ZA200808687B - Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 - Google Patents
Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1Info
- Publication number
- ZA200808687B ZA200808687B ZA200808687A ZA200808687A ZA200808687B ZA 200808687 B ZA200808687 B ZA 200808687B ZA 200808687 A ZA200808687 A ZA 200808687A ZA 200808687 A ZA200808687 A ZA 200808687A ZA 200808687 B ZA200808687 B ZA 200808687B
- Authority
- ZA
- South Africa
- Prior art keywords
- compounds
- inhibitors
- beta
- hydroxysteroid dehydrogenase
- formula
- Prior art date
Links
- 102100036506 11-beta-hydroxysteroid dehydrogenase 1 Human genes 0.000 title 1
- 101710186107 11-beta-hydroxysteroid dehydrogenase 1 Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 230000000694 effects Effects 0.000 abstract 2
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000001145 Metabolic Syndrome Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000001421 hyperglycemia Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/50—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74547506P | 2006-04-24 | 2006-04-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200808687B true ZA200808687B (en) | 2010-01-27 |
Family
ID=38564359
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200808687A ZA200808687B (en) | 2006-04-24 | 2008-10-10 | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
Country Status (33)
Country | Link |
---|---|
US (1) | US8153807B2 (pt) |
EP (1) | EP2021336B1 (pt) |
JP (1) | JP5269765B2 (pt) |
KR (1) | KR101059614B1 (pt) |
CN (1) | CN101432275B (pt) |
AT (1) | ATE472542T1 (pt) |
AU (1) | AU2007244955B2 (pt) |
BR (1) | BRPI0710467A2 (pt) |
CA (1) | CA2646624C (pt) |
CO (1) | CO6140034A2 (pt) |
CR (2) | CR10401A (pt) |
CY (1) | CY1110753T1 (pt) |
DE (1) | DE602007007473D1 (pt) |
DK (1) | DK2021336T3 (pt) |
EA (1) | EA015106B1 (pt) |
EC (1) | ECSP088833A (pt) |
ES (1) | ES2345792T3 (pt) |
HK (1) | HK1126208A1 (pt) |
HR (1) | HRP20100397T1 (pt) |
IL (1) | IL194810A (pt) |
MA (1) | MA30686B1 (pt) |
MX (1) | MX2008013649A (pt) |
MY (1) | MY148079A (pt) |
NO (1) | NO20084318L (pt) |
NZ (1) | NZ571176A (pt) |
PL (1) | PL2021336T3 (pt) |
PT (1) | PT2021336E (pt) |
RS (1) | RS51450B (pt) |
SI (1) | SI2021336T1 (pt) |
TN (1) | TNSN08417A1 (pt) |
UA (1) | UA94741C2 (pt) |
WO (1) | WO2007127688A2 (pt) |
ZA (1) | ZA200808687B (pt) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5265521B2 (ja) | 2006-04-21 | 2013-08-14 | イーライ リリー アンド カンパニー | 11−β−ヒドロキシステロイドデヒドロゲナーゼ1阻害剤としてのビフェニルアミドラクタム誘導体 |
CA2646678C (en) | 2006-04-21 | 2014-02-11 | Eli Lilly And Company | Cyclohexylimidazole lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
EA015675B1 (ru) * | 2006-04-21 | 2011-10-31 | Эли Лилли Энд Компани | Производные циклогексилпиразол-лактама в качестве ингибиторов 11-бета-гидроксистероиддегидрогеназы 1 |
ATE473210T1 (de) | 2006-04-24 | 2010-07-15 | Lilly Co Eli | Substituierte pyrrolidinone als hemmer von 11- beta-hydroxysteroiddehydrogenase 1 |
DK2049475T3 (da) | 2006-04-24 | 2012-03-05 | Lilly Co Eli | Cyclohexyl-substituerede pyrrolidinoner som inhibitorer af 11-beta-hydroxysteroid dehydrogenase1 |
EP2021337B1 (en) | 2006-04-25 | 2010-01-13 | Eli Lilly And Company | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
EA015499B1 (ru) | 2006-04-25 | 2011-08-30 | Эли Лилли Энд Компани | Ингибиторы 11-бета-гидроксистероид дегидрогеназы типа 1 |
BRPI0710875A2 (pt) * | 2006-04-25 | 2012-01-10 | Lilly Co Eli | composto inibidor de 11-beta-hidroxiesteróide desidrogenase 1, composição farmacêutica e intermediário para preparar o dito composto |
