ZA201303544B - Compositions and methods for 3-hydroxypropionic acid production - Google Patents

Compositions and methods for 3-hydroxypropionic acid production

Info

Publication number
ZA201303544B
ZA201303544B ZA2013/03544A ZA201303544A ZA201303544B ZA 201303544 B ZA201303544 B ZA 201303544B ZA 2013/03544 A ZA2013/03544 A ZA 2013/03544A ZA 201303544 A ZA201303544 A ZA 201303544A ZA 201303544 B ZA201303544 B ZA 201303544B
Authority
ZA
South Africa
Prior art keywords
compositions
methods
acid production
hydroxypropionic acid
hydroxypropionic
Prior art date
Application number
ZA2013/03544A
Other languages
English (en)
Inventor
Holly Jessen
Jeanette Huryta
Alan Berry
Michael Catlett
Brian Rush
Beth Mastel
Debbie Yaver
Michelle Barnhardt
Original Assignee
Novozymes As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes As filed Critical Novozymes As
Publication of ZA201303544B publication Critical patent/ZA201303544B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14Fungi; Culture media therefor
    • C12N1/16Yeasts; Culture media therefor
    • C12N1/18Baker's yeast; Brewer's yeast
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0006Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1096Transferases (2.) transferring nitrogenous groups (2.6)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93Ligases (6)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42Hydroxy-carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/52Propionic acid; Butyric acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y101/00Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/010593-Hydroxypropionate dehydrogenase (1.1.1.59)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y206/00Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01Transaminases (2.6.1)
    • C12Y206/01001Aspartate transaminase (2.6.1.1), i.e. aspartate-aminotransferase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y206/00Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01Transaminases (2.6.1)
    • C12Y206/01018Beta-alanine-pyruvate transaminase (2.6.1.18)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y206/00Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01Transaminases (2.6.1)
    • C12Y206/010194-Aminobutyrate—2-oxoglutarate transaminase (2.6.1.19)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y401/00Carbon-carbon lyases (4.1)
    • C12Y401/01Carboxy-lyases (4.1.1)
    • C12Y401/01031Phosphoenolpyruvate carboxylase (4.1.1.31)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ZA2013/03544A 2010-11-22 2013-05-15 Compositions and methods for 3-hydroxypropionic acid production ZA201303544B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41619910P 2010-11-22 2010-11-22
US201161535181P 2011-09-15 2011-09-15
PCT/US2011/061717 WO2012074818A2 (en) 2010-11-22 2011-11-21 Compositions and methods for 3-hydroxypropionic acid production

Publications (1)

Publication Number Publication Date
ZA201303544B true ZA201303544B (en) 2014-11-26

Family

ID=45099210

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2013/03544A ZA201303544B (en) 2010-11-22 2013-05-15 Compositions and methods for 3-hydroxypropionic acid production

Country Status (11)

