ZA200600799B - Use of pinolenic acid - Google Patents
Use of pinolenic acid Download PDFInfo
- Publication number
- ZA200600799B ZA200600799B ZA200600799A ZA200600799A ZA200600799B ZA 200600799 B ZA200600799 B ZA 200600799B ZA 200600799 A ZA200600799 A ZA 200600799A ZA 200600799 A ZA200600799 A ZA 200600799A ZA 200600799 B ZA200600799 B ZA 200600799B
- Authority
- ZA
- South Africa
- Prior art keywords
- acid
- composition
- use according
- pinolenic
- derivative
- Prior art date
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- HXQHFNIKBKZGRP-URPRIDOGSA-N (5Z,9Z,12Z)-octadecatrienoic acid Chemical compound CCCCC\C=C/C\C=C/CC\C=C/CCCC(O)=O HXQHFNIKBKZGRP-URPRIDOGSA-N 0.000 title claims description 85
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- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
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- H05B39/00—Circuit arrangements or apparatus for operating incandescent light sources
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
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- A—HUMAN NECESSITIES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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Applications Claiming Priority (2)
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|---|---|---|---|
| EP05250517 | 2005-01-31 | ||
| GBGB0514463.9A GB0514463D0 (en) | 2005-01-31 | 2005-07-14 | Use of pinolenic acid |
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| ZA200600799B true ZA200600799B (en) | 2006-09-27 |
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|---|---|
| US (1) | US20060172023A1 (de) |
| EP (2) | EP1685834B1 (de) |
| JP (2) | JP2006213711A (de) |
| KR (1) | KR100895800B1 (de) |
| CN (1) | CN1853621A (de) |
| AR (1) | AR053803A1 (de) |
| AT (1) | ATE429218T1 (de) |
| AU (1) | AU2006200169B2 (de) |
| BR (1) | BRPI0600199A (de) |
| CA (1) | CA2533196C (de) |
| DE (1) | DE602006006354D1 (de) |
| DK (1) | DK1685834T3 (de) |
| ES (1) | ES2344017T3 (de) |
| GB (1) | GB0514463D0 (de) |
| MY (1) | MY148723A (de) |
| PL (1) | PL1685834T3 (de) |
| RU (1) | RU2358476C2 (de) |
| ZA (1) | ZA200600799B (de) |
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| WO2008000440A1 (en) * | 2006-06-27 | 2008-01-03 | Lipid Nutrition B.V. | Use of a polyunsaturated fatty acid compound |
| US20080241292A1 (en) * | 2006-10-27 | 2008-10-02 | Iomedix Development International Srl | Composition and method for weight loss |
| WO2008090198A1 (en) * | 2007-01-25 | 2008-07-31 | Janssen Pharmaceutica Nv | Use of mtp inhibitors for increasing levels of satiety hormones |
| EP2150130A1 (de) * | 2007-04-24 | 2010-02-10 | Lipid Nutrition B.V. | Joghurt |
| WO2008128766A2 (en) * | 2007-04-24 | 2008-10-30 | Lipid Nutrition B.V. | Beverage composition |
| WO2008154522A1 (en) * | 2007-06-09 | 2008-12-18 | Arizona Chemical Company | Pinolenic acid compositions, products made thereof, and methods of making pinolenic acid compositions and products |
| EP2002731A1 (de) * | 2007-06-11 | 2008-12-17 | Lipid Nutrition B.V. | Verwendung von Pinolensäure zur Erhöhung der fettarmen Körpermasse |
| EP2002730A1 (de) * | 2007-06-11 | 2008-12-17 | Lipid Nutrition B.V. | Pinolensäure-Zubereitungen zur Behandlung von Fettleber |
| EP2090172A1 (de) | 2007-10-29 | 2009-08-19 | Lipid Nutrition B.V. | Teigzusammensetzung |
| ATE490693T1 (de) * | 2007-10-29 | 2010-12-15 | Lipid Nutrition Bv | Dressingzusammensetzung |
