ZA853440B - Indoline and 2-indolinone derivatives - Google Patents
Indoline and 2-indolinone derivativesInfo
- Publication number
- ZA853440B ZA853440B ZA853440A ZA853440A ZA853440B ZA 853440 B ZA853440 B ZA 853440B ZA 853440 A ZA853440 A ZA 853440A ZA 853440 A ZA853440 A ZA 853440A ZA 853440 B ZA853440 B ZA 853440B
- Authority
- ZA
- South Africa
- Prior art keywords
- indoline
- indolinone derivatives
- indolinone
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61021084A | 1984-05-14 | 1984-05-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA853440B true ZA853440B (en) | 1986-12-30 |
Family
ID=24444125
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA853440A ZA853440B (en) | 1984-05-14 | 1985-05-07 | Indoline and 2-indolinone derivatives |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0161918B1 (OSRAM) |
| JP (1) | JPH0643417B2 (OSRAM) |
| KR (1) | KR870000274B1 (OSRAM) |
| AR (1) | AR241531A1 (OSRAM) |
| AT (1) | ATE54915T1 (OSRAM) |
| AU (1) | AU577372B2 (OSRAM) |
| CA (1) | CA1248099A (OSRAM) |
| DE (1) | DE3578822D1 (OSRAM) |
| DK (1) | DK207785A (OSRAM) |
| EG (1) | EG17342A (OSRAM) |
| ES (1) | ES8609308A1 (OSRAM) |
| GR (1) | GR851121B (OSRAM) |
| HU (1) | HU194873B (OSRAM) |
| IL (1) | IL75122A (OSRAM) |
| MY (1) | MY101520A (OSRAM) |
| NZ (1) | NZ212023A (OSRAM) |
| PH (1) | PH21862A (OSRAM) |
| PT (1) | PT80414B (OSRAM) |
| SU (1) | SU1486060A3 (OSRAM) |
| ZA (1) | ZA853440B (OSRAM) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4591591A (en) * | 1984-03-08 | 1986-05-27 | Eli Lilly And Company | Pyridazinone derivatives as inotropic agents |
| DE3631085A1 (de) * | 1986-09-12 | 1988-03-24 | Boehringer Mannheim Gmbh | Heterocyclisch substituierte indolinone, verfahren zu ihrer herstellung, arzneimittel sowie zwischenprodukte |
| DE3706427A1 (de) * | 1987-02-27 | 1988-09-08 | Boehringer Mannheim Gmbh | Neue substituierte 3h-indole, zwischenprodukte, verfahren zu ihrer herstellung sowie arzneimittel |
| US5196416A (en) * | 1987-08-28 | 1993-03-23 | Eli Lilly And Company | Transdermal flux-enhancing pharmaceutical compositions comprising azone, ethanol and water |
| EP0306192B1 (en) * | 1987-08-28 | 1992-05-27 | Eli Lilly And Company | Permeation enhancement compositions |
| EP0326307B1 (en) * | 1988-01-23 | 1994-08-17 | Kyowa Hakko Kogyo Co., Ltd. | Novel pyridazinone derivatives and pharmaceutical preparations containing them |
| GB8816944D0 (en) * | 1988-07-15 | 1988-08-17 | Sobio Lab | Compounds |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| ES2393885T7 (es) | 2007-06-04 | 2014-01-30 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| WO2009149279A2 (en) | 2008-06-04 | 2009-12-10 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| AU2009270833B2 (en) | 2008-07-16 | 2015-02-19 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| EP3366698A1 (en) | 2011-03-01 | 2018-08-29 | Synergy Pharmaceuticals Inc. | Guanylate cyclase c agonists |
| AU2014218599C1 (en) | 2013-02-25 | 2018-09-06 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists for use in colonic cleansing |
| WO2014151206A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| US9486494B2 (en) | 2013-03-15 | 2016-11-08 | Synergy Pharmaceuticals, Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| EP3004138B1 (en) | 2013-06-05 | 2024-03-13 | Bausch Health Ireland Limited | Ultra-pure agonists of guanylate cyclase c, method of making and using same |