Country Link
US (7) US9090918B2 (https=)
EP (2) EP2643450A2 (https=)
JP (1) JP6061862B2 (https=)
KR (1) KR20130119945A (https=)
CN (2) CN103502432A (https=)
AU (1) AU2011336923B2 (https=)
BR (1) BR112013012630B1 (https=)
CA (1) CA2818499A1 (https=)
MX (1) MX2013005654A (https=)
WO (1) WO2012074818A2 (https=)
ZA (1) ZA201303544B (https=)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007106524A2 (en) 2006-03-13 2007-09-20 Cargill Inc. Yeast cells having disrupted pathway from dihydroxyacetone phosphate to glycerol
BR112013003003A2 (pt) 2010-08-06 2016-06-14 Mascoma Corp produção de produtos malonil-coa derivados através de rotas anaeróbicas
US9090918B2 (en) 2010-11-22 2015-07-28 Novozymes A/A Compositions and methods for 3-hydroxypropionic acid production
ES2645680T3 (es) * 2010-11-22 2017-12-07 Cargill, Incorporated Células de levadura y proceso para convertir acetaldehído en etanol
AU2012275348A1 (en) * 2011-06-28 2014-02-20 Brookhaven Science Associates, Llc Modified plants with increased oil content
IN2014CN02136A (https=) * 2011-08-24 2015-05-29 Novozymes Inc
CA2849303C (en) 2011-09-30 2019-09-17 Novozymes, Inc. Dehydrogenase variants and polynucleotides encoding same
CN114395496A (zh) * 2012-03-06 2022-04-26 利戈斯股份有限公司 用于产生丙二酸的重组宿主细胞
IN2014DN10168A (https=) * 2012-05-30 2015-08-21 Lanzatech New Zealand Ltd
MX2015001780A (es) 2012-08-10 2015-09-28 Opx Biotechnologies Inc Microorganismos y métodos para la producción de ácidos grasos y productos derivados de ácidos grasos.
CA2888093A1 (en) * 2012-10-11 2014-04-17 Technical University Of Denmark Genetically engineered yeast
CN105209626B (zh) * 2012-11-30 2019-09-03 诺维信股份有限公司 通过重组酵母生产3-羟基丙酸
US9441250B2 (en) * 2013-03-14 2016-09-13 Butamax Advanced Biofuels Llc Glycerol 3- phosphate dehydrogenase for butanol production
US20150044746A1 (en) * 2013-03-15 2015-02-12 Opx Biotechnologies, Inc. Method of enhanced bioproduction
US10442749B2 (en) 2013-03-15 2019-10-15 Cargill, Incorporated Recovery of 3-hydroxypropionic acid
US20150119601A1 (en) 2013-03-15 2015-04-30 Opx Biotechnologies, Inc. Monofunctional mcr + 3-hp dehydrogenase
EP3008179A1 (en) 2013-06-14 2016-04-20 Technical University of Denmark 3hp tolerance
EP3008178A1 (en) * 2013-06-14 2016-04-20 Technical University of Denmark Microbial production of 3-hydroxypropionic acid
US9556443B2 (en) 2013-07-19 2017-01-31 Samsung Electronics Co., Ltd. Yeast cell with inactivated NADH dehydrogenase and method of producing lactate using the yeast cell
EP3022310B1 (en) 2013-07-19 2019-10-16 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
US9845484B2 (en) 2013-07-31 2017-12-19 Novozymes A/S 3-hydroxypropionic acid production by recombinant yeasts expressing an insect aspartate 1-decarboxylase
WO2015031504A1 (en) * 2013-08-27 2015-03-05 The Regents Of The University Of California RECOMBINANT PATHWAY AND ORGANISMS FOR MALONYL-CoA SYNTHESIS
WO2015036278A1 (de) 2013-09-12 2015-03-19 Basf Se Verfahren zur dehydratisierung von 3-hydroxypropionsäure zu acrylsäure
BR112016005241B1 (pt) 2013-09-12 2020-12-08 Basf Se processo para desidratar continuamente ácido 3-hidroxipropiônico aquoso para ácido acrílico aquoso na fase líquida
WO2015036273A1 (de) 2013-09-12 2015-03-19 Basf Se Verfahren zur herstellung von acrylsäure
JP6499587B2 (ja) 2013-11-22 2019-04-10 Jmtcエンザイム株式会社 形質転換体およびその製造方法、ならびに乳酸の製造方法
JP6515502B2 (ja) * 2013-11-22 2019-05-22 Agc株式会社 形質転換体の製造方法、形質転換体、および単座組込み用ベクターキット
KR101555867B1 (ko) 2014-04-18 2015-10-01 부산대학교 산학협력단 3-하이드록시프로피온산을 분해하지 않는 슈도모나스 데니트리피칸스 결실 변이균주 및 이를 이용한 3-하이드록시프로피온산의 생산방법