| WO2009056251A1 (en) * | 2007-10-29 | 2009-05-07 | Lipid Nutrition B.V. | Soup or sauce composition and process for its production |
| KR101034458B1 (ko) * | 2008-03-03 | 2011-05-17 | 고려대학교 산학협력단 | 피놀레닌산 고함유 δ5-지방산의 제조방법 |
| WO2009118968A1 (ja) * | 2008-03-26 | 2009-10-01 | 日清オイリオグループ株式会社 | 満腹感誘発剤及びこれを含有する飲食品 |
| EP2316445A4 (de) * | 2008-06-11 | 2011-12-21 | Ricom Corp | Humaner beta3 adrenerger rezeptor-ligand und diesen enthaltendes nahrungsmittel oder pharmazeutisches präparat |
| WO2013108428A1 (ja) * | 2012-01-19 | 2013-07-25 | 日本水産株式会社 | 食欲抑制剤 |
| US9456916B2 (en) | 2013-03-12 | 2016-10-04 | Medibotics Llc | Device for selectively reducing absorption of unhealthy food |
| CA2904898C (en) | 2013-03-11 | 2019-10-15 | Jan Remmereit | Lipid compositions containing bioactive fatty acids |
| US9067070B2 (en) | 2013-03-12 | 2015-06-30 | Medibotics Llc | Dysgeusia-inducing neurostimulation for modifying consumption of a selected nutrient type |
| JP2015205846A (ja) * | 2014-04-22 | 2015-11-19 | 出光興産株式会社 | レプチン分泌促進剤 |
| CL2015003182A1 (es) * | 2015-10-29 | 2016-04-29 | Univ Concepcion | Un producto nutracéutico modulador del apetito y sensibilizador a la insulina en mamíferos |
| WO2017091647A1 (en) * | 2015-11-25 | 2017-06-01 | Sciadonics, Inc. | Lipid formulations containing bioactive fatty acids |
| KR101796034B1 (ko) * | 2016-07-28 | 2017-11-09 | 강릉원주대학교 산학협력단 | 증포발효 인삼열매 추출물을 유효성분으로 함유하는 비만 치료용 조성물 |
| WO2020028263A1 (en) * | 2018-07-30 | 2020-02-06 | Sciadonics, Inc. | 5,11,14-eicosatrienoic acid compositions and methods for their production |
| AR114010A1 (es) * | 2018-10-17 | 2020-07-08 | Team Foods Colombia Sa | Composición lipídica con micronutrientes para la prevención y/o el tratamiento de enfermedades metabólicas |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3260774D1 (en) * | 1981-06-15 | 1984-10-25 | Unilever Nv | Margarine fat blend |
| JPS6158536A (ja) | 1984-08-31 | 1986-03-25 | Nippon Oil & Fats Co Ltd | 栄養組成物 |
| JPS61238729A (ja) | 1985-04-16 | 1986-10-24 | Nippon Oil & Fats Co Ltd | コレステロ−ル低下剤 |
| US5567751A (en) * | 1995-06-01 | 1996-10-22 | Witco Corporation | Alkyl-tin PVC stabilizers with added aromatic ether alcohol to prevent precipitation |
| FR2756465B1 (fr) | 1996-12-03 | 1999-02-19 | D A Noste | Additif alimentaire, composition cosmetique et medicament a base d'huile de graines de pin |
| US5813416A (en) | 1997-04-03 | 1998-09-29 | Rudolph; James M. | File with sanitizing agent |
| EP1175901B1 (de) * | 1999-04-15 | 2006-05-31 | Kaneka Corporation | Agonisten des peroxisom aktivator-responsiven rezeptors |
| US6838431B2 (en) | 1999-07-27 | 2005-01-04 | Pacific Health Laboratories, Inc. | Nutritional intervention composition containing a source of proteinase inhibitor extending post meal satiety |
| PT1088552E (pt) | 1999-09-30 | 2006-06-30 | Loders Croklaan Bv | Composicoes contendo acido pinolenico e sua utilizacao como componente na saude |
| DE60101859T2 (de) * | 2000-02-24 | 2004-12-30 | Unilever N.V. | Pinolensäure gegen Diabetes |
| CN1665566A (zh) | 2000-09-21 | 2005-09-07 | 营养21公司 | 用铬络合物、共轭脂肪酸和 /或共轭脂肪醇治疗糖尿病、减少身体脂肪、改善胰岛素敏感性、缓解高血糖症和高胆固醇血症的方法和组合物 |
| JP4104814B2 (ja) * | 2000-09-22 | 2008-06-18 | 株式会社カネカ | 配合食用油脂 |
| US6429190B1 (en) | 2000-12-15 | 2002-08-06 | Pacifichealth Laboratories, Inc. | Method for extending the satiety of food by adding a nutritional composition designed to stimulate cholecystokinin(CCK) |
