FI875595A0 - Nya bicykliska difosfonatfoereningar, farmaceutiska kompositioner och foerfarande foer behandling av avvikande kalcium- och fosfatmetabolism. - Google Patents

Nya bicykliska difosfonatfoereningar, farmaceutiska kompositioner och foerfarande foer behandling av avvikande kalcium- och fosfatmetabolism.

Info

Publication number
FI875595A0
FI875595A0 FI875595A FI875595A FI875595A0 FI 875595 A0 FI875595 A0 FI 875595A0 FI 875595 A FI875595 A FI 875595A FI 875595 A FI875595 A FI 875595A FI 875595 A0 FI875595 A0 FI 875595A0
Authority
FI
Finland
Prior art keywords
och
foer
pharmaceutical composition
kalcium
fosfatmetabolism
Prior art date
Application number
FI875595A
Other languages
English (en)
Other versions
FI875595A (fi
FI87652B (fi
FI87652C (fi
Inventor
Frank Hallock Ebetino
Kent Warren Buckingham
Jocelyn Elaine Mcosker
Original Assignee
Norwich Eaton Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Norwich Eaton Pharma filed Critical Norwich Eaton Pharma
Publication of FI875595A0 publication Critical patent/FI875595A0/fi
Publication of FI875595A publication Critical patent/FI875595A/fi
Publication of FI87652B publication Critical patent/FI87652B/fi
Application granted granted Critical
Publication of FI87652C publication Critical patent/FI87652C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/5765—Six-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Paints Or Removers (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI875595A 1986-12-19 1987-12-18 Foerfarande foer framstaellning av oktahydropyridindifosfonsyror och farmaceutiskt godtagbara salter och estrar daerav FI87652C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/945,069 US4868164A (en) 1986-12-19 1986-12-19 Octahydro-pyridine diphosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
US94506986 1986-12-19

Publications (4)

Publication Number Publication Date
FI875595A0 true FI875595A0 (fi) 1987-12-18
FI875595A FI875595A (fi) 1988-06-20
FI87652B FI87652B (fi) 1992-10-30
FI87652C FI87652C (fi) 1993-02-10

Family

ID=25482572

Family Applications (1)

Application Number Title Priority Date Filing Date
FI875595A FI87652C (fi) 1986-12-19 1987-12-18 Foerfarande foer framstaellning av oktahydropyridindifosfonsyror och farmaceutiskt godtagbara salter och estrar daerav

Country Status (18)

Country Link
US (3) US4868164A (fi)
EP (1) EP0273514B1 (fi)
JP (1) JP2573973B2 (fi)
KR (1) KR950009196B1 (fi)
AT (1) ATE59046T1 (fi)
AU (1) AU615886B2 (fi)
CA (1) CA1321793C (fi)
DE (1) DE3766695D1 (fi)
DK (1) DK171068B1 (fi)
FI (1) FI87652C (fi)
HK (1) HK79393A (fi)
IE (1) IE873456L (fi)
IL (1) IL84660A (fi)
MY (1) MY102266A (fi)
NO (2) NO174625C (fi)
NZ (1) NZ222985A (fi)
PH (1) PH25583A (fi)
ZA (1) ZA879502B (fi)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4868164A (en) * 1986-12-19 1989-09-19 Norwich Eaton Pharmaceuticals, Inc. Octahydro-pyridine diphosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
IL86951A (en) * 1987-07-06 1996-07-23 Procter & Gamble Pharma Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them
DE3822650A1 (de) * 1988-07-05 1990-02-01 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
ES2118967T3 (es) * 1992-05-29 1998-10-01 Procter & Gamble Pharma Compuestos de fosfonato que contienen nitrogeno cuaternario para tratar un metabolismo anormal del calcio y fosfato asi como el calculo y la placa dentales.
RU2124019C1 (ru) * 1992-05-29 1998-12-27 Дзе Проктер энд Гэмбл Фармасьютикалз, Инк. Тиозамещенные пиридинилбисфосфоновые кислоты или их фармацевтически приемлемые соли или эфиры, фармацевтическая композиция на их основе и способ лечения
NZ253524A (en) * 1992-05-29 1997-01-29 Procter & Gamble Pharma Sulphur-containing phosphonate derivatives and medicaments (for treating abnormal calcium and phosphate metabolism)
US5763611A (en) * 1992-05-29 1998-06-09 The Procter & Gamble Company Thio-substituted cyclic phosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
US5391743A (en) * 1992-05-29 1995-02-21 Procter & Gamble Pharmaceuticals, Inc. Quaternary nitrogen-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism and methods of treating and preventing dental calculus and plaque
US5753634A (en) * 1992-05-29 1998-05-19 The Procter & Gamble Company Quaternary nitrogen containing phosphonate compounds, pharmaceutical compostions, and methods for treating abnormal calcium and phosphate metabolism
DE69324684T2 (de) * 1992-06-30 1999-11-25 Procter & Gamble Pharma Arzneimitteln zur behandlung von arthritis die phosphonate und nsaids enthalten
KR970705400A (ko) * 1994-09-09 1997-10-09 레이셔 야코버스 코넬리스 골 활성 포스포네이트 및 부갑상선 호르몬을 사용한 골다공증의 치료방법(methods for the treatment of osteoporosis using bone active phosphonates and parathyroid hormone)
EP0753523A1 (en) 1995-07-10 1997-01-15 Gador S.A. Amino-substituted bisphosphonic acids
US7781418B2 (en) * 2006-12-14 2010-08-24 Isis Innovation Ltd. Composition for treating bone disorders
US11793452B2 (en) 2019-10-03 2023-10-24 Johnson & Johnson Consumer Inc. Method of visualizing and quantifying remineralization