WO2015200545A1 (en) * 2014-06-26 2015-12-30 Lygos, Inc. Recombinant host cells for the production of malonate
WO2016026763A1 (en) 2014-08-18 2016-02-25 Basf Se Process for preparing acrylic acid using a heterogeneous alumina catalyst
CN107002019B (zh) * 2014-08-29 2021-11-23 Sk新技术株式会社 产生3-羟基丙酸的重组酵母和使用其产生3-羟基丙酸的方法
EP2993228B1 (en) 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters
ES2759269T3 (es) 2014-10-10 2020-05-08 Jmtc Enzyme Corp Transformante y procedimiento para la producción del mismo, y procedimiento para la producción de ácido láctico
BR112017012718A2 (pt) * 2014-12-19 2018-05-15 Novozymes As célula de levedura recombinante, e, métodos para produzir 3-hp e para produzir ácido acrílico ou um sal do mesmo.
WO2016100910A1 (en) * 2014-12-19 2016-06-23 Novozymes A/S Recombinant host cells for the production of 3-hydroxypropionic acid
WO2016135020A1 (de) 2015-02-24 2016-09-01 Basf Se Verfahren zur kontinuierlichen dehydratisierung von 3-hydroxypropionsäure zu acrylsäure
CN107406821B (zh) * 2015-02-27 2021-10-15 诺维信公司 用于生产3-羟基丙酸的突变宿主细胞
WO2016162175A1 (de) 2015-04-07 2016-10-13 Basf Se Verfahren zur dehydratisierung von 3-hydroxypropionsäure zu acrylsäure
CN108291231B (zh) 2015-06-11 2022-04-08 纳路Ic有限公司 由3-羟基丙酸诱导表达的启动子系统及用其生物生产3-羟基丙酸的方法
WO2016200239A1 (ko) * 2015-06-11 2016-12-15 부산대학교 산학협력단 3-하이드록시프로피온산에 의해 발현이 유도되는 프로모터 시스템 및 이를 이용한 3-하이드록시프로피온산의 생물학적 생산방법
CN107849522A (zh) * 2015-07-21 2018-03-27 多伦多大学管理委员会 用于产生1,3‑丁二醇的方法和微生物
EP3341475A1 (en) 2015-08-24 2018-07-04 Novozymes A/S Beta-alanine aminotransferases for the production of 3-hydroxypropionic acid
US20180258437A1 (en) * 2015-11-12 2018-09-13 Lygos, Inc. Recombinant host cells and methods for the production of l-aspartate and beta-alanine
CN109072172A (zh) * 2015-11-12 2018-12-21 利戈斯股份有限公司 用于厌氧产生L-天冬氨酸和β-丙氨酸的重组宿主细胞和方法
DE102016114555A1 (de) 2016-08-05 2018-02-08 Thyssenkrupp Ag Prozess zur Herstellung von Acrylsäure aus einer wässrigen 3-Hydroxypropanol-Lösung
EP3551759A1 (en) 2016-12-06 2019-10-16 Novozymes A/S Improved processes for production of ethanol from xylose-containing cellulosic substrates using engineered yeast strains
US11345938B2 (en) 2017-02-02 2022-05-31 Cargill, Incorporated Genetically modified cells that produce C6-C10 fatty acid derivatives
US11091753B2 (en) 2017-05-31 2021-08-17 Novozymes A/S Xylose fermenting yeast strains and processes thereof for ethanol production
CN110730824A (zh) 2017-06-02 2020-01-24 诺维信公司 用于乙醇生产的改善的酵母
EP3668831B1 (de) 2017-08-17 2021-06-23 Basf Se Verfahren zur kontinuierlichen herstellung von acrylsäure-n-butylester oder acrylsäure-isobutylester
AU2018322748B2 (en) 2017-08-29 2024-05-02 Novozymes A/S Baker's yeast expressing anti-staling/freshness amylases
EP3746545A1 (en) 2018-01-29 2020-12-09 Novozymes A/S Microorganisms with improved nitrogen utilization for ethanol production
KR102419608B1 (ko) * 2018-02-08 2022-07-08 주식회사 엘지화학 고농도 3-하이드록시프로피온산 수용액의 제조 방법
WO2019231944A2 (en) 2018-05-31 2019-12-05 Novozymes A/S Processes for enhancing yeast growth and productivity
US20220119821A1 (en) * 2018-06-25 2022-04-21 Lygos, Inc. Recombinant host cells and methods for the production of aspartic acid and b-alanine
MX2021000893A (es) 2018-07-25 2021-03-31 Novozymes As Levadura que expresa enzimas para la producción de etanol.
CN113286889A (zh) 2018-10-08 2021-08-20 诺维信公司 用于生产乙醇的表达酶的酵母
JP7370587B2 (ja) * 2018-10-30 2023-10-30 GreenEarthInstitute株式会社 有機化合物の製造方法およびコリネ型細菌
JP2022515078A (ja) 2018-12-18 2022-02-17 ブラスケム エス.エー. マロン酸セミアルデヒドからの3-HPおよびアセチル-CoA誘導体の共産生経路
