ZA902086B - Novel insulin compounds - Google Patents

Novel insulin compounds

Info

Publication number
ZA902086B
ZA902086B ZA902086A ZA902086A ZA902086B ZA 902086 B ZA902086 B ZA 902086B ZA 902086 A ZA902086 A ZA 902086A ZA 902086 A ZA902086 A ZA 902086A ZA 902086 B ZA902086 B ZA 902086B
Authority
ZA
South Africa
Prior art keywords
image
insulin compounds
novel insulin
coded
amino acid
Prior art date
Application number
ZA902086A
Other languages
English (en)
Inventor
Per Balschmidt
Balschmidt Per
Finn Benned Hansen
Benned Hansen Finn
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of ZA902086B publication Critical patent/ZA902086B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ZA902086A 1989-03-20 1990-03-19 Novel insulin compounds ZA902086B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK134189A DK134189D0 (da) 1989-03-20 1989-03-20 Insulinforbindelser

Publications (1)

Publication Number Publication Date
ZA902086B true ZA902086B (en) 1990-11-28

Family

ID=8103787

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA902086A ZA902086B (en) 1989-03-20 1990-03-19 Novel insulin compounds

Country Status (23)

Country Link
US (1) US5430016A (no)
EP (1) EP0463072B1 (no)
JP (1) JPH04503808A (no)
KR (1) KR920701250A (no)
CN (1) CN1045793A (no)
AT (1) ATE116661T1 (no)
AU (1) AU637365B2 (no)
CA (1) CA2049961A1 (no)
DD (1) DD298788A5 (no)
DE (1) DE69015811T2 (no)
DK (2) DK134189D0 (no)
ES (1) ES2068384T3 (no)
FI (1) FI914419A0 (no)
GR (1) GR1002545B (no)
HU (1) HUT58349A (no)
IE (1) IE66564B1 (no)
IL (1) IL93792A0 (no)
NO (1) NO300640B1 (no)
NZ (1) NZ232953A (no)
PT (1) PT93502B (no)
WO (1) WO1990011299A1 (no)
YU (1) YU53290A (no)
ZA (1) ZA902086B (no)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
DE3844211A1 (de) * 1988-12-29 1990-07-05 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
US5304473A (en) * 1991-06-11 1994-04-19 Eli Lilly And Company A-C-B proinsulin, method of manufacturing and using same, and intermediates in insulin production
CZ342492A3 (en) * 1991-11-26 1993-06-16 Lilly Co Eli Derivatives of tri-arginine insulin, process of their preparation and a pharmaceutical composition in which said derivatives are comprised
US5948751A (en) * 1996-06-20 1999-09-07 Novo Nordisk A/S X14-mannitol
BR9813111A (pt) 1997-10-24 2000-08-15 Lilly Co Eli Composições de insulina insolúveis
US6531448B1 (en) * 1997-12-23 2003-03-11 Eli Lilly And Company Insoluble compositions for controlling blood glucose
US7378390B2 (en) * 1999-12-29 2008-05-27 Novo Nordisk A/S Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
US20050014679A1 (en) * 2001-12-20 2005-01-20 Beals John Michael Insulin molecule having protracted time action
CA2518776A1 (en) * 2003-04-29 2004-11-11 Eli Lilly And Company Insulin analogs having protracted time action
US9220837B2 (en) 2007-03-19 2015-12-29 Insuline Medical Ltd. Method and device for drug delivery
US8622991B2 (en) 2007-03-19 2014-01-07 Insuline Medical Ltd. Method and device for drug delivery
WO2008114224A2 (en) * 2007-03-19 2008-09-25 Insuline Medical Ltd. Method and device for substance measurement
AU2008227875B2 (en) * 2007-03-19 2014-06-12 Insuline Medical Ltd. Drug delivery device
EP2231229A1 (en) * 2007-12-18 2010-09-29 Insuline Medical Ltd. Drug delivery device with sensor for closed-loop operation
RU2524423C2 (ru) 2008-01-09 2014-07-27 Санофи-Авентис Дойчланд Гмбх Новые производные инсулина с чрезвычайно замедленным профилем время/действие
AU2009203810B2 (en) * 2008-01-09 2013-07-25 Sanofi-Aventis Deutschland Gmbh Novel insulin derivatives having an extremely delayed time-action profile
CA2740685C (en) 2008-10-17 2018-09-11 Sanofi-Aventis Deutschland Gmbh Combination of an insulin and a glp-1 agonist
RU2532893C2 (ru) 2008-11-07 2014-11-10 Инсьюлин Медикал Лтд. Устройство и способ доставки лекарственных средств
JP5973918B2 (ja) 2009-11-13 2016-08-23 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Ｇｌｐ−１アゴニスト及びメチオニンを含む薬学的組成物
AU2010317995B2 (en) 2009-11-13 2014-04-17 Sanofi-Aventis Deutschland Gmbh Pharmaceutical composition comprising a GLP-1 agonist, an insulin, and methionine
JP6199186B2 (ja) 2010-08-30 2017-09-20 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング ２型糖尿病の治療用の医薬の製造のためのａｖｅ００１０の使用
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
RU2650616C2 (ru) 2011-08-29 2018-04-16 Санофи-Авентис Дойчланд Гмбх Фармацевтическая комбинация для применения при гликемическом контроле у пациентов с сахарным диабетом 2 типа
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
EA201591839A1 (ru) 2013-05-02 2016-05-31 Глаксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед Терапевтические пептиды
HRP20230470T1 (hr) 2014-12-12 2023-07-21 Sanofi-Aventis Deutschland Gmbh Formulacija fiksnog omjera inzulin glargin/liksisenatid
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
CN106323840A (zh) * 2016-09-13 2017-01-11 西南石油大学 一种页岩孔隙度测量方法
CN109735589B (zh) * 2019-01-02 2020-07-10 珠海冀百康生物科技有限公司 一种胰岛素DesB30的制备方法
CN113773398B (zh) * 2020-06-10 2023-05-23 宁波鲲鹏生物科技有限公司 一种德谷胰岛素衍生物及其应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55138393A (en) * 1979-04-13 1980-10-29 Shionogi & Co Ltd Semisynthesis of insulin
DK147437A (en) * 1980-02-11 1900-01-01 Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof
IE50892B1 (en) * 1980-02-11 1986-08-06 Novo Industri As Process for preparing insulin esters
DE3326472A1 (de) * 1983-07-22 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE3326473A1 (de) * 1983-07-22 1985-01-31 Hoechst Ag, 6230 Frankfurt Pharmazeutisches mittel zur behandlung des diabetes mellitus
DE3327709A1 (de) * 1983-07-29 1985-02-07 Hoechst Ag, 6230 Frankfurt Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung
DK58285D0 (da) * 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
US4946828A (en) * 1985-03-12 1990-08-07 Novo Nordisk A/S Novel insulin peptides
DK113585D0 (da) * 1985-03-12 1985-03-12 Novo Industri As Nye peptider
DK347086D0 (da) * 1986-07-21 1986-07-21 Novo Industri As Novel peptides
US5008241A (en) * 1985-03-12 1991-04-16 Novo Nordisk A/S Novel insulin peptides
DK119785D0 (da) * 1985-03-15 1985-03-15 Nordisk Gentofte Insulinpraeparat
DK129385A (da) * 1985-03-22 1986-09-23 Novo Industri As Peptider og fremstilling deraf
DK437786D0 (da) * 1986-09-12 1986-09-12 Nordisk Gentofte Insulinprecursorer
DE3717370A1 (de) * 1987-05-22 1988-12-01 Hoechst Ag Mischkristalle aus insulin und insulinderivaten, verfahren zur herstellung dieser mischkristalle, diese mischkristalle enthaltende pharmazeutische mittel und ihre verwendung zur behandlung von diabetes mellitus
DK336188D0 (da) * 1988-06-20 1988-06-20 Nordisk Gentofte Propeptider
DE3844211A1 (de) * 1988-12-29 1990-07-05 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung

