ZA746790B - Improvements relating to n-(methoxymethyl-furylmethyl)-6,7-benzomorphanes and -morphinanes - Google Patents

Improvements relating to n-(methoxymethyl-furylmethyl)-6,7-benzomorphanes and -morphinanes

Info

Publication number
ZA746790B
ZA746790B ZA00746790A ZA746790A ZA746790B ZA 746790 B ZA746790 B ZA 746790B ZA 00746790 A ZA00746790 A ZA 00746790A ZA 746790 A ZA746790 A ZA 746790A ZA 746790 B ZA746790 B ZA 746790B
Authority
ZA
South Africa
Prior art keywords
morphinanes
benzomorphanes
furylmethyl
methoxymethyl
improvements relating
Prior art date
Application number
ZA00746790A
Other languages
English (en)
Inventor
H Merz
A Langbein
G Walther
K Stockhaus
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of ZA746790B publication Critical patent/ZA746790B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA00746790A 1973-10-27 1974-10-25 Improvements relating to n-(methoxymethyl-furylmethyl)-6,7-benzomorphanes and -morphinanes ZA746790B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19732354002 DE2354002A1 (de) 1973-10-27 1973-10-27 Neue n-(methoxymethyl-furylmethyl)6,7-benzomorphane und -morphinane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
ZA746790B true ZA746790B (en) 1976-06-30

Family

ID=5896658

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00746790A ZA746790B (en) 1973-10-27 1974-10-25 Improvements relating to n-(methoxymethyl-furylmethyl)-6,7-benzomorphanes and -morphinanes

Country Status (27)

Country Link
US (1) US3981874A (fr)
JP (1) JPS5738590B2 (fr)
AT (6) AT335633B (fr)
BE (1) BE821505A (fr)
BG (3) BG27902A3 (fr)
CA (1) CA1056377A (fr)
CH (6) CH609048A5 (fr)
CS (3) CS171196B2 (fr)
DD (1) DD115909A5 (fr)
DE (1) DE2354002A1 (fr)
DK (1) DK138325C (fr)
ES (6) ES431055A1 (fr)
FI (1) FI62079C (fr)
FR (1) FR2248838B1 (fr)
GB (1) GB1482552A (fr)
HU (1) HU176479B (fr)
IE (1) IE41528B1 (fr)
IL (1) IL45938A (fr)
NL (1) NL7413980A (fr)
NO (1) NO140859C (fr)
PH (1) PH11894A (fr)
PL (3) PL92086B1 (fr)
RO (5) RO65656A (fr)
SE (1) SE422791B (fr)
SU (6) SU511005A3 (fr)
YU (5) YU36951B (fr)
ZA (1) ZA746790B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1513961A (en) * 1975-02-25 1978-06-14 Acf Chemiefarma Nv 6,7-benzomorphans method for their preparation and intermediates
US4208523A (en) * 1978-11-30 1980-06-17 Sterling Drug Inc. 11-Lower-alkyl-, 11-phenyl-lower-alkyl- and 11-cyclo-lower-alkyl-lower-alkyl-hexahydro-2,6-methano-3-benzazocines
ES2395081T3 (es) 2007-07-26 2013-02-08 Vitae Pharmaceuticals, Inc. Síntesis de inhibidores de la 11beta-hidroxiesteroide deshidrogenasa de tipo 1
TW200927115A (en) * 2007-11-16 2009-07-01 Boehringer Ingelheim Int Aryl-and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
EP2229368A1 (fr) 2007-12-11 2010-09-22 Vitae Pharmaceuticals, Inc. Inhibiteurs cycliques d'urée de la 11béta-hydroxystéroïde déhydrogénase 1
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
JP5490020B2 (ja) 2008-01-24 2014-05-14 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状カルバゼート及びセミカルバジドインヒビター
ATE531696T1 (de) * 2008-02-12 2011-11-15 Boehringer Ingelheim Int Harnstoff-derivate von benzomorphanen, entsprechende gerüste, medikamente mit solchen verbindungen und ihre verwendung
WO2009102460A2 (fr) 2008-02-15 2009-08-20 Vitae Pharmaceuticals, Inc. Inhibiteurs de 11beta-hydroxystéroïde deshydrogénase 1
WO2009134400A1 (fr) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Inhibiteurs cycliques de la 11-bêta-hydroxystéroïde déhydrogénase 1
EP2291370B1 (fr) 2008-05-01 2013-11-27 Vitae Pharmaceuticals, Inc. Inhibiteurs cycliques de la 11-bêta-hydroxystéroïde déhydrogénase 1
CL2009001058A1 (es) 2008-05-01 2010-09-10 Vitae Pharmaceuticals Inc Compuestos derivados de oxazinas sustituidas, inhibidores de la 11b-hidroxiesteroide deshidrogenasa de tipo-1; composicion farmaceutica; y uso del compuesto para inhibir la actividad de 11b-hsd1, como en el tratamiento de la diabetes, dislipidemia, hipertension, obesidad, cancer, glaucoma, entre otras.
EP2288596B1 (fr) 2008-05-13 2016-11-30 Boehringer Ingelheim International GmbH Dérivés d acide carboxylique alicyclique de benzomorphanes et échafaudages afférents, médicaments contenant ces composés, et utilisation de ceux-ci
CA2730499A1 (fr) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Inhibiteurs cycliques de la 11 beta-hydroxysteroide deshydrogenase 1
CA2729998A1 (fr) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Inhibiteurs de la 11 beta-hydroxysteroide deshydrogenase 1
MA33216B1 (fr) 2009-04-30 2012-04-02 Boehringer Ingelheim Int Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1
WO2011011123A1 (fr) 2009-06-11 2011-01-27 Vitae Pharmaceuticals, Inc. Inhibiteurs cycliques de la 11-bêta-hydroxystéroïde déshydrogénase 1 basée sur la structure 1,3-oxazinan-2-one
UY33001A (es) 2009-11-06 2011-05-31 Boehringer Ingelheim Int Derivados arilo y heteroarilcarbonilo de hexahidroindenopiridina y octahidrobenzoquinolina
JP5860042B2 (ja) 2010-06-16 2016-02-16 ヴァイティー ファーマシューティカルズ，インコーポレイテッド 置換５、６及び７員複素環、そのような化合物を含有する医薬及びそれらの使用
TWI537258B (zh) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
JP2014524438A (ja) 2011-08-17 2014-09-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング インデノピリジン誘導体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3632591A (en) * 1968-07-19 1972-01-04 Sterling Drug Inc 1 2 3 4 5 6 - hexahydro-3-(cycloaliphatic or cycloaliphatic 11-dimethyl-2 alkyl)-66-methano-3-benzazocines
US3833595A (en) * 1968-12-26 1974-09-03 Sumitomo Chemical Co 2-aroylalkyl benzomorphans
CS166804B2 (fr) * 1971-02-08 1976-03-29 Boehringer Sohn Ingelheim