CN109852605A (zh) * 2019-01-16 2019-06-07 徐州工程学院 一种诱变筛选高产3-羟基丙酸菌株的方法
WO2021021458A1 (en) 2019-07-26 2021-02-04 Novozymes A/S Microorganisms with improved nitrogen transport for ethanol production
CN112390855B (zh) * 2019-07-31 2022-04-29 上海交通大学医学院附属仁济医院 Pretide-146a在制备缓解或治疗自身免疫性疾病的药物中的应用
WO2021026201A1 (en) 2019-08-05 2021-02-11 Novozymes A/S Enzyme blends and processes for producing a high protein feed ingredient from a whole stillage byproduct
MX2021015818A (es) 2019-08-06 2022-02-03 Novozymes As Proteinas de fusion para mejorar la expresion de enzimas.
EP4031661A1 (en) 2019-09-16 2022-07-27 Novozymes A/S Polypeptides having beta-glucanase activity and polynucleotides encoding same
CA3158982A1 (en) 2019-12-10 2021-06-17 Monica TASSONE Microorganism for improved pentose fermentation
EP4103709A2 (en) 2020-02-10 2022-12-21 Novozymes A/S Polypeptides having alpha-amylase activity and polynucleotides encoding same
US12290768B2 (en) 2020-06-29 2025-05-06 Basf Se Device for carrying out material exchange processes
KR102639658B1 (ko) * 2020-07-31 2024-02-22 주식회사 엘지화학 3-하이드록시프로피온산의 2단계 제조 방법
CN111985041B (zh) * 2020-09-17 2021-03-30 青岛理工大学 一种加固边坡挡墙高度确定方法及加固边坡挡墙
US10947552B1 (en) 2020-09-30 2021-03-16 Alpine Roads, Inc. Recombinant fusion proteins for producing milk proteins in plants
US10894812B1 (en) 2020-09-30 2021-01-19 Alpine Roads, Inc. Recombinant milk proteins
AU2021353004A1 (en) 2020-09-30 2023-04-13 Nobell Foods, Inc. Recombinant milk proteins and food compositions comprising the same
CN116367900A (zh) * 2020-09-30 2023-06-30 基因组公司 生产生物丙烯醛和生物丙烯酸的发酵方法
CN116438309A (zh) 2020-11-02 2023-07-14 诺维信公司 葡糖淀粉酶变体和编码它们的多核苷酸
EP4242312A4 (en) * 2020-11-05 2024-04-24 Lg Chem, Ltd. Microorganisms having capability of producing 3-hydroxypropionic acid from glucose and uses thereof
CN116323957A (zh) * 2020-11-05 2023-06-23 株式会社Lg化学 生产3-羟基丙酸的方法
US11788092B2 (en) 2021-02-08 2023-10-17 Lanzatech, Inc. Recombinant microorganisms and uses therefor
AU2022288057A1 (en) 2021-06-07 2023-12-21 Novozymes A/S Engineered microorganism for improved ethanol fermentation
FR3125040B1 (fr) 2021-07-09 2024-04-26 Snf Sa Procédé d’obtention de bio-monomère à partir de diméthylaminoethanol d’origine renouvelable
FR3125048B1 (fr) 2021-07-09 2024-04-19 Snf Sa Polymère biosourcé à biodégradabilité améliorée
FR3125042B1 (fr) 2021-07-09 2024-04-12 Snf Sa Procédé d’obtention d’alkyl(méth)acrylamide substitué biosourcé
WO2023168244A1 (en) 2022-03-03 2023-09-07 Cargill, Incorporated Genetically modified yeast and fermentation processes for the production of 3-hydroxypropionate
WO2023168233A1 (en) 2022-03-03 2023-09-07 Cargill, Incorporated Genetically modified yeast and fermentation processes for the production of 3-hydroxypropionate
CN115595328B (zh) * 2022-03-07 2026-02-13 中国科学院微生物研究所 天冬氨酸脱羧酶在发酵生产维生素b5中的应用
CN116024184B (zh) * 2022-07-26 2024-03-15 南京科技职业学院 醛脱氢酶突变体及其在制备5-羟甲基-2-呋喃甲酸中的应用
EP4638768A2 (en) 2022-12-19 2025-10-29 Novozymes A/S Processes for producing fermentation products using fiber-degrading enzymes with engineered yeast
WO2024226289A1 (en) 2023-04-26 2024-10-31 Cargill, Incorporated Methods for producing propionic acid
WO2024258820A2 (en) 2023-06-13 2024-12-19 Novozymes A/S Processes for producing fermentation products using engineered yeast expressing a beta-xylosidase
CN121794035A (zh) 2023-09-15 2026-04-03 嘉吉公司 升膜蒸发器原位清洁方法和系统
CN121488048A (zh) * 2024-01-31 2026-02-06 株式会社Lg化学 用于生产3-羟基丙酸的方法
WO2025261823A1 (en) 2024-06-21 2025-12-26 Basf Se Process for manufacture of (meth)acrylates

