TWI368510B - Tricyclic δ-opioid modulators - Google Patents

Tricyclic δ-opioid modulators

Info

Publication number
TWI368510B
TWI368510B TW093118831A TW93118831A TWI368510B TW I368510 B TWI368510 B TW I368510B TW 093118831 A TW093118831 A TW 093118831A TW 93118831 A TW93118831 A TW 93118831A TW I368510 B TWI368510 B TW I368510B
Authority
TW
Taiwan
Prior art keywords
tricyclic
opioid modulators
opioid
modulators
Prior art date
Application number
TW093118831A
Other languages
English (en)
Other versions
TW200528105A (en
Inventor
John R Carson
Ellen Codd
Christine M Razler
Andrea Works
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33563931&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TWI368510(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of TW200528105A publication Critical patent/TW200528105A/zh
Application granted granted Critical
Publication of TWI368510B publication Critical patent/TWI368510B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Psychology (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW093118831A 2003-06-27 2004-06-28 Tricyclic δ-opioid modulators TWI368510B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US48338903P 2003-06-27 2003-06-27

Publications (2)

Publication Number Publication Date
TW200528105A TW200528105A (en) 2005-09-01
TWI368510B true TWI368510B (en) 2012-07-21

Family

ID=33563931

Family Applications (1)

Application Number Title Priority Date Filing Date
TW093118831A TWI368510B (en) 2003-06-27 2004-06-28 Tricyclic δ-opioid modulators

Country Status (20)

Country Link
US (4) US7589103B2 (zh)
EP (1) EP1644373A1 (zh)
JP (1) JP4810423B2 (zh)
KR (1) KR101132208B1 (zh)
CN (1) CN100513407C (zh)
AR (1) AR044940A1 (zh)
AU (1) AU2004253898A1 (zh)
BR (1) BRPI0411998A (zh)
CA (1) CA2530444C (zh)
CR (1) CR8166A (zh)
EA (1) EA015491B1 (zh)
EC (1) ECSP056256A (zh)
HK (1) HK1097532A1 (zh)
IL (1) IL172713A0 (zh)
NO (1) NO333611B1 (zh)
NZ (1) NZ572901A (zh)
TW (1) TWI368510B (zh)
UA (1) UA86024C2 (zh)
WO (1) WO2005003131A1 (zh)
ZA (1) ZA200600770B (zh)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0300105D0 (sv) * 2003-01-16 2003-01-16 Astrazeneca Ab Diarylmethylidene piperdine derivatives, preparations thereof and uses thereof
SE0300103D0 (sv) * 2003-01-16 2003-01-16 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
EP1644373A1 (en) 2003-06-27 2006-04-12 Janssen Pharmaceutica N.V. Tricyclic delta opioid modulators
US7772271B2 (en) 2004-07-14 2010-08-10 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US8013006B2 (en) 2004-07-14 2011-09-06 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7868037B2 (en) 2004-07-14 2011-01-11 Ptc Therapeutics, Inc. Methods for treating hepatitis C
MX2007000762A (es) 2004-07-22 2007-04-02 Ptc Therapeutics Inc Tienopiridinas para tratamientode hepatitis c.
BRPI0513075A (pt) * 2004-08-05 2008-04-22 Janssen Pharmaceutica Nv moduladores gama-opióides tricìclicos
CN101115751A (zh) * 2004-12-22 2008-01-30 詹森药业有限公司 三环δ-阿片样物质调节剂
CA2592462A1 (en) * 2004-12-22 2006-06-29 Janssen Pharmaceutica N.V. Tricyclic delta-opioid modulators
WO2006069277A1 (en) * 2004-12-22 2006-06-29 Janssen Pharmaceutica N.V. TRICYCLIC δ-OPIOID MODULATORS
EP1846400A2 (en) * 2005-01-06 2007-10-24 Janssen Pharmaceutica N.V. Tricyclic delta-opioid modulators
CN101193894A (zh) * 2005-06-09 2008-06-04 马林克罗特公司 通过制备色谱法分离和纯化纳曲酮的方法
BRPI0611885A2 (pt) * 2005-06-16 2010-10-05 Janssen Pharmaceutica Nv moduladores opióides tricìclicos
CA2664345A1 (en) 2006-09-29 2008-04-03 Nippon Zoki Pharmaceutical Co., Ltd. Oxepin derivative
WO2008096360A2 (en) 2007-02-06 2008-08-14 Technion Research & Development Foundation Ltd. Frictionless molecular rotary motors
MX2010008400A (es) 2008-01-30 2010-08-23 Nippon Zoki Pharmaceutical Co Derivado de piperidina.
US8653285B2 (en) 2008-08-01 2014-02-18 Nippon Zoki Pharmaceutical Co., Ltd. Aminopropylidene derivative
IT1402691B1 (it) * 2010-11-10 2013-09-13 Lamberti Spa Tioxantoni a bassa migrabilita'
EP3535243B1 (en) 2016-11-04 2021-12-15 Auckland Uniservices Limited Substituted 9h-xanthen-9-one, 9h-thioxanthen-9-one and acridin-9(10h)-one derivatives and related compounds csf-1r inhibitors for the treatment of cancer
KR20190097245A (ko) * 2016-12-28 2019-08-20 헨켈 아게 운트 코. 카게아아 티오크산톤 유도체 광개시제
CN110483871A (zh) * 2019-08-15 2019-11-22 陈全明 一种抗压耐磨的hdpe双壁波纹管

