ZA879502B - Novel bicyclic diphosphonate compounds,pharmaceutical compositions,and methods for treating abnormal calcium and phosphate metabolism - Google Patents
Novel bicyclic diphosphonate compounds,pharmaceutical compositions,and methods for treating abnormal calcium and phosphate metabolismInfo
- Publication number
- ZA879502B ZA879502B ZA879502A ZA879502A ZA879502B ZA 879502 B ZA879502 B ZA 879502B ZA 879502 A ZA879502 A ZA 879502A ZA 879502 A ZA879502 A ZA 879502A ZA 879502 B ZA879502 B ZA 879502B
- Authority
- ZA
- South Africa
- Prior art keywords
- methods
- pharmaceutical compositions
- phosphate metabolism
- present
- abnormal calcium
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title abstract 2
- 229910019142 PO4 Inorganic materials 0.000 title abstract 2
- 230000002159 abnormal effect Effects 0.000 title abstract 2
- 229910052791 calcium Inorganic materials 0.000 title abstract 2
- 239000011575 calcium Substances 0.000 title abstract 2
- 230000004060 metabolic process Effects 0.000 title abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 title abstract 2
- 239000010452 phosphate Substances 0.000 title abstract 2
- -1 bicyclic diphosphonate compounds Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical group OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/5765—Six-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Paints Or Removers (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/945,069 US4868164A (en) | 1986-12-19 | 1986-12-19 | Octahydro-pyridine diphosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA879502B true ZA879502B (en) | 1988-06-16 |
Family
ID=25482572
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA879502A ZA879502B (en) | 1986-12-19 | 1987-12-18 | Novel bicyclic diphosphonate compounds,pharmaceutical compositions,and methods for treating abnormal calcium and phosphate metabolism |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US4868164A (xx) |
| EP (1) | EP0273514B1 (xx) |
| JP (1) | JP2573973B2 (xx) |
| KR (1) | KR950009196B1 (xx) |
| AT (1) | ATE59046T1 (xx) |
| AU (1) | AU615886B2 (xx) |
| CA (1) | CA1321793C (xx) |
| DE (1) | DE3766695D1 (xx) |
| DK (1) | DK171068B1 (xx) |
| FI (1) | FI87652C (xx) |
| HK (1) | HK79393A (xx) |
| IE (1) | IE873456L (xx) |
| IL (1) | IL84660A (xx) |
| MY (1) | MY102266A (xx) |
| NO (2) | NO174625C (xx) |
| NZ (1) | NZ222985A (xx) |
| PH (1) | PH25583A (xx) |
| ZA (1) | ZA879502B (xx) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4868164A (en) * | 1986-12-19 | 1989-09-19 | Norwich Eaton Pharmaceuticals, Inc. | Octahydro-pyridine diphosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |
| IL86951A (en) * | 1987-07-06 | 1996-07-23 | Procter & Gamble Pharma | Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them |
| DE3822650A1 (de) * | 1988-07-05 | 1990-02-01 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| ES2118967T3 (es) * | 1992-05-29 | 1998-10-01 | Procter & Gamble Pharma | Compuestos de fosfonato que contienen nitrogeno cuaternario para tratar un metabolismo anormal del calcio y fosfato asi como el calculo y la placa dentales. |
| RU2124019C1 (ru) * | 1992-05-29 | 1998-12-27 | Дзе Проктер энд Гэмбл Фармасьютикалз, Инк. | Тиозамещенные пиридинилбисфосфоновые кислоты или их фармацевтически приемлемые соли или эфиры, фармацевтическая композиция на их основе и способ лечения |
| NZ253524A (en) * | 1992-05-29 | 1997-01-29 | Procter & Gamble Pharma | Sulphur-containing phosphonate derivatives and medicaments (for treating abnormal calcium and phosphate metabolism) |
| US5763611A (en) * | 1992-05-29 | 1998-06-09 | The Procter & Gamble Company | Thio-substituted cyclic phosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |
| US5391743A (en) * | 1992-05-29 | 1995-02-21 | Procter & Gamble Pharmaceuticals, Inc. | Quaternary nitrogen-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism and methods of treating and preventing dental calculus and plaque |
| US5753634A (en) * | 1992-05-29 | 1998-05-19 | The Procter & Gamble Company | Quaternary nitrogen containing phosphonate compounds, pharmaceutical compostions, and methods for treating abnormal calcium and phosphate metabolism |
| DE69324684T2 (de) * | 1992-06-30 | 1999-11-25 | Procter & Gamble Pharma | Arzneimitteln zur behandlung von arthritis die phosphonate und nsaids enthalten |
| KR970705400A (ko) * | 1994-09-09 | 1997-10-09 | 레이셔 야코버스 코넬리스 | 골 활성 포스포네이트 및 부갑상선 호르몬을 사용한 골다공증의 치료방법(methods for the treatment of osteoporosis using bone active phosphonates and parathyroid hormone) |
| EP0753523A1 (en) | 1995-07-10 | 1997-01-15 | Gador S.A. | Amino-substituted bisphosphonic acids |
| US7781418B2 (en) * | 2006-12-14 | 2010-08-24 | Isis Innovation Ltd. | Composition for treating bone disorders |
| US11793452B2 (en) | 2019-10-03 | 2023-10-24 | Johnson & Johnson Consumer Inc. | Method of visualizing and quantifying remineralization |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3553314A (en) * | 1968-12-23 | 1971-01-05 | Procter & Gamble | Oral compositions for calculus retardation |
| US3979385A (en) * | 1969-11-19 | 1976-09-07 | Henkel & Cie G.M.B.H. | 1-Aminoalkane-1,1-diphosphonic acids and their salts |
| DE1958123C3 (de) * | 1969-11-19 | 1978-09-28 | Henkel Kgaa, 4000 Duesseldorf | Verfahren zur Herstellung von 1 -Aminoalkan-1,1 -diphosphonsäuren oder deren Salzen |
| US3683080A (en) * | 1970-08-28 | 1972-08-08 | Procter & Gamble | Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue |
| US3899496A (en) * | 1970-10-06 | 1975-08-12 | Henkel & Cie Gmbh | Production of 1-aminoalkane-1,1-diphosphonic acids |
| DE2104476C2 (de) * | 1971-02-01 | 1983-12-01 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur Verhinderung von Ausfällungen in Wasser oder wäßrigen Lösungen |
| US4034086A (en) * | 1973-08-27 | 1977-07-05 | Henkel & Cie G.M.B.H. | Pyrrolidone-5,5-diphosphonic acids |
| DE2343147C2 (de) * | 1973-08-27 | 1982-06-09 | Henkel KGaA, 4000 Düsseldorf | Pyrrolidon-5,5-diphosphonsäuren, deren wasserlösliche Salze, und Verfahren zu ihrer Herstellung |
| DE2343196C3 (de) * | 1973-08-27 | 1980-01-10 | Henkel Kgaa, 4000 Duesseldorf | Aiacycloalkan-2^-diphosphonsäuren oder deren wasserlösliche Salze |
| US3988443A (en) * | 1973-08-27 | 1976-10-26 | Henkel & Cie G.M.B.H. | Azacycloalkane-2,2-diphosphonic acids |
| DE2456666A1 (de) * | 1974-11-30 | 1976-08-12 | Henkel & Cie Gmbh | Verfahren zum stabilisieren von calcium-hydrogenphosphat-dihydrat gegen hydrolyse |
| DE2543349C2 (de) * | 1975-09-29 | 1984-05-10 | Henkel KGaA, 4000 Düsseldorf | Preaparate zur herstellung von99m technetium-radiagnostica |
| DK506476A (da) * | 1975-12-01 | 1977-06-02 | Henkel & Cie Gmbh | Farmaceutiske preparater til behandling af calciumstofs skifteforstyrrelser |
| DE2745083C2 (de) * | 1977-10-07 | 1985-05-02 | Henkel KGaA, 4000 Düsseldorf | Hydroxydiphosphonsäuren und Verfahren zu deren Herstellung |
| US4230700A (en) * | 1977-12-07 | 1980-10-28 | The Procter & Gamble Company | Methods for inhibiting mobilization of calcium phosphate in animal tissue |
| SU1002300A1 (ru) * | 1981-10-29 | 1983-03-07 | Ордена Ленина институт элементоорганических соединений им.А.Н.Несмеянова | Способ получени @ -аминозамещенных- @ -оксипропилидендифосфоновых кислот |
