PH25769A - Certain cycloalkane-1,1-diphosphonic acids, derivatives thereof having the ability to treat diseases associated with abnormal calcium, phosphate metabolism - Google Patents

Certain cycloalkane-1,1-diphosphonic acids, derivatives thereof having the ability to treat diseases associated with abnormal calcium, phosphate metabolism

Info

Publication number
PH25769A
PH25769A PH37782A PH37782A PH25769A PH 25769 A PH25769 A PH 25769A PH 37782 A PH37782 A PH 37782A PH 37782 A PH37782 A PH 37782A PH 25769 A PH25769 A PH 25769A
Authority
PH
Philippines
Prior art keywords
phosphate metabolism
cycloalkane
derivatives
abnormal calcium
ability
Prior art date
Application number
PH37782A
Inventor
James John Benedict
Karen Yvonne Johnson
Original Assignee
Procter
Gamble Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter, Gamble Company filed Critical Procter
Publication of PH25769A publication Critical patent/PH25769A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3843—Polyphosphonic acids containing no further substituents than -PO3H2 groups
    • C07F9/3852—Cycloaliphatic derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3856—Polyphosphonic acids containing halogen or nitro(so) substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/5765—Six-membered rings condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nutrition Science (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Novel cyclic geminal-diphosphonic acid compounds, and pharmaceutical compositions containing these compounds, which are useful for treating diseases characterized by abnormal calcium and phosphate metabolism; and a method of treating diseases characterized by abnormal calcium and phosphate metabolism utilizing these novel cyclic diphosphonic acid compounds.
PH37782A 1984-12-21 1988-11-09 Certain cycloalkane-1,1-diphosphonic acids, derivatives thereof having the ability to treat diseases associated with abnormal calcium, phosphate metabolism PH25769A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/684,544 US4687768A (en) 1984-12-21 1984-12-21 Certain hexahydroindan-2,2-diphosphonic acids useful in treating diseases associated with abnormal calcium and phosphate metabolism

Publications (1)

Publication Number Publication Date
PH25769A true PH25769A (en) 1991-10-18

Family

ID=24748496

Family Applications (2)

Application Number Title Priority Date Filing Date
PH33193A PH23500A (en) 1984-12-21 1985-12-17 Certain hexahydroindan-2,2-diphosphonic acids useful in treating diseases associated with abnormal calcium and phosphate metabolsim
PH37782A PH25769A (en) 1984-12-21 1988-11-09 Certain cycloalkane-1,1-diphosphonic acids, derivatives thereof having the ability to treat diseases associated with abnormal calcium, phosphate metabolism

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PH33193A PH23500A (en) 1984-12-21 1985-12-17 Certain hexahydroindan-2,2-diphosphonic acids useful in treating diseases associated with abnormal calcium and phosphate metabolsim

Country Status (14)

