NO20060979L - Nye tricykliske nukleosider eller nukleotider som terapeutiske midler - Google Patents

Nye tricykliske nukleosider eller nukleotider som terapeutiske midler

Info

Publication number
NO20060979L
NO20060979L NO20060979A NO20060979A NO20060979L NO 20060979 L NO20060979 L NO 20060979L NO 20060979 A NO20060979 A NO 20060979A NO 20060979 A NO20060979 A NO 20060979A NO 20060979 L NO20060979 L NO 20060979L
Authority
NO
Norway
Prior art keywords
nucleotides
therapeutic agents
novel tricyclic
tricyclic nucleosides
nucleosides
Prior art date
Application number
NO20060979A
Other languages
English (en)
Norwegian (no)
Inventor
Phillip Dan Cook
Gergory Ewing
Yi Jin
John Lambert
Vasanthakumar Rajappan
Vivek K Rajwanshi
Kandasamy Sakthivel
Original Assignee
Biota Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biota Inc filed Critical Biota Inc
Publication of NO20060979L publication Critical patent/NO20060979L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO20060979A 2003-08-27 2006-02-28 Nye tricykliske nukleosider eller nukleotider som terapeutiske midler NO20060979L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49842503P 2003-08-27 2003-08-27
PCT/US2004/027819 WO2005021568A2 (en) 2003-08-27 2004-08-27 Novel tricyclic nucleosides or nucleotides as therapeutic agents

Publications (1)

Publication Number Publication Date
NO20060979L true NO20060979L (no) 2006-05-02

Family

ID=34272671

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20060979A NO20060979L (no) 2003-08-27 2006-02-28 Nye tricykliske nukleosider eller nukleotider som terapeutiske midler

Country Status (18)

Country Link
US (3) US7713941B2 (de)
EP (1) EP1660511B1 (de)
JP (1) JP2007504152A (de)
KR (1) KR20060123707A (de)
CN (1) CN1863813B (de)
AT (1) ATE486883T1 (de)
AU (1) AU2004269026B2 (de)
BR (1) BRPI0414019A (de)
CA (1) CA2537114C (de)
DE (1) DE602004029904D1 (de)
ES (1) ES2355565T3 (de)
IL (1) IL173888A0 (de)
MX (1) MXPA06002198A (de)
NO (1) NO20060979L (de)
NZ (1) NZ546055A (de)
RU (1) RU2006109491A (de)
WO (1) WO2005021568A2 (de)
ZA (1) ZA200602439B (de)

