ZA857905B - Metal complexes of bis-indole compounds and aqueous pharmaceutical compositions containing them - Google Patents

Metal complexes of bis-indole compounds and aqueous pharmaceutical compositions containing them

Info

Publication number
ZA857905B
ZA857905B ZA857905A ZA857905A ZA857905B ZA 857905 B ZA857905 B ZA 857905B ZA 857905 A ZA857905 A ZA 857905A ZA 857905 A ZA857905 A ZA 857905A ZA 857905 B ZA857905 B ZA 857905B
Authority
ZA
South Africa
Prior art keywords
bis
pharmaceutical compositions
compositions containing
metal complexes
aqueous pharmaceutical
Prior art date
Application number
ZA857905A
Other languages
English (en)
Inventor
Geza Takacsi Nagy
Gabor Szepesi
Maria Gazdag
Zsofia Pap
Kalman Burger
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of ZA857905B publication Critical patent/ZA857905B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
ZA857905A 1984-10-16 1985-10-15 Metal complexes of bis-indole compounds and aqueous pharmaceutical compositions containing them ZA857905B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU843861A HU195513B (en) 1984-10-16 1984-10-16 Process for producing stable solutions of alkaloides with bis-indole skeleton

Publications (1)

Publication Number Publication Date
ZA857905B true ZA857905B (en) 1986-06-25

Family

ID=10965811

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA857905A ZA857905B (en) 1984-10-16 1985-10-15 Metal complexes of bis-indole compounds and aqueous pharmaceutical compositions containing them

Country Status (29)

Country Link
US (1) US4684638A (da)
JP (1) JPS61106584A (da)
CN (1) CN1007958B (da)
AT (1) AT389996B (da)
AU (1) AU580342B2 (da)
BE (1) BE903447A (da)
CA (1) CA1272192A (da)
CH (1) CH667459A5 (da)
CS (1) CS251798B2 (da)
DD (1) DD239207A5 (da)
DE (1) DE3536745A1 (da)
DK (1) DK169972B1 (da)
ES (1) ES8701185A1 (da)
FI (1) FI84134C (da)
FR (1) FR2571724B1 (da)
GB (1) GB2165540B (da)
GR (1) GR852510B (da)
HU (1) HU195513B (da)
IE (1) IE58467B1 (da)
IL (1) IL76719A (da)
IN (1) IN162910B (da)
IT (1) IT1186776B (da)
LT (1) LT2203B (da)
LU (1) LU86115A1 (da)
LV (1) LV5175A3 (da)
NL (1) NL192779C (da)
SE (1) SE466017B (da)
SU (1) SU1706372A3 (da)
ZA (1) ZA857905B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1341262C (en) * 1987-08-06 2001-06-26 Camille A. Boulet A new process of the synthesis of 3',4'-anhydrovinblastine, vinblastine and vincristine
US5170515A (en) * 1987-09-16 1992-12-15 Toto Ltd. Water closet
FR2623089B1 (fr) * 1987-11-13 1990-04-27 Pf Medicament Composition pharmaceutique pour l'administration parenterale de navelbine
HU204995B (en) * 1989-11-07 1992-03-30 Richter Gedeon Vegyeszet Process for producing pharmaceutical composition comprising alkaloid with bis-indole skeleton, with antitumour activity and suitable fr parenteral purposes
US20110015221A1 (en) * 2003-12-23 2011-01-20 Pierre Fabre Medicament Pharmaceutical composition of vinflunine which is intended for parenteral administration preparation method thereof and use of same
FR2863891B1 (fr) * 2003-12-23 2006-03-24 Pf Medicament Composition pharmaceutique de vinflunine destinee a une administration parentale, procede de preparation et utilisation
US8017368B2 (en) * 2005-10-20 2011-09-13 University Of South Florida Molecular delivery to cells using aspirin-related compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE595570C (de) * 1932-10-07 1934-04-16 I G Farbenindustrie Akt Ges Verfahren zur Darstellung waesseriger Loesungen von Schwermetallverbindungen der aromatischen Halogenylsulfamide
US3426024A (en) * 1967-11-17 1969-02-04 Vanderbilt Co R T Amine complexes of zinc salts of chlorinated thiobisphenols
DE2502932C2 (de) * 1975-01-24 1985-04-18 Bayer Ag, 5090 Leverkusen Metallkomplexe von N-Trityl-azolen, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Fungizide
FR2349335A1 (fr) * 1976-04-28 1977-11-25 Inst Int Pathologie Cellulaire Complexes d'alcaloides bis-indoliques du type vinblastine avec la tubuline, leur procede d'obtention et leur utilisation
DE2967049D1 (en) * 1978-04-11 1984-07-19 Efamol Ltd Pharmaceutical and dietary composition comprising gamma-linolenic acids
ATE11014T1 (de) * 1981-07-14 1985-01-15 Efamol Limited Pharmazeutische und diaetetische zusammensetzung zur erhoehung der serie-l-pg-produktion.
IT1170152B (it) * 1982-07-19 1987-06-03 Lilly Co Eli Miglioramenti a o riguardanti formulazioni di vinca-alcaloidi

