ZA83328B - 5,6,7-trinor-4,8-itner-m-phenylene prostaglandin i2 derivative - Google Patents

5,6,7-trinor-4,8-itner-m-phenylene prostaglandin i2 derivative

Info

Publication number
ZA83328B
ZA83328B ZA83328A ZA83328A ZA83328B ZA 83328 B ZA83328 B ZA 83328B ZA 83328 A ZA83328 A ZA 83328A ZA 83328 A ZA83328 A ZA 83328A ZA 83328 B ZA83328 B ZA 83328B
Authority
ZA
South Africa
Prior art keywords
carbon atoms
hydrogen
itner
trinor
derivative
Prior art date
Application number
ZA83328A
Other languages
English (en)
Inventor
Ohno Kiyotaka
Nagase Hiroshi
Matsumoto Kazuhisa
Nishio Shintaro
Original Assignee
Toray Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11630492&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA83328(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Toray Industries filed Critical Toray Industries
Publication of ZA83328B publication Critical patent/ZA83328B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/09—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis
    • C07C29/12—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of esters of mineral acids
    • C07C29/124—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of esters of mineral acids of halides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/56—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by isomerisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4015—Esters of acyclic unsaturated acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
ZA83328A 1982-01-20 1983-01-18 5,6,7-trinor-4,8-itner-m-phenylene prostaglandin i2 derivative ZA83328B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57006150A JPS58124778A (ja) 1982-01-20 1982-01-20 ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体

Publications (1)

Publication Number Publication Date
ZA83328B true ZA83328B (en) 1983-10-26

Family

ID=11630492

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA83328A ZA83328B (en) 1982-01-20 1983-01-18 5,6,7-trinor-4,8-itner-m-phenylene prostaglandin i2 derivative

Country Status (8)