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL39710A (en) 1972-06-19 1975-04-25 Imi Inst For Res & Dev Recovery of acids from aqueous solutions by solvent extraction
US4771001A (en) 1986-03-27 1988-09-13 Neurex Corp. Production of lactic acid by continuous fermentation using an inexpensive raw material and a simplified method of lactic acid purification
US5210296A (en) 1990-11-19 1993-05-11 E. I. Du Pont De Nemours And Company Recovery of lactate esters and lactic acid from fermentation broth
US5132456A (en) 1991-05-07 1992-07-21 The Regents Of The University Of California Sorption of carboxylic acid from carboxylic salt solutions at PHS close to or above the pKa of the acid, with regeneration with an aqueous solution of ammonia or low-molecular-weight alkylamine
US5420304A (en) 1992-03-19 1995-05-30 Biopak Technology, Ltd. Method to produce cyclic esters
AT398982B (de) 1993-02-18 1995-02-27 Vogelbusch Gmbh Verfahren zur abtrennung und reinigung von milchsäure
US5510526A (en) 1993-06-29 1996-04-23 Cargill, Incorporated Lactic acid production, separation and/or recovery process
IL109003A (en) 1994-03-16 1999-09-22 Yissum Res Dev Co Process and extractant composition for extracting water-soluble carboxylic and mineral acids
IT1294728B1 (it) 1997-09-12 1999-04-12 Biopolo S C A R L Ceppi di lievito per la riproduzione di acido lattico
WO1999053035A1 (en) 1998-04-13 1999-10-21 The University Of Georgia Research Foundation, Inc. Pyruvate carboxylase overexpression for enhanced production of oxaloacetate-derived biochemicals in microbial cells
US6329183B1 (en) * 1998-08-04 2001-12-11 Metabolix, Inc. Polyhydroxyalkanoate production from polyols
WO2000071738A1 (en) 1999-05-21 2000-11-30 Cargill Dow Llc Methods and materials for the synthesis of organic products
BR0008355A (pt) 1999-08-30 2002-07-16 Wisconsin Alumni Res Found Produção de ácido 3-hidroxipropionico em organismos recombinantes
US6852517B1 (en) 1999-08-30 2005-02-08 Wisconsin Alumni Research Foundation Production of 3-hydroxypropionic acid in recombinant organisms
JP4098455B2 (ja) 2000-03-10 2008-06-11 株式会社日立製作所 マーク画像中の電子透かし情報の参照方法及び計算機
BR0115877A (pt) 2000-11-20 2003-10-07 Cargill Inc ácido 3-hidroxipropiÈnico e outros compostos orgánicos
BR0115558A (pt) 2000-11-22 2004-08-17 Cargill Dow Polymers Llc ácido nucleico isolado, construção de expressão recombinante, célula de levedura transformada com a construção de expressão recombinante, e, método para produzir ácido lático
CA2474152A1 (en) 2001-11-23 2003-06-19 Natureworks Llc Methods and materials for the production of organic products in cells of candida species
DE60327804D1 (de) 2002-01-18 2009-07-09 Novozymes As Alanin-2,3-aminomutase
CN1642897A (zh) 2002-03-25 2005-07-20 嘉吉有限公司 制造β-羟基羧酸衍生物的方法
ES2529254T3 (es) 2002-05-30 2015-02-18 Cargill Inc. Proceso de fermentación usando velocidades de incorporación de oxígeno específicas como un control del proceso
BR0315969B1 (pt) 2002-11-01 2013-03-19 processo para preparaÇço de 1,3-propanodiol.
WO2004076398A1 (en) 2003-02-24 2004-09-10 Cargill Incorporated Process for preparing 3-hydroxycarboxylic acids
DE602004022305D1 (de) 2003-06-26 2009-09-10 Novozymes As Verfahren zur trennung und rückgewinnung von 3-hydroxypropionsäure und acrylsäure
