ZA201202704B - Anti-hepsin antibodies and methods using same - Google Patents

Anti-hepsin antibodies and methods using same

Info

Publication number
ZA201202704B
ZA201202704B ZA2012/02704A ZA201202704A ZA201202704B ZA 201202704 B ZA201202704 B ZA 201202704B ZA 2012/02704 A ZA2012/02704 A ZA 2012/02704A ZA 201202704 A ZA201202704 A ZA 201202704A ZA 201202704 B ZA201202704 B ZA 201202704B
Authority
ZA
South Africa
Prior art keywords
methods
same
hepsin antibodies
hepsin
antibodies
Prior art date
Application number
ZA2012/02704A
Other languages
English (en)
Inventor
Rajkumar Ganesan
Daniel Kirchhofer
Paul M Moran
Yingnan Zhang
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of ZA201202704B publication Critical patent/ZA201202704B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA2012/02704A 2009-10-22 2012-04-13 Anti-hepsin antibodies and methods using same ZA201202704B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25395309P 2009-10-22 2009-10-22
PCT/US2010/053591 WO2011050188A1 (en) 2009-10-22 2010-10-21 Anti-hepsin antibodies and methods using same

Publications (1)

Publication Number Publication Date
ZA201202704B true ZA201202704B (en) 2013-06-26

Family

ID=43332807

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2012/02704A ZA201202704B (en) 2009-10-22 2012-04-13 Anti-hepsin antibodies and methods using same

Country Status (17)

Country Link
US (1) US8435511B2 (cg-RX-API-DMAC7.html)
EP (1) EP2491059B1 (cg-RX-API-DMAC7.html)
JP (1) JP5814925B2 (cg-RX-API-DMAC7.html)
KR (1) KR20120105447A (cg-RX-API-DMAC7.html)
CN (1) CN102648211B (cg-RX-API-DMAC7.html)
AR (1) AR078716A1 (cg-RX-API-DMAC7.html)
AU (1) AU2010310585A1 (cg-RX-API-DMAC7.html)
BR (1) BR112012009412A2 (cg-RX-API-DMAC7.html)
CA (1) CA2778481A1 (cg-RX-API-DMAC7.html)
ES (1) ES2534646T3 (cg-RX-API-DMAC7.html)
IL (1) IL219136A0 (cg-RX-API-DMAC7.html)
MX (1) MX2012004647A (cg-RX-API-DMAC7.html)
NZ (1) NZ599337A (cg-RX-API-DMAC7.html)
RU (1) RU2559533C2 (cg-RX-API-DMAC7.html)
TW (1) TW201121566A (cg-RX-API-DMAC7.html)
WO (1) WO2011050188A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201202704B (cg-RX-API-DMAC7.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101490088B (zh) * 2006-06-22 2015-04-08 健泰科生物技术公司 用于靶向hepsin的方法和组合物
WO2009151920A2 (en) * 2008-06-11 2009-12-17 Fred Hutchinson Cancer Research Center Hepsin inhibitors
RU2539772C2 (ru) 2009-10-22 2015-01-27 Дженентек, Инк. Способы и композиции для модуляции гепсином стимулирующего макрофаги белка
CN102218057B (zh) * 2011-04-24 2012-08-08 吉林大学 3,4-二氯异香豆素在制备抗球虫病药物中的用途
WO2017162659A1 (en) 2016-03-24 2017-09-28 Bayer Pharma Aktiengesellschaft Intracellular hepsin as therapeutic target for the treatment of cancer with centrosome amplification
WO2021158660A2 (en) * 2020-02-05 2021-08-12 Navaux, Inc. Anti-hepsin antibodies and uses thereof

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KR20120105447A (ko) 2012-09-25
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JP5814925B2 (ja) 2015-11-17
EP2491059A1 (en) 2012-08-29
US20110262452A1 (en) 2011-10-27
CN102648211A (zh) 2012-08-22
AU2010310585A1 (en) 2012-05-03
TW201121566A (en) 2011-07-01
HK1171032A1 (en) 2013-03-15
EP2491059B1 (en) 2015-02-25
AR078716A1 (es) 2011-11-30
WO2011050188A8 (en) 2012-04-12
CN102648211B (zh) 2015-04-01
ES2534646T3 (es) 2015-04-27
RU2559533C2 (ru) 2015-08-10
CA2778481A1 (en) 2011-04-28
RU2012120864A (ru) 2013-11-27
MX2012004647A (es) 2012-06-19
BR112012009412A2 (pt) 2016-11-29
WO2011050188A1 (en) 2011-04-28
JP2013507966A (ja) 2013-03-07
IL219136A0 (en) 2012-06-28

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