ZA201800611B - Modified monocytes/macrophage expressing chimeric antigen receptors and uses thereof - Google Patents

Modified monocytes/macrophage expressing chimeric antigen receptors and uses thereof

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Publication number
ZA201800611B
ZA201800611B ZA2018/00611A ZA201800611A ZA201800611B ZA 201800611 B ZA201800611 B ZA 201800611B ZA 2018/00611 A ZA2018/00611 A ZA 2018/00611A ZA 201800611 A ZA201800611 A ZA 201800611A ZA 201800611 B ZA201800611 B ZA 201800611B
Authority
ZA
South Africa
Prior art keywords
chimeric antigen
antigen receptors
expressing chimeric
macrophage expressing
modified monocytes
Prior art date
Application number
ZA2018/00611A
Other languages
English (en)
Inventor
Gill Saar
Klichinsky Michael
H June Carl
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of ZA201800611B publication Critical patent/ZA201800611B/en

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
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    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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ZA2018/00611A 2015-07-28 2018-01-29 Modified monocytes/macrophage expressing chimeric antigen receptors and uses thereof ZA201800611B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562197675P 2015-07-28 2015-07-28
PCT/US2016/044440 WO2017019848A1 (en) 2015-07-28 2016-07-28 Modified monocytes/macrophage expressing chimeric antigen receptors and uses thereof

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ZA201800611B true ZA201800611B (en) 2023-05-31

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Country Status (13)

Country Link
US (13) US11034749B2 (https=)
EP (1) EP3328402A4 (https=)
JP (4) JP7032304B2 (https=)
KR (2) KR20240132100A (https=)
CN (3) CN108025024B (https=)
AU (3) AU2016298229B2 (https=)
BR (1) BR112018001858B1 (https=)
HK (1) HK1256141A1 (https=)
IL (4) IL315940A (https=)
MX (2) MX393707B (https=)
RU (1) RU2766690C2 (https=)
WO (1) WO2017019848A1 (https=)
ZA (1) ZA201800611B (https=)

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US10434153B1 (en) 2015-05-20 2019-10-08 Kim Leslie O'Neill Use of car and bite technology coupled with an scFv from an antibody against human thymidine kinase 1 to specifically target tumors
RU2766690C2 (ru) * 2015-07-28 2022-03-15 Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания Модифицированные моноциты/макрофаги, экспрессирующие химерные антигенные рецепторы, и их применения
US11352439B2 (en) 2015-08-13 2022-06-07 Kim Leslie O'Neill Macrophage CAR (MOTO-CAR) in immunotherapy
CN108243607A (zh) 2015-09-09 2018-07-03 西雅图儿童医院（Dba西雅图儿童研究所） 用于免疫疗法的巨噬细胞的遗传工程
KR20180054600A (ko) * 2015-10-13 2018-05-24 브라이엄 영 유니버시티 면역치료에서의 대식세포 키메라 항원 수용체(moto-car)
US10875919B2 (en) * 2016-04-26 2020-12-29 Alector Llc Chimeric receptors and methods of use thereof
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US10415017B2 (en) 2017-05-17 2019-09-17 Thunder Biotech, Inc. Transgenic macrophages, chimeric antigen receptors, and associated methods
JP7164598B2 (ja) * 2017-05-17 2022-11-01 サンダー・バイオテック・インコーポレイテッド トランスジェニックマクロファージ、キメラ抗原受容体、及び関連する方法
AU2018275894B2 (en) 2017-06-02 2025-04-24 Juno Therapeutics, Inc. Articles of manufacture and methods for treatment using adoptive cell therapy
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