ZA861953B - Insulin precursors,process for their preparation and process for the preparation of human insulin - Google Patents

Insulin precursors,process for their preparation and process for the preparation of human insulin

Info

Publication number
ZA861953B
ZA861953B ZA861953A ZA861953A ZA861953B ZA 861953 B ZA861953 B ZA 861953B ZA 861953 A ZA861953 A ZA 861953A ZA 861953 A ZA861953 A ZA 861953A ZA 861953 B ZA861953 B ZA 861953B
Authority
ZA
South Africa
Prior art keywords
preparation
insulin
human insulin
precursors
insulin precursors
Prior art date
Application number
ZA861953A
Other languages
English (en)
Inventor
Lars Thim
Kjeld Norris
Mogens Trier Hansen
Original Assignee
Novo Industri As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Industri As filed Critical Novo Industri As
Publication of ZA861953B publication Critical patent/ZA861953B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
ZA861953A 1985-03-22 1986-03-17 Insulin precursors,process for their preparation and process for the preparation of human insulin ZA861953B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK129385A DK129385A (da) 1985-03-22 1985-03-22 Peptider og fremstilling deraf

Publications (1)

Publication Number Publication Date
ZA861953B true ZA861953B (en) 1986-11-26

Family

ID=8103207

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA861953A ZA861953B (en) 1985-03-22 1986-03-17 Insulin precursors,process for their preparation and process for the preparation of human insulin

Country Status (16)

Country Link
EP (1) EP0195691B1 (fr)
JP (3) JPH0648993B2 (fr)
AT (1) ATE69266T1 (fr)
AU (1) AU586855B2 (fr)
CA (1) CA1340823C (fr)
DE (1) DE3682303D1 (fr)
DK (1) DK129385A (fr)
ES (2) ES8802402A1 (fr)
FI (1) FI87801C (fr)
GR (1) GR860764B (fr)
IE (1) IE58842B1 (fr)
MX (1) MX163837B (fr)
NO (1) NO172646C (fr)
NZ (1) NZ215570A (fr)
PT (1) PT82241B (fr)
ZA (1) ZA861953B (fr)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK58285D0 (da) * 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
DE3682233D1 (de) * 1985-06-12 1991-12-05 Lubrizol Genetics Inc Modifiziertes zein.
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
DK437786D0 (da) * 1986-09-12 1986-09-12 Nordisk Gentofte Insulinprecursorer
US5426036A (en) * 1987-05-05 1995-06-20 Hoechst Aktiengesellschaft Processes for the preparation of foreign proteins in streptomycetes
DE3837271A1 (de) * 1988-11-03 1990-05-10 Hoechst Ag Verfahren zur selektiven spaltung von fusionsproteinen
CA1340772C (fr) * 1987-12-30 1999-09-28 Patricia Tekamp-Olson Expression et secretion de proteines heterologues dans une levure au moyen de sequences leader tronquees du facteur alpha
DK336188D0 (da) * 1988-06-20 1988-06-20 Nordisk Gentofte Propeptider
DE58906966D1 (de) * 1988-06-23 1994-03-24 Hoechst Ag Mini-Proinsulin, seine Herstellung und Verwendung.
US6875589B1 (en) 1988-06-23 2005-04-05 Hoechst Aktiengesellschaft Mini-proinsulin, its preparation and use
EP0367163B1 (fr) * 1988-11-03 1996-01-03 Hoechst Aktiengesellschaft Procédé de préparation d'un précurseur d'insuline chez les streptomyces
US5716927A (en) * 1988-12-23 1998-02-10 Novo Nordisk A/S Insulin analogs having a modified B-chain
DE3844211A1 (de) * 1988-12-29 1990-07-05 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
NZ232375A (en) * 1989-02-09 1992-04-28 Lilly Co Eli Insulin analogues modified at b29
DK134189D0 (da) * 1989-03-20 1989-03-20 Nordisk Gentofte Insulinforbindelser
CA2051375C (fr) * 1989-05-04 2000-09-12 Dennis J. Henner Procede et compositions pour l'isolement de la relaxine humaine
CZ283234B6 (cs) * 1990-09-05 1998-02-18 Hoechst Aktiengesellschaft Enymatický způsob konverse preproinsulinů na insuliny
ZA928916B (en) * 1991-11-26 1994-05-18 Lilly Co Eli Tri-arginine insulins
US6001604A (en) * 1993-12-29 1999-12-14 Bio-Technology General Corp. Refolding of proinsulins without addition of reducing agents
WO1996020724A1 (fr) * 1994-12-29 1996-07-11 Bio-Technology General Corp. Production d'insuline humaine
KR0150565B1 (ko) * 1995-02-15 1998-08-17 김정재 유전자 조환에 의한 사람 인슐린 전구체의 제조 및 이를 이용한 인슐린의 제조방법
CA2223272A1 (fr) * 1995-05-05 1996-11-07 Ronald Eugene Chance Insuline monocatenaire a bioactivite elevee
GB9513967D0 (en) * 1995-07-08 1995-09-06 Univ Leicester Insulin
KR100381494B1 (ko) * 1997-06-30 2003-07-22 바이오 테크놀로지 제네랄 코오포레이션 인간인슐린의제조방법
WO1999009816A1 (fr) * 1997-08-22 1999-03-04 Roche Diagnostics Gmbh Procede de preparation de proteines precurseurs d'insuline
DE19930676B4 (de) * 1999-07-02 2006-01-19 Sanofi-Aventis Deutschland Gmbh Verfahren zur Stabilisierung von Insulin, Insulinderivaten und/oder deren Vorläufer in komplexen Mischungen bei deren Lagerung in wäßrigen Lösungsmitteln
ES2266187T3 (es) 2000-03-24 2007-03-01 Genentech, Inc. Uso de la insulina para el tratamiento de trastornos del cartilago.
AR025646A1 (es) 2000-09-13 2002-12-04 Beta Lab Sa Cepa de levaduras metilotroficas recombinantes productoras de un precursor de insulina, construcciones de adn y metodo para obtener la cepa.
US7638618B2 (en) 2001-02-20 2009-12-29 Sanofi-Aventis Deutschland Gmbh Nucleic acids encoding a hirudin and pro-insulin as superscretable peptides and for parallel improvement of the exported forms of one or more polypeptides of interest
US7202059B2 (en) 2001-02-20 2007-04-10 Sanofi-Aventis Deutschland Gmbh Fusion proteins capable of being secreted into a fermentation medium
US7312192B2 (en) * 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
EP1463751B1 (fr) 2001-12-21 2013-05-22 Human Genome Sciences, Inc. Proteines hybrides d'albumine
EP2307441B1 (fr) 2008-08-07 2016-03-23 Biocon Limited Procédé pour la fabrication de composés de l'insuline
AR072563A1 (es) * 2009-07-15 2010-09-08 Beta Lab Sa Un procedimiento para obtener insulina aspartica que utiliza una cepa de levaduras de pichia pastoris
PL239062B1 (pl) * 2016-01-22 2021-11-02 Inst Biotechnologii I Antybiotykow Sposób wytwarzania insuliny i jej pochodnych
AU2017322552B2 (en) 2016-09-06 2021-12-02 Chemical & Biopharmaceutical Laboratories Of Patras S.A. Proinsulin derivatives
KR102666154B1 (ko) * 2018-08-08 2024-05-20 주식회사 대웅제약 지속형 인슐린 아날로그 및 그 복합체
KR102646845B1 (ko) * 2018-08-08 2024-03-14 주식회사 대웅제약 클로스트리파인을 이용한 지속형 인슐린 아날로그 복합체의 활성형 제조방법
US11524987B2 (en) * 2018-09-25 2022-12-13 Amphastar Pharmaceuticals, Inc. Highly purified recombinant human insulin (RHI) API and methods of producing the same
KR20200080747A (ko) * 2018-12-27 2020-07-07 주식회사 폴루스 인슐린 전구체의 인슐린 효소 전환용 조성물 및 이를 이용하여 인슐린 전구체를 인슐린으로 전환하는 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH16156A (en) * 1980-03-27 1983-07-18 Lilly Co Eli Process for producing an insulin precursor
NZ199391A (en) * 1981-01-02 1985-12-13 Genentech Inc Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin
DE3209184A1 (de) * 1982-03-13 1983-09-15 Hoechst Ag, 6230 Frankfurt Verfahren zur umwandlung von praeproinsulinanaloga zu insulinen
DK172738B1 (da) * 1983-04-07 1999-06-21 Chiron Corp Fremgangsmåde til at udtrykke modent insulin og DNA-struktur til anvendelse ved fremgangsmåden
DK58285D0 (da) * 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf

