MX2021004885A - Derivados de piperazinil y piperidinil-quinazolin-4(3h)-ona que tienen actividad contra el dolor. - Google Patents

Derivados de piperazinil y piperidinil-quinazolin-4(3h)-ona que tienen actividad contra el dolor.

Info

Publication number
MX2021004885A
MX2021004885A MX2021004885A MX2021004885A MX2021004885A MX 2021004885 A MX2021004885 A MX 2021004885A MX 2021004885 A MX2021004885 A MX 2021004885A MX 2021004885 A MX2021004885 A MX 2021004885A MX 2021004885 A MX2021004885 A MX 2021004885A
Authority
MX
Mexico
Prior art keywords
quinazolin
piperazinyl
piperidinyl
derivatives
subunit
Prior art date
Application number
MX2021004885A
Other languages
English (en)
Inventor
Carmen Almansa-Rosales
Ariadna Fernández-Donis
José Luis Díaz-Fernández
Adriana Lorente-Crivillé
Original Assignee
Acondicionamiento Tarrasense
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acondicionamiento Tarrasense filed Critical Acondicionamiento Tarrasense
Publication of MX2021004885A publication Critical patent/MX2021004885A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se refiere a derivados de piperazinil y piperidinil-quinazolin-4(3H)-ona que tienen actividad farmacológica hacia la subunidad a2d, en particular la subunidad a2d-1, del canal de calcio dependiente del voltaje, en particular que tienen actividad farmacológica dual hacia tanto la subunidad a2d, en particular la subunidad a2d-1, del canal de calcio dependiente del voltaje como hacia el receptor opioideo µ. La presente invención también se refiere a procedimientos de preparación de tales compuestos, a composiciones farmacéuticas que los comprenden, y a su uso en terapia, en particular para el tratamiento de dolor.
MX2021004885A 2018-10-31 2019-10-31 Derivados de piperazinil y piperidinil-quinazolin-4(3h)-ona que tienen actividad contra el dolor. MX2021004885A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18382772 2018-10-31
PCT/EP2019/079846 WO2020089400A1 (en) 2018-10-31 2019-10-31 Piperazinyl and piperidinyl quinazolin-4(3h)-one derivatives having activity against pain

Publications (1)

Publication Number Publication Date
MX2021004885A true MX2021004885A (es) 2021-09-10

Family

ID=64426834

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021004885A MX2021004885A (es) 2018-10-31 2019-10-31 Derivados de piperazinil y piperidinil-quinazolin-4(3h)-ona que tienen actividad contra el dolor.

Country Status (9)

Country Link
US (1) US20220002314A1 (es)
EP (1) EP3873895A1 (es)
JP (1) JP7249428B2 (es)
CN (1) CN113260614A (es)
AR (1) AR116934A1 (es)
CA (1) CA3117860A1 (es)
MX (1) MX2021004885A (es)
TW (1) TWI824050B (es)
WO (1) WO2020089400A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112694485B (zh) * 2020-09-10 2023-04-07 四川海品信医药科技有限公司 一种阿片受体激动剂噻吩类化合物及其制备方法
US20240182489A1 (en) * 2021-03-18 2024-06-06 Acondicionamiento Tarrasense New 5,6,7,8-Tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(3H)-one Derivatives as Sigma Ligands

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5053411A (en) * 1989-04-20 1991-10-01 Anaquest, Inc. N-aryl-N-[4-(1-heterocyclicalkyl)piperidinyl]amides and pharmaceutical compositions and methods employing such compounds
AUPR201600A0 (en) 2000-12-11 2001-01-11 Fujisawa Pharmaceutical Co., Ltd. Quinazolinone derivative
CA2465491A1 (en) * 2001-11-07 2003-05-15 Merck & Co., Inc. Mitotic kinesin inhibitors
JP2005536553A (ja) 2002-08-21 2005-12-02 サイトキネティクス・インコーポレーテッド 化合物、組成物および方法
EP3548490A1 (en) * 2016-11-30 2019-10-09 Esteve Pharmaceuticals, S.A. 2-phenyl-2h-pyrazolo[3,4-d]pyridazine derivatives having activity against pain
WO2020089397A1 (en) * 2018-10-31 2020-05-07 Esteve Pharmaceuticals, S.A. Substituted quinazolin-4(3h)-one derivatives having multimodal activity against pain
MX2022014855A (es) * 2020-05-27 2022-12-15 Esteve Pharmaceuticals Sa Derivados de pirazolo[1,5-a]pirimidina que tienen actividad multimodal contra el dolor.

Also Published As

Publication number Publication date
TW202035391A (zh) 2020-10-01
CA3117860A1 (en) 2020-05-07
TWI824050B (zh) 2023-12-01
AR116934A1 (es) 2021-06-30
US20220002314A1 (en) 2022-01-06
JP2022509434A (ja) 2022-01-20
JP7249428B2 (ja) 2023-03-30
CN113260614A (zh) 2021-08-13
EP3873895A1 (en) 2021-09-08
WO2020089400A1 (en) 2020-05-07

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