Country Link
US (1) US4474802A (fr)
EP (1) EP0084856B2 (fr)
JP (1) JPS58124778A (fr)
AT (1) ATE23716T1 (fr)
AU (1) AU556348B2 (fr)
CA (1) CA1226280A (fr)
DE (1) DE3367774D1 (fr)
ZA (1) ZA83328B (fr)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3765646D1 (de) * 1986-01-24 1990-11-29 Toray Industries 2,5,6,7-tetranor-4,8-inter-m-phenylen-pgi2-derivate.
US4880939A (en) * 1986-12-11 1989-11-14 Toray Industries 2,5,6,7-tetranor-18,18,19,19-tetradehydro-4,8-inter-m-phenylene PGI2 derivatives
ATE105555T1 (de) * 1989-02-27 1994-05-15 Toray Industries Verfahren zur herstellung von 5,6,7, -trinor4,8,-inter-m-phenylen pgi,2 abkoemmlingen.
KR960016542B1 (ko) * 1989-03-14 1996-12-14 토레이 가부시기가이샤 2,5,6,7-테트라놀-4,8-인터-m-페닐렌 PGI₂유도체, 이것의 제조 방법 및 이를 함유하는 약제
JP2608135B2 (ja) * 1989-03-31 1997-05-07 科研製薬株式会社 糖尿病性神経障害治療剤
DE4104607A1 (de) * 1991-02-12 1992-08-13 Schering Ag Prostacyclin- und carbacyclinderivate als mittel zur behandlung von fiebrigen erkrankungen
US5496850A (en) * 1991-04-11 1996-03-05 Toray Industries, Inc. Antimetastasis agent of malignant tumors
JP3230246B2 (ja) * 1991-04-11 2001-11-19 東レ株式会社 悪性腫瘍転移抑制剤
US5233059A (en) * 1991-07-25 1993-08-03 Iowa State University Research Foundation, Inc. Synthesis of benzoprostacyclins using palladium catalysis
US5169959A (en) * 1991-09-23 1992-12-08 Iowa State University Research Foundation, Inc. Free radical-catalyzed synthesis of benzoprostacyclins
WO1993007876A1 (fr) * 1991-10-25 1993-04-29 Toray Industries, Inc. Remede contre les maladies hepatiques
JP3102141B2 (ja) * 1992-05-29 2000-10-23 東レ株式会社 養毛育毛剤
US5654339A (en) * 1992-08-07 1997-08-05 Schering Aktiengesellschaft Use of prostane derivatives of formulate I and II for treatment of chronic polyarthritis
CA2123890C (fr) * 1992-09-18 1998-01-20 Kiyotaka Ohno Nouveau derive acide sulfonique et son utilisation en medecine
JPH07126161A (ja) * 1993-10-29 1995-05-16 Toray Ind Inc 心不全治療剤
JP3541417B2 (ja) * 1994-02-24 2004-07-14 日産化学工業株式会社 フェニル置換ヒドロキシシクロペンテノン類、ペンタノン類及びフェニル置換プロスタグランジンｉ２類中間体並びにその製造法及び光学分割法
DE69527507T2 (de) * 1994-11-17 2002-11-07 Toray Industries Transdermal absorbierbare zubereitung
AU4732096A (en) * 1995-02-27 1996-09-18 Toray Industries, Inc. Remedy for pulmonary heart
CZ168896A3 (en) * 1995-06-27 1997-01-15 Egyt Gyogyszervegyeszeti Gyar Oxaindene derivatives and process for preparing thereof
DE19530884C2 (de) * 1995-08-11 1997-07-31 Schering Ag Verwendung von Prostan-Derivaten sowie deren Kombination mit Antibiotika zur Behandlung von bakteriellen Meningitis
US6232343B1 (en) 1996-05-07 2001-05-15 Toray Industries, Inc. Ophthalmic preparations
EP0867185B1 (fr) * 1996-09-17 2002-06-12 Toray Industries, Inc. Agent de potentialisation de la fonction plaquettaire et procede de traitement du dysfonctionnement plaquettaire
AU6117398A (en) * 1997-02-27 1998-09-18 Toray Industries, Inc. Drugs for ameliorating pulmonary circulation
EP0925788A4 (fr) * 1997-03-13 1999-12-01 Toray Industries Medicament pour traiter les lesions vasculaires diabetiques
ES2328191T3 (es) * 1997-03-14 2009-11-10 Toray Industries, Inc. Preparacion de derivado de la prostaglandina i de liberacion sostenida.
US6653345B2 (en) 1997-09-16 2003-11-25 Toray Industries, Inc. C-C chemokine synthesis inhibitor
EP1043031A4 (fr) 1997-12-26 2007-05-02 Astellas Pharma Inc Compositions medicinales a liberation prolongee
JP4019481B2 (ja) 1998-01-23 2007-12-12 ソニー株式会社 情報処理装置および方法、情報処理システム、並びに提供媒体
WO2000009161A1 (fr) * 1998-08-12 2000-02-24 Toray Industries, Inc. Agents qui regulent la production de l'inhibiteur 1 des activateurs du plasminogene
WO2000009135A1 (fr) * 1998-08-14 2000-02-24 Toray Industries, Inc. Agents de protection des cellules péridermiques
