ATE71373T1 - 1,4-disubstituierte piperazin-verbindungen, ihre herstellung und ihre verwendung. - Google Patents
1,4-disubstituierte piperazin-verbindungen, ihre herstellung und ihre verwendung.Info
- Publication number
- ATE71373T1 ATE71373T1 AT88302523T AT88302523T ATE71373T1 AT E71373 T1 ATE71373 T1 AT E71373T1 AT 88302523 T AT88302523 T AT 88302523T AT 88302523 T AT88302523 T AT 88302523T AT E71373 T1 ATE71373 T1 AT E71373T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- piperazine compounds
- preparation
- disubstituted piperazine
- disubstituted
- Prior art date
Links
- -1 1,4-DISUBSTITUTED PIPERAZINE COMPOUNDS Chemical class 0.000 title abstract 2
- 229940123251 Platelet activating factor antagonist Drugs 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003367 polycyclic group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 abstract 1
- 239000003848 thrombocyte activating factor antagonist Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6980487 | 1987-03-24 | ||
EP19880302523 EP0284359B1 (de) | 1987-03-24 | 1988-03-23 | 1,4-Disubstituierte Piperazin-Verbindungen, ihre Herstellung und ihre Verwendung |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE71373T1 true ATE71373T1 (de) | 1992-01-15 |
Family
ID=13413302
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT88302523T ATE71373T1 (de) | 1987-03-24 | 1988-03-23 | 1,4-disubstituierte piperazin-verbindungen, ihre herstellung und ihre verwendung. |
Country Status (13)
Country | Link |
---|---|
US (1) | US4880809A (de) |
EP (1) | EP0284359B1 (de) |
CN (1) | CN88101588A (de) |
AT (1) | ATE71373T1 (de) |
AU (1) | AU608580B2 (de) |
DE (1) | DE3867512D1 (de) |
DK (1) | DK155088A (de) |
FI (1) | FI881380A (de) |
HU (1) | HU202509B (de) |
IL (1) | IL85700A0 (de) |
NO (1) | NO881253L (de) |
PT (1) | PT87056B (de) |
ZA (1) | ZA882073B (de) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY102447A (en) * | 1986-06-16 | 1992-06-30 | Ciba Geigy Ag | Disubtituted piperazines |
EP0318235A3 (de) * | 1987-11-25 | 1991-05-02 | Takeda Chemical Industries, Ltd. | PAF-Antagonist, 1,4-disubstituierte Piperazin-Verbindungen und deren Herstellung |
PT90619B (pt) * | 1988-05-23 | 1994-10-31 | Glaxo Group Ltd | Processo para a preparacao de compostos de piperazina |
GB8823776D0 (en) * | 1988-10-11 | 1988-11-16 | Scras | New 2-methoxycarbonyl sustituted n n'-di-(trimethoxybenzoyl)piperazines |
GB8823775D0 (en) * | 1988-10-11 | 1988-11-16 | Scras | New 2-carbonyl substituted n n'-di-(trimethoxybenzoyl)piperazines |
US4997836A (en) * | 1988-11-11 | 1991-03-05 | Takeda Chemical Industries, Ltd. | Trisubstituted piperazine compounds, their production and use |
CA2003210A1 (en) * | 1988-11-18 | 1990-05-18 | Susumu Tsushima | Anti-hyperendothelinemia agent |
GB8908587D0 (en) * | 1989-04-15 | 1989-06-01 | Scras Societe De Conseils De R | New 2-substituted n,n'-ditrimethoxybenzoyl piperazines |
US5192766A (en) * | 1989-04-28 | 1993-03-09 | Sankyo Company, Limited | N-acryloylpiperazine derivatives, their preparation and their use as PAF antagonists |
US5369106A (en) * | 1989-04-28 | 1994-11-29 | Sankyo Company, Limited | N-acryloylpiperazine derivatives, their preparation and their use of PAF antagonists |
EP0489690A1 (de) * | 1990-12-05 | 1992-06-10 | Ciba-Geigy Ag | Substituierte N-Benzoyl-N'-(2-phenylethyl)-piperazine |
ES2036926B1 (es) * | 1991-08-08 | 1994-01-16 | Uriach & Cia Sa J | "procedimiento para la obtencion de derivados de la (2-alquil-3-piridil)metilpiperazina". |
ES2062943B1 (es) * | 1993-03-23 | 1995-11-16 | Uriach & Cia Sa J | Nuevos derivados de la (2-metil-3-piridil) cianometilpiperazinas. |
ATE199721T1 (de) * | 1994-07-04 | 2001-03-15 | Takeda Chemical Industries Ltd | Phosphonsäure verbindungen imre herstellung und verwendung |
ES2087038B1 (es) * | 1994-11-07 | 1997-03-16 | Uriach & Cia Sa J | Nuevas piperidinas con actividad antagonista del paf. |
US5859295A (en) * | 1994-12-05 | 1999-01-12 | University Of Kentucky Research Foundation | Canavanine analogs and their use as chemotherapeutic agents |
US5889006A (en) * | 1995-02-23 | 1999-03-30 | Schering Corporation | Muscarinic antagonists |
