ZA200710001B - Isoquinoline derivatives as inhibitors or Rho-kinase - Google Patents

Isoquinoline derivatives as inhibitors or Rho-kinase

Info

Publication number
ZA200710001B
ZA200710001B ZA200710001A ZA200710001A ZA200710001B ZA 200710001 B ZA200710001 B ZA 200710001B ZA 200710001 A ZA200710001 A ZA 200710001A ZA 200710001 A ZA200710001 A ZA 200710001A ZA 200710001 B ZA200710001 B ZA 200710001B
Authority
ZA
South Africa
Prior art keywords
rho
kinase
inhibitors
isoquinoline derivatives
isoquinoline
Prior art date
Application number
ZA200710001A
Other languages
English (en)
Inventor
Plettenburg Oliver
Hofmeister Armin
Kadereit Dieter
Peukert Stefan
Ruf Sven
Ritter Kurt
Loehn Matthias
Vashchenko Yuri
Monecke Peter
Dreyer Matthias
Kannt Aimo
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of ZA200710001B publication Critical patent/ZA200710001B/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Reproductive Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Molecular Biology (AREA)
ZA200710001A 2005-06-28 2007-11-20 Isoquinoline derivatives as inhibitors or Rho-kinase ZA200710001B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05013868 2005-06-28

Publications (1)

Publication Number Publication Date
ZA200710001B true ZA200710001B (en) 2008-11-26

Family

ID=35395794

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200710001A ZA200710001B (en) 2005-06-28 2007-11-20 Isoquinoline derivatives as inhibitors or Rho-kinase

Country Status (34)

Country Link
US (2) US8501736B2 (ja)
EP (1) EP1899322B1 (ja)
JP (1) JP5097701B2 (ja)
KR (1) KR101327780B1 (ja)
CN (1) CN101213187B (ja)
AR (1) AR054518A1 (ja)
AT (1) ATE441641T1 (ja)
AU (1) AU2006264043B2 (ja)
BR (1) BRPI0613597A2 (ja)
CA (1) CA2611295C (ja)
CY (1) CY1110108T1 (ja)
DE (1) DE602006008945D1 (ja)
DK (1) DK1899322T3 (ja)
DO (1) DOP2006000149A (ja)
ES (1) ES2331853T3 (ja)
GT (1) GT200600273A (ja)
HK (1) HK1122276A1 (ja)
HR (1) HRP20090589T1 (ja)
IL (1) IL188380A (ja)
MA (1) MA29535B1 (ja)
MX (1) MX2008000017A (ja)
MY (1) MY146037A (ja)
NZ (1) NZ565040A (ja)
PA (1) PA8683501A1 (ja)
PE (1) PE20070141A1 (ja)
PL (1) PL1899322T3 (ja)
PT (1) PT1899322E (ja)
RS (1) RS51139B (ja)
RU (1) RU2443688C2 (ja)
SI (1) SI1899322T1 (ja)
TW (1) TWI372756B (ja)
UY (1) UY29641A1 (ja)
WO (1) WO2007000240A1 (ja)
ZA (1) ZA200710001B (ja)

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KR102090792B1 (ko) 2012-05-15 2020-03-18 캔써 리서치 테크놀로지 리미티드 5-[[4-[[모르폴린-2-일]메틸아미노]-5-(트리플루오로메틸)-2-피리딜]아미노]피라진-2-카보니트릴 및 그의 치료적 용도
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CN105636953B (zh) 2013-07-31 2018-01-02 诺华股份有限公司 1,4‑二取代的哒嗪衍生物及其用于治疗与smn缺乏相关的病症的用途
FR3017868A1 (fr) * 2014-02-21 2015-08-28 Servier Lab Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GB201403536D0 (en) 2014-02-28 2014-04-16 Cancer Rec Tech Ltd Inhibitor compounds
TWI770552B (zh) 2014-12-24 2022-07-11 美商基利科學股份有限公司 喹唑啉化合物
MX2017008518A (es) 2014-12-24 2017-10-25 Gilead Sciences Inc Compuestos de isoquinolina para el tratamiento de virus de inmunodeficiencia humana (vih).
JP6385584B2 (ja) 2014-12-24 2018-09-05 ギリアード サイエンシーズ， インコーポレイテッド Ｈｉｖの処置のための縮合ピリミジン化合物
PE20200008A1 (es) 2017-03-30 2020-01-06 Hoffmann La Roche Isoquinolinas como inhibidores de hpk1
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