| US20160184387A1 (en) | 2013-08-09 | 2016-06-30 | Dominique Charmot | Compounds and methods for inhibiting phosphate transport |
| EP3972599B1 (en) | 2019-05-21 | 2025-10-22 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
| KR20250151545A (ko) * | 2023-03-10 | 2025-10-21 | 조에티스 서비시즈 엘엘씨 | 포스포다이에스터레이스 3(pde3) 억제제 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES8101067A1 (es) * | 1978-08-25 | 1980-12-01 | Thomae Gmbh Dr K | Procedimiento para la preparacion de nuevos bencimidazoles sustituidos en posicion 5 o 6 con un anillo de piridazinona |
| US4258185A (en) * | 1978-10-17 | 1981-03-24 | Yoshitomi Pharmaceutical Industries, Ltd. | Pyridazinone compounds |
| DE3124699A1 (de) * | 1981-06-24 | 1983-01-13 | Basf Ag, 6700 Ludwigshafen | Neue 2-aryl-3,4-diaza-bicyclo(4.n.0.)alken-(2)-one-(5),verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| JPS588016A (ja) * | 1981-07-06 | 1983-01-18 | Mitsubishi Chem Ind Ltd | 強心剤 |
-
1985
- 1985-05-07 CA CA000480903A patent/CA1248099A/en not_active Expired
- 1985-05-07 IL IL75122A patent/IL75122A/xx unknown
- 1985-05-07 ZA ZA853440A patent/ZA853440B/xx unknown
- 1985-05-08 GR GR851121A patent/GR851121B/el unknown
- 1985-05-08 PT PT80414A patent/PT80414B/pt not_active IP Right Cessation
- 1985-05-09 AR AR85300328A patent/AR241531A1/es active
- 1985-05-09 NZ NZ212023A patent/NZ212023A/en unknown
- 1985-05-09 PH PH32245A patent/PH21862A/en unknown
- 1985-05-10 EP EP85303310A patent/EP0161918B1/en not_active Expired - Lifetime
- 1985-05-10 AT AT85303310T patent/ATE54915T1/de not_active IP Right Cessation
- 1985-05-10 DE DE8585303310T patent/DE3578822D1/de not_active Expired - Lifetime
- 1985-05-10 DK DK207785A patent/DK207785A/da not_active Application Discontinuation
- 1985-05-12 EG EG296/85D patent/EG17342A/xx active
- 1985-05-13 JP JP60102499A patent/JPH0643417B2/ja not_active Expired - Lifetime
- 1985-05-13 ES ES543078A patent/ES8609308A1/es not_active Expired
- 1985-05-13 HU HU851801A patent/HU194873B/hu not_active IP Right Cessation
- 1985-05-13 SU SU853911552A patent/SU1486060A3/ru active
- 1985-05-13 AU AU42405/85A patent/AU577372B2/en not_active Ceased
- 1985-05-14 KR KR1019850003271A patent/KR870000274B1/ko not_active Expired
-
1987
- 1987-09-22 MY MYPI87001859A patent/MY101520A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6122080A (ja) | 1986-01-30 |
| CA1248099A (en) | 1989-01-03 |
| GR851121B (OSRAM) | 1985-11-25 |
| IL75122A0 (en) | 1985-09-29 |
| PT80414B (en) | 1987-04-16 |
| EP0161918A2 (en) | 1985-11-21 |
| ES8609308A1 (es) | 1986-09-01 |
| HU194873B (en) | 1988-03-28 |
| EP0161918A3 (en) | 1986-11-20 |
| EG17342A (en) | 1991-03-30 |
| EP0161918B1 (en) | 1990-07-25 |
| MY101520A (en) | 1991-11-30 |
| AU4240585A (en) | 1985-11-21 |
| KR870000274B1 (ko) | 1987-02-23 |
| PT80414A (en) | 1985-06-01 |
| AU577372B2 (en) | 1988-09-22 |
| SU1486060A3 (ru) | 1989-06-07 |
| PH21862A (en) | 1988-03-25 |
| KR850008166A (ko) | 1985-12-13 |
| DE3578822D1 (de) | 1990-08-30 |
| NZ212023A (en) | 1988-04-29 |
| JPH0643417B2 (ja) | 1994-06-08 |
| IL75122A (en) | 1989-02-28 |
| DK207785A (da) | 1985-11-15 |
| ATE54915T1 (de) | 1990-08-15 |
| ES543078A0 (es) | 1986-09-01 |
| HUT37783A (en) | 1986-02-28 |
| DK207785D0 (da) | 1985-05-10 |
| AR241531A1 (es) | 1992-08-31 |
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