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2368006A (en) * 1943-10-07 1945-01-23 Searle & Co Heterocyclic tertiary amines
FR1159125A (fr) * 1953-03-27 1958-06-23 Promonta Chem Fab Procédé pour préparer des dérivés de la phényl-thiazine présentant comme substituant basique un noyau hétérocyclique contenant un atome d'azote
US2901478A (en) * 1957-02-11 1959-08-25 Promonta Chem Fab Phenothiazine compounds
US3179665A (en) * 1959-12-16 1965-04-20 Wander Ag Dr A 9-(n-ethyl and n-propyl piperidyl-3'-methyl)-thioxanthenes
DE1159954B (de) * 1961-11-25 1963-12-27 Boehringer & Soehne Gmbh Verfahren zur Herstellung neuer 10-(Alkoxypiperidinopropyl)-phenthiazine und ihrer Salze
DE1670118A1 (de) 1966-07-22 1970-11-05 Boehringer Mannheim Gmbh Verfahren zur Herstellung neuer Derivate des 6,11-Dihydro-dibenz[b,e]oxepins und ihrer Salze
US3470188A (en) * 1967-01-05 1969-09-30 Smithkline Corp 9-cycloalkyl-lower alkyl-piperidylidene derivatives of xanthenes and thioxanthenes
NL6818027A (zh) * 1968-01-09 1969-07-11
GB1250534A (zh) 1969-03-03 1971-10-20
US3987042A (en) * 1969-03-03 1976-10-19 Claude Gueremy Phenothiazine derivative
US3931232A (en) * 1974-06-24 1976-01-06 Smithkline Corporation 3-Alkyl xanthene compounds
US4086350A (en) * 1974-11-06 1978-04-25 Smithkline Corporation Pharmaceutical compositions and method of producing anti-psychotic activity without extrapyramidal symptoms
ZA756550B (en) * 1974-11-06 1976-09-29 Smithkline Corp Pharmaceutical compositions and method of producing antipsychotic activity without extrapyramidal symptoms
US4285956A (en) * 1978-05-12 1981-08-25 Kefalas A/S Xanthene and thioxanthene derivatives, compositions thereof and treatment therewith
US4356184A (en) * 1980-06-04 1982-10-26 G. D. Searle & Co. Anti-allergic or antihypertensive 1-piperidinylmethyl benzenamines
US4666907A (en) * 1983-10-05 1987-05-19 Merck Frosst Canada, Inc. Phenothiazine and derivatives and analogs and use as leukotriene biosynthesis inhibitors
US4777177A (en) * 1984-10-19 1988-10-11 Ciba-Geigy Corporation Pesticidal thioxanthen-9-ylidenepiperidines
FR2689013B1 (fr) * 1992-03-30 1995-05-05 Rhone Poulenc Rorer Sa Nouvelle application thérapeutique des dérivés de la phénothiazine.
ZA978792B (en) * 1996-10-04 1998-04-06 Novo Nordisk As N-substituted azaheterocyclic compounds.
SE9604786D0 (sv) * 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
TW548271B (en) * 1996-12-20 2003-08-21 Astra Pharma Inc Novel piperidine derivatives having an exocyclic double bond with analgesic effects
US6040318A (en) * 1997-06-25 2000-03-21 Novo Nordisk A/S Tricycle substituted with azaheterocyclic carboxylic acids
EP0991633A1 (en) * 1997-06-25 2000-04-12 Novo Nordisk A/S Novel heterocyclic compounds
JP4754068B2 (ja) 1997-12-24 2011-08-24 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド δ−オピオイドレセプターに結合する４−［アリール（ピペリジン−４−イル）］アミノベンズアミド類