PT2049513E (pt) | 2006-04-28 | 2012-03-20 | Lilly Co Eli | Pirrolidinonas substituídas com piperidinilo como inibidores de 11-beta-hidroxiesteróide desidrogenase i |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
EP2243479A3 (en) | 2009-04-20 | 2011-01-19 | Abbott Laboratories | Novel amide and amidine derivates and uses thereof |
US8871208B2 (en) * | 2009-12-04 | 2014-10-28 | Abbvie Inc. | 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors and uses thereof |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
US8933024B2 (en) | 2010-06-18 | 2015-01-13 | Sanofi | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
US8828994B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
EP2683699B1 (de) | 2011-03-08 | 2015-06-24 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
US8901114B2 (en) | 2011-03-08 | 2014-12-02 | Sanofi | Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP3235813A1 (en) | 2016-04-19 | 2017-10-25 | Cidqo 2012, S.L. | Aza-tetra-cyclo derivatives |
WO2019120257A1 (zh) * | 2017-12-21 | 2019-06-27 | 广东众生睿创生物科技有限公司 | 作为ppar激动剂的吡咯烷衍生物的无定形及其制备方法 |
CN110483514B (zh) * | 2019-09-16 | 2022-06-14 | 启元生物(杭州)有限公司 | 一种氰基取代的环肼衍生物及其应用 |
CN110724142B (zh) * | 2019-10-29 | 2022-09-02 | 启元生物(杭州)有限公司 | 一种作为jak激酶抑制剂的酰胺或磺酰胺取代的肼衍生物 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004056744A1 (en) | 2002-12-23 | 2004-07-08 | Janssen Pharmaceutica N.V. | Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors |
US7687644B2 (en) * | 2004-05-07 | 2010-03-30 | Janssen Pharmaceutica Nv | Adamantyl pyrrolidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
EA011097B1 (ru) * | 2004-05-07 | 2008-12-30 | Янссен Фармацевтика Н.В. | Производные пирролидин-2-она и пиперидин-2-она, используемые в качестве ингибиторов 11-бета-гидроксистероид-дегидрогеназы |
EP1802623A1 (en) | 2004-10-12 | 2007-07-04 | Novo Nordisk A/S | 11beta-hydroxysteroid dehydrogenase type 1 active spiro compounds |
ATE419848T1 (de) * | 2004-10-29 | 2009-01-15 | Lilly Co Eli | Cycloalkyl-lactam-derivate als inhibitoren von 11-beta-hydroxysteroiddehydrogenase 1 |
WO2006053024A2 (en) | 2004-11-10 | 2006-05-18 | Incyte Corporation | Lactam compounds and their use as pharmaceuticals |
ATE399546T1 (de) * | 2004-12-20 | 2008-07-15 | Lilly Co Eli | Cycloalkyl-lactam-derivate als inhibitoren von 11-beta-hydroxysteroiddehydrogenase 1 |
US7834194B2 (en) * | 2004-12-21 | 2010-11-16 | Eli Lilly And Company | Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
JPWO2006104280A1 (ja) * | 2005-03-31 | 2008-09-11 | 武田薬品工業株式会社 | 糖尿病の予防・治療剤 |
WO2007066921A1 (en) * | 2005-12-08 | 2007-06-14 | Ho Young Lee | Structure of sticking extraneous matter and warm foot digital compression plate |
WO2007084314A2 (en) | 2006-01-12 | 2007-07-26 | Incyte Corporation | MODULATORS OF 11-ß HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
CA2646678C (en) | 2006-04-21 | 2014-02-11 | Eli Lilly And Company | Cyclohexylimidazole lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
JP5265521B2 (ja) | 2006-04-21 | 2013-08-14 | イーライ リリー アンド カンパニー | 11−β−ヒドロキシステロイドデヒドロゲナーゼ1阻害剤としてのビフェニルアミドラクタム誘導体 |
EA015675B1 (ru) * | 2006-04-21 | 2011-10-31 | Эли Лилли Энд Компани | Производные циклогексилпиразол-лактама в качестве ингибиторов 11-бета-гидроксистероиддегидрогеназы 1 |
DK2049475T3 (da) * | 2006-04-24 | 2012-03-05 | Lilly Co Eli | Cyclohexyl-substituerede pyrrolidinoner som inhibitorer af 11-beta-hydroxysteroid dehydrogenase1 |