EP1646597A2 (en) 2003-06-26 2006-04-19 Cargill Incorporated Process for separating and recovering 3-hydroxypropionic acid and acrylic acid
US7326557B2 (en) 2003-11-14 2008-02-05 Rice University Increasing intracellular NADPH availability in E. coli
WO2005118719A2 (en) 2003-12-04 2005-12-15 Cargill, Incorporated Production of 3-hydroxypropionic acid using beta-alanine/pyruvate aminotransferase
MX2007001195A (es) 2004-07-30 2007-10-03 Cargill Inc Alanina 2,3-aminomutasas.
US7987056B2 (en) 2004-09-20 2011-07-26 The Regents Of The University Of Colorado, A Body Corporate Mixed-library parallel gene mapping quantitative micro-array technique for genome-wide identification of trait conferring genes
CN101068923A (zh) 2004-10-25 2007-11-07 科德克希思公司 改良的丙氨酸2,3-氨基变位酶和相关多核苷酸
DK2305826T3 (en) 2005-08-10 2016-06-27 Univ Florida Materials and methods for the efficient production of lactic acid
US7846688B2 (en) 2005-08-15 2010-12-07 The Regents Of The University Of Colorado Broad host range vectors for shotgun and expression library cloning in Gram negative bacteria
DE102005048818A1 (de) 2005-10-10 2007-04-12 Degussa Ag Mikrobiologische Herstellung von 3-Hydroxypropionsäure
WO2007106524A2 (en) 2006-03-13 2007-09-20 Cargill Inc. Yeast cells having disrupted pathway from dihydroxyacetone phosphate to glycerol
WO2007130745A1 (en) 2006-03-15 2007-11-15 Regents Of The University Of Colorado Enhanced alcohol tolerant microorganism and methods of use thereof
US20080103060A1 (en) 2006-08-08 2008-05-01 Regents Of The University Of Colorado Compositions and methods for chemical reporter vectors
US8030045B2 (en) * 2006-08-30 2011-10-04 Cargill, Incorporated Beta-alanine/alpha-ketoglutarate aminotransferase for 3-hydroxypropionic acid production
US8938765B2 (en) 2006-12-22 2015-01-20 Time Warner Cable Enterprises Llc Methods, apparatus and user interface for providing content on demand
CA2675026A1 (en) 2007-01-12 2008-07-24 The Regents Of The University Of Colorado, A Body Corporate Compositions and methods for enhancing tolerance for the production of organic chemicals produced by microorganisms
US8673601B2 (en) 2007-01-22 2014-03-18 Genomatica, Inc. Methods and organisms for growth-coupled production of 3-hydroxypropionic acid
US8048624B1 (en) 2007-12-04 2011-11-01 Opx Biotechnologies, Inc. Compositions and methods for 3-hydroxypropionate bio-production from biomass
NZ598403A (en) 2007-12-19 2012-07-27 Novozymes As Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
WO2009089457A1 (en) 2008-01-11 2009-07-16 Novozymes A/S Methods for producing 3-hydroxypropionic acid and compounds thereof
WO2010006076A2 (en) 2008-07-08 2010-01-14 Opx Biotechnologies Inc. Methods, compositions and systems for biosynthetic bio production of 1,4-butanediol
US20100021978A1 (en) 2008-07-23 2010-01-28 Genomatica, Inc. Methods and organisms for production of 3-hydroxypropionic acid
CN102317436B (zh) * 2008-07-23 2014-06-25 Opx生物工艺学公司 用于增加微生物对3-羟基丙酸(3-hp)的耐受性以及增加3-羟基丙酸产量的方法、系统和组合物
WO2010017230A2 (en) 2008-08-04 2010-02-11 The Regents Of The University Of Colorado Methods, systems and compositions related to microbial bio-production of butanol and/or isobutanol
