ZA86407B - Derivatives of alpha-(2-oxo 2,4,5,6,7,7a-hexahydro thieno(3,2-c)5-pyrildyl)phenyl acetic acid,process for preparing them and their therapeutic use - Google Patents
Derivatives of alpha-(2-oxo 2,4,5,6,7,7a-hexahydro thieno(3,2-c)5-pyrildyl)phenyl acetic acid,process for preparing them and their therapeutic useInfo
- Publication number
- ZA86407B ZA86407B ZA86407A ZA86407A ZA86407B ZA 86407 B ZA86407 B ZA 86407B ZA 86407 A ZA86407 A ZA 86407A ZA 86407 A ZA86407 A ZA 86407A ZA 86407 B ZA86407 B ZA 86407B
- Authority
- ZA
- South Africa
- Prior art keywords
- pyrildyl
- oxo
- alpha
- derivatives
- preparing
- Prior art date
Links
- WLJVXDMOQOGPHL-PPJXEINESA-N 2-phenylacetic acid Chemical compound O[14C](=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-PPJXEINESA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8501908A FR2576901B1 (fr) | 1985-01-31 | 1985-01-31 | Nouveaux derives de l'acide a-(oxo-2 hexahydro-2,4,5,6,7,7a thieno (3,2-c) pyridyl-5) phenyl acetique, leur procede de preparation et leur application therapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA86407B true ZA86407B (en) | 1986-09-24 |
Family
ID=9316132
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA86407A ZA86407B (en) | 1985-01-31 | 1986-01-20 | Derivatives of alpha-(2-oxo 2,4,5,6,7,7a-hexahydro thieno(3,2-c)5-pyrildyl)phenyl acetic acid,process for preparing them and their therapeutic use |
Country Status (24)
Country | Link |
---|---|
US (1) | US4740510A (ru) |
EP (1) | EP0192535A1 (ru) |
JP (1) | JPS61246186A (ru) |
AU (1) | AU581487B2 (ru) |
CA (1) | CA1265517A (ru) |
CS (1) | CS253741B2 (ru) |
DD (1) | DD242229A5 (ru) |
DK (1) | DK157553C (ru) |
ES (1) | ES8703881A1 (ru) |
FI (1) | FI860473A (ru) |
FR (1) | FR2576901B1 (ru) |
GR (1) | GR860287B (ru) |
HU (1) | HU193625B (ru) |
IL (1) | IL77598A (ru) |
MA (1) | MA20619A1 (ru) |
NO (1) | NO162965C (ru) |
NZ (1) | NZ214982A (ru) |
OA (1) | OA08196A (ru) |
PL (1) | PL145159B1 (ru) |
PT (1) | PT81946B (ru) |
SU (1) | SU1389679A3 (ru) |
TN (1) | TNSN86012A1 (ru) |
YU (1) | YU11986A (ru) |
ZA (1) | ZA86407B (ru) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2652579B1 (fr) * | 1989-10-02 | 1992-01-24 | Sanofi Sa | Derives d'hydroxy-2 thiophene et furanne condenses avec un cycle azote, sur procede de preparation et leur application en therapeutique. |
FI101150B (fi) * | 1991-09-09 | 1998-04-30 | Sankyo Co | Menetelmä lääkeaineina käyttökelpoisten tetrahydrotienopyridiinin johd annaisten valmistamiseksi |
DE69526443T2 (de) * | 1994-10-07 | 2002-12-12 | Ube Industries, Ltd. | 2-silyloxy-tetrahydrothienopyridin, sein salz und verfahren zu seiner herstellung |
NZ334389A (en) * | 1996-08-28 | 2001-05-25 | Ube Industries | Cyclic amine derivatives |
NZ506574A (en) | 1998-02-27 | 2003-06-30 | Sankyo Co | Cyclic amino derivative having a sulphinyl, sulphonyl or disulphanyl group useful in the treatment of thrombosis or embolism |
PT1728794E (pt) | 2000-07-06 | 2008-07-15 | Ube Industries | Sal de adição maleato de derivados de hidropiridina |
HUP0400644A3 (en) * | 2000-12-25 | 2009-06-29 | Ube Industries | Pharmaceutical compositions containing aspirin |
GB0125708D0 (en) * | 2001-10-26 | 2001-12-19 | Generics Uk Ltd | Novel compounds and processes |
