ZA882073B - 1,4-disubstituted piperazine compounds,their production and use - Google Patents

1,4-disubstituted piperazine compounds,their production and use

Info

Publication number
ZA882073B
ZA882073B ZA882073A ZA882073A ZA882073B ZA 882073 B ZA882073 B ZA 882073B ZA 882073 A ZA882073 A ZA 882073A ZA 882073 A ZA882073 A ZA 882073A ZA 882073 B ZA882073 B ZA 882073B
Authority
ZA
South Africa
Prior art keywords
group
piperazine compounds
production
disubstituted piperazine
disubstituted
Prior art date
Application number
ZA882073A
Other languages
English (en)
Inventor
Hirosada Sugihara
Sugihara Hirosada
Katsumi Itoh
Itoh Katsumi
Kohei Nishikawa
Nishikawa Kohei
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of ZA882073B publication Critical patent/ZA882073B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA882073A 1987-03-24 1988-03-23 1,4-disubstituted piperazine compounds,their production and use ZA882073B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6980487 1987-03-24

Publications (1)

Publication Number Publication Date
ZA882073B true ZA882073B (en) 1989-11-29

Family

ID=13413302

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA882073A ZA882073B (en) 1987-03-24 1988-03-23 1,4-disubstituted piperazine compounds,their production and use

Country Status (13)

Country Link
US (1) US4880809A (xx)
EP (1) EP0284359B1 (xx)
CN (1) CN88101588A (xx)
AT (1) ATE71373T1 (xx)
AU (1) AU608580B2 (xx)
DE (1) DE3867512D1 (xx)
DK (1) DK155088A (xx)
FI (1) FI881380A (xx)
HU (1) HU202509B (xx)
IL (1) IL85700A0 (xx)
NO (1) NO881253L (xx)
PT (1) PT87056B (xx)
ZA (1) ZA882073B (xx)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY102447A (en) * 1986-06-16 1992-06-30 Ciba Geigy Ag Disubtituted piperazines
US4937246A (en) * 1987-11-25 1990-06-26 Takeda Chemical Industries, Ltd. PAF antagonist, 1,4-disubstituted piperazine compounds and production thereof
PT90619B (pt) * 1988-05-23 1994-10-31 Glaxo Group Ltd Processo para a preparacao de compostos de piperazina
GB8823776D0 (en) * 1988-10-11 1988-11-16 Scras New 2-methoxycarbonyl sustituted n n'-di-(trimethoxybenzoyl)piperazines
GB8823775D0 (en) * 1988-10-11 1988-11-16 Scras New 2-carbonyl substituted n n'-di-(trimethoxybenzoyl)piperazines
US4997836A (en) * 1988-11-11 1991-03-05 Takeda Chemical Industries, Ltd. Trisubstituted piperazine compounds, their production and use
EP0369810A3 (en) * 1988-11-18 1991-05-02 Takeda Chemical Industries, Ltd. Paf antagonists as anti-hyperendothelinemia agents
GB8908587D0 (en) * 1989-04-15 1989-06-01 Scras Societe De Conseils De R New 2-substituted n,n'-ditrimethoxybenzoyl piperazines
US5192766A (en) * 1989-04-28 1993-03-09 Sankyo Company, Limited N-acryloylpiperazine derivatives, their preparation and their use as PAF antagonists
US5369106A (en) * 1989-04-28 1994-11-29 Sankyo Company, Limited N-acryloylpiperazine derivatives, their preparation and their use of PAF antagonists
EP0489690A1 (de) * 1990-12-05 1992-06-10 Ciba-Geigy Ag Substituierte N-Benzoyl-N'-(2-phenylethyl)-piperazine
ES2036926B1 (es) * 1991-08-08 1994-01-16 Uriach & Cia Sa J "procedimiento para la obtencion de derivados de la (2-alquil-3-piridil)metilpiperazina".
ES2062943B1 (es) * 1993-03-23 1995-11-16 Uriach & Cia Sa J Nuevos derivados de la (2-metil-3-piridil) cianometilpiperazinas.
CN1151744A (zh) * 1994-07-04 1997-06-11 武田药品工业株式会社 膦酸化合物及其制备和应用
ES2087038B1 (es) * 1994-11-07 1997-03-16 Uriach & Cia Sa J Nuevas piperidinas con actividad antagonista del paf.
US5859295A (en) * 1994-12-05 1999-01-12 University Of Kentucky Research Foundation Canavanine analogs and their use as chemotherapeutic agents
IL117149A0 (en) * 1995-02-23 1996-06-18 Schering Corp Muscarinic antagonists
US5889006A (en) * 1995-02-23 1999-03-30 Schering Corporation Muscarinic antagonists
US6001835A (en) * 1996-04-03 1999-12-14 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
DE19754490A1 (de) * 1997-12-09 1999-06-10 Boehringer Ingelheim Pharma Durch einen Aminocarbonylrest substituierte Bicyclen, ihre Herstellung und ihre Verwendung als Arzneimittel
CN1181065C (zh) * 2002-05-08 2004-12-22 上海医药工业研究院 芳烷甲酰烷基哌嗪衍生物及其作为脑神经保护剂的应用
JP2006511445A (ja) * 2002-06-07 2006-04-06 コーティカル・ピーティーワイ・リミテッド マクロファージ遊走阻止因子（ｍｉｆ）のサイトカインまたは生物学的活性を阻害するナフタレン誘導体
US7842693B2 (en) * 2002-06-12 2010-11-30 Chemocentryx, Inc. Substituted piperazines
DK1531822T3 (da) 2002-06-12 2009-12-07 Chemocentryx Inc 1-aryl-4-substituerede piperazin derivater til anvendelse som CCR1 antagonister til behandlingen af inflammation og immunforstyrrelser
US20050256130A1 (en) * 2002-06-12 2005-11-17 Chemocentryx, Inc. Substituted piperazines
US7589199B2 (en) 2002-06-12 2009-09-15 Chemocentryx, Inc. Substituted piperazines
US7435831B2 (en) * 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
CN1950082B (zh) * 2004-03-03 2013-02-06 凯莫森特里克斯股份有限公司 双环和桥连的含氮杂环化物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4130646A (en) * 1975-07-25 1978-12-19 E. R. Squibb & Sons, Inc. 1,2,3,4-Tetrahydro-2-((4-(phenyl)-1-piperazinyl)methyl)-1-naphthalenols and derivatives and analogs thereof
JPS52133993A (en) * 1976-04-29 1977-11-09 Takeda Chem Ind Ltd 1.2-dihydronaphthalene derivatives and method of preparing the same
GB1574019A (en) * 1977-01-14 1980-09-03 Joullie International Sa Therapeutically useful 3,4,5-trimethoxybenzene derivatives
FI68821C (fi) * 1977-07-18 1985-11-11 Sandoz Ag Analogifoerfarande foer framstaellning av nya tetralinderivat vilka saenker blodtryck och oekar blodetsgenomstroemning
US4173998A (en) * 1978-02-16 1979-11-13 Carrier Corporation Formed coil assembly
CH643549A5 (de) * 1979-08-25 1984-06-15 Merz & Co N-(trimethoxybenzyl)-n'-phenylpiperazine.
IT1176613B (it) * 1984-08-14 1987-08-18 Ravizza Spa Derivati piperazinici farmacologicamente attivi e processo per la loro preparazione
DE3685829T2 (de) * 1985-02-04 1992-12-17 Searle & Co Heterocyclische amide.
MY102447A (en) * 1986-06-16 1992-06-30 Ciba Geigy Ag Disubtituted piperazines
KR910006138B1 (ko) * 1986-09-30 1991-08-16 에자이 가부시끼가이샤 환상아민 유도체