IL117149A0 (en) * | 1995-02-23 | 1996-06-18 | Schering Corp | Muscarinic antagonists |
US6001835A (en) * | 1996-04-03 | 1999-12-14 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
DE19754490A1 (de) * | 1997-12-09 | 1999-06-10 | Boehringer Ingelheim Pharma | Durch einen Aminocarbonylrest substituierte Bicyclen, ihre Herstellung und ihre Verwendung als Arzneimittel |
CN1181065C (zh) * | 2002-05-08 | 2004-12-22 | 上海医药工业研究院 | 芳烷甲酰烷基哌嗪衍生物及其作为脑神经保护剂的应用 |
JP2006511445A (ja) * | 2002-06-07 | 2006-04-06 | コーティカル・ピーティーワイ・リミテッド | マクロファージ遊走阻止因子(mif)のサイトカインまたは生物学的活性を阻害するナフタレン誘導体 |
US7842693B2 (en) * | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
DE60328690D1 (de) * | 2002-06-12 | 2009-09-17 | Chemocentryx Inc | 1-aryl-4-substituierte piperazin-derivate zur verwendung als ccr1-antagonisten zur behandlung von entzündungen und immunerkrankungen |
US7589199B2 (en) | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
US20050256130A1 (en) * | 2002-06-12 | 2005-11-17 | Chemocentryx, Inc. | Substituted piperazines |
US7435831B2 (en) * | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
CA2558211C (en) * | 2004-03-03 | 2013-09-03 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4130646A (en) * | 1975-07-25 | 1978-12-19 | E. R. Squibb & Sons, Inc. | 1,2,3,4-Tetrahydro-2-((4-(phenyl)-1-piperazinyl)methyl)-1-naphthalenols and derivatives and analogs thereof |
JPS52133993A (en) * | 1976-04-29 | 1977-11-09 | Takeda Chem Ind Ltd | 1.2-dihydronaphthalene derivatives and method of preparing the same |
GB1574019A (en) * | 1977-01-14 | 1980-09-03 | Joullie International Sa | Therapeutically useful 3,4,5-trimethoxybenzene derivatives |
FI68821C (fi) * | 1977-07-18 | 1985-11-11 | Sandoz Ag | Analogifoerfarande foer framstaellning av nya tetralinderivat vilka saenker blodtryck och oekar blodetsgenomstroemning |
US4173998A (en) * | 1978-02-16 | 1979-11-13 | Carrier Corporation | Formed coil assembly |
CH643549A5 (de) * | 1979-08-25 | 1984-06-15 | Merz & Co | N-(trimethoxybenzyl)-n'-phenylpiperazine. |
IT1176613B (it) * | 1984-08-14 | 1987-08-18 | Ravizza Spa | Derivati piperazinici farmacologicamente attivi e processo per la loro preparazione |
EP0190685B1 (de) * | 1985-02-04 | 1992-07-01 | G.D. Searle & Co. | Heterocyclische Amide |
MY102447A (en) * | 1986-06-16 | 1992-06-30 | Ciba Geigy Ag | Disubtituted piperazines |
KR910006138B1 (ko) * | 1986-09-30 | 1991-08-16 | 에자이 가부시끼가이샤 | 환상아민 유도체 |
-
1988
- 1988-03-11 IL IL85700A patent/IL85700A0/xx unknown
- 1988-03-14 US US07/167,961 patent/US4880809A/en not_active Expired - Fee Related
- 1988-03-22 NO NO881253A patent/NO881253L/no unknown
- 1988-03-22 HU HU881435A patent/HU202509B/hu not_active IP Right Cessation
- 1988-03-22 DK DK155088A patent/DK155088A/da not_active IP Right Cessation
- 1988-03-23 FI FI881380A patent/FI881380A/fi not_active Application Discontinuation
- 1988-03-23 AT AT88302523T patent/ATE71373T1/de not_active IP Right Cessation
- 1988-03-23 AU AU13539/88A patent/AU608580B2/en not_active Expired - Fee Related
- 1988-03-23 DE DE8888302523T patent/DE3867512D1/de not_active Expired - Fee Related
- 1988-03-23 EP EP19880302523 patent/EP0284359B1/de not_active Expired - Lifetime
- 1988-03-23 PT PT87056A patent/PT87056B/pt not_active IP Right Cessation
- 1988-03-23 ZA ZA882073A patent/ZA882073B/xx unknown
- 1988-03-24 CN CN198888101588A patent/CN88101588A/zh not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
NO881253L (no) | 1988-09-26 |
CN88101588A (zh) | 1988-11-23 |
HUT46899A (en) | 1988-12-28 |
DK155088D0 (da) | 1988-03-22 |
AU608580B2 (en) | 1991-04-11 |
DK155088A (da) | 1988-09-25 |
ZA882073B (en) | 1989-11-29 |
HU202509B (en) | 1991-03-28 |
AU1353988A (en) | 1988-09-22 |
PT87056A (pt) | 1988-04-01 |
IL85700A0 (en) | 1988-08-31 |
US4880809A (en) | 1989-11-14 |
NO881253D0 (no) | 1988-03-22 |
FI881380A (fi) | 1988-09-25 |
EP0284359B1 (de) | 1992-01-08 |
PT87056B (pt) | 1992-07-31 |
FI881380A0 (fi) | 1988-03-23 |
EP0284359A1 (de) | 1988-09-28 |
DE3867512D1 (de) | 1992-02-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |