ZA883171B - Pateurizable,freeze-driable hemoglobin-based blood substitute - Google Patents

Pateurizable,freeze-driable hemoglobin-based blood substitute

Info

Publication number
ZA883171B
ZA883171B ZA883171A ZA883171A ZA883171B ZA 883171 B ZA883171 B ZA 883171B ZA 883171 A ZA883171 A ZA 883171A ZA 883171 A ZA883171 A ZA 883171A ZA 883171 B ZA883171 B ZA 883171B
Authority
ZA
South Africa
Prior art keywords
hemosafe
hemoglobin
derived
human
freeze
Prior art date
Application number
ZA883171A
Other languages
English (en)
Inventor
Jen-Chang Hsia
Hsia Jen-Chang
Original Assignee
Jen Chang Hsia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jen Chang Hsia filed Critical Jen Chang Hsia
Publication of ZA883171B publication Critical patent/ZA883171B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0023—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/04—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dental Preparations (AREA)
  • Materials For Medical Uses (AREA)
ZA883171A 1987-05-05 1988-05-04 Pateurizable,freeze-driable hemoglobin-based blood substitute ZA883171B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878710598A GB8710598D0 (en) 1987-05-05 1987-05-05 Hemoglobin based blood substitute

Publications (1)

Publication Number Publication Date
ZA883171B true ZA883171B (en) 1989-03-29

Family

ID=10616838

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA883171A ZA883171B (en) 1987-05-05 1988-05-04 Pateurizable,freeze-driable hemoglobin-based blood substitute

Country Status (15)

Country Link
US (2) US4857636A (xx)
EP (1) EP0290252B1 (xx)
JP (1) JPS63297330A (xx)
KR (1) KR910009343B1 (xx)
CN (1) CN1032471C (xx)
AT (1) ATE84970T1 (xx)
AU (1) AU610883B2 (xx)
CA (1) CA1306583C (xx)
DE (1) DE3877811T2 (xx)
DK (1) DK174286B1 (xx)
ES (1) ES2053729T3 (xx)
GB (1) GB8710598D0 (xx)
IL (1) IL86258A (xx)
NZ (1) NZ224479A (xx)
ZA (1) ZA883171B (xx)

