ZA200704476B - Pyrazolo[1,5-a]pyrimidines useful as inhibitors of protein kinases - Google Patents

Pyrazolo[1,5-a]pyrimidines useful as inhibitors of protein kinases

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Publication number
ZA200704476B
ZA200704476B ZA200704476A ZA200704476A ZA200704476B ZA 200704476 B ZA200704476 B ZA 200704476B ZA 200704476 A ZA200704476 A ZA 200704476A ZA 200704476 A ZA200704476 A ZA 200704476A ZA 200704476 B ZA200704476 B ZA 200704476B
Authority
ZA
South Africa
Prior art keywords
inhibitors
protein kinases
pyrazolo
pyrimidines useful
compounds
Prior art date
Application number
ZA200704476A
Other languages
English (en)
Inventor
Jimenez Juan-Miguel
Knegtel Ronald
Charrier Jean-Damien
Stamos Dean
Li Pan
Jon R Come
Aronov Alex
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of ZA200704476B publication Critical patent/ZA200704476B/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61P37/02—Immunomodulators
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
ZA200704476A 2004-11-04 2005-11-04 Pyrazolo[1,5-a]pyrimidines useful as inhibitors of protein kinases ZA200704476B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US62544604P 2004-11-04 2004-11-04

Publications (1)

Publication Number Publication Date
ZA200704476B true ZA200704476B (en) 2008-09-25

Family

ID=35809833

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200704476A ZA200704476B (en) 2004-11-04 2005-11-04 Pyrazolo[1,5-a]pyrimidines useful as inhibitors of protein kinases

Country Status (20)

Country Link
US (1) US7528138B2 (OSRAM)
EP (1) EP1812440B1 (OSRAM)
JP (2) JP5030229B2 (OSRAM)
KR (1) KR20070090172A (OSRAM)
CN (1) CN101094853B (OSRAM)
AT (1) ATE482213T1 (OSRAM)
AU (1) AU2005304784B2 (OSRAM)
CA (1) CA2586375A1 (OSRAM)
DE (1) DE602005023763D1 (OSRAM)
DK (1) DK1812440T3 (OSRAM)
ES (1) ES2354824T3 (OSRAM)
IL (1) IL182893A0 (OSRAM)
MX (1) MX337817B (OSRAM)
NO (1) NO20072795L (OSRAM)
NZ (1) NZ555236A (OSRAM)
PT (1) PT1812440E (OSRAM)
RU (1) RU2417996C2 (OSRAM)
SI (1) SI1812440T1 (OSRAM)
WO (1) WO2006052913A1 (OSRAM)
ZA (1) ZA200704476B (OSRAM)

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