SG11201604815RA - Human mesothelin chimeric antigen receptors and uses thereof - Google Patents

Human mesothelin chimeric antigen receptors and uses thereof

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Publication number
SG11201604815RA
SG11201604815RA SG11201604815RA SG11201604815RA SG11201604815RA SG 11201604815R A SG11201604815R A SG 11201604815RA SG 11201604815R A SG11201604815R A SG 11201604815RA SG 11201604815R A SG11201604815R A SG 11201604815RA SG 11201604815R A SG11201604815R A SG 11201604815RA
Authority
SG
Singapore
Prior art keywords
chimeric antigen
antigen receptors
human mesothelin
mesothelin chimeric
human
Prior art date
Application number
SG11201604815RA
Inventor
Gregory Beatty
Boris Engels
Neeraja Idamakanti
Carl H June
Andreas Loew
Huijuan Song
Qilong Wu
Original Assignee
Novartis Ag
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Univ Pennsylvania filed Critical Novartis Ag
Publication of SG11201604815RA publication Critical patent/SG11201604815RA/en

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    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
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    • A61K39/001168Mesothelin [MSLN]
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SG11201604815RA 2013-12-19 2014-12-19 Human mesothelin chimeric antigen receptors and uses thereof SG11201604815RA (en)

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CN2013089979 2013-12-19
CN2014082610 2014-07-21
CN2014090509 2014-11-06
PCT/CN2014/094393 WO2015090230A1 (en) 2013-12-19 2014-12-19 Human mesothelin chimeric antigen receptors and uses thereof

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US (2) US10640569B2 (en)
EP (2) EP3083964B1 (en)
JP (5) JP6779785B2 (en)
CN (2) CN116478927A (en)
AU (4) AU2014366047B2 (en)
BR (1) BR112016013187A2 (en)
CA (3) CA3225456A1 (en)
ES (1) ES2918501T3 (en)
HK (1) HK1224332A1 (en)
IL (1) IL245764A0 (en)
MX (1) MX2016008076A (en)
RU (1) RU2714902C2 (en)
SG (1) SG11201604815RA (en)
TW (1) TWI672379B (en)
WO (1) WO2015090230A1 (en)

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ES2760023T3 (en) 2013-02-20 2020-05-12 Univ Pennsylvania Cancer treatment using humanized anti-EGFRvIII chimeric antigen receptor
TW201446794A (en) 2013-02-20 2014-12-16 Novartis Ag Effective targeting of primary human leukemia using anti-CD123 chimeric antigen receptor engineered T cells
WO2014145252A2 (en) 2013-03-15 2014-09-18 Milone Michael C Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
TWI654206B (en) 2013-03-16 2019-03-21 諾華公司 Treatment of cancer with a humanized anti-CD19 chimeric antigen receptor
EP3083964B1 (en) * 2013-12-19 2022-01-26 Novartis AG Human mesothelin chimeric antigen receptors and uses thereof
EP3087101A4 (en) 2013-12-20 2017-12-06 Novartis AG Regulatable chimeric antigen receptor
ES2963718T3 (en) 2014-01-21 2024-04-01 Novartis Ag Antigen-presenting capacity of CAR-T cells enhanced by co-introduction of co-stimulatory molecules
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