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3553314A (en) * 1968-12-23 1971-01-05 Procter & Gamble Oral compositions for calculus retardation
US3979385A (en) * 1969-11-19 1976-09-07 Henkel & Cie G.M.B.H. 1-Aminoalkane-1,1-diphosphonic acids and their salts
DE1958123C3 (de) * 1969-11-19 1978-09-28 Henkel Kgaa, 4000 Duesseldorf Verfahren zur Herstellung von 1 -Aminoalkan-1,1 -diphosphonsäuren oder deren Salzen
US3683080A (en) * 1970-08-28 1972-08-08 Procter & Gamble Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue
US3899496A (en) * 1970-10-06 1975-08-12 Henkel & Cie Gmbh Production of 1-aminoalkane-1,1-diphosphonic acids
DE2104476C2 (de) * 1971-02-01 1983-12-01 Henkel KGaA, 4000 Düsseldorf Verfahren zur Verhinderung von Ausfällungen in Wasser oder wäßrigen Lösungen
US4034086A (en) * 1973-08-27 1977-07-05 Henkel & Cie G.M.B.H. Pyrrolidone-5,5-diphosphonic acids
DE2343147C2 (de) * 1973-08-27 1982-06-09 Henkel KGaA, 4000 Düsseldorf Pyrrolidon-5,5-diphosphonsäuren, deren wasserlösliche Salze, und Verfahren zu ihrer Herstellung
DE2343196C3 (de) * 1973-08-27 1980-01-10 Henkel Kgaa, 4000 Duesseldorf Aiacycloalkan-2^-diphosphonsäuren oder deren wasserlösliche Salze
US3988443A (en) * 1973-08-27 1976-10-26 Henkel & Cie G.M.B.H. Azacycloalkane-2,2-diphosphonic acids
DE2456666A1 (de) * 1974-11-30 1976-08-12 Henkel & Cie Gmbh Verfahren zum stabilisieren von calcium-hydrogenphosphat-dihydrat gegen hydrolyse
DE2543349C2 (de) * 1975-09-29 1984-05-10 Henkel KGaA, 4000 Düsseldorf Preaparate zur herstellung von99m technetium-radiagnostica
DK506476A (da) * 1975-12-01 1977-06-02 Henkel & Cie Gmbh Farmaceutiske preparater til behandling af calciumstofs skifteforstyrrelser
DE2745083C2 (de) * 1977-10-07 1985-05-02 Henkel KGaA, 4000 Düsseldorf Hydroxydiphosphonsäuren und Verfahren zu deren Herstellung
US4230700A (en) * 1977-12-07 1980-10-28 The Procter & Gamble Company Methods for inhibiting mobilization of calcium phosphate in animal tissue
SU1002300A1 (ru) * 1981-10-29 1983-03-07 Ордена Ленина институт элементоорганических соединений им.А.Н.Несмеянова Способ получени @ -аминозамещенных- @ -оксипропилидендифосфоновых кислот
DE3428524A1 (de) * 1984-08-02 1986-02-13 Boehringer Mannheim Gmbh, 6800 Mannheim Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4687768A (en) * 1984-12-21 1987-08-18 The Procter & Gamble Company Certain hexahydroindan-2,2-diphosphonic acids useful in treating diseases associated with abnormal calcium and phosphate metabolism
DE3540150A1 (de) * 1985-11-13 1987-05-14 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4868164A (en) * 1986-12-19 1989-09-19 Norwich Eaton Pharmaceuticals, Inc. Octahydro-pyridine diphosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism

Also Published As

Publication number Publication date
FI875595A (fi) 1988-06-20
NO922565D0 (no) 1992-06-29
DE3766695D1 (de) 1991-01-24
NO176144B (no) 1994-10-31
AU615886B2 (en) 1991-10-17
IL84660A0 (en) 1988-04-29
KR950009196B1 (ko) 1995-08-16
NO922565L (no) 1988-06-20
US4868164A (en) 1989-09-19
JP2573973B2 (ja) 1997-01-22
HK79393A (en) 1993-08-13
NO174625B (no) 1994-02-28
AU8280987A (en) 1988-06-23
JPS63239290A (ja) 1988-10-05
DK171068B1 (da) 1996-05-20
IL84660A (en) 1994-10-21
CA1321793C (en) 1993-08-31
US5137880A (en) 1992-08-11
NO875305L (no) 1988-06-20
MY102266A (en) 1992-05-15
ATE59046T1 (de) 1990-12-15
FI87652B (fi) 1992-10-30
DK670387A (da) 1988-06-20
ZA879502B (en) 1988-06-16
PH25583A (en) 1991-08-08
NO875305D0 (no) 1987-12-18
NZ222985A (en) 1990-09-26
US5393746A (en) 1995-02-28
EP0273514A1 (en) 1988-07-06
IE873456L (en) 1988-06-19
NO176144C (no) 1995-02-08
DK670387D0 (da) 1987-12-18
FI87652C (fi) 1993-02-10
KR880007473A (ko) 1988-08-27
EP0273514B1 (en) 1990-12-12
NO174625C (no) 1994-06-08

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Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: NORWICH EATON PHARMACEUTICALS, INC.