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US5753616A (en) * 1986-11-10 1998-05-19 Biopure Corporation Method for producing a stable polymerized hemoglobin blood-substitute
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US5955581A (en) * 1986-11-10 1999-09-21 Biopure Corporation Method for producing a stable polymerized hemoglobin blood-substitute
GB8710598D0 (en) * 1987-05-05 1987-06-10 Star Medical Diagnostics Ltd Hemoglobin based blood substitute
US5189146A (en) * 1987-05-05 1993-02-23 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence Pasteurizable, freeze-driable hemoglobin-based blood substitute
US5545727A (en) * 1989-05-10 1996-08-13 Somatogen, Inc. DNA encoding fused di-alpha globins and production of pseudotetrameric hemoglobin
US5844090A (en) * 1994-05-09 1998-12-01 Somatogen, Inc. Modified hemoglobin-like compounds
US5386014A (en) * 1989-11-22 1995-01-31 Enzon, Inc. Chemically modified hemoglobin as an effective, stable, non-immunogenic red blood cell substitute
US5234903A (en) * 1989-11-22 1993-08-10 Enzon, Inc. Chemically modified hemoglobin as an effective, stable non-immunogenic red blood cell substitute
WO1992013875A1 (en) * 1991-02-12 1992-08-20 Texas Tech University Improved blood substitute
US5439882A (en) * 1989-12-29 1995-08-08 Texas Tech University Health Sciences Center Blood substitute
ATE136466T1 (de) * 1989-12-29 1996-04-15 Univ Texas Tech Polyhämoglobin durch purinderivate und glutathion stabilisiert
ATE133955T1 (de) * 1990-03-14 1996-02-15 Univ Toronto Acylphosphatester und modifikation von proteinen damit
US5248766A (en) * 1990-08-17 1993-09-28 Baxter International Inc. Oxirane-modified hemoglobin based composition
AU9067791A (en) * 1990-11-20 1992-06-11 Enzon, Inc. Method of enhancing long-term storage stability of hemoglobin products
ES2069908T3 (es) * 1990-11-29 1995-05-16 Upjohn Co Composiciones de hemoglobina entrecruzada con imidoesteres.
US5250665A (en) * 1991-05-31 1993-10-05 The University Of Toronto Innovations Foundation Specifically β-β cross-linked hemoglobins and method of preparation
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US5591457A (en) * 1992-02-07 1997-01-07 Vasogen Inc Method of inhibiting the aggregation of blood platelets and stimulating the immune systems of a human
US5980954A (en) 1992-02-07 1999-11-09 Vasogen Ireland Limited Treatment of autoimmune diseases
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US5399671A (en) * 1992-11-18 1995-03-21 Kluger; Ronald Specifically crosslinked hemoglobin with free functionality
ATE146189T1 (de) * 1993-03-16 1996-12-15 Hemosol Inc Selektive vernetzung von hemoglobin mittels oxidierten, ringgeöffneten sacchariden
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US5807831A (en) * 1993-08-16 1998-09-15 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5817632A (en) * 1993-08-16 1998-10-06 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5824781A (en) * 1993-08-16 1998-10-20 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5725839A (en) * 1993-08-16 1998-03-10 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules for ERI or MRI
US5804561A (en) * 1993-08-16 1998-09-08 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5767089A (en) * 1993-08-16 1998-06-16 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5840701A (en) * 1993-08-16 1998-11-24 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
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US5741893A (en) * 1993-08-16 1998-04-21 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
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US5691452A (en) * 1995-03-23 1997-11-25 Biopure Corporation Method for preserving a hemoglobin blood substitute
US6271351B1 (en) 1995-03-23 2001-08-07 Biopure Corporation Method for preserving a hemoglobin blood substitute
US6288027B1 (en) 1995-03-23 2001-09-11 Biopure Corporation Preserving a hemoglobin blood substitute with a transparent overwrap
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US6358678B1 (en) 1998-02-11 2002-03-19 The United States Of America As Represented By The Secretary Of The Navy Applications of reversible crosslinking and co-treatment in stabilization and viral inactivations of erythrocytes
DE69831248T2 (de) * 1997-02-28 2006-04-13 The Regents Of The University Of California, Oakland Verfahren und zusammensetzungen zur optimierung des sauerstofftransportes in zellfreien systemen
US5814601A (en) * 1997-02-28 1998-09-29 The Regents Of The University Of California Methods and compositions for optimization of oxygen transport by cell-free systems
CA2233725A1 (en) * 1998-03-31 1999-09-30 Hemosol Inc. Hemoglobin-hydroxyethyl starch complexes
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DE10031744A1 (de) * 2000-06-29 2002-01-17 Sanguibio Tech Ag Mit Blutplasma verträgliche, vernetzte und mit Polyalkylenoxiden konjugierte Säugetierhämoglobine als künstliche medizinische Sauerstoffträger, ihre Herstellung und ihre Verwendung
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Also Published As

Publication number Publication date
DK242888D0 (da) 1988-05-04
EP0290252B1 (en) 1993-01-27
DK242888A (da) 1988-11-06
AU1563588A (en) 1988-11-10
KR880013571A (ko) 1988-12-21
CN1032471C (zh) 1996-08-07
IL86258A0 (en) 1988-11-15
CN1030425A (zh) 1989-01-18
NZ224479A (en) 1991-04-26
DE3877811D1 (xx) 1993-03-11
JPS63297330A (ja) 1988-12-05
US5364932A (en) 1994-11-15
DK174286B1 (da) 2002-11-11
ATE84970T1 (de) 1993-02-15
JPH0532372B2 (xx) 1993-05-14
US4857636A (en) 1989-08-15
AU610883B2 (en) 1991-05-30
IL86258A (en) 1994-11-28
EP0290252A3 (en) 1989-01-18
GB8710598D0 (en) 1987-06-10
ES2053729T3 (es) 1994-08-01
EP0290252A2 (en) 1988-11-09
CA1306583C (en) 1992-08-18
KR910009343B1 (ko) 1991-11-12
DE3877811T2 (de) 1993-05-27

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