ZA201404444B - 4'-azido,3'-fluoro substituted nucleoside derivatives as inhibitors of hcv rna replication - Google Patents

4'-azido,3'-fluoro substituted nucleoside derivatives as inhibitors of hcv rna replication

Info

Publication number
ZA201404444B
ZA201404444B ZA2014/04444A ZA201404444A ZA201404444B ZA 201404444 B ZA201404444 B ZA 201404444B ZA 2014/04444 A ZA2014/04444 A ZA 2014/04444A ZA 201404444 A ZA201404444 A ZA 201404444A ZA 201404444 B ZA201404444 B ZA 201404444B
Authority
ZA
South Africa
Prior art keywords
azido
inhibitors
hcv rna
fluoro substituted
rna replication
Prior art date
Application number
ZA2014/04444A
Other languages
English (en)
Inventor
Zhuming Zhang
Francisco Xavier Talamas
Jing Zhang
Mark Smith
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ZA201404444B publication Critical patent/ZA201404444B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
ZA2014/04444A 2011-12-20 2014-06-17 4'-azido,3'-fluoro substituted nucleoside derivatives as inhibitors of hcv rna replication ZA201404444B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161577712P 2011-12-20 2011-12-20
PCT/EP2012/075688 WO2013092447A1 (en) 2011-12-20 2012-12-17 4'-azido, 3'-fluoro substituted nucleoside derivatives as inhibitors of hcv rna replication

Publications (1)

Publication Number Publication Date
ZA201404444B true ZA201404444B (en) 2015-08-26

Family

ID=47469968

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2014/04444A ZA201404444B (en) 2011-12-20 2014-06-17 4'-azido,3'-fluoro substituted nucleoside derivatives as inhibitors of hcv rna replication

Country Status (31)

Country Link
US (1) US9708357B2 (OSRAM)
EP (1) EP2794628B1 (OSRAM)
JP (1) JP6118336B2 (OSRAM)
KR (1) KR101687084B1 (OSRAM)
CN (2) CN108409820A (OSRAM)
AU (1) AU2012357986B2 (OSRAM)
BR (1) BR112014015066A2 (OSRAM)
CA (1) CA2869317C (OSRAM)
CL (1) CL2014001599A1 (OSRAM)
CO (1) CO6990719A2 (OSRAM)
CR (1) CR20140255A (OSRAM)
CY (1) CY1119015T1 (OSRAM)
DK (1) DK2794628T3 (OSRAM)
EA (1) EA024847B1 (OSRAM)
ES (1) ES2626484T3 (OSRAM)
HK (1) HK1200835A1 (OSRAM)
HU (1) HUE033332T2 (OSRAM)
IL (1) IL232843B (OSRAM)
IN (1) IN2014CN04530A (OSRAM)
LT (1) LT2794628T (OSRAM)
MA (1) MA35749B1 (OSRAM)
MX (1) MX350810B (OSRAM)
PE (1) PE20141599A1 (OSRAM)
PH (1) PH12014501283A1 (OSRAM)
PL (1) PL2794628T3 (OSRAM)
PT (1) PT2794628T (OSRAM)
SG (1) SG11201403086YA (OSRAM)
SI (1) SI2794628T1 (OSRAM)
UA (1) UA110428C2 (OSRAM)
WO (1) WO2013092447A1 (OSRAM)
ZA (1) ZA201404444B (OSRAM)

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Also Published As

Publication number Publication date
JP6118336B2 (ja) 2017-04-19
JP2015500851A (ja) 2015-01-08
IL232843A0 (en) 2014-07-31
US20140369959A1 (en) 2014-12-18
HK1200835A1 (en) 2015-08-14
IN2014CN04530A (OSRAM) 2015-09-11
PT2794628T (pt) 2017-07-05
MA35749B1 (fr) 2014-12-01
CN104011060A (zh) 2014-08-27
AU2012357986A1 (en) 2014-06-19
MX2014007028A (es) 2014-09-16
WO2013092447A1 (en) 2013-06-27
LT2794628T (lt) 2017-07-10
CA2869317C (en) 2016-05-17
ES2626484T3 (es) 2017-07-25
AU2012357986B2 (en) 2017-02-02
CY1119015T1 (el) 2018-01-10
EA024847B1 (ru) 2016-10-31
US9708357B2 (en) 2017-07-18
HK1199037A1 (en) 2015-06-19
UA110428C2 (uk) 2015-12-25
NZ625844A (en) 2016-08-26
HUE033332T2 (en) 2017-11-28
EP2794628A1 (en) 2014-10-29
CR20140255A (es) 2014-08-20
PH12014501283A1 (en) 2014-09-08
CA2869317A1 (en) 2013-06-27
EP2794628B1 (en) 2017-03-29
CL2014001599A1 (es) 2014-11-03
PE20141599A1 (es) 2014-10-30
KR101687084B1 (ko) 2016-12-15
CN108409820A (zh) 2018-08-17
CO6990719A2 (es) 2014-07-10
EA201491180A1 (ru) 2014-11-28
PL2794628T3 (pl) 2017-09-29
DK2794628T3 (en) 2017-07-10
IL232843B (en) 2018-02-28
MX350810B (es) 2017-09-20
SI2794628T1 (sl) 2017-07-31
BR112014015066A2 (pt) 2017-06-13
KR20140108303A (ko) 2014-09-05
SG11201403086YA (en) 2014-07-30

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