Also Published As

Publication number Publication date
ES547862A0 (es) 1986-11-16
AU580342B2 (en) 1989-01-12
LU86115A1 (de) 1986-03-24
DE3536745A1 (de) 1986-04-17
US4684638A (en) 1987-08-04
CA1272192A (en) 1990-07-31
FI84134B (fi) 1991-07-15
CH667459A5 (de) 1988-10-14
FR2571724B1 (fr) 1988-08-26
IN162910B (da) 1988-07-23
DK472085D0 (da) 1985-10-15
NL192779C (nl) 1998-02-03
BE903447A (fr) 1986-04-15
LV5175A3 (lv) 1993-10-10
ATA297985A (de) 1989-08-15
GB8525360D0 (en) 1985-11-20
SU1706372A3 (ru) 1992-01-15
CN85107053A (zh) 1986-06-10
GB2165540A (en) 1986-04-16
NL192779B (nl) 1997-10-01
FR2571724A1 (fr) 1986-04-18
DK169972B1 (da) 1995-04-18
JPS61106584A (ja) 1986-05-24
IT1186776B (it) 1987-12-16
SE8504786L (sv) 1986-04-17
AU4871485A (en) 1986-04-24
ES8701185A1 (es) 1986-11-16
CN1007958B (zh) 1990-05-16
NL8502821A (nl) 1986-05-16
FI853123L (fi) 1986-04-17
GB2165540B (en) 1988-04-27
IL76719A (en) 1989-10-31
HU195513B (en) 1988-05-30
LT2203B (lt) 1993-10-15
IT8522482A0 (it) 1985-10-15
SE8504786D0 (sv) 1985-10-15
GR852510B (da) 1986-02-18
IE58467B1 (en) 1993-09-22
FI84134C (fi) 1991-10-25
CS251798B2 (en) 1987-08-13
IE852531L (en) 1986-04-16
DD239207A5 (de) 1986-09-17
DK472085A (da) 1986-04-17
FI853123A0 (fi) 1985-08-15
DE3536745C2 (da) 1992-01-23
IL76719A0 (en) 1986-02-28
AT389996B (de) 1990-02-26
JPH0339489B2 (da) 1991-06-14
SE466017B (sv) 1991-12-02

Similar Documents

Publication Publication Date Title
AU567915B2 (en) Pharmaceutical compositions containing iron complexes of 3-hydroxy-4-pyrones
IL75326A0 (en) Quinolone derivatives and pharmaceutical compositions containing them
ZA864602B (en) 2-arylimidazoles and pharmaceutical compositions containing these compounds
GB2157563B (en) Pharmaceutical compositions containing iron complexes
PT81015B (en) Process for the preparation of piridazo-diazocine derivatives and pharmaceutical compositions therewith
IL74865A0 (en) 9a-aza-9a-homoerythromycin derivatives and pharmaceutical compositions containing them
HUT49459A (en) Synergetic plant-protection composition containing derivatives of piridin-sulphonamid
GB8426845D0 (en) Complexes of technetium-99m
EP0186505A3 (en) Pharmaceutical compositions containing organogermanium compound and their use
EP0159194A3 (en) Iron 3-hydroxypyrone or 3-hydroxypyridone complexes and pharmaceutical compositions containing them
IL76188A (en) 3-aralkylidene-hydroxy-flavanone derivatives and pharmaceutical compositions containing them
PT80246A (en) Process for the preparation of novel cephalosporin derivatives and of pharmaceutical compositions containing the same
ZA859730B (en) Pharmaceutical compositions containing new imidazo derivatives
PT81502A (en) Process for the preparation of cholecalciferol derivatives and of pharmaceutical compositions containing the same
NZ213798A (en) Guanine derivatives and pharmaceutical compositions
GB2207866B (en) Use of metal chelates as mulluscicides
GB2165540B (en) Metal complexes of bis-indole compounds and aqueous pharmaceutical compositions containing them
NZ225466A (en) 1-aminoalkyl-1h-indole derivatives and pharmaceutical compositions containing certain derivatives thereof
GB2167414B (en) Flavolignan derivatives and pharmaceutical compositions containing them
PH21022A (en) Phenylquinoline derivatives and pharmaceutical composition containing said compounds
ZW19384A1 (en) Reduction of metal compounds
PH24135A (en) Quinoline derivatives and pharmaceutical composition containing said compounds
PH21046A (en) Imidazole derivatives and pharmaceutical composition containing said compound
PT81083A (en) Process for the preparation of substituted 7-oxomitosanes and of pharmaceutical compositions containing the same
GB8605633D0 (en) Forming batches of tobacco &c