JOP20210117A1 - مشتقات أمينو ترايازولو كوينازولين بها استبدال في الموضع-9 كمضادات مستقبل أدينوزين، تركيبات صيدلانية واستخدامها - Google Patents
مشتقات أمينو ترايازولو كوينازولين بها استبدال في الموضع-9 كمضادات مستقبل أدينوزين، تركيبات صيدلانية واستخدامهاInfo
- Publication number
- JOP20210117A1 JOP20210117A1 JOP/2021/0117A JOP20210117A JOP20210117A1 JO P20210117 A1 JOP20210117 A1 JO P20210117A1 JO P20210117 A JOP20210117 A JO P20210117A JO P20210117 A1 JOP20210117 A1 JO P20210117A1
- Authority
- JO
- Jordan
- Prior art keywords
- pharmaceutical compositions
- substituted amino
- receptor antagonists
- adenosine receptor
- quinazoline derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
يتعلق الاختراع الحالي، في تجسيماته المتعددة، بتوفير مركبات أمينو ترايازولو كوينازولين بها استبدال في الموضع-9 بالصيغة البنيوية (I): (I)، وأملاح مقبولة صيدلانية منها، حيث تكون الحلقة A، R1 وR2 كما تم تعريفها هنا، تركيبات صيدلانية تشتمل على واحد أو أكثر من هذه المركبات (بمفردها وفي توليفة مع عامل آخر فعال علاجياً واحد أو أكثر)، وطرق لتحضيرها واستخدامها، بمفردها وفي توليفة مع عوامل علاجية أخرى، كمضادات لمستقبلات A2a و/أو A2b، وفي علاج مجموعة متنوعة من الأمراض، الحالات، أو الاضطرابات والتي تتوسط، جزئياً على الأقل، بمستقبل الأدينوزين A2a و/أو مستقبل الأدينوزين A2b.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862774077P | 2018-11-30 | 2018-11-30 | |
PCT/US2019/063136 WO2020112700A1 (en) | 2018-11-30 | 2019-11-26 | 9-substituted amino triazolo quinazoline derivatives as adenosine receptor antagonists, pharmaceutical compositions and their use |
Publications (1)
Publication Number | Publication Date |
---|---|
JOP20210117A1 true JOP20210117A1 (ar) | 2023-01-30 |
Family
ID=69005832
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JOP/2021/0117A JOP20210117A1 (ar) | 2018-11-30 | 2019-11-26 | مشتقات أمينو ترايازولو كوينازولين بها استبدال في الموضع-9 كمضادات مستقبل أدينوزين، تركيبات صيدلانية واستخدامها |
JOP/2021/0116A JOP20210116A1 (ar) | 2018-11-30 | 2019-11-26 | مشتقات أمينو ترايازولو كوينازولين بها استبدال في الموضع-9 كمضادات مستقبل أدينوزين، تركيبات صيدلانية واستخدامها |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JOP/2021/0116A JOP20210116A1 (ar) | 2018-11-30 | 2019-11-26 | مشتقات أمينو ترايازولو كوينازولين بها استبدال في الموضع-9 كمضادات مستقبل أدينوزين، تركيبات صيدلانية واستخدامها |
Country Status (25)
Country | Link |
---|---|
US (2) | US11312719B2 (ar) |
EP (1) | EP3886988A1 (ar) |
JP (1) | JP7241871B2 (ar) |
KR (1) | KR102653800B1 (ar) |
CN (1) | CN113329791A (ar) |
AR (1) | AR117164A1 (ar) |
AU (1) | AU2019385905B2 (ar) |
BR (1) | BR112021010427B1 (ar) |
CA (1) | CA3120862C (ar) |
CL (1) | CL2021001406A1 (ar) |
CO (1) | CO2021006888A2 (ar) |
CR (1) | CR20210271A (ar) |
DO (1) | DOP2021000104A (ar) |
EA (1) | EA202191498A1 (ar) |
EC (1) | ECSP21036982A (ar) |
IL (1) | IL283334A (ar) |
JO (2) | JOP20210117A1 (ar) |
MA (1) | MA54298A (ar) |
MX (1) | MX2021006329A (ar) |
NI (1) | NI202100043A (ar) |
PE (1) | PE20211768A1 (ar) |
PH (1) | PH12021551196A1 (ar) |
SG (1) | SG11202105180PA (ar) |
TW (1) | TW202039496A (ar) |
WO (1) | WO2020112700A1 (ar) |
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PL2170959T3 (pl) | 2007-06-18 | 2014-03-31 | Merck Sharp & Dohme | Przeciwciała przeciwko ludzkiemu receptorowi programowanej śmierci PD-1 |
US11466017B2 (en) | 2011-03-10 | 2022-10-11 | Board Of Regents, The University Of Texas System | Heterocyclic inhibitors of PTPN11 |
WO2017210134A1 (en) | 2016-05-31 | 2017-12-07 | Board Of Regents, University Of Texas System | Heterocyclic inhibitors of ptpn11 |
KR102611661B1 (ko) | 2018-05-02 | 2023-12-08 | 나비레 파르마, 인코퍼레이티드 | Ptpn11의 치환된 헤테로사이클릭 억제제 |
JP2021534124A (ja) | 2018-08-10 | 2021-12-09 | ナビール ファーマ,インコーポレイティド | 癌治療用ptpn11(shp2)阻害剤としての6−(4−アミノ−3−メチル−2−オキサ−8−アザスピロ[4.5]デカン−8−イル)−3−(2,3−ジクロロフェニル)−2−メチルピリミジン−4(3h)−オン誘導体及び関連化合物 |