Families Citing this family (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
BR0316363A (pt) 2002-11-15 2005-10-04 Idenix Cayman Ltd Nucleosìdeos 2'-ramificado e mutação de flaviviridae
PL3521297T3 (pl) 2003-05-30 2022-04-04 Gilead Pharmasset Llc Zmodyfikowane fluorowane analogi nukleozydów
KR20060123707A (ko) * 2003-08-27 2006-12-04 바이오타, 인코포레이티드 치료제로서의 신규 트리시클릭 뉴클레오시드 또는뉴클레오티드
AU2005254057B2 (en) 2004-06-15 2011-02-17 Isis Pharmaceuticals, Inc. C-purine nucleoside analogs as inhibitors of RNA-dependent RNA viral polymerase
ES2725457T3 (es) 2004-09-14 2019-09-24 Gilead Pharmasset Llc Preparación de ribofuranosil pirimidinas y purinas 2'fluoro-2'-alquil-sustituidas u otras opcionalmente sustituidas y sus derivados
WO2006121468A1 (en) 2004-11-22 2006-11-16 Genelabs Technologies, Inc. 5-nitro-nucleoside compounds for treating viral infections
BRPI0607769A2 (pt) * 2005-02-28 2009-10-06 Genelabs Tech Inc pró-fármacos nucleosìdeo-tricìclicos para tratamento de infecções virais
RU2422454C2 (ru) 2005-12-09 2011-06-27 Ф. Хоффманн-Ля Рош Аг Антивирусные нуклеозиды
US7659274B2 (en) * 2006-01-25 2010-02-09 Osi Pharmaceuticals, Inc. Unsaturated mTOR inhibitors
US7666851B1 (en) * 2006-05-18 2010-02-23 Steven Albert Benner Three ring fused analogs of isoguanosine
WO2008005542A2 (en) * 2006-07-07 2008-01-10 Gilead Sciences, Inc., Antiviral phosphinate compounds
SI2065388T1 (sl) 2006-09-19 2012-03-30 Daiichi Sankyo Co Ltd Derivati pirazolo pirimidina
PL2084174T3 (pl) * 2006-10-10 2013-12-31 Gilead Pharmasset Llc Sposób otrzymywania nukleozydów rybofuranozylopirymidynowych
US20080261913A1 (en) 2006-12-28 2008-10-23 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of liver disorders
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
JP2011513195A (ja) * 2007-05-10 2011-04-28 バイオクライスト ファーマシューティカルズ， インコーポレイテッド ウイルス感染およびがんの処置に使用するためのテトラヒドロフロ［３，４−ｄ］ジオキソラン化合物
US20090048189A1 (en) * 2007-08-15 2009-02-19 Genelabs Technologies, Inc. Tricyclic-nucleoside compounds for treating viral infections
WO2009029729A1 (en) * 2007-08-31 2009-03-05 Genelabs Technologies, Inc. Amino tricyclic-nucleoside compounds, compositions, and methods of use
GB0718575D0 (en) * 2007-09-24 2007-10-31 Angeletti P Ist Richerche Bio Nucleoside derivatives as inhibitors of viral polymerases
US20090318380A1 (en) 2007-11-20 2009-12-24 Pharmasset, Inc. 2',4'-substituted nucleosides as antiviral agents
AU2008338273B2 (en) 2007-12-19 2014-10-02 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
PL2231689T3 (pl) * 2008-01-18 2017-01-31 Inst Of Organic Chemistry And Biochemistry Of The Acad Of Sciences Of The Czech Republic Nowe 7-deazapurynowe nukleozydy o właściwościach cytostatycznych
TW200942243A (en) 2008-03-05 2009-10-16 Biocryst Pharm Inc Antiviral therapeutic agents
EP2264044B1 (de) * 2008-03-12 2014-08-20 Japan Advanced Institute of Science and Technology Verfahren für den nachweis von methylcytosin anhand einer lichtempfindlichen sonde
US8227431B2 (en) 2008-03-17 2012-07-24 Hetero Drugs Limited Nucleoside derivatives
DK2280973T3 (da) 2008-04-23 2013-03-04 Gilead Sciences Inc Carbanukleosidanaloge til antiviral behandling
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
WO2010015637A1 (en) * 2008-08-06 2010-02-11 Novartis Ag New antiviral modified nucleosides
CA2744987C (en) 2008-12-02 2018-01-16 Chiralgen, Ltd. Method for the synthesis of phosphorus atom modified nucleic acids
US8815829B2 (en) 2008-12-09 2014-08-26 Rfs Pharma, Llc 3′-azido purine nucleotide prodrugs for treatment of viral infections
CL2009002206A1 (es) 2008-12-23 2011-08-26 Gilead Pharmasset Llc Compuestos derivados de pirrolo -(2-3-d]-pirimidin-7(6h)-tetrahidrofuran-2-il fosfonamidato, composicion farmaceutica; y su uso en el tratamiento de enfermedades virales.
AU2009329917B2 (en) 2008-12-23 2016-03-31 Gilead Pharmasset Llc Nucleoside analogs
MX2011006891A (es) 2008-12-23 2011-10-06 Pharmasset Inc Fosforamidatos de nucleosidos.
SG172848A1 (en) 2009-01-07 2011-08-29 Scynexis Inc Cyclosporine derivative for use in the treatment of hcv and hiv infection
US8609627B2 (en) 2009-02-06 2013-12-17 Rfs Pharma, Llc Purine nucleoside monophosphate prodrugs for treatment of cancer and viral infections
