ZA201104796B - Human anti-il-6 antibodies with extended in vivo half-life and their use in treatment of oncology,autoimmune diseases and inflammatory diseases - Google Patents

Human anti-il-6 antibodies with extended in vivo half-life and their use in treatment of oncology,autoimmune diseases and inflammatory diseases

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Publication number
ZA201104796B
ZA201104796B ZA2011/04796A ZA201104796A ZA201104796B ZA 201104796 B ZA201104796 B ZA 201104796B ZA 2011/04796 A ZA2011/04796 A ZA 2011/04796A ZA 201104796 A ZA201104796 A ZA 201104796A ZA 201104796 B ZA201104796 B ZA 201104796B
Authority
ZA
South Africa
Prior art keywords
oncology
antibodies
extended
life
treatment
Prior art date
Application number
ZA2011/04796A
Other languages
English (en)
Inventor
Bahija Jallal
William Dall'acqua
Michael Bowen
Anthony Coyle
Herren Wu
Peter A Kiener
Original Assignee
Medimmune Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune Llc filed Critical Medimmune Llc
Publication of ZA201104796B publication Critical patent/ZA201104796B/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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ZA2011/04796A 2009-01-29 2011-06-28 Human anti-il-6 antibodies with extended in vivo half-life and their use in treatment of oncology,autoimmune diseases and inflammatory diseases ZA201104796B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14810609P 2009-01-29 2009-01-29
US18418209P 2009-06-04 2009-06-04
PCT/US2010/022478 WO2010088444A1 (en) 2009-01-29 2010-01-29 Human anti-il-6 antibodies with extended in vivo half-life and their use in treatment of oncology, autoimmune diseases and inflammatory diseases

Publications (1)

Publication Number Publication Date
ZA201104796B true ZA201104796B (en) 2018-11-28

Family

ID=42396023

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Application Number Title Priority Date Filing Date
ZA2011/04796A ZA201104796B (en) 2009-01-29 2011-06-28 Human anti-il-6 antibodies with extended in vivo half-life and their use in treatment of oncology,autoimmune diseases and inflammatory diseases
ZA2012/07249A ZA201207249B (en) 2009-01-29 2012-09-27 Human anti-il-6 antibodies with extended in vivo half-life

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Application Number Title Priority Date Filing Date
ZA2012/07249A ZA201207249B (en) 2009-01-29 2012-09-27 Human anti-il-6 antibodies with extended in vivo half-life

Country Status (14)

Country Link
US (3) US20120034212A1 (cg-RX-API-DMAC7.html)
EP (1) EP2391384A4 (cg-RX-API-DMAC7.html)
JP (3) JP2012516158A (cg-RX-API-DMAC7.html)
KR (1) KR20110108398A (cg-RX-API-DMAC7.html)
CN (2) CN104119438A (cg-RX-API-DMAC7.html)
AU (1) AU2010208125B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI1007005A2 (cg-RX-API-DMAC7.html)
CA (1) CA2749200A1 (cg-RX-API-DMAC7.html)
HK (1) HK1201847A1 (cg-RX-API-DMAC7.html)
MX (1) MX337590B (cg-RX-API-DMAC7.html)
RU (2) RU2650594C1 (cg-RX-API-DMAC7.html)
SG (3) SG172354A1 (cg-RX-API-DMAC7.html)
WO (1) WO2010088444A1 (cg-RX-API-DMAC7.html)
ZA (2) ZA201104796B (cg-RX-API-DMAC7.html)

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US10005830B2 (en) 2009-03-05 2018-06-26 Ablynx N.V. Antigen binding dimer-complexes, methods of making/avoiding and uses thereof
EP2805731B1 (en) * 2009-09-03 2018-10-31 Ablynx N.V. Stable formulations of polypeptides and uses thereof
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JP6322411B2 (ja) 2011-09-30 2018-05-09 中外製薬株式会社 複数の生理活性を有する抗原の消失を促進する抗原結合分子
TWI827333B (zh) 2011-09-30 2023-12-21 日商中外製藥股份有限公司 促進抗原消失的抗原結合分子
TWI682939B (zh) 2012-02-24 2020-01-21 日商中外製藥股份有限公司 經ＦｃγＲＩＩＢ促進抗原消失之抗原結合分子
WO2013175276A1 (en) * 2012-05-23 2013-11-28 Argen-X B.V Il-6 binding molecules
KR102321372B1 (ko) 2012-10-22 2021-11-11 원니스 바이오테크 컴퍼니 리미티드 인터류킨-6에 대한 항체 및 그의 용도
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TWI713453B (zh) 2014-06-23 2020-12-21 美商健生生物科技公司 干擾素α及ω抗體拮抗劑
UA122673C2 (uk) 2014-11-07 2020-12-28 Елевен Байотерапьютікс, Інк. Антитіло, що специфічно зв'язується з людським il-6
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KR20180116359A (ko) 2016-02-23 2018-10-24 세센 바이오, 아이엔씨. 인터루킨-6의 길항제 제제 및 이의 용도
JP2019519470A (ja) * 2016-04-07 2019-07-11 ヤンセン バイオテツク，インコーポレーテツド Ｉｌ−６受容体へのｉｌ−６の結合を遮断する薬剤を用いたうつ病の治療
KR102050463B1 (ko) 2016-08-10 2019-11-29 아주대학교산학협력단 항체 중쇄불변부위 이종이중체 (heterodimeric Fc)에 융합된 사이토카인 (heterodimeric Fc-fused cytokine) 및 이를 포함하는 약제학적 조성물
US11203636B2 (en) * 2017-02-01 2021-12-21 Yale University Treatment of existing left ventricular heart failure
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CN113015745B (zh) 2018-10-09 2025-02-11 免疫医疗有限责任公司 针对金黄色葡萄球菌白细胞毒素的抗体
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CA2749200A1 (en) 2010-08-05
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