CZ302135B6 (cs) * | 2007-07-09 | 2010-11-10 | Zentiva, A. S. | Zpusob výroby 5-[2-cyklopropyl-1-(2-fluorfenyl)-2-oxoethyl]-4, 5, 6, 7-tetrahydrothieno[3,2-c]pyridin-2-yl acetátu (prasugrelu) |
WO2009062044A2 (en) * | 2007-11-09 | 2009-05-14 | Dr. Reddy's Laboratories Ltd. | Processes for the preparation of prasugrel, and its salts and polymorphs |
WO2009066326A2 (en) * | 2007-11-19 | 2009-05-28 | Msn Laboratories Limited | Improved process for the preparation of prasugrel and its pharmaceutically acceptable salts |
CN101289454B (zh) * | 2008-06-10 | 2011-02-16 | 上海医药工业研究院 | 2-氧-2,4,5,6,7,7α-六氢噻吩并[3,2-c]吡啶的制备方法 |
DE102008046630A1 (de) * | 2008-09-10 | 2010-03-11 | Emitec Gesellschaft Für Emissionstechnologie Mbh | Modulares Tanksystem für ein flüssiges Reduktionsmittel mit einem Sumpfelement |
CN101402593A (zh) * | 2008-11-11 | 2009-04-08 | 上海现代制药股份有限公司 | 用于制备普拉格雷的中间体及其制备方法 |
CN101402643B (zh) * | 2008-11-11 | 2012-11-28 | 上海现代制药股份有限公司 | 一种适于工业生产的普拉格雷的制备方法 |
CN101402642B (zh) * | 2008-11-11 | 2013-01-09 | 上海现代制药股份有限公司 | 一种新型环保制备普拉格雷的方法 |
CZ2008748A3 (cs) | 2008-11-26 | 2010-06-02 | Zentiva, A. S | Zpusob výroby vysoce cistého 5-[2-cyklopropyl-1-(2-fluorfenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c] pyridin-2-yl acetátu, prasugrelu |
US20120202066A1 (en) * | 2009-10-07 | 2012-08-09 | Manne Satyanarayana Reddy | Processes For Preparing Prasugrel And Pharmaceutically Acceptable Salts Thereof |
HU229031B1 (en) | 2009-12-21 | 2013-07-29 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Process for producing prasurgel and its intermediate |
HU229035B1 (en) | 2009-12-21 | 2013-07-29 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Process for producing prasurgel |
CN102863457B (zh) * | 2010-02-02 | 2013-10-09 | 江苏威凯尔医药科技有限公司 | 光学活性2-羟基四氢噻吩并吡啶衍生物及其制备方法与在制药中的用途 |
EP2545059A1 (en) | 2010-03-09 | 2013-01-16 | Synthon BV | A process for making prasugrel |
CN102212069A (zh) * | 2010-04-06 | 2011-10-12 | 刘桂坤 | 环烷衍生物及其制备方法和在心脑血管病药物上的应用 |
CN101845052B (zh) * | 2010-06-11 | 2012-01-11 | 天津药物研究院 | 一类含氮杂环的噻吩并吡啶酮衍生物、其制备方法和用途 |
EP2613783B1 (en) * | 2010-08-26 | 2019-06-12 | IPCA Laboratories Limited | Methods for the treatment or prophylaxis of thrombosis or embolism |
CN101948479B (zh) * | 2010-09-29 | 2013-01-30 | 横店集团家园化工有限公司 | 普拉格雷中间体及其制备方法 |
CN101985451B (zh) * | 2010-11-02 | 2012-04-25 | 北京赛科药业有限责任公司 | 普拉格雷中间体的制备方法 |
CN102002056B (zh) * | 2010-11-02 | 2012-04-25 | 北京赛科药业有限责任公司 | 一种普拉格雷中间体的制备方法 |
CN102276623A (zh) * | 2011-06-13 | 2011-12-14 | 安徽省虹升生物科技有限公司 | 一种利用有机硅保护剂进行制备普拉格雷的新方法 |
CA2839608C (en) * | 2011-06-27 | 2020-07-14 | Ipca Laboratories Limited | (7as,2's)-2-oxoclopidogrel as anti-thrombotic compounds |
CN104341433B (zh) * | 2013-08-02 | 2017-12-15 | 鲁南制药集团股份有限公司 | 一种普拉格雷中间体的制备方法 |
CN104447867B (zh) * | 2013-09-17 | 2017-12-26 | 江苏天士力帝益药业有限公司 | 一种噻吩并哌啶衍生物、制备方法及其应用 |
CN107698620A (zh) | 2015-06-23 | 2018-02-16 | 江苏天士力帝益药业有限公司 | 一种氘代噻吩并哌啶衍生物、制备方法及其应用 |
CN108570060A (zh) * | 2018-05-13 | 2018-09-25 | 日照市普达医药科技有限公司 | 一种4,5,6,7-四氢噻吩并[3,2-c]吡啶类衍生物对血栓的治疗作用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2495157A1 (fr) * | 1980-11-28 | 1982-06-04 | Sanofi Sa | Procede nouveau de preparation des tetrahydro-5, 6, 7, 7a 4h-thieno (3, 2-c) pyridinones-2 |
