN1190433C (pt)
AR (1) AR032711A1 (pt)
AT (1) ATE289604T1 (pt)
AU (1) AU2002253043B2 (pt)
BR (1) BR0205220A (pt)
CA (1) CA2411973A1 (pt)
CZ (1) CZ299487B6 (pt)
DE (1) DE60203042T2 (pt)
DK (1) DK1395583T3 (pt)
DZ (1) DZ3441A1 (pt)
ES (1) ES2235029T3 (pt)
HK (1) HK1059781A1 (pt)
HU (1) HUP0303329A3 (pt)
IL (1) IL153176A (pt)
MX (1) MXPA03004242A (pt)
NO (1) NO323781B1 (pt)
NZ (1) NZ523135A (pt)
PL (1) PL359650A1 (pt)
PT (1) PT1395583E (pt)
RU (1) RU2279431C2 (pt)
SI (1) SI1395583T1 (pt)
SK (1) SK286064B6 (pt)
UA (1) UA74426C2 (pt)
WO (1) WO2002066472A1 (pt)
ZA (1) ZA200209897B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1212320T1 (en) * 1999-08-23 2005-10-31 Solvay Pharmaceuticals B.V. Phenylpiperazines as serotonin reuptake inhibitors
AR032712A1 (es) 2001-02-21 2003-11-19 Solvay Pharm Bv Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen
JP5080716B2 (ja) 2001-07-20 2012-11-21 サイコジェニックス・インコーポレーテッド 注意欠陥・多動性障害の治療
EP1683790A1 (en) * 2005-01-24 2006-07-26 Institut National De La Sante Et De La Recherche Medicale (Inserm) 3,4-dihydro-2-naphthamide derivatives as selective dopamine D3 ligands
GB0708818D0 (en) * 2007-05-08 2007-06-13 Portela & Ca Sa Compounds
WO2011082266A2 (en) 2009-12-30 2011-07-07 Arqule, Inc. Substituted heterocyclic compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0900792B1 (en) * 1997-09-02 2003-10-29 Duphar International Research B.V Piperazine and piperidine derivatives as 5-HT1A and dopamine D2-receptor (ant)agonists
NZ508506A (en) * 1998-06-19 2004-01-30 H 4,5,6 and 7-indole and indoline derivatives, their preparation and use
AR020773A1 (es) * 1998-10-16 2002-05-29 Duphar Int Res Compuesto derivados de 3-(tetrahidropiridin-4-il)indol, metodo para prepararlo, una composicion farmaceutica que los contiene, metodo para preparar dicha composicion y uso del compuesto
SI1212320T1 (en) 1999-08-23 2005-10-31 Solvay Pharmaceuticals B.V. Phenylpiperazines as serotonin reuptake inhibitors
EP1336406A1 (en) 2002-02-14 2003-08-20 Solvay Pharmaceuticals B.V. Partial dopamine-D2 receptor agonist plus serotonin and/or noradrenaline inhibitory activity

Also Published As

Publication number Publication date
ATE289604T1 (de) 2005-03-15
NO323781B1 (no) 2007-07-02
HUP0303329A2 (hu) 2004-01-28
EP1395583B1 (en) 2005-02-23
KR100848482B1 (ko) 2008-07-28
CN1190433C (zh) 2005-02-23
US20030162791A1 (en) 2003-08-28
KR20030072215A (ko) 2003-09-13
CZ299487B6 (cs) 2008-08-13
HK1059781A1 (en) 2004-07-16
DE60203042D1 (de) 2005-03-31
ZA200209897B (en) 2004-03-05
US6828325B2 (en) 2004-12-07
NZ523135A (en) 2005-02-25
SK18052002A3 (sk) 2003-05-02
PL359650A1 (en) 2004-08-23
MXPA03004242A (es) 2003-09-22
AU2002253043B2 (en) 2006-06-08
RU2279431C2 (ru) 2006-07-10
EP1395583A1 (en) 2004-03-10
HUP0303329A3 (en) 2008-12-29
ES2235029T3 (es) 2005-07-01
UA74426C2 (uk) 2005-12-15
IL153176A (en) 2012-10-31
WO2002066472A1 (en) 2002-08-29
NO20025902L (no) 2002-12-09
JP4178033B2 (ja) 2008-11-12
CZ20023933A3 (cs) 2003-03-12
DE60203042T2 (de) 2006-01-19
NO20025902D0 (no) 2002-12-09
SK286064B6 (sk) 2008-02-05
JP2004518746A (ja) 2004-06-24
CN1463269A (zh) 2003-12-24
DZ3441A1 (fr) 2002-08-29
CA2411973A1 (en) 2002-08-29
DK1395583T3 (da) 2005-03-29
PT1395583E (pt) 2005-06-30
SI1395583T1 (pt) 2005-08-31
AR032711A1 (es) 2003-11-19
IL153176A0 (en) 2003-06-24

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B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DA INT:CL: C07D 413/12

Ipc: C07D 413/12 (2006.01), A61P 25/16 (2006.01), A61P

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.