Country Link
US (2) US4687768A (en)
EP (3) EP0304961B1 (en)
JP (3) JPH0699456B2 (en)
AT (3) ATE46167T1 (en)
AU (1) AU583873B2 (en)
CA (1) CA1279872C (en)
DE (3) DE3572822D1 (en)
DK (1) DK173943B1 (en)
ES (1) ES8704958A1 (en)
IE (1) IE58272B1 (en)
IL (1) IL77242A (en)
NZ (1) NZ214650A (en)
PH (2) PH23500A (en)
ZA (1) ZA859361B (en)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL77243A (en) * 1984-12-21 1996-11-14 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds
US4902679A (en) * 1985-12-13 1990-02-20 Norwich Eaton Pharmaceuticals, Inc. Methods of treating diseases with certain geminal diphosphonates
GB8618259D0 (en) * 1986-07-25 1986-09-03 Leo Pharm Prod Ltd Pharmaceutical compositions
US4868164A (en) * 1986-12-19 1989-09-19 Norwich Eaton Pharmaceuticals, Inc. Octahydro-pyridine diphosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
US4963681A (en) * 1987-07-06 1990-10-16 Norwich Eaton Pharmaceuticals, Inc. Process for synthesis of aminomethylene phosphonoalkylphosphinates
IL86951A (en) * 1987-07-06 1996-07-23 Procter & Gamble Pharma Methylene phosphonoalkyl-phosphinates and pharmaceutical compositions containing them
US4877603A (en) * 1987-12-18 1989-10-31 The Procter & Gamble Company Oral compositions
DE3822650A1 (en) * 1988-07-05 1990-02-01 Boehringer Mannheim Gmbh NEW DIPHOSPHONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
US5220021A (en) * 1989-04-03 1993-06-15 The Upjohn Company Geminal bisphosphonic acids and derivatives as anti-arthritic agents
DE69002328T2 (en) * 1989-04-03 1993-12-09 Upjohn Co GEMINAL BISPHOSPHONIC ACIDS AND THEIR DERIVATIVES AS ANTI-ARTHRITIC AGENTS.
MX21452A (en) * 1989-07-07 1994-01-31 Ciba Geigy Ag PHARMACEUTICAL PREPARATIONS THAT ARE TOPICALLY ADMINISTERED.
US5139786A (en) * 1989-07-07 1992-08-18 Ciba-Geigy Corporation Topical formulations
US5324519A (en) * 1989-07-24 1994-06-28 Atrix Laboratories, Inc. Biodegradable polymer composition
US5487897A (en) * 1989-07-24 1996-01-30 Atrix Laboratories, Inc. Biodegradable implant precursor
PT95286A (en) * 1989-09-14 1991-05-22 Symphar Sa PREPARATION PROCESS OF GEM-DIFFOSPHONATE DERIVATIVES, SUBSTITUTED BY NAPHTHALENE AND TETRAHYDRO-NAPHTHALENE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US5763611A (en) * 1992-05-29 1998-06-09 The Procter & Gamble Company Thio-substituted cyclic phosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
EP0643716B1 (en) * 1992-05-29 1999-12-08 THE PROCTER & GAMBLE PHARMACEUTICALS, INC. Quaternary nitrogen-containing phosphonate compounds for treating abnormal calcium and phosphate metabolism
US5391743A (en) * 1992-05-29 1995-02-21 Procter & Gamble Pharmaceuticals, Inc. Quaternary nitrogen-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism and methods of treating and preventing dental calculus and plaque
DE69319732T2 (en) * 1992-05-29 1999-02-11 Procter & Gamble Pharmaceuticals, Inc., Norwich, N.Y. QUATERNAR NITROGEN-CONTAINING PHOSPHONATE COMPOUNDS FOR THE TREATMENT OF ABNORMAL CALCIUM AND PHOSPHATE METABOLISM AND DENTALIZATION
WO1993024500A1 (en) * 1992-05-29 1993-12-09 The Procter & Gamble Pharmaceuticals, Inc. Thio-substituted nitrogen-containing heterocyclic phosphonate compounds for treating abnormal calcium and phosphate metabolism
RU2136691C1 (en) * 1992-05-29 1999-09-10 Дзе Проктер энд Гэмбл Фармасьютикалз, Инк. Sulfur-containing phosphonic acids or their pharmaceutically acceptable salts or esters and pharmaceutical composition based on said
US5753634A (en) * 1992-05-29 1998-05-19 The Procter & Gamble Company Quaternary nitrogen containing phosphonate compounds, pharmaceutical compostions, and methods for treating abnormal calcium and phosphate metabolism
SK160994A3 (en) * 1992-06-30 1996-01-10 Procter & Gamble Pharma Compositions for the treatment of arthritis containing phosphonates and nsaid
US5591730A (en) * 1993-10-12 1997-01-07 The Regents Of The University Of California Inhibition of urinary calculi growth
US5681873A (en) * 1993-10-14 1997-10-28 Atrix Laboratories, Inc. Biodegradable polymeric composition
US5753633A (en) * 1997-04-11 1998-05-19 Colgate-Palmolive Company Method of inhibiting bone resorption
US6187329B1 (en) 1997-12-23 2001-02-13 Board Of Regents Of The University Of Texas System Variable permeability bone implants, methods for their preparation and use
US6255359B1 (en) 1997-12-23 2001-07-03 Board Of Regents Of The University Of Texas System Permeable compositions and methods for their preparation
US6733767B2 (en) 1998-03-19 2004-05-11 Merck & Co., Inc. Liquid polymeric compositions for controlled release of bioactive substances
US7128927B1 (en) 1998-04-14 2006-10-31 Qlt Usa, Inc. Emulsions for in-situ delivery systems
US8226598B2 (en) * 1999-09-24 2012-07-24 Tolmar Therapeutics, Inc. Coupling syringe system and methods for obtaining a mixed composition
US7115589B2 (en) 1999-12-17 2006-10-03 Ariad Pharmaceuticals, Inc. Purine derivatives
CA2394650A1 (en) * 1999-12-17 2001-06-21 Chi B. Vu Novel heterocycles
AU2277201A (en) * 1999-12-17 2001-06-25 Ariad Pharmaceuticals, Inc. Novel purines
TW200413381A (en) 2002-11-04 2004-08-01 Hoffmann La Roche Novel amino-substituted dihydropyrimido [4,5-d]pyrimidinone derivatives, their manufacture and use as pharmaceutical agents
WO2005009348A2 (en) * 2003-06-25 2005-02-03 Ariad Pharmaceuticals, Inc. Substituted purine derivatives
US8362086B2 (en) 2005-08-19 2013-01-29 Merial Limited Long acting injectable formulations
US7781418B2 (en) 2006-12-14 2010-08-24 Isis Innovation Ltd. Composition for treating bone disorders
CA2653189A1 (en) 2008-02-04 2009-08-04 University Of Ottawa Estrogenic compounds, process for their production and pharmaceutical uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3683080A (en) * 1970-08-28 1972-08-08 Procter & Gamble Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue
US3988433A (en) * 1973-08-10 1976-10-26 The Procter & Gamble Company Oral compositions for preventing or removing stains from teeth
DE2343147C2 (en) * 1973-08-27 1982-06-09 Henkel KGaA, 4000 Düsseldorf Pyrrolidone-5,5-diphosphonic acids, their water-soluble salts, and processes for their preparation
US4034086A (en) * 1973-08-27 1977-07-05 Henkel & Cie G.M.B.H. Pyrrolidone-5,5-diphosphonic acids
US3988443A (en) * 1973-08-27 1976-10-26 Henkel & Cie G.M.B.H. Azacycloalkane-2,2-diphosphonic acids
DE2343196C3 (en) * 1973-08-27 1980-01-10 Henkel Kgaa, 4000 Duesseldorf Aiacycloalkan-2 ^ -diphosphonic acids or their water-soluble salts
DE2543349C2 (en) * 1975-09-29 1984-05-10 Henkel KGaA, 4000 Düsseldorf Preparations for the production of 99m technetium-radiagnostica
DK506476A (en) * 1975-12-01 1977-06-02 Henkel & Cie Gmbh PHARMACEUTICALS FOR THE TREATMENT OF CALCIUM SUBSTANCE SHIFT DISORDERS
US4330537A (en) * 1977-12-07 1982-05-18 The Procter & Gamble Company Compositions for inhibiting mobilization of calcium phosphate in animal tissue