TWI441829B (zh) 2009-02-25 2014-06-21 Daiichi Sankyo Co Ltd 三環吡唑并嘧啶衍生物
AU2010226466A1 (en) 2009-03-20 2011-10-20 Alios Biopharma, Inc. Substituted nucleoside and nucleotide analogs
WO2010114905A1 (en) 2009-03-31 2010-10-07 Arqule, Inc. Peri-fused pyrazolo-pyrimidine compounds
CA2760205A1 (en) 2009-05-12 2010-11-18 Schering Corporation Fused tricyclic aryl compounds useful for the treatment of viral diseases
TWI598358B (zh) 2009-05-20 2017-09-11 基利法瑪席特有限責任公司 核苷磷醯胺
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
EP2435424B1 (de) 2009-05-29 2015-01-21 Merck Sharp & Dohme Corp. Aus drei miteinander verbundenen aryleinheiten zusammengesetzte antivirale verbindungen zur behandlung von krankheiten wie hepatitis c
CA2762885A1 (en) 2009-05-29 2010-12-02 Schering Corporation Antiviral compounds composed of three aligned aryl moieties to treat diseases such as hepatitis c
EP2451461A4 (de) 2009-07-06 2013-05-29 Ontorii Inc Neuartige nukleinsäure-prodrugs und verwendungsverfahren dafür
ME01528B (me) 2009-09-21 2014-04-20 Gilead Sciences Inc POSTUPCI l INTERMEDIJERI ZA PROIZVODNJU 1'-CIJANOKARBANUKLEOZIDIH ANALOGA
WO2011087740A1 (en) * 2009-12-22 2011-07-21 Schering Corporation Fused tricyclic compounds and methods of use thereof for the treatment of viral diseases
AU2011224698A1 (en) * 2010-03-09 2012-11-01 Merck Sharp & Dohme Corp. Fused Tricyclic Silyl Compounds and methods of use thereof for the treatment of viral diseases
US8563530B2 (en) 2010-03-31 2013-10-22 Gilead Pharmassel LLC Purine nucleoside phosphoramidate
PL2609923T4 (pl) 2010-03-31 2017-11-30 Gilead Pharmasset Llc Proces krystalizacji 2-(((s)-(perfluorofenoksy) (fenoksy)fosforylo)amino)propanianu (s)-izopropylu
PE20130151A1 (es) 2010-03-31 2013-02-21 Gilead Pharmasset Llc Sintesis estereoselectiva de activos que contienen fosforo
MX2013000656A (es) 2010-07-19 2013-04-03 Gilead Sciences Inc Metodos para la preparacion de profarmacos de fosforamidato diastereomericamente puros.
EP2595980B1 (de) 2010-07-22 2014-09-03 Gilead Sciences, Inc. Verfahren und verbindungen zur behandlung von paramyxoviridae-vireninfektionen
JPWO2012026433A1 (ja) 2010-08-23 2013-10-28 第一三共株式会社 三環性ピラゾロピリミジン誘導体のフリー体結晶
CA2809120C (en) 2010-08-23 2015-10-13 Daiichi Sankyo Company, Limited Crystal of tricyclic pyrazolopyrimidine derivative
ES2701020T3 (es) 2010-09-22 2019-02-20 Alios Biopharma Inc Nucleósidos azido y análogos nucleotídicos
BR112013005872A2 (pt) 2010-09-22 2019-09-24 Alios Biopharma Inc compostos, composição farmacêutica e respectivos usos
EP2620428B1 (de) 2010-09-24 2019-05-22 Wave Life Sciences Ltd. Asymmetrische hilfsgruppe
TW201242974A (en) 2010-11-30 2012-11-01 Gilead Pharmasset Llc Compounds
US9243025B2 (en) 2011-03-31 2016-01-26 Idenix Pharmaceuticals, Llc Compounds and pharmaceutical compositions for the treatment of viral infections
ES2626488T3 (es) 2011-07-19 2017-07-25 Wave Life Sciences Pte. Ltd. Procedimientos para la síntesis de ácidos nucleicos funcionalizados
US9403863B2 (en) 2011-09-12 2016-08-02 Idenix Pharmaceuticals Llc Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of viral infections
MD4589C1 (ro) 2011-09-16 2019-03-31 Gilead Pharmasset Llc Compoziţie farmaceutică cu conţinut de sofosbuvir şi utilizarea acesteia în tratamentul hepatitei virale C
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
WO2013096680A1 (en) 2011-12-22 2013-06-27 Alios Biopharma, Inc. Substituted phosphorothioate nucleotide analogs
UA117095C2 (uk) 2011-12-22 2018-06-25 Аліос Біофарма, Інк. Нуклеозидна сполука або її фармацевтично прийнятна сіль
EP2639238A1 (de) * 2012-03-15 2013-09-18 Universität Bern Tricyclische Nukleoside und daraus hergestellte oligomere Verbindungen
NZ631601A (en) 2012-03-21 2016-06-24 Alios Biopharma Inc Solid forms of a thiophosphoramidate nucleotide prodrug
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9012427B2 (en) 2012-03-22 2015-04-21 Alios Biopharma, Inc. Pharmaceutical combinations comprising a thionucleotide analog
MX2014014323A (es) 2012-05-25 2015-02-12 Janssen R & D Ireland Nucleosidos de espirooxetano de uracilo.
