ZA200602439B - Novel tricyclic nucleosides or nucleotides as therapeutic agents - Google Patents
Novel tricyclic nucleosides or nucleotides as therapeutic agents Download PDFInfo
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- ZA200602439B ZA200602439B ZA200602439A ZA200602439A ZA200602439B ZA 200602439 B ZA200602439 B ZA 200602439B ZA 200602439 A ZA200602439 A ZA 200602439A ZA 200602439 A ZA200602439 A ZA 200602439A ZA 200602439 B ZA200602439 B ZA 200602439B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- independently
- halogen
- compound
- bond
- Prior art date
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Classifications
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
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- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
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- Engineering & Computer Science (AREA)
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- Virology (AREA)
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- Public Health (AREA)
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- Oncology (AREA)
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- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
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US49842503P | 2003-08-27 | 2003-08-27 |
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ZA200602439A ZA200602439B (en) | 2003-08-27 | 2006-03-24 | Novel tricyclic nucleosides or nucleotides as therapeutic agents |
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US (3) | US7713941B2 (de) |
EP (1) | EP1660511B1 (de) |
JP (1) | JP2007504152A (de) |
KR (1) | KR20060123707A (de) |
CN (1) | CN1863813B (de) |
AT (1) | ATE486883T1 (de) |
AU (1) | AU2004269026B2 (de) |
BR (1) | BRPI0414019A (de) |
CA (1) | CA2537114C (de) |
DE (1) | DE602004029904D1 (de) |
ES (1) | ES2355565T3 (de) |
IL (1) | IL173888A0 (de) |
MX (1) | MXPA06002198A (de) |
NO (1) | NO20060979L (de) |
NZ (1) | NZ546055A (de) |
RU (1) | RU2006109491A (de) |
WO (1) | WO2005021568A2 (de) |
ZA (1) | ZA200602439B (de) |
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MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
BR0316363A (pt) | 2002-11-15 | 2005-10-04 | Idenix Cayman Ltd | Nucleosìdeos 2'-ramificado e mutação de flaviviridae |
PL3521297T3 (pl) | 2003-05-30 | 2022-04-04 | Gilead Pharmasset Llc | Zmodyfikowane fluorowane analogi nukleozydów |
KR20060123707A (ko) * | 2003-08-27 | 2006-12-04 | 바이오타, 인코포레이티드 | 치료제로서의 신규 트리시클릭 뉴클레오시드 또는뉴클레오티드 |
AU2005254057B2 (en) | 2004-06-15 | 2011-02-17 | Isis Pharmaceuticals, Inc. | C-purine nucleoside analogs as inhibitors of RNA-dependent RNA viral polymerase |
ES2725457T3 (es) | 2004-09-14 | 2019-09-24 | Gilead Pharmasset Llc | Preparación de ribofuranosil pirimidinas y purinas 2'fluoro-2'-alquil-sustituidas u otras opcionalmente sustituidas y sus derivados |
WO2006121468A1 (en) | 2004-11-22 | 2006-11-16 | Genelabs Technologies, Inc. | 5-nitro-nucleoside compounds for treating viral infections |
BRPI0607769A2 (pt) * | 2005-02-28 | 2009-10-06 | Genelabs Tech Inc | pró-fármacos nucleosìdeo-tricìclicos para tratamento de infecções virais |
RU2422454C2 (ru) | 2005-12-09 | 2011-06-27 | Ф. Хоффманн-Ля Рош Аг | Антивирусные нуклеозиды |
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CN1863813B (zh) | 2011-03-30 |
CA2537114A1 (en) | 2005-03-10 |
WO2005021568B1 (en) | 2005-06-09 |
MXPA06002198A (es) | 2007-08-14 |
BRPI0414019A (pt) | 2006-10-24 |
US7713941B2 (en) | 2010-05-11 |
JP2007504152A (ja) | 2007-03-01 |
EP1660511A2 (de) | 2006-05-31 |
AU2004269026B2 (en) | 2010-02-25 |
WO2005021568A3 (en) | 2005-04-21 |
KR20060123707A (ko) | 2006-12-04 |
EP1660511B1 (de) | 2010-11-03 |
AU2004269026A1 (en) | 2005-03-10 |
ES2355565T3 (es) | 2011-03-29 |
NZ546055A (en) | 2010-05-28 |
RU2006109491A (ru) | 2006-08-10 |
IL173888A0 (en) | 2006-07-05 |
NO20060979L (no) | 2006-05-02 |
US20080200423A1 (en) | 2008-08-21 |
US20100311684A1 (en) | 2010-12-09 |
CA2537114C (en) | 2012-10-02 |
DE602004029904D1 (de) | 2010-12-16 |
CN1863813A (zh) | 2006-11-15 |
US7268119B2 (en) | 2007-09-11 |
WO2005021568A2 (en) | 2005-03-10 |
US20070135363A1 (en) | 2007-06-14 |
ATE486883T1 (de) | 2010-11-15 |
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