US20030092760A1 (en) * 2001-03-12 2003-05-15 Toray Industries, Inc. Therapeutic agent for renal failure
HU227157B1 (en) 2001-07-30 2010-09-28 Chinoin Gyogyszer Es Vegyeszet Production of beraprost ester by selective oxidation
JP3340732B1 (ja) * 2001-10-05 2002-11-05 日本医薬品工業株式会社 シクロペンタベンゾフラン誘導体の製造方法及びその製造原料となる新規化合物
GB0215757D0 (en) * 2002-07-08 2002-08-14 Cascade Biochem Ltd Benzoprostacyclin intermediates methods for their preparation and products derived therefrom
ES2636943T3 (es) 2003-05-09 2017-10-10 Toray Industries, Inc. Beraprost y un inhibidor del sistema renina-angiotensina para usar en el tratamiento de enfermedades renales
EP1642584A1 (fr) * 2003-06-25 2006-04-05 Cardiovascular Institute, Ltd Preparation a usage externe permettant d'ameliorer la fonction coitale
CA2618708C (fr) 2005-07-08 2013-11-12 Toray Industries, Inc. Agent therapeutique et procede de traitement servant a ameliorer l'uremie
JP5424291B2 (ja) * 2006-03-03 2014-02-26 独立行政法人国立循環器病研究センター 骨髄細胞の動員剤および動員方法
JP5271272B2 (ja) 2006-11-16 2013-08-21 ジェンムス ファーマ インコーポレイティド Ａ型インフルエンザウィルス感染の治療のための薬剤としてのｅｐ２およびｅｐ４作動薬
NO2315587T3 (fr) * 2008-08-13 2018-03-24
WO2011047048A1 (fr) 2009-10-14 2011-04-21 Gemmus Pharma, Inc. Traitement par polythérapie pour infections virales
TWI513462B (zh) 2009-11-13 2015-12-21 Toray Industries 糖尿病之治療或預防藥
EP3461817B1 (fr) 2011-06-16 2020-11-04 Lung Biotechnology Inc. Sel de potassium de beraprost
CN103509044A (zh) * 2012-06-21 2014-01-15 上海天伟生物制药有限公司 贝前列素钠中间体及其制备方法
WO2014015247A1 (fr) 2012-07-19 2014-01-23 Cayman Chemical Company, Inc. Composés de difluorolactame comme agonistes sélectifs du récepteur ep4, destinés à être utilisés dans le traitement de maladies et d'affections médiées par ep4
CN103242274B (zh) * 2013-05-22 2014-11-05 孙威 一种贝前列素钠化合物及其制备方法
JP6694385B2 (ja) 2013-08-09 2020-05-13 アーデリクス，インコーポレーテッド リン酸塩輸送阻害のための化合物及び方法
WO2017027706A1 (fr) 2015-08-12 2017-02-16 United Therapeutics Corporation Procédé de préparation de béraprost
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CN106632372B (zh) * 2016-09-26 2019-04-02 上海北卡医药技术有限公司 一种中间体及其制备方法和用途
CA3046025A1 (fr) 2016-12-14 2018-06-21 Respira Therapeutics, Inc. Procedes et compositions de traitement de l'hypertension pulmonaire et d'autres troubles des poumons
CN107325122B (zh) * 2017-01-06 2020-05-01 常州博海威医药科技股份有限公司 制备贝前列腺素的新中间体及其制备方法
EP3658187A1 (fr) 2017-07-27 2020-06-03 Allergan, Inc. Agonistes du récepteur de la prostacycline pour la réduction de la graisse corporelle
CN109305986B (zh) * 2018-11-13 2021-02-19 济南康和医药科技有限公司 一种贝前列素钠中间体的合成方法
US10577340B1 (en) * 2018-11-26 2020-03-03 Chirogate International Inc. Beraprost-314d crystals and methods for preparation thereof
WO2020237096A1 (fr) 2019-05-21 2020-11-26 Ardelyx, Inc. Combinaison pour baisser le phosphate sérique chez un patient
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CN112569181B (zh) * 2019-09-27 2023-03-21 中国科学院上海高等研究院 一种快速增溶肾上腺素的方法
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Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2734791A1 (de) * 1977-07-29 1979-02-15 Schering Ag Neue prostaglandin-i tief 2 -derivate und verfahren zu ihrer herstellung
JPS5931510B2 (ja) * 1979-09-03 1984-08-02 東レ株式会社 ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体
JPS57144276A (en) * 1981-03-03 1982-09-06 Toray Ind Inc 5,6,7-trinor-4,8-inter-m-phenylene pgi2 derivative

Also Published As

Publication number Publication date
US4474802A (en) 1984-10-02
EP0084856B1 (fr) 1986-11-20
AU1060983A (en) 1983-07-28
ATE23716T1 (de) 1986-12-15
DE3367774D1 (de) 1987-01-08
EP0084856A1 (fr) 1983-08-03
CA1226280A (fr) 1987-09-01
AU556348B2 (en) 1986-10-30
JPH0153672B2 (fr) 1989-11-15
EP0084856B2 (fr) 1994-05-04
JPS58124778A (ja) 1983-07-25

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