ZA200803668B - Piperidin-4-yl-pyridazin-3-ylamine derivatives as fast dissociating dopamine 2 receptor antagonists - Google Patents

Piperidin-4-yl-pyridazin-3-ylamine derivatives as fast dissociating dopamine 2 receptor antagonists

Info

Publication number
ZA200803668B
ZA200803668B ZA200803668A ZA200803668A ZA200803668B ZA 200803668 B ZA200803668 B ZA 200803668B ZA 200803668 A ZA200803668 A ZA 200803668A ZA 200803668 A ZA200803668 A ZA 200803668A ZA 200803668 B ZA200803668 B ZA 200803668B
Authority
ZA
South Africa
Prior art keywords
pyridazin
piperidin
receptor antagonists
ylamine derivatives
fast dissociating
Prior art date
Application number
ZA200803668A
Other languages
English (en)
Inventor
De Bruyn Marcel Frans Leopold
Kennis Ludo Edmond Josephine
Van Den Keybus Frans Alf Maria
Macdonald Gregor James
Langlois Xavier Jean Michel
Van Roosbroeck Yves Emie Maria
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ZA200803668B publication Critical patent/ZA200803668B/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA200803668A 2005-10-26 2008-04-25 Piperidin-4-yl-pyridazin-3-ylamine derivatives as fast dissociating dopamine 2 receptor antagonists ZA200803668B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05110028 2005-10-26

Publications (1)

Publication Number Publication Date
ZA200803668B true ZA200803668B (en) 2009-09-30

Family

ID=35734993

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200803668A ZA200803668B (en) 2005-10-26 2008-04-25 Piperidin-4-yl-pyridazin-3-ylamine derivatives as fast dissociating dopamine 2 receptor antagonists

Country Status (35)

Country Link
US (3) US8940743B2 (zh)
EP (1) EP1943242B1 (zh)
JP (1) JP5140598B2 (zh)
KR (1) KR101351910B1 (zh)
CN (1) CN101291925B (zh)
AP (1) AP2607A (zh)
AR (1) AR058151A1 (zh)
AT (1) ATE495167T1 (zh)
AU (1) AU2006307930B2 (zh)
BR (1) BRPI0617787A2 (zh)
CA (1) CA2623160C (zh)
CR (1) CR10020A (zh)
CY (1) CY1111977T1 (zh)
DE (1) DE602006019624D1 (zh)
DK (1) DK1943242T3 (zh)
EA (1) EA015681B1 (zh)
EC (1) ECSP088396A (zh)
ES (1) ES2359020T3 (zh)
GT (1) GT200800033A (zh)
HK (1) HK1124317A1 (zh)
HN (1) HN2008000646A (zh)
HR (1) HRP20110226T1 (zh)
IL (1) IL191016A (zh)
JO (1) JO2769B1 (zh)
MY (1) MY145609A (zh)
NO (1) NO20082350L (zh)
NZ (1) NZ566785A (zh)
PL (1) PL1943242T3 (zh)
PT (1) PT1943242E (zh)
RS (1) RS51674B (zh)
SI (1) SI1943242T1 (zh)
TW (1) TWI399373B (zh)
UA (1) UA94058C2 (zh)
WO (1) WO2007048779A1 (zh)
ZA (1) ZA200803668B (zh)

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JO2769B1 (en) 2005-10-26 2014-03-15 جانسين فارماسوتيكا ان. في Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor
JO2642B1 (en) * 2006-12-08 2012-06-17 جانسين فارماسوتيكا ان. في Dopamine 2 receptor antagonists are rapidly hydrolyzed
JO2849B1 (en) 2007-02-13 2015-03-15 جانسين فارماسوتيكا ان. في Dopamine 2 receptor antagonists are rapidly hydrolyzed
JP5431305B2 (ja) * 2007-04-23 2014-03-05 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 高速解離性ドパミン２受容体アンタゴニストとしての４−アルコキシピリダジン誘導体
WO2008128996A1 (en) 2007-04-23 2008-10-30 Janssen Pharmaceutica N.V. Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists
RU2480462C2 (ru) * 2007-04-23 2013-04-27 Янссен Фармацевтика Н.В. Производные пиридина, используемые в качестве быстро диссоциирующихся антагонистов допаминовых рецепторов 2
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Also Published As

Publication number Publication date
US8940743B2 (en) 2015-01-27
HN2008000646A (es) 2011-02-16
KR101351910B1 (ko) 2014-01-16
EP1943242B1 (en) 2011-01-12
NO20082350L (no) 2008-07-01
US20150141432A1 (en) 2015-05-21
CA2623160C (en) 2013-10-15
IL191016A (en) 2013-10-31
CN101291925B (zh) 2013-04-10
PT1943242E (pt) 2011-04-06
UA94058C2 (ru) 2011-04-11
CA2623160A1 (en) 2007-05-03
BRPI0617787A2 (pt) 2009-12-01
HRP20110226T1 (hr) 2011-05-31
RS51674B (en) 2011-10-31
ATE495167T1 (de) 2011-01-15
TWI399373B (zh) 2013-06-21
JP5140598B2 (ja) 2013-02-06
EA200801184A1 (ru) 2008-08-29
TW200732321A (en) 2007-09-01
ECSP088396A (es) 2008-05-30
HK1124317A1 (en) 2009-07-10
PL1943242T3 (pl) 2011-06-30
US20080227791A1 (en) 2008-09-18
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DE602006019624D1 (de) 2011-02-24
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