HK1122276A1 - Isoquinoline derivatives as inhibitors of rho-kinase - Google Patents
Isoquinoline derivatives as inhibitors of rho-kinaseInfo
- Publication number
- HK1122276A1 HK1122276A1 HK08113534.8A HK08113534A HK1122276A1 HK 1122276 A1 HK1122276 A1 HK 1122276A1 HK 08113534 A HK08113534 A HK 08113534A HK 1122276 A1 HK1122276 A1 HK 1122276A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- rho
- kinase
- inhibitors
- isoquinoline derivatives
- isoquinoline
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Gynecology & Obstetrics (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- AIDS & HIV (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05013868 | 2005-06-28 | ||
PCT/EP2006/005648 WO2007000240A1 (en) | 2005-06-28 | 2006-06-13 | Isoquinoline derivatives as inhibitors of rho-kinase |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1122276A1 true HK1122276A1 (en) | 2009-05-15 |
Family
ID=35395794
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK08113534.8A HK1122276A1 (en) | 2005-06-28 | 2008-12-12 | Isoquinoline derivatives as inhibitors of rho-kinase |
Country Status (34)
Country | Link |
---|---|
US (2) | US8501736B2 (xx) |
EP (1) | EP1899322B1 (xx) |
JP (1) | JP5097701B2 (xx) |
KR (1) | KR101327780B1 (xx) |
CN (1) | CN101213187B (xx) |
AR (1) | AR054518A1 (xx) |
AT (1) | ATE441641T1 (xx) |
AU (1) | AU2006264043B2 (xx) |
BR (1) | BRPI0613597A2 (xx) |
CA (1) | CA2611295C (xx) |
CY (1) | CY1110108T1 (xx) |
DE (1) | DE602006008945D1 (xx) |
DK (1) | DK1899322T3 (xx) |
DO (1) | DOP2006000149A (xx) |
ES (1) | ES2331853T3 (xx) |
GT (1) | GT200600273A (xx) |
HK (1) | HK1122276A1 (xx) |
HR (1) | HRP20090589T1 (xx) |
IL (1) | IL188380A (xx) |
MA (1) | MA29535B1 (xx) |
MX (1) | MX2008000017A (xx) |
MY (1) | MY146037A (xx) |
NZ (1) | NZ565040A (xx) |
PA (1) | PA8683501A1 (xx) |
PE (1) | PE20070141A1 (xx) |
PL (1) | PL1899322T3 (xx) |
PT (1) | PT1899322E (xx) |
RS (1) | RS51139B (xx) |
RU (1) | RU2443688C2 (xx) |
SI (1) | SI1899322T1 (xx) |
TW (1) | TWI372756B (xx) |
UY (1) | UY29641A1 (xx) |
WO (1) | WO2007000240A1 (xx) |
ZA (1) | ZA200710001B (xx) |
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MX2009005825A (es) * | 2006-12-27 | 2009-06-16 | Sanofi Aventis | Derivados de isoquinolina e isoquinolinona sustituidos en calidad de inhibidores de rho-quinasa. |
BRPI0721180A2 (pt) * | 2006-12-27 | 2014-03-18 | Sanofi Aventis | Derivados de isoquinolina substituídos com cicloalquilamina |
CA2673919C (en) * | 2006-12-27 | 2015-06-23 | Sanofi-Aventis | Cycloalkylamine substituted isoquinolone and isoquinolinone derivatives |
MY148902A (en) * | 2006-12-27 | 2013-06-14 | Sanofi Aventis | Substituted isoquinolines and their use as rho-kinase inhibitors |
GB0719644D0 (en) | 2007-10-05 | 2007-11-14 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
GB0803018D0 (en) | 2008-02-19 | 2008-03-26 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
