ZA200903598B - Lipase variants for pharmaceutical use - Google Patents

Lipase variants for pharmaceutical use

Info

Publication number
ZA200903598B
ZA200903598B ZA200903598A ZA200903598A ZA200903598B ZA 200903598 B ZA200903598 B ZA 200903598B ZA 200903598 A ZA200903598 A ZA 200903598A ZA 200903598 A ZA200903598 A ZA 200903598A ZA 200903598 B ZA200903598 B ZA 200903598B
Authority
ZA
South Africa
Prior art keywords
pharmaceutical use
lipase variants
lipase
variants
pharmaceutical
Prior art date
Application number
ZA200903598A
Other languages
English (en)
Inventor
Allan Svendsen
Michael Skjoet
Debbie Yaver
Lars Lehmann Hylling Christensen
Signe Eskildsen Iarsen
Nina Lundin
Michael Lamsa
Peter Colin Gregory
Original Assignee
Novozymes As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes As filed Critical Novozymes As
Publication of ZA200903598B publication Critical patent/ZA200903598B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01003—Triacylglycerol lipase (3.1.1.3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Nutrition Science (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Detergent Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
ZA200903598A 2006-12-21 2009-05-25 Lipase variants for pharmaceutical use ZA200903598B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87119606P 2006-12-21 2006-12-21

Publications (1)

Publication Number Publication Date
ZA200903598B true ZA200903598B (en) 2010-04-28

Family

ID=38043020

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200903598A ZA200903598B (en) 2006-12-21 2009-05-25 Lipase variants for pharmaceutical use

Country Status (16)

Country Link
US (3) US8273348B2 (ru)
EP (6) EP2455460A3 (ru)
JP (1) JP5406040B2 (ru)
KR (1) KR20090101930A (ru)
CN (2) CN105112386A (ru)
AR (1) AR064494A1 (ru)
AU (1) AU2007337150A1 (ru)
BR (1) BRPI0721103A2 (ru)
CA (3) CA3081308C (ru)
IL (1) IL198893A0 (ru)
MX (1) MX2009006597A (ru)
NO (1) NO20092729L (ru)
RU (1) RU2009128067A (ru)
TW (1) TW200829698A (ru)
WO (1) WO2008079685A2 (ru)
ZA (1) ZA200903598B (ru)

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US10072256B2 (en) 2006-05-22 2018-09-11 Abbott Products Gmbh Process for separating and determining the viral load in a pancreatin sample
RU2009128067A (ru) 2006-12-21 2011-01-27 Новозимс А/С (Dk) Варианты липаз для их применения в фармацевтике
ES2429492T3 (es) 2008-02-29 2013-11-15 Dsm Ip Assets B.V. Lipasas con alta especificidad hacia ácidos grasos de cadena corta y usos de las mismas
MX2010009077A (es) 2008-02-29 2010-09-24 Novozymes As Variante de enzima lipolitica con estabilidad mejorada y polinucleotidos que codifican para la misma.
CN102112602A (zh) * 2008-02-29 2011-06-29 宝洁公司 包含脂肪酶的洗涤剂组合物
BR112013032861A2 (pt) 2011-07-22 2017-01-24 Novozymes North America Inc métodos para aumentar a atividade da enzima celulolítica durante a hidrólise do material celulósico, para hidrolisar um material celulósico pré-tratado, para a produção de um produto da fermentação, e para a fermentação de um material celulósico pré-tratado
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CN111187676A (zh) * 2011-12-29 2020-05-22 诺维信公司 具有脂肪酶变体的洗涤剂组合物
ES2794644T3 (es) * 2012-02-03 2020-11-18 Novozymes As Variantes de lipasa y polinucleótidos que las codifican
WO2013149858A1 (en) 2012-04-02 2013-10-10 Novozymes A/S Lipase variants and polynucleotides encoding same
ES2865080T3 (es) * 2012-10-12 2021-10-14 Danisco Us Inc Composiciones y métodos que comprenden una variante de enzima lipolítica
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CN105555951A (zh) * 2013-07-19 2016-05-04 丹尼斯科美国公司 包含脂解酶变体的组合物和方法
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WO2018139634A1 (ja) * 2017-01-30 2018-08-02 学校法人日本医科大学 アデノ随伴ウイルス（ａａｖ）キャプシドタンパク質の変異体
EP3461892A3 (en) * 2017-09-27 2019-06-12 The Procter & Gamble Company Detergent compositions comprising lipases
JP7317811B2 (ja) * 2017-09-27 2023-07-31 ノボザイムス アクティーゼルスカブ リパーゼ変異体及びかかるリパーゼ変異体を含むマイクロカプセル組成物
WO2019154954A1 (en) * 2018-02-08 2019-08-15 Novozymes A/S Lipase variants and compositions thereof
CN111334369B (zh) * 2020-03-11 2022-10-21 陕西科技大学 一种酶法制备卵磷脂型pufa的方法
US20240035005A1 (en) * 2020-10-29 2024-02-01 Novozymes A/S Lipase variants and compositions comprising such lipase variants
CN113846074B (zh) * 2021-10-20 2022-10-21 南京林业大学 一种疏棉状嗜热丝孢菌脂肪酶突变体g91c及其应用
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Also Published As

Publication number Publication date
WO2008079685A3 (en) 2008-11-06
EP2455460A3 (en) 2012-12-26
EP2455459A3 (en) 2013-04-24
EP2455462A2 (en) 2012-05-23
US8273348B2 (en) 2012-09-25
EP2455462A3 (en) 2013-05-29
EP2099907A2 (en) 2009-09-16
JP5406040B2 (ja) 2014-02-05
JP2010512795A (ja) 2010-04-30
EP2261328B1 (en) 2013-11-20
EP2455459A2 (en) 2012-05-23
US20100034797A1 (en) 2010-02-11
TW200829698A (en) 2008-07-16
RU2009128067A (ru) 2011-01-27
US20120308543A1 (en) 2012-12-06
EP2455459B1 (en) 2016-03-16
CA2670643A1 (en) 2008-07-03
MX2009006597A (es) 2009-07-02
AR064494A1 (es) 2009-04-08
NO20092729L (no) 2009-09-18
EP2455460A2 (en) 2012-05-23
CA3081308C (en) 2024-02-20
CA2670643C (en) 2017-04-25
EP2261328A1 (en) 2010-12-15
CN101743308B (zh) 2015-09-16
CN105112386A (zh) 2015-12-02
CN101743308A (zh) 2010-06-16
EP2455462B1 (en) 2016-03-16
CA2961041A1 (en) 2008-07-03
EP2455461B1 (en) 2016-03-16
IL198893A0 (en) 2010-02-17
US9029115B2 (en) 2015-05-12
US9539311B2 (en) 2017-01-10
AU2007337150A1 (en) 2008-07-03
EP2455461A3 (en) 2013-05-29
CA2961041C (en) 2020-07-14
BRPI0721103A2 (pt) 2014-03-04
CA3081308A1 (en) 2008-07-03
KR20090101930A (ko) 2009-09-29
US20150209414A1 (en) 2015-07-30
EP2455461A2 (en) 2012-05-23
WO2008079685A2 (en) 2008-07-03

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