ZA751031B - 1 - <3 - naphth - 1 - yloxy) - 2 - hydroxypropyl> - piperazine derivatives and the preparation thereof - Google Patents

1 - <3 - naphth - 1 - yloxy) - 2 - hydroxypropyl> - piperazine derivatives and the preparation thereof

Info

Publication number
ZA751031B
ZA751031B ZA00751031A ZA751031A ZA751031B ZA 751031 B ZA751031 B ZA 751031B ZA 00751031 A ZA00751031 A ZA 00751031A ZA 751031 A ZA751031 A ZA 751031A ZA 751031 B ZA751031 B ZA 751031B
Authority
ZA
South Africa
Prior art keywords
naphth
yloxy
hydroxypropyl
preparation
piperazine derivatives
Prior art date
Application number
ZA00751031A
Other languages
English (en)
Inventor
E Roesch
M Thiel
G Sponer
E Witte
K Stach
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of ZA751031B publication Critical patent/ZA751031B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA00751031A 1974-02-23 1975-02-19 1 - <3 - naphth - 1 - yloxy) - 2 - hydroxypropyl> - piperazine derivatives and the preparation thereof ZA751031B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2408804A DE2408804C2 (de) 1974-02-23 1974-02-23 1-(2-Methoxyphenyl)-4-[3-(naphth-1-yl-oxy)-2-hydroxy-propyl]-piperazin, dessen Salze, Verfahren zu ihrer Herstellung sowie Arzneimittel, die diese Verbindungen enthalten

Publications (1)

Publication Number Publication Date
ZA751031B true ZA751031B (en) 1976-02-25

Family

ID=5908286

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00751031A ZA751031B (en) 1974-02-23 1975-02-19 1 - <3 - naphth - 1 - yloxy) - 2 - hydroxypropyl> - piperazine derivatives and the preparation thereof

Country Status (20)

Country Link
US (1) US3997666A (fr)
JP (1) JPS6029712B2 (fr)
AR (1) AR206339A1 (fr)
AT (1) AT340937B (fr)
BE (1) BE825755A (fr)
CA (1) CA1039282A (fr)
CH (2) CH612958A5 (fr)
DE (1) DE2408804C2 (fr)
DK (1) DK135124C (fr)
ES (1) ES434829A1 (fr)
FI (1) FI59248C (fr)
FR (1) FR2261770B1 (fr)
GB (1) GB1445548A (fr)
IE (1) IE40678B1 (fr)
NL (2) NL175059B (fr)
PL (1) PL92131B1 (fr)
SE (1) SE405601B (fr)
SU (2) SU549085A3 (fr)
YU (2) YU37156B (fr)
ZA (1) ZA751031B (fr)

