ZA200600770B - Tricyclic delta opioid modulators - Google Patents
Tricyclic delta opioid modulators Download PDFInfo
- Publication number
- ZA200600770B ZA200600770B ZA200600770A ZA200600770A ZA200600770B ZA 200600770 B ZA200600770 B ZA 200600770B ZA 200600770 A ZA200600770 A ZA 200600770A ZA 200600770 A ZA200600770 A ZA 200600770A ZA 200600770 B ZA200600770 B ZA 200600770B
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- ZA
- South Africa
- Prior art keywords
- ethyl
- compound
- formula
- pain
- neuralgia
- Prior art date
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- 235000019371 penicillin G benzathine Nutrition 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 230000037081 physical activity Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
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- 108020001213 potassium channel Proteins 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
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- 230000002040 relaxant effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
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- 201000009032 substance abuse Diseases 0.000 description 1
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- CYFLXLSBHQBMFT-UHFFFAOYSA-N sulfamoxole Chemical group O1C(C)=C(C)N=C1NS(=O)(=O)C1=CC=C(N)C=C1 CYFLXLSBHQBMFT-UHFFFAOYSA-N 0.000 description 1
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- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 description 1
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Classifications
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- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Landscapes
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| AR (1) | AR044940A1 (ja) |
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| SE0300105D0 (sv) * | 2003-01-16 | 2003-01-16 | Astrazeneca Ab | Diarylmethylidene piperdine derivatives, preparations thereof and uses thereof |
| CN100513407C (zh) | 2003-06-27 | 2009-07-15 | 詹森药业有限公司 | 三环δ阿片样物质调节剂 |
| US7772271B2 (en) | 2004-07-14 | 2010-08-10 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| EP1771169A1 (en) | 2004-07-14 | 2007-04-11 | PTC Therapeutics, Inc. | Methods for treating hepatitis c |
| US7868037B2 (en) | 2004-07-14 | 2011-01-11 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| AU2005275182A1 (en) | 2004-07-22 | 2006-02-23 | Ptc Therapeutics, Inc. | Thienopyridines for treating Hepatitis C |
| EP1910353A1 (en) * | 2004-08-05 | 2008-04-16 | Janssen Pharmaceutica N.V. | Tricyclic delta- opioid modulators |
| CN101119992A (zh) * | 2004-12-22 | 2008-02-06 | 詹森药业有限公司 | 三环δ阿片样物质调节剂 |
| BRPI0519198A2 (pt) * | 2004-12-22 | 2008-12-30 | Janssen Pharmaceutica Nv | moduladores de delta-opiàide tricÍclicos |
| WO2006069276A2 (en) | 2004-12-22 | 2006-06-29 | Janssen Pharmaceutica N.V. | TRICYCLIC ō-OPIOID MODULATORS |
| EP1846400A2 (en) * | 2005-01-06 | 2007-10-24 | Janssen Pharmaceutica N.V. | Tricyclic delta-opioid modulators |
| US7935821B2 (en) * | 2005-06-09 | 2011-05-03 | Mallinckrodt Inc. | Method for separation and purification of naltrexone by preparative chromatography |