| DE10102050A1 (de) * | 2001-01-17 | 2002-07-18 | Basf Ag | Zubereitung zur Verbesserung der Nahrungsverwertung |
| GB0105069D0 (en) * | 2001-03-01 | 2001-04-18 | Univ Ulster The | Modified peptide |
| CN1164292C (zh) * | 2001-04-05 | 2004-09-01 | 尹嘉斌 | 治疗高血脂及高血糖类疾病的天然药物 |
| ES2327397T3 (es) * | 2001-04-30 | 2009-10-29 | TROMMSDORFF GMBH & CO. KG ARZNEIMITTEL | Esteres de uridina farmaceuticamente activos. |
| US20020192266A1 (en) * | 2001-05-21 | 2002-12-19 | Miles Douglas C. | Therapeutic and nutritive dietary composition and method of use |
| US6888016B2 (en) * | 2001-10-16 | 2005-05-03 | Loders Croklaan Usa Llc | Mixtures for stimulating glucose up-take |
| US20050038415A1 (en) | 2003-08-06 | 2005-02-17 | Rohr William L. | Method and apparatus for the treatment of obesity |
| DE602004014716D1 (de) * | 2004-03-06 | 2008-08-14 | Cognis Ip Man Gmbh | Use of unsaturated fatty acids for the reduction of appetite or food intake |
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2005
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2006
- 2006-01-13 EP EP06250162A patent/EP1685834B1/de not_active Not-in-force
- 2006-01-13 PL PL06250162T patent/PL1685834T3/pl unknown
- 2006-01-13 AT AT06250162T patent/ATE429218T1/de not_active IP Right Cessation
- 2006-01-13 ES ES06250162T patent/ES2344017T3/es active Active
- 2006-01-13 DE DE602006006354T patent/DE602006006354D1/de active Active
- 2006-01-13 EP EP09075115A patent/EP2072048A1/de not_active Withdrawn
- 2006-01-13 DK DK06250162T patent/DK1685834T3/da active
- 2006-01-16 AU AU2006200169A patent/AU2006200169B2/en not_active Ceased
- 2006-01-19 CA CA2533196A patent/CA2533196C/en not_active Expired - Fee Related
- 2006-01-27 ZA ZA200600799A patent/ZA200600799B/en unknown
- 2006-01-27 MY MYPI20060431A patent/MY148723A/en unknown
- 2006-01-28 CN CNA2006100599066A patent/CN1853621A/zh active Pending
- 2006-01-30 US US11/341,517 patent/US20060172023A1/en not_active Abandoned
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- 2006-01-30 BR BRPI0600199-8A patent/BRPI0600199A/pt not_active IP Right Cessation
- 2006-01-30 RU RU2006102649/13A patent/RU2358476C2/ru not_active IP Right Cessation
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- 2006-01-31 AR ARP060100351A patent/AR053803A1/es not_active Application Discontinuation
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Also Published As
| Publication number | Publication date |
|---|---|
| AR053803A1 (es) | 2007-05-23 |
| RU2006102649A (ru) | 2007-08-20 |
| BRPI0600199A (pt) | 2006-09-19 |
| JP2012111778A (ja) | 2012-06-14 |
| RU2358476C2 (ru) | 2009-06-20 |
| PL1685834T3 (pl) | 2009-09-30 |
| CA2533196C (en) | 2011-05-24 |
| EP1685834A1 (de) | 2006-08-02 |
| US20060172023A1 (en) | 2006-08-03 |
| GB0514463D0 (en) | 2005-08-17 |
| ES2344017T3 (es) | 2010-08-16 |
| KR20060093029A (ko) | 2006-08-23 |
| DE602006006354D1 (de) | 2009-06-04 |
| CN1853621A (zh) | 2006-11-01 |
| AU2006200169B2 (en) | 2007-08-23 |
| MY148723A (en) | 2013-05-31 |
| EP1685834B1 (de) | 2009-04-22 |
| DK1685834T3 (da) | 2009-07-20 |
| JP2006213711A (ja) | 2006-08-17 |
| EP2072048A1 (de) | 2009-06-24 |
| ATE429218T1 (de) | 2009-05-15 |
| CA2533196A1 (en) | 2006-07-31 |
| AU2006200169A1 (en) | 2006-08-17 |
| KR100895800B1 (ko) | 2009-05-08 |
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