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US4882330A (en) * 1986-11-21 1989-11-21 A. H. Robins Company, Incorporated 1-aryloxy-4-[((4-aryl)-1-piperazinyl]-2-butanols useful as antiallergy agents
JPS63141967A (ja) * 1986-11-21 1988-06-14 エイ・エッチ・ロビンス・カンパニー・インコーポレーテッド 抗アレルギー薬として有用な１−アリールオキシー４−［（４−アリール）−１−ピペラジニル］−２−ブタノール
DE3918543A1 (de) * 1989-06-07 1990-12-13 Boehringer Mannheim Gmbh Verwendung von naftopidil zur therapie der dysurie bei benigner prostata-hypertrophie
DE3918542A1 (de) * 1989-06-07 1990-12-13 Boehringer Mannheim Gmbh Hydroxylierte 1-phenyl-4-(3-(napthth-1-yl-oxy)-2-hydroxy -propyl)-piperazine, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
US5932538A (en) * 1996-02-02 1999-08-03 Nitromed, Inc. Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses
US20020143007A1 (en) * 1996-02-02 2002-10-03 Garvey David S. Nitrosated and nitrosylated alpha-adrenergic receptor antagonists, compositions and methods of use
US20050065161A1 (en) * 1996-02-02 2005-03-24 Nitromed, Inc. Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses
EP0972766A4 (fr) 1997-01-30 2000-05-03 Senju Pharma Co Derives d'hydroquinone
EP1891954A3 (fr) 1998-09-30 2009-01-14 Takeda Pharmaceutical Company Limited Agents pour améliorer le pouvoir de vidange de la vessie
US20020065286A1 (en) * 2000-08-21 2002-05-30 Davies Michael John Treatment of wounds
US20020091129A1 (en) * 2000-11-20 2002-07-11 Mitradev Boolell Treatment of premature ejaculation
US20030229001A1 (en) * 2002-01-31 2003-12-11 Pfizer Inc. Treatment of male sexual dysfunction
ES2362998T3 (es) 2002-08-19 2011-07-18 Pfizer Inc. Terapia de combinación para enfermedades hiperproliferativas.
GB0219961D0 (en) 2002-08-28 2002-10-02 Pfizer Ltd Oxytocin inhibitors
US7323462B2 (en) * 2002-12-10 2008-01-29 Pfizer Inc. Morpholine dopamine agonists
ES2341240T3 (es) 2002-12-13 2010-06-17 Warner-Lambert Company Llc Ligando alfa-2-delta para tratar los sintomas del tracto urinario inferior.
CA2451267A1 (fr) * 2002-12-13 2004-06-13 Warner-Lambert Company Llc Utilisations pharmaceutiques de ligands alpha2delta
PA8597401A1 (es) * 2003-03-14 2005-05-24 Pfizer Derivados del acido 3-(1-[3-(1,3-benzotiazol-6-il) propilcarbamoil] cicloalquil) propanoico como inhibidores de nep
US20040220186A1 (en) * 2003-04-30 2004-11-04 Pfizer Inc. PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease
GEP20084406B (en) 2003-05-30 2008-06-25 Ranbaxy Lab Ltd Substituted pyrrole derivatives and their use as hmg-co inhibitors
US20050065158A1 (en) * 2003-07-16 2005-03-24 Pfizer Inc. Treatment of sexual dysfunction
US7291640B2 (en) * 2003-09-22 2007-11-06 Pfizer Inc. Substituted triazole derivatives as oxytocin antagonists
ATE412648T1 (de) 2005-03-21 2008-11-15 Pfizer Ltd Substituierte triazolderivate als oxytocinantagonisten
US20100222365A1 (en) * 2005-08-10 2010-09-02 Pfizer Inc Substituted triazole deriviatives as oxytocin antagonists
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
AU2006313430B2 (en) 2005-11-08 2012-09-06 Ranbaxy Laboratories Limited Process for (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
US8383660B2 (en) 2006-03-10 2013-02-26 Pfizer Inc. Dibenzyl amine compounds and derivatives
EP2077262A4 (fr) * 2006-10-23 2011-12-28 Takeda Pharmaceutical Dérivé de l'iminopyridine et son utilisation
US8404896B2 (en) 2006-12-01 2013-03-26 Bristol-Myers Squibb Company N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases
US20110039892A1 (en) 2008-04-23 2011-02-17 Takeda Pharmaceutical Company Limited Iminopyridine derivative and use thereof
US8481569B2 (en) * 2008-04-23 2013-07-09 Takeda Pharmaceutical Company Limited Iminopyridine derivatives and use thereof
CN101671317B (zh) * 2009-10-09 2011-04-27 蚌埠丰原涂山制药有限公司 一种萘哌地尔的制备方法
CN101747293B (zh) * 2009-12-29 2011-12-07 蚌埠丰原涂山制药有限公司 萘哌地尔的制备方法
JP5807423B2 (ja) * 2011-07-21 2015-11-10 大日本印刷株式会社 ナフトピジルの製造方法
CN102816136A (zh) * 2012-09-18 2012-12-12 通化吉通药业有限公司 萘哌地尔制备方法
AU2014255381A1 (en) 2013-04-17 2015-10-08 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
US9272980B2 (en) 2014-06-06 2016-03-01 Ktn Biotec, Inc. Anticancer agent
WO2016055901A1 (fr) 2014-10-08 2016-04-14 Pfizer Inc. Composés d'amide substitué
MX2021008533A (es) 2019-01-18 2021-08-19 Astrazeneca Ab Inhibidores de la pcsk9 y metodos de uso de los mismos.

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Publication number Priority date Publication date Assignee Title
CA967965A (en) * 1968-12-24 1975-05-20 Hoffmann-La Roche Limited Aromatic ethers and process for the manufacture thereof
GB1317479A (en) * 1970-11-10 1973-05-16 Pfizer Ltd 1-2-hydroxy-3-phenoxy or phenylthiopropyl-4-phenyl-piperazine derivatives
DE2235597A1 (de) * 1972-07-20 1974-01-31 Boehringer Mannheim Gmbh 1-eckige klammer auf 3-(5,6,7,8tetrahydronaphth-1-yl-oxy) -propyl eckige klammer zu -piperazin-derivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
FI750449A (fr) 1975-08-24
DE2408804A1 (de) 1975-09-04
ES434829A1 (es) 1976-12-01
NL7501877A (nl) 1975-08-26
IE40678L (en) 1975-08-23
DE2408804C2 (de) 1983-09-22
FR2261770A1 (fr) 1975-09-19
NL175059C (nl)
JPS50121286A (fr) 1975-09-23
IE40678B1 (en) 1979-08-01
YU104481A (en) 1983-04-27
AT340937B (de) 1978-01-10
DK135124B (da) 1977-03-07
DK58175A (fr) 1975-10-20
PL92131B1 (fr) 1977-03-31
YU37156B (en) 1984-08-31
FI59248B (fi) 1981-03-31
SU549085A3 (ru) 1977-02-28
YU37157B (en) 1984-08-31
CH609342A5 (fr) 1979-02-28
YU38275A (en) 1983-04-27
US3997666A (en) 1976-12-14
ATA132375A (de) 1977-05-15
JPS6029712B2 (ja) 1985-07-12
BE825755A (fr) 1975-08-20
GB1445548A (en) 1976-08-11
SU561514A3 (ru) 1977-06-05
FI59248C (fi) 1981-07-10
AR206339A1 (es) 1976-07-15
SE405601B (sv) 1978-12-18
SE7501911L (fr) 1975-08-25
CH612958A5 (fr) 1979-08-31
AU7826875A (en) 1976-08-19
FR2261770B1 (fr) 1978-08-04
DK135124C (da) 1977-08-15
CA1039282A (fr) 1978-09-26
NL175059B (nl) 1984-04-16

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