EP2326709A4 (en) 2008-09-15 2013-01-23 Opx Biotechnologies Inc METHODS, SYSTEMS AND COMPOSITIONS RELATED TO REDUCED MICROBIAL PRODUCTION OF 3-HYDROXYPROPIONIC ACID (3-HP) IN ALDEHYDMETABOLITE
WO2010059424A2 (en) 2008-11-18 2010-05-27 Novozymes, Inc. Methods and compositions for degrading cellulosic material
US20110144377A1 (en) 2009-06-16 2011-06-16 E. I. Du Pont Nemours And Company Process for the biological production of 3-hydroxypropionic acid with high yield
US8809027B1 (en) 2009-09-27 2014-08-19 Opx Biotechnologies, Inc. Genetically modified organisms for increased microbial production of 3-hydroxypropionic acid involving an oxaloacetate alpha-decarboxylase
MX2012003604A (es) 2009-09-27 2012-09-12 Opx Biotechnologies Inc Metodo para producir acido 3-hidroxipropionico y otros productos.
BR112012006873A2 (pt) 2009-10-23 2015-09-08 Novozymes Inc variante isolada, polinucleotideo isolado, metodo para produzir uma variante, planta transgenica, parte de planta ou celula d eplanta, e, metodos para degradar ou converter um materialcelulósico, para produzir um produto de fermentação, e, para fermentar um material celulósico.
US20120260371A1 (en) 2009-10-29 2012-10-11 Novozymes A/S Polypeptides Having Cellobiohydrolase Activity and Polynucleotides Encoding Same
US20110125118A1 (en) 2009-11-20 2011-05-26 Opx Biotechnologies, Inc. Production of an Organic Acid and/or Related Chemicals
EP2529023A4 (en) 2010-01-27 2015-06-10 Opx Biotechnologies Inc MICRO-ORGANISM MANUFACTURE FROM HIGH-FLOW CHEMICAL PRODUCTS AND CORRESPONDING COMPOSITIONS, METHODS AND SYSTEMS
EP3070171B1 (en) 2010-03-30 2018-06-13 Novozymes A/S Process for enhancing by-products from fermentation processes
BR112013002979A2 (pt) 2010-08-12 2016-06-07 Novozymes Inc composição, e, método para degradar ou converter um material celulósico, para produzir um produto de fermentação, e para fermentar um material celulósico.
US9090918B2 (en) * 2010-11-22 2015-07-28 Novozymes A/A Compositions and methods for 3-hydroxypropionic acid production
US20140121118A1 (en) 2010-11-23 2014-05-01 Opx Biotechnologies, Inc. Methods, systems and compositions regarding multiplex construction protein amino-acid substitutions and identification of sequence-activity relationships, to provide gene replacement such as with tagged mutant genes, such as via efficient homologous recombination
US20130345470A1 (en) 2012-06-20 2013-12-26 Opx Biotechnologies, Inc. Purification of 3-Hydroxypropionic Acid from Crude Cell Broth and Production of Acrylamide
WO2013192451A1 (en) 2012-06-20 2013-12-27 Opx Biotechnologies, Inc. Dehydration of 3-hydroxypropionic acid to acrylic acid
US20150119601A1 (en) 2013-03-15 2015-04-30 Opx Biotechnologies, Inc. Monofunctional mcr + 3-hp dehydrogenase
WO2014145344A2 (en) 2013-03-15 2014-09-18 Opx Biotechnologies, Inc. Control of growth-induction-production phases
EP2976141A4 (en) 2013-03-15 2016-10-05 Cargill Inc FLASHING FOR PRODUCTION CLEANING AND RECOVERY
US10442749B2 (en) 2013-03-15 2019-10-15 Cargill, Incorporated Recovery of 3-hydroxypropionic acid
US20150044746A1 (en) 2013-03-15 2015-02-12 Opx Biotechnologies, Inc. Method of enhanced bioproduction

