MX2022004121A - Derivados de homopiperazinil y homopiperidinil quinazolin-4(3h)-ona que tienen actividad multimodal contra el dolor. - Google Patents

Derivados de homopiperazinil y homopiperidinil quinazolin-4(3h)-ona que tienen actividad multimodal contra el dolor.

Info

Publication number
MX2022004121A
MX2022004121A MX2022004121A MX2022004121A MX2022004121A MX 2022004121 A MX2022004121 A MX 2022004121A MX 2022004121 A MX2022004121 A MX 2022004121A MX 2022004121 A MX2022004121 A MX 2022004121A MX 2022004121 A MX2022004121 A MX 2022004121A
Authority
MX
Mexico
Prior art keywords
homopiperidinyl
homopiperazinyl
quinazolin
derivatives
activity against
Prior art date
Application number
MX2022004121A
Other languages
English (en)
Inventor
Ute Christmann
Lopez Monica Garcia
Rosales Carmen Almansa
Donis Ariadna Fernandez
Fernández José Luís Díaz
Escrich Sergi Rodriguez
Original Assignee
Esteve Pharmaceuticals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Pharmaceuticals Sa filed Critical Esteve Pharmaceuticals Sa
Publication of MX2022004121A publication Critical patent/MX2022004121A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La presente invención se refiere a derivados de homopiperazinil y homopiperidinil quinazolin-4(3H)-ona que tienen actividad farmacológica dual hacia tanto la subunidad a2d del canal de calcio dependiente de voltaje como el receptor sigma-1 (s1), a procesos de preparación de dichos compuestos, a composiciones farmacéuticas que comprenden a los mismos, y a su uso en terapia, en particular para el tratamiento del dolor.
MX2022004121A 2019-10-10 2020-10-05 Derivados de homopiperazinil y homopiperidinil quinazolin-4(3h)-ona que tienen actividad multimodal contra el dolor. MX2022004121A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19382890 2019-10-10
PCT/EP2020/077770 WO2021069339A1 (en) 2019-10-10 2020-10-05 Homopiperazinyl and homopiperidinyl quinazolin-4(3h)-one derivatives having multimodal activity against pain

Publications (1)

Publication Number Publication Date
MX2022004121A true MX2022004121A (es) 2022-04-26

Family

ID=68342880

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022004121A MX2022004121A (es) 2019-10-10 2020-10-05 Derivados de homopiperazinil y homopiperidinil quinazolin-4(3h)-ona que tienen actividad multimodal contra el dolor.

Country Status (14)

Country Link
US (1) US20220380345A1 (es)
EP (1) EP4041391A1 (es)
JP (1) JP2022551156A (es)
KR (1) KR20220079938A (es)
CN (1) CN114502549A (es)
AR (1) AR120157A1 (es)
AU (1) AU2020362224A1 (es)
BR (1) BR112022006692A2 (es)
CA (1) CA3153302A1 (es)
CO (1) CO2022005072A2 (es)
IL (1) IL291978A (es)
MX (1) MX2022004121A (es)
TW (1) TW202115032A (es)
WO (1) WO2021069339A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7249428B2 (ja) * 2018-10-31 2023-03-30 アコンディシオナミエント タルラセンス 疼痛に対して活性があるピペラジニル及びピペリジニルキナゾリン－４（３ｈ）－オン誘導体

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004018058A2 (en) * 2002-08-21 2004-03-04 Cytokinetics, Inc. Compounds, compositions, and methods
US7208487B2 (en) * 2002-12-13 2007-04-24 Cytokinetics, Incorporated Compounds, compositions and methods
ATE440825T1 (de) * 2003-06-06 2009-09-15 Vertex Pharma Pyrimidin-derivate zur verwendung als modulatoren von atp-bindende kassette transportern
CN101068794B (zh) * 2004-09-02 2012-12-19 沃泰克斯药物股份有限公司 可用作离子通道调控剂的喹唑啉
WO2009002553A1 (en) * 2007-06-25 2008-12-31 Prolexys Pharmaceuticals, Inc. Methods of treating multiple myeloma and resistant cancers
CN102083314B (zh) * 2007-10-03 2014-04-30 卫材股份有限公司 Parp抑制剂化合物、组合物以及使用方法
WO2014093869A1 (en) * 2012-12-13 2014-06-19 University Of Kansas 6-substituted quinazolinone inhibitors
WO2017121645A1 (en) * 2016-01-15 2017-07-20 Laboratorios Del Dr. Esteve, S.A. 3-ethyl-3-phenylazepane derivatives having multimodal activity against pain
EP3339304A1 (en) * 2016-12-20 2018-06-27 Laboratorios del Dr. Esteve, S.A. Quinoline and isoquinoline derivatives for treating pain and pain related conditions
TW201938154A (zh) * 2017-12-04 2019-10-01 西班牙商艾斯提夫製藥股份有限公司 具有抗疼痛活性之鄰苯氧基及鄰苄氧基丙胺基衍生物
AR115012A1 (es) * 2018-03-23 2020-11-18 Esteve Pharmaceuticals Sa Derivados de aminopropoxifenilo y bencil 1-oxa-4,9-diazaespiroundecano con actividad multimodal contra el dolor
WO2020089397A1 (en) * 2018-10-31 2020-05-07 Esteve Pharmaceuticals, S.A. Substituted quinazolin-4(3h)-one derivatives having multimodal activity against pain

Also Published As

Publication number Publication date
EP4041391A1 (en) 2022-08-17
CN114502549A (zh) 2022-05-13
JP2022551156A (ja) 2022-12-07
AU2020362224A1 (en) 2022-04-21
TW202115032A (zh) 2021-04-16
AR120157A1 (es) 2022-02-02
BR112022006692A2 (pt) 2022-07-12
WO2021069339A1 (en) 2021-04-15
CA3153302A1 (en) 2021-04-15
KR20220079938A (ko) 2022-06-14
IL291978A (en) 2022-06-01
US20220380345A1 (en) 2022-12-01
CO2022005072A2 (es) 2022-05-10

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