AU2019388872A1 (en) * | 2018-11-30 | 2021-05-27 | Merck Sharp & Dohme Llc | 7-, 8-, and 10-substituted amino triazolo quinazoline derivatives as adenosine receptor antagonists, pharmaceutical compositions and their use |
WO2023158626A1 (en) * | 2022-02-16 | 2023-08-24 | Merck Sharp & Dohme Llc | Adenosine receptor antagonists, pharmaceutical compositions and their use thereof |
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WO2024118460A1 (en) * | 2022-11-29 | 2024-06-06 | Merck Sharp & Dohme Llc | Adenosine a2a and a2b receptor antagonists, pharmaceutical compositions and use thereof |
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2019
- 2019-11-26 JP JP2021530114A patent/JP7241871B2/ja active Active
- 2019-11-26 CA CA3120862A patent/CA3120862C/en active Active
- 2019-11-26 TW TW108142874A patent/TW202039496A/zh unknown
- 2019-11-26 US US16/695,367 patent/US11312719B2/en active Active
- 2019-11-26 AR ARP190103450A patent/AR117164A1/es unknown
- 2019-11-26 KR KR1020217019802A patent/KR102653800B1/ko active IP Right Grant
- 2019-11-26 MA MA054298A patent/MA54298A/fr unknown
- 2019-11-26 JO JOP/2021/0117A patent/JOP20210117A1/ar unknown
- 2019-11-26 CR CR20210271A patent/CR20210271A/es unknown
- 2019-11-26 JO JOP/2021/0116A patent/JOP20210116A1/ar unknown
- 2019-11-26 AU AU2019385905A patent/AU2019385905B2/en active Active
- 2019-11-26 BR BR112021010427-5A patent/BR112021010427B1/pt active IP Right Grant
- 2019-11-26 SG SG11202105180PA patent/SG11202105180PA/en unknown
- 2019-11-26 EA EA202191498A patent/EA202191498A1/ru unknown
- 2019-11-26 WO PCT/US2019/063136 patent/WO2020112700A1/en active Application Filing
- 2019-11-26 CN CN201980090487.8A patent/CN113329791A/zh active Pending
- 2019-11-26 MX MX2021006329A patent/MX2021006329A/es unknown
- 2019-11-26 PE PE2021000757A patent/PE20211768A1/es unknown
- 2019-11-26 EP EP19827893.9A patent/EP3886988A1/en active Pending
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2021
- 2021-05-20 IL IL283334A patent/IL283334A/en unknown
- 2021-05-24 NI NI202100043A patent/NI202100043A/es unknown
- 2021-05-25 EC ECSENADI202136982A patent/ECSP21036982A/es unknown
- 2021-05-25 PH PH12021551196A patent/PH12021551196A1/en unknown
- 2021-05-26 CO CONC2021/0006888A patent/CO2021006888A2/es unknown
- 2021-05-27 CL CL2021001406A patent/CL2021001406A1/es unknown
- 2021-05-27 DO DO2021000104A patent/DOP2021000104A/es unknown
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2022
- 2022-03-31 US US17/657,515 patent/US20220220117A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2020112700A1 (en) | 2020-06-04 |
MA54298A (fr) | 2022-03-09 |
BR112021010427B1 (pt) | 2022-09-27 |
US11312719B2 (en) | 2022-04-26 |
BR112021010427A2 (pt) | 2021-08-17 |
AR117164A1 (es) | 2021-07-14 |
IL283334A (en) | 2021-07-29 |
EP3886988A1 (en) | 2021-10-06 |
MX2021006329A (es) | 2021-08-11 |
KR20210096184A (ko) | 2021-08-04 |
DOP2021000104A (es) | 2021-07-30 |
TW202039496A (zh) | 2020-11-01 |
NI202100043A (es) | 2021-08-13 |
KR102653800B1 (ko) | 2024-04-01 |
PH12021551196A1 (en) | 2021-11-29 |
CR20210271A (es) | 2021-07-14 |
JOP20210116A1 (ar) | 2023-01-30 |
US20210107904A1 (en) | 2021-04-15 |
EA202191498A1 (ru) | 2021-08-20 |
CL2021001406A1 (es) | 2021-11-12 |
CA3120862C (en) | 2024-05-07 |
PE20211768A1 (es) | 2021-09-07 |
US20220220117A1 (en) | 2022-07-14 |
JP7241871B2 (ja) | 2023-03-17 |
CN113329791A (zh) | 2021-08-31 |
AU2019385905A1 (en) | 2021-06-03 |
CO2021006888A2 (es) | 2021-06-10 |
SG11202105180PA (en) | 2021-06-29 |
CA3120862A1 (en) | 2020-06-04 |
JP2022511441A (ja) | 2022-01-31 |
AU2019385905B2 (en) | 2023-01-12 |
ECSP21036982A (es) | 2021-06-30 |
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