| JP2008543866A (ja) * | 2005-06-16 | 2008-12-04 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 三環式オピオイドモジュレーター |
| EP2067777B1 (en) | 2006-09-29 | 2013-08-14 | Nippon Zoki Pharmaceutical Co., Ltd. | Oxepin derivative |
| WO2008096360A2 (en) | 2007-02-06 | 2008-08-14 | Technion Research & Development Foundation Ltd. | Frictionless molecular rotary motors |
| CA2713293A1 (en) | 2008-01-30 | 2009-08-06 | Nippon Zoki Pharmaceutical Co., Ltd. | Piperidine derivative |
| EP2319840B1 (en) | 2008-08-01 | 2015-12-16 | Nippon Zoki Pharmaceutical Co., Ltd. | Aminopropylidene derivative |
| IT1402691B1 (it) * | 2010-11-10 | 2013-09-13 | Lamberti Spa | Tioxantoni a bassa migrabilita' |
| WO2018083635A2 (en) | 2016-11-04 | 2018-05-11 | Auckland Uniservices Limited | Tricyclic heterocyclic derivatives and uses thereof |
| WO2018119716A1 (en) * | 2016-12-28 | 2018-07-05 | Henkel Ag & Co. Kgaa | Thioxanthone derivative photoinitiator |
| CN110483871A (zh) * | 2019-08-15 | 2019-11-22 | 陈全明 | 一种抗压耐磨的hdpe双壁波纹管 |
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| US2368006A (en) | 1943-10-07 | 1945-01-23 | Searle & Co | Heterocyclic tertiary amines |
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| DE1159954B (de) | 1961-11-25 | 1963-12-27 | Boehringer & Soehne Gmbh | Verfahren zur Herstellung neuer 10-(Alkoxypiperidinopropyl)-phenthiazine und ihrer Salze |
| DE1670118A1 (de) | 1966-07-22 | 1970-11-05 | Boehringer Mannheim Gmbh | Verfahren zur Herstellung neuer Derivate des 6,11-Dihydro-dibenz[b,e]oxepins und ihrer Salze |
| US3470188A (en) | 1967-01-05 | 1969-09-30 | Smithkline Corp | 9-cycloalkyl-lower alkyl-piperidylidene derivatives of xanthenes and thioxanthenes |
| NL6818027A (ja) | 1968-01-09 | 1969-07-11 | ||
| GB1250534A (ja) | 1969-03-03 | 1971-10-20 | ||
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| US4666907A (en) | 1983-10-05 | 1987-05-19 | Merck Frosst Canada, Inc. | Phenothiazine and derivatives and analogs and use as leukotriene biosynthesis inhibitors |
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| MXPA05002884A (es) | 2002-09-18 | 2005-06-22 | Fmc Corp | Derivados triciclicos insecticidas. |
| US20040082612A1 (en) | 2002-10-15 | 2004-04-29 | Baxter Ellen W | Benzyl substituted (piperidin-4-yl)aminobenzamido derivatives |
| EP1615920A1 (en) | 2003-04-15 | 2006-01-18 | Pfizer Products Inc. | 3-benzhydrylidene-8-aza-bicyclo [3.2.1] octane derivatives with opioid receptor activity |
| CN100513407C (zh) | 2003-06-27 | 2009-07-15 | 詹森药业有限公司 | 三环δ阿片样物质调节剂 |
| EP1910353A1 (en) * | 2004-08-05 | 2008-04-16 | Janssen Pharmaceutica N.V. | Tricyclic delta- opioid modulators |
| BRPI0519198A2 (pt) | 2004-12-22 | 2008-12-30 | Janssen Pharmaceutica Nv | moduladores de delta-opiàide tricÍclicos |
| CN101119992A (zh) * | 2004-12-22 | 2008-02-06 | 詹森药业有限公司 | 三环δ阿片样物质调节剂 |
| WO2006069276A2 (en) | 2004-12-22 | 2006-06-29 | Janssen Pharmaceutica N.V. | TRICYCLIC ō-OPIOID MODULATORS |
| EP1846400A2 (en) | 2005-01-06 | 2007-10-24 | Janssen Pharmaceutica N.V. | Tricyclic delta-opioid modulators |