US9598458B2 (en) 2012-07-13 2017-03-21 Wave Life Sciences Japan, Inc. Asymmetric auxiliary group
DK2935303T3 (da) 2012-12-21 2021-05-03 Janssen Biopharma Inc 4`-fluornukleosider, 4`-fluornukleotider og analoger dertil til behandling af HCV
EA029081B9 (ru) 2013-01-31 2018-09-28 Джилид Фармассет Ллс Комбинированный состав двух противовирусных соединений
CA2921160C (en) 2013-08-27 2021-04-13 Gilead Pharmasset Llc Combination formulation of two antiviral compounds
US9862743B2 (en) 2013-10-11 2018-01-09 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
JP6115897B2 (ja) * 2013-12-09 2017-04-19 国立大学法人 鹿児島大学 抗ｂ型肝炎ウイルス薬
MY193116A (en) 2014-01-16 2022-09-26 Wave Life Sciences Ltd Chiral design
TWI687432B (zh) 2014-10-29 2020-03-11 美商基利科學股份有限公司 絲狀病毒科病毒感染之治療
AU2016229966B2 (en) 2015-03-06 2018-09-27 Atea Pharmaceuticals, Inc. Beta-D-2'-deoxy-2'alpha-fluoro-2'-beta-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment
CA2984183C (en) 2015-05-01 2021-11-09 Pfizer Inc. Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl, pyrrolo[2,3-b]pyridinyl acrylamides and epoxides thereof
BR112018005048B8 (pt) 2015-09-16 2021-03-23 Gilead Sciences Inc uso de um composto antiviral ou sal do mesmo para o tratamento de uma infecção por coronaviridae
CN107286212B (zh) * 2016-04-11 2020-07-07 天方药业有限公司 一种高纯度去羟肌苷杂质的制备方法
US10202412B2 (en) 2016-07-08 2019-02-12 Atea Pharmaceuticals, Inc. β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N6-substituted-6-aminopurinenucleotides for the treatment of paramyxovirus and orthomyxovirus infections
US10711029B2 (en) 2016-07-14 2020-07-14 Atea Pharmaceuticals, Inc. Beta-d-2′-deoxy-2′-alpha-fluoro-2′-beta-c-substituted-4′fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection
CZ307334B6 (cs) * 2016-08-02 2018-06-13 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. Substituované heteropentadieno-pyrrolopyrimidinové ribonukleosidy pro terapeutické použití
MY197236A (en) 2016-09-07 2023-06-07 Atea Pharmaceuticals Inc 2'-substituted-n6-substituted purine nucleotides for rna virus treatment
WO2018089786A1 (en) * 2016-11-11 2018-05-17 Millennium Pharmaceuticals, Inc. Atg7 inhibitors and the uses thereof
EP4331677A3 (de) 2017-03-14 2024-05-29 Gilead Sciences, Inc. Verfahren zur behandlung von infektionen mit dem katzen-coronavirus
EP3618929B1 (de) 2017-05-01 2022-12-07 Gilead Sciences, Inc. Kristalline form von (s)-2-ethylbutyl-2-(((s)-(((2r,3s,4r,5r)-5-(4-aminopyrrolo[2,1-f]-[1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)-phosphoryl)amino)propanoat
US10675296B2 (en) 2017-07-11 2020-06-09 Gilead Sciences, Inc. Compositions comprising an RNA polymerase inhibitor and cyclodextrin for treating viral infections
EP3773753A4 (de) 2018-04-10 2021-12-22 ATEA Pharmaceuticals, Inc. Behandlung von hcv-infizierten patienten mit zirrhose
CA3134613A1 (en) 2019-04-02 2020-10-08 Aligos Therapeutics, Inc. Compounds targeting prmt5
CA3164134A1 (en) 2019-12-06 2021-06-10 Vertex Pharmaceuticals Incorporated Substituted tetrahydrofurans as modulators of sodium channels
AU2021214911A1 (en) 2020-01-27 2022-07-21 Gilead Sciences, Inc. Methods for treating SARS CoV-2 infections
TWI794742B (zh) 2020-02-18 2023-03-01 美商基利科學股份有限公司 抗病毒化合物
US10874687B1 (en) 2020-02-27 2020-12-29 Atea Pharmaceuticals, Inc. Highly active compounds against COVID-19
JP2023516087A (ja) 2020-03-12 2023-04-17 ギリアード サイエンシーズ， インコーポレイテッド １’－シアノヌクレオシドを調製する方法
KR20220164784A (ko) 2020-04-06 2022-12-13 길리애드 사이언시즈, 인코포레이티드 1'-시아노 치환된 카르바뉴클레오시드 유사체의 흡입 제형
JP2023528810A (ja) 2020-05-29 2023-07-06 ギリアード サイエンシーズ， インコーポレイテッド レムデシビル治療方法
CN115996928A (zh) 2020-06-24 2023-04-21 吉利德科学公司 1’-氰基核苷类似物及其用途
KR20230057411A (ko) 2020-08-27 2023-04-28 길리애드 사이언시즈, 인코포레이티드 바이러스 감염 치료를 위한 화합물 및 방법
CN117120444A (zh) 2021-04-16 2023-11-24 吉利德科学公司 使用酰胺制备卡巴核苷的方法
UY39800A (es) 2021-06-04 2023-01-31 Vertex Pharma N–(hidroxialquil (hetero)aril) tetrahidrofuran carboxamidas como moduladores de canales de sodio
CN114213491B (zh) * 2021-12-31 2024-04-02 中南民族大学 一类内源性核苷M1dG及其衍生物的合成方法及其应用
CN114213490B (zh) * 2021-12-31 2024-04-02 中南民族大学 一类三环核苷酸类似物及其合成方法和应用
EP4320128A1 (de) 2022-03-02 2024-02-14 Gilead Sciences, Inc. Verbindungen und verfahren zur behandlung von virusinfektionen

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6600028B1 (en) * 1997-04-02 2003-07-29 Amersham Pharmacia Biotech Uk Limited Tricyclic base analogues
EP0973788A1 (de) * 1997-04-02 2000-01-26 Amersham Pharmacia Biotech UK Limited Trizyklische basenanaloge
US6348587B1 (en) 1998-02-25 2002-02-19 Emory University 2′-Fluoronucleosides
WO2001032153A2 (en) 1999-11-04 2001-05-10 Shire Biochem Inc. Method for the treatment or prevention of flaviviridae viral infection using nucleoside analogues
EP1296690A2 (de) 2000-02-18 2003-04-02 Shire Biochem Inc. Methoden zur behandlung oder prophylaxe von flavivireninfektionen durch nucleosidanalogika
CN100457118C (zh) 2000-04-13 2009-02-04 法玛塞特有限公司 用于治疗肝炎病毒感染的3′-或2′-羟甲基取代的核苷衍生物
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
EP1736478B1 (de) 2000-05-26 2015-07-22 IDENIX Pharmaceuticals, Inc. Verfahren und Zusammensetzungen zur Behandlung von Flaviviren und Pestiviren
US20030008841A1 (en) * 2000-08-30 2003-01-09 Rene Devos Anti-HCV nucleoside derivatives
MY134070A (en) 2001-01-22 2007-11-30 Isis Pharmaceuticals Inc Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
WO2003061385A1 (en) 2002-01-17 2003-07-31 Ribapharm Inc. Tricyclic nucleoside library compounds, synthesis, and use as antiviral agents
KR20060123707A (ko) * 2003-08-27 2006-12-04 바이오타, 인코포레이티드 치료제로서의 신규 트리시클릭 뉴클레오시드 또는뉴클레오티드
BRPI0607769A2 (pt) 2005-02-28 2009-10-06 Genelabs Tech Inc pró-fármacos nucleosìdeo-tricìclicos para tratamento de infecções virais
US7624825B2 (en) * 2005-10-18 2009-12-01 Smith International, Inc. Drill bit and cutter element having aggressive leading side
US20090048189A1 (en) * 2007-08-15 2009-02-19 Genelabs Technologies, Inc. Tricyclic-nucleoside compounds for treating viral infections
WO2009029729A1 (en) * 2007-08-31 2009-03-05 Genelabs Technologies, Inc. Amino tricyclic-nucleoside compounds, compositions, and methods of use