Also Published As

Publication number Publication date
ATE92932T1 (en) 1993-08-15
DE3587527T2 (en) 1993-12-02
DE3586543D1 (en) 1992-09-24
US4939131A (en) 1990-07-03
ES8704958A1 (en) 1987-04-16
EP0304961A2 (en) 1989-03-01
JPS61210091A (en) 1986-09-18
ZA859361B (en) 1986-08-27
EP0189662A1 (en) 1986-08-06
DE3587527D1 (en) 1993-09-16
IE58272B1 (en) 1993-08-25
US4687768A (en) 1987-08-18
JPH07138271A (en) 1995-05-30
ES550243A0 (en) 1987-04-16
NZ214650A (en) 1990-06-26
ATE46167T1 (en) 1989-09-15
JP2680264B2 (en) 1997-11-19
ATE79628T1 (en) 1992-09-15
IL77242A (en) 1991-06-10
CA1279872C (en) 1991-02-05
EP0189662B1 (en) 1989-09-06
EP0304962A3 (en) 1989-04-26
DK599585D0 (en) 1985-12-20
EP0304962A2 (en) 1989-03-01
JPH0699456B2 (en) 1994-12-07
AU5153885A (en) 1986-06-26
IE853285L (en) 1986-06-21
DK599585A (en) 1986-06-22
EP0304962B1 (en) 1992-08-19
DK173943B1 (en) 2002-03-04
PH23500A (en) 1989-08-16
JPH07149775A (en) 1995-06-13
JPH07113037B2 (en) 1995-12-06
EP0304961A3 (en) 1989-05-03
DE3586543T2 (en) 1993-01-07
EP0304961B1 (en) 1993-08-11
AU583873B2 (en) 1989-05-11
DE3572822D1 (en) 1989-10-12

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