Also Published As

Publication number Publication date
FI62079B (fi) 1982-07-30
IE41528B1 (en) 1980-01-30
NO743845L (fr) 1975-05-26
ATA828974A (de) 1976-08-15
IL45938A0 (en) 1974-12-31
YU285174A (en) 1982-06-18
CA1056377A (fr) 1979-06-12
SU511005A3 (ru) 1976-04-15
YU285374A (en) 1982-06-18
PL92052B1 (fr) 1977-03-31
AT335631B (de) 1977-03-25
CH609047A5 (fr) 1979-02-15
FR2248838B1 (fr) 1977-11-04
FR2248838A1 (fr) 1975-05-23
SE422791B (sv) 1982-03-29
CS171195B2 (fr) 1976-10-29
DK559874A (fr) 1975-06-23
ATA829074A (de) 1976-07-15
AT336202B (de) 1977-04-25
PH11894A (en) 1978-08-29
AT335633B (de) 1977-03-25
ES431055A1 (es) 1976-10-16
CH609340A5 (fr) 1979-02-28
YU36950B (en) 1984-08-31
SE7413485L (fr) 1975-04-28
YU285674A (en) 1982-06-18
ATA828674A (de) 1976-07-15
ATA828574A (de) 1976-07-15
ATA828774A (de) 1976-07-15
ES431054A1 (es) 1976-10-16
ATA828874A (de) 1976-06-15
CS171196B2 (fr) 1976-10-29
FI62079C (fi) 1982-11-10
PL92086B1 (fr) 1977-03-31
RO65655A (fr) 1980-06-15
YU36519B (en) 1984-02-29
RO65656A (fr) 1980-06-15
GB1482552A (en) 1977-08-10
IE41528L (en) 1975-04-27
JPS5738590B2 (fr) 1982-08-16
SU512707A3 (ru) 1976-04-30
ES431059A1 (es) 1976-10-16
YU36949B (en) 1984-08-31
HU176479B (en) 1981-03-28
SU578870A3 (ru) 1977-10-30
CS171194B2 (fr) 1976-10-29
ES431058A1 (es) 1976-10-16
US3981874A (en) 1976-09-21
CH609048A5 (fr) 1979-02-15
BG27901A3 (bg) 1980-01-15
RO65659A (fr) 1980-06-15
DE2354002A1 (de) 1975-05-07
NO140859C (no) 1979-11-28
YU285474A (en) 1982-06-18
DK138325C (da) 1979-01-22
YU36951B (en) 1984-08-31
FI314174A (fr) 1975-04-28
NL7413980A (nl) 1975-04-29
DK138325B (da) 1978-08-14
BE821505A (fr) 1975-04-25
AT335076B (de) 1977-02-25
YU285274A (en) 1982-02-25
PL92053B1 (fr) 1977-03-31
SU508193A3 (ru) 1976-03-25
BG27902A3 (en) 1980-01-15
SU508192A3 (ru) 1976-03-25
BG27903A3 (en) 1980-01-15
RO65657A (fr) 1980-06-15
RO65658A (fr) 1979-07-15
CH609046A5 (fr) 1979-02-15
IL45938A (en) 1977-12-30
JPS5071679A (fr) 1975-06-13
SU510999A3 (ru) 1976-04-15
AT335632B (de) 1977-03-25
ES431057A1 (es) 1976-10-16
AT335634B (de) 1977-03-25
ES431056A1 (es) 1976-10-16
YU36952B (en) 1984-08-31
NO140859B (no) 1979-08-20
CH609685A5 (fr) 1979-03-15
CH609686A5 (fr) 1979-03-15
DD115909A5 (fr) 1975-10-20

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