Also Published As

Publication number Publication date
CN1863813B (zh) 2011-03-30
CA2537114A1 (en) 2005-03-10
WO2005021568B1 (en) 2005-06-09
MXPA06002198A (es) 2007-08-14
BRPI0414019A (pt) 2006-10-24
US7713941B2 (en) 2010-05-11
ZA200602439B (en) 2007-07-25
JP2007504152A (ja) 2007-03-01
EP1660511A2 (de) 2006-05-31
AU2004269026B2 (en) 2010-02-25
WO2005021568A3 (en) 2005-04-21
KR20060123707A (ko) 2006-12-04
EP1660511B1 (de) 2010-11-03
AU2004269026A1 (en) 2005-03-10
ES2355565T3 (es) 2011-03-29
NZ546055A (en) 2010-05-28
RU2006109491A (ru) 2006-08-10
IL173888A0 (en) 2006-07-05
US20080200423A1 (en) 2008-08-21
US20100311684A1 (en) 2010-12-09
CA2537114C (en) 2012-10-02
DE602004029904D1 (de) 2010-12-16
CN1863813A (zh) 2006-11-15
US7268119B2 (en) 2007-09-11
WO2005021568A2 (en) 2005-03-10
US20070135363A1 (en) 2007-06-14
ATE486883T1 (de) 2010-11-15

Similar Documents

Publication Publication Date Title
NO20060979L (no) Nye tricykliske nukleosider eller nukleotider som terapeutiske midler
BRPI0415883A (pt) compostos e composições de nucleosìdeo para o tratamento de infecções virais
CR8935A (es) Inhibidores de la arn polimerasa dependiente del arn del virus de la hepatitis c y composiciones
EA200500584A1 (ru) Нуклеозидные производные для лечения инфекционных заболеваний, вызванных вирусом гепатита c
DK1377589T3 (da) Oxazolyl-pyrazolderivater som kinaseinhibitorer
BRPI0607770A2 (pt) compostos de nucleosideo tricìclico para tratamento de infecções virais
DK1265889T3 (da) Lægemidler imod virussygdomme
BRPI0418251A (pt) fosfonatos, monofosfonamidatos, bisfosfonamidatos para o tratamento de doenças virais
NO20072526L (no) Halvfaste C-klasse immunstimulerende oligonukleotider
ECSP055864A (es) Derivados sustituidos del pirrolo-pirazol como inhibidores de la quinasa
BR0309581A (pt) Derivados de nucleosìdeo para tratamento de infecção por vìrus de hepatite c
ECSP055801A (es) Compuestos benzofuránicos, composiciones y métodos para el tratamiento y profilaxis de infecciones virales de hepatitis c y enfermedades asociadas
UY28084A1 (es) Derivados antivirales de nucleosidos
PA8556201A1 (es) Alquinos como inhibidores de metaloproteinasa de matriz
BRPI0413234A (pt) derivados de imidazola bicìclica contra flaviviridae
BRPI0517238A (pt) formulações que compreendem ecteinascidina e um dissacarìdeo
CY1112028T1 (el) 2-αμινο-7,8-διυδρ0-6η-πυριδο(4,3-d) πυριμιδιν-5-ονες, διαδικασια παρασκευης τους και φαρμακευτικα σκευασματα που τις περιεχουν
BRPI0612124A2 (pt) derivados de heteroarila para o tratamento de viroses
UY27798A1 (es) Inhibidores de la arn polimerasa dependiente de arn del virus de la hepatits c y composiciones y tratamientos que los usan.
PA8590801A1 (es) Derivados de nucleosido antivirales
NO20063331L (no) Nikotinacetylcholinreseptorligander
BRPI0410967A (pt) compostos, composições e seus usos para o tratamento de infecções por vìrus da famìlia flaviviridae
NO20063356L (no) Nikotinacetylcholinreseptorligander
DOP2005000165A (es) Inhibidores de la arn polimerasa dependiente de arn del virus de la hepatitis c y composiciones y tratamientos que los usan
CY1117554T1 (el) Υποκινητες αποπτωσης ν-ακυλσουλφοναμιδιο

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application