| JP2008543866A (ja) * | 2005-06-16 | 2008-12-04 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 三環式オピオイドモジュレーター |
-
2004
- 2004-06-22 CN CNB2004800237098A patent/CN100513407C/zh not_active Expired - Fee Related
- 2004-06-22 EP EP04755822A patent/EP1644373A1/en not_active Withdrawn
- 2004-06-22 US US10/873,527 patent/US7589103B2/en active Active
- 2004-06-22 JP JP2006517517A patent/JP4810423B2/ja not_active Expired - Fee Related
- 2004-06-22 AU AU2004253898A patent/AU2004253898A1/en not_active Abandoned
- 2004-06-22 EA EA200501868A patent/EA015491B1/ru not_active IP Right Cessation
- 2004-06-22 BR BRPI0411998-3A patent/BRPI0411998A/pt not_active IP Right Cessation
- 2004-06-22 WO PCT/US2004/019911 patent/WO2005003131A1/en active Application Filing
- 2004-06-22 CA CA2530444A patent/CA2530444C/en not_active Expired - Fee Related
- 2004-06-22 NZ NZ572901A patent/NZ572901A/en unknown
- 2004-06-22 UA UAA200512736A patent/UA86024C2/ru unknown
- 2004-06-22 KR KR1020057025145A patent/KR101132208B1/ko not_active IP Right Cessation
- 2004-06-28 AR ARP040102271A patent/AR044940A1/es not_active Application Discontinuation
- 2004-06-28 TW TW093118831A patent/TWI368510B/zh not_active IP Right Cessation
-
2005
- 2005-12-20 IL IL172713A patent/IL172713A0/en unknown
- 2005-12-27 EC EC2005006256A patent/ECSP056256A/es unknown
-
2006
- 2006-01-02 CR CR8166A patent/CR8166A/es not_active Application Discontinuation
- 2006-01-26 ZA ZA200600770A patent/ZA200600770B/en unknown
- 2006-01-27 NO NO20060446A patent/NO333611B1/no not_active IP Right Cessation
-
2007
- 2007-03-23 HK HK07103171.8A patent/HK1097532A1/xx not_active IP Right Cessation
-
2009
- 2009-08-06 US US12/536,635 patent/US7982042B2/en not_active Expired - Fee Related
-
2011
- 2011-06-10 US US13/157,846 patent/US8106207B2/en not_active Expired - Fee Related
- 2011-12-22 US US13/334,374 patent/US8350041B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1644373A1 (en) | 2006-04-12 |
| US7982042B2 (en) | 2011-07-19 |
| AR044940A1 (es) | 2005-10-12 |
| EA015491B1 (ru) | 2011-08-30 |
| US20050009860A1 (en) | 2005-01-13 |
| US7589103B2 (en) | 2009-09-15 |
| ECSP056256A (es) | 2006-04-19 |
| BRPI0411998A (pt) | 2006-09-05 |
| NO20060446L (no) | 2006-03-27 |
| US8350041B2 (en) | 2013-01-08 |
| WO2005003131A1 (en) | 2005-01-13 |
| TWI368510B (en) | 2012-07-21 |
| EA200501868A1 (ru) | 2006-06-30 |
| TW200528105A (en) | 2005-09-01 |
| IL172713A0 (en) | 2006-04-10 |
| US20110245291A1 (en) | 2011-10-06 |
| UA86024C2 (ru) | 2009-03-25 |
| CA2530444C (en) | 2012-03-13 |
| JP2007516175A (ja) | 2007-06-21 |
| NO333611B1 (no) | 2013-07-22 |
| CN100513407C (zh) | 2009-07-15 |
| JP4810423B2 (ja) | 2011-11-09 |
| CA2530444A1 (en) | 2005-01-13 |
| KR101132208B1 (ko) | 2012-04-12 |
| KR20060035645A (ko) | 2006-04-26 |
| AU2004253898A1 (en) | 2005-01-13 |
| US8106207B2 (en) | 2012-01-31 |
| US20120095010A1 (en) | 2012-04-19 |
| HK1097532A1 (en) | 2007-06-29 |
| CN1839135A (zh) | 2006-09-27 |
| NZ572901A (en) | 2010-06-25 |
| US20090298867A1 (en) | 2009-12-03 |
| CR8166A (es) | 2009-01-16 |
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