SG172354A1 - Human anti-il-6 antibodies with extended in vivo half-life and their use in treatment of oncology, autoimmune diseases and inflammatory diseases - Google Patents

Human anti-il-6 antibodies with extended in vivo half-life and their use in treatment of oncology, autoimmune diseases and inflammatory diseases Download PDF

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Publication number
SG172354A1
SG172354A1 SG2011046265A SG2011046265A SG172354A1 SG 172354 A1 SG172354 A1 SG 172354A1 SG 2011046265 A SG2011046265 A SG 2011046265A SG 2011046265 A SG2011046265 A SG 2011046265A SG 172354 A1 SG172354 A1 SG 172354A1
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Singapore
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antibody
amino acid
seq
acid sequence
domain
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SG2011046265A
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English (en)
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Michael Bowen
Herren Wu
Acqua William Dall
Peter Kiener
Bahija Jallal
Anthony Coyle
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Medimmune Llc
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Publication of SG172354A1 publication Critical patent/SG172354A1/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • C07K16/248IL-6
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07ORGANIC CHEMISTRY
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72Increased effector function due to an Fc-modification
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    • C07K2317/00Immunoglobulins specific features
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    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

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SG2011046265A 2009-01-29 2010-01-29 Human anti-il-6 antibodies with extended in vivo half-life and their use in treatment of oncology, autoimmune diseases and inflammatory diseases SG172354A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14810609P 2009-01-29 2009-01-29
US18418209P 2009-06-04 2009-06-04
PCT/US2010/022478 WO2010088444A1 (en) 2009-01-29 2010-01-29 Human anti-il-6 antibodies with extended in vivo half-life and their use in treatment of oncology, autoimmune diseases and inflammatory diseases

Publications (1)

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SG172354A1 true SG172354A1 (en) 2011-07-28

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Application Number Title Priority Date Filing Date
SG2011046265A SG172354A1 (en) 2009-01-29 2010-01-29 Human anti-il-6 antibodies with extended in vivo half-life and their use in treatment of oncology, autoimmune diseases and inflammatory diseases
SG10201704214VA SG10201704214VA (en) 2009-01-29 2010-01-29 Human anti-il-6 antibodies with extended in vivo half-life and their use in treatment of oncology, autoimmune diseases and inflammatory diseases
SG2014007637A SG2014007637A (en) 2009-01-29 2010-01-29 Human anti-il-6 antibodies with extended in vivo half-life and their use in treatment of oncology, autoimmune diseases and inflammatory diseases

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Application Number Title Priority Date Filing Date
SG10201704214VA SG10201704214VA (en) 2009-01-29 2010-01-29 Human anti-il-6 antibodies with extended in vivo half-life and their use in treatment of oncology, autoimmune diseases and inflammatory diseases
SG2014007637A SG2014007637A (en) 2009-01-29 2010-01-29 Human anti-il-6 antibodies with extended in vivo half-life and their use in treatment of oncology, autoimmune diseases and inflammatory diseases

Country Status (14)

Country Link
US (3) US20120034212A1 (cg-RX-API-DMAC7.html)
EP (1) EP2391384A4 (cg-RX-API-DMAC7.html)
JP (3) JP2012516158A (cg-RX-API-DMAC7.html)
KR (1) KR20110108398A (cg-RX-API-DMAC7.html)
CN (2) CN104119438A (cg-RX-API-DMAC7.html)
AU (1) AU2010208125B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI1007005A2 (cg-RX-API-DMAC7.html)
CA (1) CA2749200A1 (cg-RX-API-DMAC7.html)
HK (1) HK1201847A1 (cg-RX-API-DMAC7.html)
MX (1) MX337590B (cg-RX-API-DMAC7.html)
RU (2) RU2650594C1 (cg-RX-API-DMAC7.html)
SG (3) SG172354A1 (cg-RX-API-DMAC7.html)
WO (1) WO2010088444A1 (cg-RX-API-DMAC7.html)
ZA (2) ZA201104796B (cg-RX-API-DMAC7.html)

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US10005830B2 (en) 2009-03-05 2018-06-26 Ablynx N.V. Antigen binding dimer-complexes, methods of making/avoiding and uses thereof
EP2805731B1 (en) * 2009-09-03 2018-10-31 Ablynx N.V. Stable formulations of polypeptides and uses thereof
JP6173911B2 (ja) * 2010-09-10 2017-08-09 メディミューン リミテド 抗体誘導体
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JP6352634B2 (ja) * 2011-09-30 2018-07-04 中外製薬株式会社 標的抗原に対する免疫応答を誘導する抗原結合分子
JP6322411B2 (ja) 2011-09-30 2018-05-09 中外製薬株式会社 複数の生理活性を有する抗原の消失を促進する抗原結合分子
TWI827333B (zh) 2011-09-30 2023-12-21 日商中外製藥股份有限公司 促進抗原消失的抗原結合分子
TWI682939B (zh) 2012-02-24 2020-01-21 日商中外製藥股份有限公司 經FcγRIIB促進抗原消失之抗原結合分子
WO2013175276A1 (en) * 2012-05-23 2013-11-28 Argen-X B.V Il-6 binding molecules
KR102321372B1 (ko) 2012-10-22 2021-11-11 원니스 바이오테크 컴퍼니 리미티드 인터류킨-6에 대한 항체 및 그의 용도
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TWI713453B (zh) 2014-06-23 2020-12-21 美商健生生物科技公司 干擾素α及ω抗體拮抗劑
UA122673C2 (uk) 2014-11-07 2020-12-28 Елевен Байотерапьютікс, Інк. Антитіло, що специфічно зв'язується з людським il-6
AU2016302768B2 (en) * 2015-07-31 2019-08-22 Medimmune Limited Methods for treating hepcidin-mediated disorders
KR20180116359A (ko) 2016-02-23 2018-10-24 세센 바이오, 아이엔씨. 인터루킨-6의 길항제 제제 및 이의 용도
JP2019519470A (ja) * 2016-04-07 2019-07-11 ヤンセン バイオテツク,インコーポレーテツド Il−6受容体へのil−6の結合を遮断する薬剤を用いたうつ病の治療
KR102050463B1 (ko) 2016-08-10 2019-11-29 아주대학교산학협력단 항체 중쇄불변부위 이종이중체 (heterodimeric Fc)에 융합된 사이토카인 (heterodimeric Fc-fused cytokine) 및 이를 포함하는 약제학적 조성물
US11203636B2 (en) * 2017-02-01 2021-12-21 Yale University Treatment of existing left ventricular heart failure
PE20211196A1 (es) * 2018-01-05 2021-07-01 Novo Nordisk As Metodos para tratar inflamacion mediada por il-6 sin inmunosupresion
BR112021001214A2 (pt) 2018-07-24 2021-04-27 Medimmune, Llc anticorpo dirigido contra o fator de aglutinação a (clfa) de s. aureus
CN113015745B (zh) 2018-10-09 2025-02-11 免疫医疗有限责任公司 针对金黄色葡萄球菌白细胞毒素的抗体
US11168133B2 (en) 2018-10-09 2021-11-09 Medimmune, Llc Combinations of anti-Staphylococcus aureus antibodies
WO2020185986A1 (en) 2019-03-13 2020-09-17 Medimmune, Llc Decreasing staphylococcus aureus infections in colonized patients
JP7701273B2 (ja) 2019-05-01 2025-07-01 ノヴォ ノルディスク アー/エス 抗il-6抗体製剤
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