Also Published As

Publication number Publication date
JP2013542747A (ja) 2013-11-28
CN107828671A (zh) 2018-03-23
US9090918B2 (en) 2015-07-28
CN103502432A (zh) 2014-01-08
JP6061862B2 (ja) 2017-01-18
AU2011336923A1 (en) 2013-05-30
US20140065681A1 (en) 2014-03-06
CN107828671B (zh) 2022-03-08
US12054721B2 (en) 2024-08-06
KR20130119945A (ko) 2013-11-01
US20220064654A1 (en) 2022-03-03
WO2012074818A3 (en) 2012-09-27
US10633664B2 (en) 2020-04-28
US11118187B2 (en) 2021-09-14
US20120135481A1 (en) 2012-05-31
BR112013012630B1 (pt) 2021-09-08
EP3287519B1 (en) 2020-03-18
AU2011336923B2 (en) 2017-02-16
CA2818499A1 (en) 2012-06-07
US10260072B2 (en) 2019-04-16
US20160177317A1 (en) 2016-06-23
EP2643450A2 (en) 2013-10-02
EP3287519A1 (en) 2018-02-28
US9777280B2 (en) 2017-10-03
US20190249181A1 (en) 2019-08-15
MX2013005654A (es) 2013-07-17
WO2012074818A2 (en) 2012-06-07
US20180044684A1 (en) 2018-02-15
US20200291408A1 (en) 2020-09-17
BR112013012630A2 (pt) 2020-09-24

Similar Documents

Publication Publication Date Title
ZA201303544B (en) Compositions and methods for 3-hydroxypropionic acid production
ZA201308086B (en) Derivatives of 1-anino-2-cyclopropylboronic acid
EP2545178A4 (en) ACIDIFICATION BY FERMENTATION
ZA201308606B (en) Nutritional compositions having alpha-hica and eicosapentaenoic acid
EP2527400A4 (en) polylactic acid
SG11201404601QA (en) Acetic acid production method
IL222548A0 (en) Novel hydroxamic acid derivative
SI2637710T1 (sl) Formulacije na osnovi hialuronske kisline
IL227699A0 (en) Preparations containing peroxy alpha-ketocarboxylic acid and methods for their production and use
IL223153A0 (en) Compositions comprising acid and derivatives thereof and uses thereof
PL2534252T3 (pl) Sposób wytwarzania kwasu mlekowego
EP2646412A4 (en) SYNTHETIC ACID AND ASSOCIATED METHODS
SG11201406131SA (en) Process for making ethylene and acetic acid
ZA201205713B (en) Process for manufacturing succinic acid
SG11201402979PA (en) Biotechnological production of 3-hydroxyisobutyric acid
EP2578725A4 (en) COATED ELEMENT AND METHOD FOR PRODUCING THE SAME
ZA201400918B (en) Pyrrolidine-3-ylacetic acid derivative
EP2616430A4 (en) NOVEL PHENOXYISOBUTYRIC ACID COMPONENTS AND METHODS OF SYNTHESIS
EP2782902A4 (en) DERIVATIVES FROM PHENOXYISOBUTTERIC ACID
ZA201108148B (en) Triazine-aryl-bis-indoles and process for preparation thereof
GB201021522D0 (en) Novel compounds and methods for their production
HU1000328D0 (en) Nanostuctured indometachine compositions and process for their preparation
HU1000329D0 (en) Nanostuctured ibuprofene compositions and process for their preparation
GB201121663D0 (en) Process and compositions
HU1000693D0 (en) Sweetener composition and process for its production