FR2495156A1 (fr) * | 1980-11-28 | 1982-06-04 | Sanofi Sa | Derives de la thieno-pyridinone, leur procede de preparation et leur application therapeutique |
FR2528848A1 (fr) * | 1982-06-16 | 1983-12-23 | Sanofi Sa | Nouveau derive de thieno-pyridone, son procede de preparation et son application therapeutique |
FR2530247B1 (fr) * | 1982-07-13 | 1986-05-16 | Sanofi Sa | Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique |
DE3302125A1 (de) * | 1983-01-22 | 1984-07-26 | Boehringer Ingelheim KG, 6507 Ingelheim | Aminosaeure-derivate, verfahren zu ihrer herstellung und verwendung |
-
1985
- 1985-01-31 FR FR8501908A patent/FR2576901B1/fr not_active Expired
- 1985-12-27 ES ES550448A patent/ES8703881A1/es not_active Expired
- 1985-12-27 DD DD85285569A patent/DD242229A5/de unknown
-
1986
- 1986-01-14 IL IL77598A patent/IL77598A/xx unknown
- 1986-01-16 AU AU52424/86A patent/AU581487B2/en not_active Ceased
- 1986-01-20 ZA ZA86407A patent/ZA86407B/xx unknown
- 1986-01-22 SU SU864010535A patent/SU1389679A3/ru active
- 1986-01-27 MA MA20844A patent/MA20619A1/fr unknown
- 1986-01-27 CA CA000500411A patent/CA1265517A/fr not_active Expired - Fee Related
- 1986-01-29 PL PL1986257691A patent/PL145159B1/pl unknown
- 1986-01-29 YU YU00119/86A patent/YU11986A/xx unknown
- 1986-01-30 DK DK047186A patent/DK157553C/da not_active IP Right Cessation
- 1986-01-30 PT PT81946A patent/PT81946B/pt not_active IP Right Cessation
- 1986-01-30 GR GR860287A patent/GR860287B/el unknown
- 1986-01-30 NZ NZ214982A patent/NZ214982A/xx unknown
- 1986-01-30 NO NO860332A patent/NO162965C/no unknown
- 1986-01-30 OA OA58777A patent/OA08196A/xx unknown
- 1986-01-30 CS CS86675A patent/CS253741B2/cs unknown
- 1986-01-31 JP JP61020006A patent/JPS61246186A/ja active Pending
- 1986-01-31 FI FI860473A patent/FI860473A/fi not_active Application Discontinuation
- 1986-01-31 TN TNTNSN86012A patent/TNSN86012A1/fr unknown
- 1986-01-31 US US06/825,068 patent/US4740510A/en not_active Expired - Fee Related
- 1986-01-31 HU HU86456A patent/HU193625B/hu not_active IP Right Cessation
- 1986-01-31 EP EP86400215A patent/EP0192535A1/fr not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
GR860287B (en) | 1986-06-02 |
AU581487B2 (en) | 1989-02-23 |
FI860473A (fi) | 1986-08-01 |
DK47186D0 (da) | 1986-01-30 |
FR2576901B1 (fr) | 1987-03-20 |
ES8703881A1 (es) | 1987-03-01 |
HU193625B (en) | 1987-11-30 |
PL257691A1 (en) | 1986-11-04 |
PT81946B (pt) | 1987-12-30 |
IL77598A (en) | 1988-12-30 |
YU11986A (en) | 1987-08-31 |
DK157553B (da) | 1990-01-22 |
EP0192535A1 (fr) | 1986-08-27 |
ES550448A0 (es) | 1987-03-01 |
AU5242486A (en) | 1986-08-07 |
CA1265517A (fr) | 1990-02-06 |
OA08196A (fr) | 1987-10-30 |
NO162965C (no) | 1990-03-14 |
SU1389679A3 (ru) | 1988-04-15 |
HUT40440A (en) | 1986-12-28 |
CS253741B2 (en) | 1987-12-17 |
PT81946A (fr) | 1986-02-01 |
TNSN86012A1 (fr) | 1990-01-01 |
NO162965B (no) | 1989-12-04 |
US4740510A (en) | 1988-04-26 |
FI860473A0 (fi) | 1986-01-31 |
MA20619A1 (fr) | 1986-10-01 |
FR2576901A1 (fr) | 1986-08-08 |
NO860332L (no) | 1986-08-01 |
DD242229A5 (de) | 1987-01-21 |
DK157553C (da) | 1990-06-11 |
DK47186A (da) | 1986-08-01 |
JPS61246186A (ja) | 1986-11-01 |
NZ214982A (en) | 1988-04-29 |
PL145159B1 (en) | 1988-08-31 |
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