| DE3428524A1 (de) * | 1984-08-02 | 1986-02-13 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| US4687768A (en) * | 1984-12-21 | 1987-08-18 | The Procter & Gamble Company | Certain hexahydroindan-2,2-diphosphonic acids useful in treating diseases associated with abnormal calcium and phosphate metabolism |
| DE3540150A1 (de) * | 1985-11-13 | 1987-05-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| US4868164A (en) * | 1986-12-19 | 1989-09-19 | Norwich Eaton Pharmaceuticals, Inc. | Octahydro-pyridine diphosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |
-
1986
- 1986-12-19 US US06/945,069 patent/US4868164A/en not_active Expired - Lifetime
-
1987
- 1987-11-30 IL IL8466087A patent/IL84660A/en not_active IP Right Cessation
- 1987-12-10 MY MYPI87003173A patent/MY102266A/en unknown
- 1987-12-16 EP EP87202533A patent/EP0273514B1/en not_active Expired - Lifetime
- 1987-12-16 DE DE8787202533T patent/DE3766695D1/de not_active Expired - Fee Related
- 1987-12-16 AT AT87202533T patent/ATE59046T1/de not_active IP Right Cessation
- 1987-12-17 CA CA000554628A patent/CA1321793C/en not_active Expired - Fee Related
- 1987-12-18 NZ NZ222985A patent/NZ222985A/xx unknown
- 1987-12-18 FI FI875595A patent/FI87652C/fi not_active IP Right Cessation
- 1987-12-18 IE IE873456A patent/IE873456L/xx not_active IP Right Cessation
- 1987-12-18 PH PH36260A patent/PH25583A/en unknown
- 1987-12-18 DK DK670387A patent/DK171068B1/da not_active IP Right Cessation
- 1987-12-18 ZA ZA879502A patent/ZA879502B/xx unknown
- 1987-12-18 AU AU82809/87A patent/AU615886B2/en not_active Ceased
- 1987-12-18 NO NO875305A patent/NO174625C/no not_active IP Right Cessation
- 1987-12-19 KR KR1019870014561A patent/KR950009196B1/ko not_active IP Right Cessation
- 1987-12-19 JP JP62322651A patent/JP2573973B2/ja not_active Expired - Fee Related
-
1989
- 1989-09-14 US US07/407,848 patent/US5137880A/en not_active Expired - Lifetime
-
1992
- 1992-06-17 US US07/899,794 patent/US5393746A/en not_active Expired - Fee Related
- 1992-06-29 NO NO922565A patent/NO176144C/no not_active IP Right Cessation
-
1993
- 1993-08-05 HK HK793/93A patent/HK79393A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FI875595A (fi) | 1988-06-20 |
| NO922565D0 (no) | 1992-06-29 |
| FI875595A0 (fi) | 1987-12-18 |
| DE3766695D1 (de) | 1991-01-24 |
| NO176144B (no) | 1994-10-31 |
| AU615886B2 (en) | 1991-10-17 |
| IL84660A0 (en) | 1988-04-29 |
| KR950009196B1 (ko) | 1995-08-16 |
| NO922565L (no) | 1988-06-20 |
| US4868164A (en) | 1989-09-19 |
| JP2573973B2 (ja) | 1997-01-22 |
| HK79393A (en) | 1993-08-13 |
| NO174625B (no) | 1994-02-28 |
| AU8280987A (en) | 1988-06-23 |
| JPS63239290A (ja) | 1988-10-05 |
| DK171068B1 (da) | 1996-05-20 |
| IL84660A (en) | 1994-10-21 |
| CA1321793C (en) | 1993-08-31 |
| US5137880A (en) | 1992-08-11 |
| NO875305L (no) | 1988-06-20 |
| MY102266A (en) | 1992-05-15 |
| ATE59046T1 (de) | 1990-12-15 |
| FI87652B (fi) | 1992-10-30 |
| DK670387A (da) | 1988-06-20 |
| PH25583A (en) | 1991-08-08 |
| NO875305D0 (no) | 1987-12-18 |
| NZ222985A (en) | 1990-09-26 |
| US5393746A (en) | 1995-02-28 |
| EP0273514A1 (en) | 1988-07-06 |
| IE873456L (en) | 1988-06-19 |
| NO176144C (no) | 1995-02-08 |
| DK670387D0 (da) | 1987-12-18 |
| FI87652C (fi) | 1993-02-10 |
| KR880007473A (ko) | 1988-08-27 |
| EP0273514B1 (en) | 1990-12-12 |
| NO174625C (no) | 1994-06-08 |
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| IL86951A0 (en) | Methylene phosphonoalkylphosphinates and pharmaceutical compositions containing them | |
| ES8802428B9 (en) | Pharmaceutical compositions containing geminal diphosphonates. | |
| NZ222985A (en) | Bicyclic diphosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |