GR900100206A - Μέ?οδος παρασκευής νέων συν?έσεων ινσουλίνης. - Google Patents

Μέ?οδος παρασκευής νέων συν?έσεων ινσουλίνης.

Info

Publication number
GR900100206A
GR900100206A GR900100206A GR900100206A GR900100206A GR 900100206 A GR900100206 A GR 900100206A GR 900100206 A GR900100206 A GR 900100206A GR 900100206 A GR900100206 A GR 900100206A GR 900100206 A GR900100206 A GR 900100206A
Authority
GR
Greece
Prior art keywords
xqyμz
uæμ
μuzwðsvuæ
wxwð
qxw
Prior art date
Application number
GR900100206A
Other languages
English (en)
Other versions
GR1002545B (el
Inventor
Per Balschmidt
Benned Finn Hansen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of GR900100206A publication Critical patent/GR900100206A/el
Publication of GR1002545B publication Critical patent/GR1002545B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
GR900100206A 1989-03-20 1990-03-20 Μεθοδος παρασκευης νεων συνθεσεων ινσουλινης. GR1002545B (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK134189A DK134189D0 (da) 1989-03-20 1989-03-20 Insulinforbindelser

Publications (2)

Publication Number Publication Date
GR900100206A true GR900100206A (el) 1991-07-31
GR1002545B GR1002545B (el) 1997-01-28

Family

ID=8103787

Family Applications (1)

Application Number Title Priority Date Filing Date
GR900100206A GR1002545B (el) 1989-03-20 1990-03-20 Μεθοδος παρασκευης νεων συνθεσεων ινσουλινης.

Country Status (23)

Country Link
US (1) US5430016A (el)
EP (1) EP0463072B1 (el)
JP (1) JPH04503808A (el)
KR (1) KR920701250A (el)
CN (1) CN1045793A (el)
AT (1) ATE116661T1 (el)
AU (1) AU637365B2 (el)
CA (1) CA2049961A1 (el)
DD (1) DD298788A5 (el)
DE (1) DE69015811T2 (el)
DK (2) DK134189D0 (el)
ES (1) ES2068384T3 (el)
FI (1) FI914419A0 (el)
GR (1) GR1002545B (el)
HU (1) HUT58349A (el)
IE (1) IE66564B1 (el)
IL (1) IL93792A0 (el)
NO (1) NO300640B1 (el)
NZ (1) NZ232953A (el)
PT (1) PT93502B (el)
WO (1) WO1990011299A1 (el)
YU (1) YU53290A (el)
ZA (1) ZA902086B (el)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
DE3844211A1 (de) * 1988-12-29 1990-07-05 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
US5304473A (en) * 1991-06-11 1994-04-19 Eli Lilly And Company A-C-B proinsulin, method of manufacturing and using same, and intermediates in insulin production
TW224471B (el) * 1991-11-26 1994-06-01 Lilly Co Eli
US5948751A (en) * 1996-06-20 1999-09-07 Novo Nordisk A/S X14-mannitol
CA2306905A1 (en) 1997-10-24 1999-05-06 Eli Lilly And Company Fatty acid-acylated insulin analogs
CO4970787A1 (es) * 1997-12-23 2000-11-07 Lilly Co Eli Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea
US7378390B2 (en) * 1999-12-29 2008-05-27 Novo Nordisk A/S Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
AU2002346490A1 (en) * 2001-12-20 2003-07-09 Eli Lilly And Company Insulin molecule having protracted time action
BRPI0409600A (pt) * 2003-04-29 2006-04-18 Lilly Co Eli análogo de insulina, composição, método de tratamento de hiperglicemia, e, análogo de pró-insulina
CN101678169A (zh) * 2007-03-19 2010-03-24 茵苏莱恩医药有限公司 药物输送设备
US20100292557A1 (en) * 2007-03-19 2010-11-18 Benny Pesach Method and device for substance measurement
US8622991B2 (en) 2007-03-19 2014-01-07 Insuline Medical Ltd. Method and device for drug delivery
US9220837B2 (en) 2007-03-19 2015-12-29 Insuline Medical Ltd. Method and device for drug delivery
US8409133B2 (en) * 2007-12-18 2013-04-02 Insuline Medical Ltd. Drug delivery device with sensor for closed-loop operation
EP2229407B1 (de) 2008-01-09 2016-11-16 Sanofi-Aventis Deutschland GmbH Neue insulinderivate mit extrem verzögertem zeit- / wirkungsprofil
JP5695909B2 (ja) * 2008-01-09 2015-04-08 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 極度に遅延した時間作用プロファイルを有する新規なインスリン誘導体
HUE037449T2 (hu) 2008-10-17 2018-08-28 Sanofi Aventis Deutschland Egy inzulin és egy GLP-1 agonista kombinációja
WO2010052579A2 (en) 2008-11-07 2010-05-14 Insuline Medical Ltd. Device and method for drug delivery
WO2011058082A1 (de) 2009-11-13 2011-05-19 Sanofi-Aventis Deutschland Gmbh Pharmazeutische zusammensetzung umfassend einen glp-1-agonisten und methionin
AR080669A1 (es) 2009-11-13 2012-05-02 Sanofi Aventis Deutschland Composicion farmaceutica que comprende un agonista de glp-1, una insulina y metionina
ES2606554T3 (es) 2010-08-30 2017-03-24 Sanofi-Aventis Deutschland Gmbh Uso de AVE0010 para la fabricación de un medicamento para el tratamiento de la diabetes mellitus de tipo 2
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
BR112014004726A2 (pt) 2011-08-29 2017-04-04 Sanofi Aventis Deutschland combinação farmacêutica para uso no controle glicêmico em pacientes de diabetes tipo 2
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
SG11201508469YA (en) 2013-05-02 2015-11-27 Glaxosmithkline Ip Dev Ltd Therapeutic peptides
PL3229828T3 (pl) 2014-12-12 2023-07-31 Sanofi-Aventis Deutschland Gmbh Formulacja o ustalonym stosunku insuliny glargine/liksysenatydu
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
CN106323840A (zh) * 2016-09-13 2017-01-11 西南石油大学 一种页岩孔隙度测量方法
CN109735589B (zh) * 2019-01-02 2020-07-10 珠海冀百康生物科技有限公司 一种胰岛素DesB30的制备方法
CN113773398B (zh) * 2020-06-10 2023-05-23 宁波鲲鹏生物科技有限公司 一种德谷胰岛素衍生物及其应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4343898A (en) * 1980-02-11 1982-08-10 Novo Industri A/S Process for preparing esters of human insulin
EP0195691A1 (en) * 1985-03-22 1986-09-24 Novo Nordisk A/S Process for the preparation of Insulin Precursors and process for the preparation of human insulin
EP0347845A2 (en) * 1988-06-20 1989-12-27 Novo Nordisk A/S Insulin precursors, their preparation, and DNA sequences, expression vehicles and primers and a process for producing human insulin and analogues
EP0376156A2 (de) * 1988-12-29 1990-07-04 Hoechst Aktiengesellschaft Neue Insulinderivate, Verfahren zu deren Herstellung, ihre Verwendung und eine sie enthaltende pharmazeutische Zubereitung

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55138393A (en) * 1979-04-13 1980-10-29 Shionogi & Co Ltd Semisynthesis of insulin
DK147437A (en) * 1980-02-11 1900-01-01 Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof
DE3326472A1 (de) * 1983-07-22 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE3326473A1 (de) * 1983-07-22 1985-01-31 Hoechst Ag, 6230 Frankfurt Pharmazeutisches mittel zur behandlung des diabetes mellitus
DE3327709A1 (de) * 1983-07-29 1985-02-07 Hoechst Ag, 6230 Frankfurt Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung
DK58285D0 (da) * 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
US5008241A (en) * 1985-03-12 1991-04-16 Novo Nordisk A/S Novel insulin peptides
DK347086D0 (da) * 1986-07-21 1986-07-21 Novo Industri As Novel peptides
US4946828A (en) * 1985-03-12 1990-08-07 Novo Nordisk A/S Novel insulin peptides
DK113585D0 (da) * 1985-03-12 1985-03-12 Novo Industri As Nye peptider
DK119785D0 (da) * 1985-03-15 1985-03-15 Nordisk Gentofte Insulinpraeparat
DK437786D0 (da) * 1986-09-12 1986-09-12 Nordisk Gentofte Insulinprecursorer
DE3717370A1 (de) * 1987-05-22 1988-12-01 Hoechst Ag Mischkristalle aus insulin und insulinderivaten, verfahren zur herstellung dieser mischkristalle, diese mischkristalle enthaltende pharmazeutische mittel und ihre verwendung zur behandlung von diabetes mellitus

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4343898A (en) * 1980-02-11 1982-08-10 Novo Industri A/S Process for preparing esters of human insulin
EP0195691A1 (en) * 1985-03-22 1986-09-24 Novo Nordisk A/S Process for the preparation of Insulin Precursors and process for the preparation of human insulin
EP0347845A2 (en) * 1988-06-20 1989-12-27 Novo Nordisk A/S Insulin precursors, their preparation, and DNA sequences, expression vehicles and primers and a process for producing human insulin and analogues
EP0376156A2 (de) * 1988-12-29 1990-07-04 Hoechst Aktiengesellschaft Neue Insulinderivate, Verfahren zu deren Herstellung, ihre Verwendung und eine sie enthaltende pharmazeutische Zubereitung

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BIOCH. JOURNAL, vol. 186, 1980, pages 945-952, London, GB; P. R\SEN et al.: "Binding of insulin to bovine liver plasma membrane" *
CLAIMS SEARCHED: ALL *
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE USA, vol. 83, no. 18, September 1986, pages 6766-6770, Washington, DC, US; L. THIM et al.: "Secretion and processing of insulin precursors in yeast" *
PROTEIN ENGINEERING, vol. 2, no. 2, July 1988, pages 157-166, IRL Press Ltd, Eynsham, Oxford, GB; J. MARKUSSEN et al.: "Soluble, prolonged-acting insulin derivatives. III. Degree of protraction. crystallizability and chemical stability of insulins substituted in positions A21,B13,B23,B27 and B30" *

Also Published As

Publication number Publication date
IE901004L (en) 1990-09-20
ZA902086B (en) 1990-11-28
YU53290A (sh) 1992-12-21
WO1990011299A1 (en) 1990-10-04
KR920701250A (ko) 1992-08-11
DE69015811D1 (de) 1995-02-16
IE66564B1 (en) 1996-01-24
IL93792A0 (en) 1990-12-23
FI914419A0 (fi) 1991-09-19
HUT58349A (en) 1992-02-28
AU5344890A (en) 1990-10-22
NZ232953A (en) 1992-10-28
DE69015811T2 (de) 1995-05-11
JPH04503808A (ja) 1992-07-09
NO300640B1 (no) 1997-06-30
PT93502B (pt) 1996-02-29
GR1002545B (el) 1997-01-28
PT93502A (pt) 1990-11-07
US5430016A (en) 1995-07-04
DD298788A5 (de) 1992-03-12
CA2049961A1 (en) 1990-09-21
DK134189D0 (da) 1989-03-20
AU637365B2 (en) 1993-05-27
EP0463072B1 (en) 1995-01-04
NO913687D0 (no) 1991-09-19
ES2068384T3 (es) 1995-04-16
NO913687L (no) 1991-11-19
HU902706D0 (en) 1991-12-30
ATE116661T1 (de) 1995-01-15
EP0463072A1 (en) 1992-01-02
DK0463072T3 (da) 1995-06-12
CN1045793A (zh) 1990-10-03

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