Also Published As

Publication number Publication date
ES553231A0 (es) 1988-05-16
ES8708251A1 (es) 1987-10-01
IE58842B1 (en) 1993-11-17
NZ215570A (en) 1989-07-27
FI861198A (fi) 1986-09-23
JPH088871B2 (ja) 1996-01-31
FI861198A0 (fi) 1986-03-21
NO172646B (no) 1993-05-10
EP0195691A1 (fr) 1986-09-24
JP2553326B2 (ja) 1996-11-13
JPH0648993B2 (ja) 1994-06-29
JPH06133777A (ja) 1994-05-17
CA1340823C (fr) 1999-11-16
NO861120L (no) 1986-09-23
DE3682303D1 (de) 1991-12-12
PT82241A (en) 1986-04-01
IE860737L (en) 1986-09-22
PT82241B (pt) 1988-11-30
ATE69266T1 (de) 1991-11-15
DK129385A (da) 1986-09-23
AU586855B2 (en) 1989-07-27
ES557227A0 (es) 1987-10-01
JPH0823985A (ja) 1996-01-30
MX163837B (es) 1992-06-25
JPS61221200A (ja) 1986-10-01
NO172646C (no) 1993-08-18
EP0195691B1 (fr) 1991-11-06
GR860764B (en) 1986-07-21
ES8802402A1 (es) 1988-05-16
DK129385D0 (da) 1985-03-22
FI87801B (fi) 1992-11-13
AU5500586A (en) 1986-09-25
FI87801C (fi) 1993-02-25

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