ATE473210T1 (de) | 2006-04-24 | 2010-07-15 | Lilly Co Eli | Substituierte pyrrolidinone als hemmer von 11- beta-hydroxysteroiddehydrogenase 1 |
EA015499B1 (ru) | 2006-04-25 | 2011-08-30 | Эли Лилли Энд Компани | Ингибиторы 11-бета-гидроксистероид дегидрогеназы типа 1 |
BRPI0710875A2 (pt) * | 2006-04-25 | 2012-01-10 | Lilly Co Eli | composto inibidor de 11-beta-hidroxiesteróide desidrogenase 1, composição farmacêutica e intermediário para preparar o dito composto |
EP2021337B1 (en) * | 2006-04-25 | 2010-01-13 | Eli Lilly And Company | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
PT2049513E (pt) | 2006-04-28 | 2012-03-20 | Lilly Co Eli | Pirrolidinonas substituídas com piperidinilo como inibidores de 11-beta-hidroxiesteróide desidrogenase i |
US20090008890A1 (en) * | 2007-06-13 | 2009-01-08 | Woodford James R | Suspension system for an all-terrain vehicle |
CL2008001839A1 (es) | 2007-06-21 | 2009-01-16 | Incyte Holdings Corp | Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades. |
US8871208B2 (en) * | 2009-12-04 | 2014-10-28 | Abbvie Inc. | 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors and uses thereof |
-
2007
- 2007-04-23 EA EA200870470A patent/EA015106B1/ru not_active IP Right Cessation
- 2007-04-23 CA CA2646624A patent/CA2646624C/en not_active Expired - Fee Related
- 2007-04-23 AT AT07761091T patent/ATE472542T1/de active
- 2007-04-23 CN CN2007800149090A patent/CN101432275B/zh not_active Expired - Fee Related
- 2007-04-23 RS RSP-2010/0399A patent/RS51450B/en unknown
- 2007-04-23 BR BRPI0710467-7A patent/BRPI0710467A2/pt not_active IP Right Cessation
- 2007-04-23 KR KR1020087025921A patent/KR101059614B1/ko not_active IP Right Cessation
- 2007-04-23 AU AU2007244955A patent/AU2007244955B2/en not_active Ceased
- 2007-04-23 SI SI200730353T patent/SI2021336T1/sl unknown
- 2007-04-23 US US12/297,873 patent/US8153807B2/en not_active Expired - Fee Related
- 2007-04-23 PL PL07761091T patent/PL2021336T3/pl unknown
- 2007-04-23 EP EP07761091A patent/EP2021336B1/en active Active
- 2007-04-23 UA UAA200812287A patent/UA94741C2/ru unknown
- 2007-04-23 NZ NZ571176A patent/NZ571176A/en not_active IP Right Cessation
- 2007-04-23 PT PT07761091T patent/PT2021336E/pt unknown
- 2007-04-23 JP JP2009507912A patent/JP5269765B2/ja not_active Expired - Fee Related
- 2007-04-23 DK DK07761091.3T patent/DK2021336T3/da active
- 2007-04-23 DE DE602007007473T patent/DE602007007473D1/de active Active
- 2007-04-23 MX MX2008013649A patent/MX2008013649A/es active IP Right Grant
- 2007-04-23 ES ES07761091T patent/ES2345792T3/es active Active
- 2007-04-23 MY MYPI20084249A patent/MY148079A/en unknown
- 2007-04-23 WO PCT/US2007/067182 patent/WO2007127688A2/en active Application Filing
-
2008
- 2008-10-10 ZA ZA200808687A patent/ZA200808687B/xx unknown
- 2008-10-15 NO NO20084318A patent/NO20084318L/no not_active Application Discontinuation
- 2008-10-17 CO CO08110817A patent/CO6140034A2/es unknown
- 2008-10-17 EC EC2008008833A patent/ECSP088833A/es unknown
- 2008-10-20 TN TNP2008000417A patent/TNSN08417A1/en unknown
- 2008-10-22 IL IL194810A patent/IL194810A/en active IP Right Grant
- 2008-10-24 CR CR10401A patent/CR10401A/es not_active Application Discontinuation
- 2008-10-24 CR CR10402A patent/CR10402A/es unknown
- 2008-11-20 MA MA31398A patent/MA30686B1/fr unknown
-
2009
- 2009-05-25 HK HK09104719.3A patent/HK1126208A1/xx not_active IP Right Cessation
-
2010
- 2010-07-20 HR HR20100397T patent/HRP20100397T1/hr unknown
- 2010-08-30 CY CY20101100792T patent/CY1110753T1/el unknown
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