Also Published As

Publication number Publication date
EP0284359B1 (en) 1992-01-08
CN88101588A (zh) 1988-11-23
FI881380A0 (fi) 1988-03-23
PT87056B (pt) 1992-07-31
EP0284359A1 (en) 1988-09-28
DK155088A (da) 1988-09-25
NO881253L (no) 1988-09-26
DK155088D0 (da) 1988-03-22
DE3867512D1 (de) 1992-02-20
FI881380A (fi) 1988-09-25
AU1353988A (en) 1988-09-22
NO881253D0 (no) 1988-03-22
HUT46899A (en) 1988-12-28
HU202509B (en) 1991-03-28
AU608580B2 (en) 1991-04-11
ATE71373T1 (de) 1992-01-15
US4880809A (en) 1989-11-14
IL85700A0 (en) 1988-08-31
PT87056A (pt) 1988-04-01

Similar Documents

Publication Publication Date Title
IL85700A0 (en) 1,4-disubstituted piperazine compounds,their production and use
DE69001187D1 (de) 6-epifumagillole, ihre herstellung und ihre verwendung.
DE69023171T2 (de) Kondensierte heterozyklische Verbindungen, ihre Herstellung und Verwendung.
DE69426157D1 (de) 1,4-di(phenylalkyl)piperazinderivate
ATE126517T1 (de) Verwendung von bis(3,4- dialkylbenzyliden)sorbitolacetale und diese enthaltende zusammensetzungen.
DE69020676T2 (de) Tricyclische Carbapenemverbindungen.
DE68920796T2 (de) Chinolinderivate, ihre Herstellung und Verwendung.
PT733621E (pt) Novos derivados de imidazole e processo para a sua preparacao
NO953052L (no) Nye pyrrolokarbazoler
DE69432542D1 (de) Tetraderivate, ihre Herstellung und Verwendung
DE69004598T2 (de) 6-Amino-6-desoxyfumagillole, ihre Herstellung und ihre Verwendung.
ATE168679T1 (de) Neue tetracyclische verbindungen
CA1246583A (en) 4-ISOXAZOLYL)-THIAZOLE-2-OXAMIC ACIDS AND THEIR DERIVATIVES
ATE137747T1 (de) Aminobenzolverbindungen, herstellung und verwendung
WO1991000729A3 (en) Bis-dioxopiperazines, and their use as protecting agents
ATE80162T1 (de) Antibiotisch wirkende isoxazolderivate, ihre herstellung und verwendung.