WO2009156100A1 (en) * | 2008-06-24 | 2009-12-30 | Sanofi-Aventis | Substituted isoquinolines and isoquinolinones as rho kinase inhibitors |
WO2009156092A2 (en) * | 2008-06-24 | 2009-12-30 | Sanofi-Aventis | Bi- and polycyclic substituted isoquinoline and isoquinolinone derivatives |
WO2009156099A1 (en) * | 2008-06-24 | 2009-12-30 | Sanofi-Aventis | 6-substituted isoquinolines and isoquinolinones |
GB0812969D0 (en) * | 2008-07-15 | 2008-08-20 | Sentinel Oncology Ltd | Pharmaceutical compounds |
RU2504544C2 (ru) * | 2008-10-02 | 2014-01-20 | Асахи Касеи Фарма Корпорейшн | 8-замещенные производные изохинолина и их применение |
EP2177218A1 (en) | 2008-10-15 | 2010-04-21 | Medizinische Universität Wien | Regenerative therapy |
JP5391372B2 (ja) * | 2009-07-08 | 2014-01-15 | 公益財団法人名古屋産業科学研究所 | 芳香族アミン化合物の製造方法 |
CN102844305B (zh) * | 2010-03-31 | 2014-07-02 | 埃科特莱茵药品有限公司 | 抗菌异喹啉-3-基脲衍生物 |
BR112013013790A2 (pt) | 2010-12-17 | 2016-09-13 | Hoffmann La Roche | compostos heterocíclos nitrogenosos 6,6-fundidos substituídos e usos dos mesmos |
GB201104267D0 (en) | 2011-03-14 | 2011-04-27 | Cancer Rec Tech Ltd | Pyrrolopyridineamino derivatives |
RU2641693C2 (ru) | 2011-11-09 | 2018-01-22 | Кансер Ресёрч Текнолоджи Лимитед | Соединения 5-(пиридин-2-иламино)-пиразин-2-карбонитрила и их терапевтическое применение |
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GB201216017D0 (en) | 2012-09-07 | 2012-10-24 | Cancer Rec Tech Ltd | Inhibitor compounds |
GB201216018D0 (en) | 2012-09-07 | 2012-10-24 | Cancer Rec Tech Ltd | Pharmacologically active compounds |
EP3027600B1 (en) | 2013-07-31 | 2022-04-06 | Novartis AG | 1,4-disubstituted pyridazine derivatives and their use for treating smn-deficiency-related conditions |
FR3017868A1 (fr) | 2014-02-21 | 2015-08-28 | Servier Lab | Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
GB201403536D0 (en) | 2014-02-28 | 2014-04-16 | Cancer Rec Tech Ltd | Inhibitor compounds |
TWI770552B (zh) | 2014-12-24 | 2022-07-11 | 美商基利科學股份有限公司 | 喹唑啉化合物 |
US9701677B2 (en) | 2014-12-24 | 2017-07-11 | Gilead Sciences, Inc. | Fused pyrimidine compounds |
US9624195B2 (en) | 2014-12-24 | 2017-04-18 | Gilead Sciences, Inc. | Isoquinoline compounds |
CN117024411A (zh) | 2017-03-30 | 2023-11-10 | 豪夫迈·罗氏有限公司 | 作为hpk1抑制剂的异喹啉 |
GB201709840D0 (en) | 2017-06-20 | 2017-08-02 | Inst Of Cancer Research: Royal Cancer Hospital | Methods and medical uses |
US10696638B2 (en) | 2017-12-26 | 2020-06-30 | Industrial Technology Research Institute | Compounds for inhibiting AGC kinase and pharmaceutical compositions comprising the same |
CN110117278B (zh) * | 2018-02-07 | 2022-07-19 | 石家庄以岭药业股份有限公司 | 烷氧基苯并五元(六元)杂环胺类化合物及其药物用途 |
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CN110407777B (zh) * | 2019-08-15 | 2022-09-09 | 湖北远大富驰医药化工股份有限公司 | 一种呋虫胺的合成方法 |
CN111574413B (zh) * | 2020-06-08 | 2022-04-05 | 杭州尚合生物医药科技有限公司 | 一种2-氨甲基吡啶与dmf-dma作为胺源的磺酰脒的制备方法 |
CN113372341A (zh) * | 2021-07-02 | 2021-09-10 | 黄淮学院 | 三氟醋酸二氢异喹啉衍生物的合成方法及装置 |
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