ZA200603399B - Treatment of proliferative diseases using an antisense iap oligomer and chemotherapeutic agent - Google Patents

Treatment of proliferative diseases using an antisense iap oligomer and chemotherapeutic agent Download PDF

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Publication number
ZA200603399B
ZA200603399B ZA200603399A ZA200603399A ZA200603399B ZA 200603399 B ZA200603399 B ZA 200603399B ZA 200603399 A ZA200603399 A ZA 200603399A ZA 200603399 A ZA200603399 A ZA 200603399A ZA 200603399 B ZA200603399 B ZA 200603399B
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South Africa
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seq
nucleobase
cells
cancer
cell
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ZA200603399A
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English (en)
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Lacasse Eric
Mcmanus Daniel
Jon P Durkin
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Aegera Therapeutics Inc
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Publication of ZA200603399B publication Critical patent/ZA200603399B/en

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/09—Recombinant DNA-technology
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/31—Combination therapy

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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ZA200603399A 2003-10-30 2004-10-29 Treatment of proliferative diseases using an antisense iap oligomer and chemotherapeutic agent ZA200603399B (en)

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US51626303P 2003-10-30 2003-10-30

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US (1) US8012944B2 (es)
EP (1) EP1691842A4 (es)
JP (1) JP2007509861A (es)
KR (1) KR20060127393A (es)
CN (2) CN101862459A (es)
AU (1) AU2004284855A1 (es)
BR (1) BRPI0415779A (es)
CA (1) CA2542884A1 (es)
IL (1) IL175242A0 (es)
MX (1) MXPA06004920A (es)
NO (1) NO20062420L (es)
NZ (1) NZ547191A (es)
RU (2) RU2376018C2 (es)
SG (1) SG157422A1 (es)
TW (1) TWI332841B (es)
WO (1) WO2005042030A1 (es)
ZA (1) ZA200603399B (es)

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SG157422A1 (en) 2009-12-29
IL175242A0 (en) 2006-09-05
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WO2005042030A1 (en) 2005-05-12
CA2542884A1 (en) 2005-05-12
EP1691842A4 (en) 2008-06-11
NO20062420L (no) 2006-07-31
RU2376018C2 (ru) 2009-12-20
CN101862459A (zh) 2010-10-20
EP1691842A1 (en) 2006-08-23
NZ547191A (en) 2009-08-28
RU2010101234A (ru) 2011-07-20
TW200528117A (en) 2005-09-01
MXPA06004920A (es) 2007-02-16
RU2006117024A (ru) 2007-12-10
KR20060127393A (ko) 2006-12-12
US20050119217A1 (en) 2005-06-02
CN1901939A (zh) 2007-01-24
JP2007509861A (ja) 2007-04-19
US8012944B2 (en) 2011-09-06
TWI332841B (en) 2010-11-11
AU2004284855A1 (en) 2005-05-12

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