Also Published As

Publication number Publication date
ES2068384T3 (es) 1995-04-16
NO913687D0 (no) 1991-09-19
CA2049961A1 (en) 1990-09-21
IE901004L (en) 1990-09-20
EP0463072B1 (en) 1995-01-04
PT93502A (pt) 1990-11-07
IE66564B1 (en) 1996-01-24
ATE116661T1 (de) 1995-01-15
WO1990011299A1 (en) 1990-10-04
HU902706D0 (en) 1991-12-30
KR920701250A (ko) 1992-08-11
CN1045793A (zh) 1990-10-03
JPH04503808A (ja) 1992-07-09
DE69015811D1 (de) 1995-02-16
GR900100206A (el) 1991-07-31
IL93792A0 (en) 1990-12-23
DD298788A5 (de) 1992-03-12
NO300640B1 (no) 1997-06-30
AU5344890A (en) 1990-10-22
GR1002545B (el) 1997-01-28
NZ232953A (en) 1992-10-28
FI914419A0 (fi) 1991-09-19
US5430016A (en) 1995-07-04
NO913687L (no) 1991-11-19
PT93502B (pt) 1996-02-29
DE69015811T2 (de) 1995-05-11
YU53290A (sh) 1992-12-21
DK134189D0 (da) 1989-03-20
DK0463072T3 (da) 1995-06-12
HUT58349A (en) 1992-02-28
AU637365B2 (en) 1993-05-27
EP0463072A1 (en) 1992-01-02

Similar Documents

Publication Publication Date Title
ZA902086B (en) Novel insulin compounds
HUT56558A (en) Process for producing oxetanones
AU4799793A (en) Beta -aminoalkyl and beta -n-peptidylaminoalkyl boronic acids
GR3019425T3 (en) Hydrochlorofluorocarbon azeotropic or azeotropic-like mixture
GR3020961T3 (en) Endothelin antagonist
DK0585285T3 (da) Stabiliserede enzymer
AU6954887A (en) Oligopeptidyl nitrile derivatives, agents containing them, a process for their preparation, and their use
ES8501364A1 (es) Un metodo para la preparacion de nuevos polipeptidos.
HU9401584D0 (en) Preparation of substituted piperidines
CA2257381A1 (en) Method for producing peptides
ES8708227A1 (es) Un procedimiento para preparar acido 7beta-(metiltio-fluorado)acetamido-7alfa-metoxi-3-(1-(2-hidroxialquil)-1h-tetrazol-5-il)tiometil-1-destia-1-oxa-3-cefem-4-carboxilico.
ES8605769A1 (es) Un procedimiento para la preparacion de un peptido
IL74114A0 (en) Process for the preparation of alkanephosphonous acids
MX173831B (es) Compuestos de naftil-azo-pirazolona y procedimiento para la preparacion de los mismos
EP0292256A3 (en) Peptides having anf activity
ZA9410212B (en) Process for the preparation of 2,4,5-tribromopyrrole-3-carbonitrile
IL117289A0 (en) Aqueous spectinomycin composition
CA2066430A1 (en) Process for the preparation of methylenebisphosphonic acids
KR840005082A (ko) 노나펩타이드의 제조방법
ES8400411A1 (es) Procedimiento para la preparacion de nuevas sulfiminas.
ES8702900A1 (es) Procedimiento de obtencion de un compuesto de guanidiltia- zol, util como inhibidor de secrecion gastrica