WO2001046191A1 (en) 1999-12-22 2001-06-28 Ortho-Mcneil Pharmaceutical, Inc. 4-[aryl(8-azabicyclo[3.2.1]octan-3-yl)]aminobenzoic acid derivatives
JP2003525938A (ja) * 2000-03-03 2003-09-02 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド ３−（ジアリールメチレン）−８−アザビシクロ［３．２．１］オクタン誘導体
AU2001249250A1 (en) 2000-03-29 2001-10-08 Research Triangle Institute Selective ligands for the delta opioid receptor
SE0001207D0 (sv) * 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds
CA2426942C (en) 2000-10-31 2014-06-03 Mark P. Wentland 8-carboxamido-2,6-methano-3-benzazocines
WO2002048122A2 (en) 2000-12-14 2002-06-20 Ortho-Mcneil Pharmaceutical, Inc. Benzamidine derivatives
SE0101765D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
US6601009B2 (en) * 2001-07-12 2003-07-29 Yahoo Inc Method and system of automatic bandwidth detection
JP4337138B2 (ja) * 2001-08-31 2009-09-30 味の素株式会社 新規ジアリールアルケン誘導体及び新規ジアリールアルカン誘導体
SE0103313D0 (sv) * 2001-10-03 2001-10-03 Astrazeneca Ab Novel compounds
WO2003032912A2 (en) * 2001-10-16 2003-04-24 Hypnion, Inc. Treatment of cns disorders using cns target modulators
US7060711B2 (en) * 2001-10-25 2006-06-13 Biofrontera Bioscience Gmbh Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist
EP1306376A1 (en) * 2001-10-25 2003-05-02 Biofrontera Pharmaceuticals AG Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist
EP1321169A1 (en) * 2001-12-18 2003-06-25 Biofrontera Pharmaceuticals AG Combination of a serotonin receptor antagonist with a histidine decarboxylase inhibitor as a medicament
CN1681388A (zh) 2002-09-18 2005-10-12 Fmc有限公司 三环衍生物杀虫剂
WO2004035541A1 (en) 2002-10-15 2004-04-29 Janssen Pharmaceutica, N.V. Benzyl substituted (piperidin-4-yl) aminobenzamido derivatives as delta-opiod receptor modulators
EP1615920A1 (en) 2003-04-15 2006-01-18 Pfizer Products Inc. 3-benzhydrylidene-8-aza-bicyclo [3.2.1] octane derivatives with opioid receptor activity
EP1644373A1 (en) 2003-06-27 2006-04-12 Janssen Pharmaceutica N.V. Tricyclic delta opioid modulators
BRPI0513075A (pt) * 2004-08-05 2008-04-22 Janssen Pharmaceutica Nv moduladores gama-opióides tricìclicos
CN101115751A (zh) 2004-12-22 2008-01-30 詹森药业有限公司 三环δ-阿片样物质调节剂
WO2006069277A1 (en) * 2004-12-22 2006-06-29 Janssen Pharmaceutica N.V. TRICYCLIC δ-OPIOID MODULATORS
CA2592462A1 (en) * 2004-12-22 2006-06-29 Janssen Pharmaceutica N.V. Tricyclic delta-opioid modulators
EP1846400A2 (en) 2005-01-06 2007-10-24 Janssen Pharmaceutica N.V. Tricyclic delta-opioid modulators
BRPI0611885A2 (pt) * 2005-06-16 2010-10-05 Janssen Pharmaceutica Nv moduladores opióides tricìclicos

Also Published As

Publication number Publication date
ECSP056256A (es) 2006-04-19
IL172713A0 (en) 2006-04-10
AR044940A1 (es) 2005-10-12
UA86024C2 (ru) 2009-03-25
US20120095010A1 (en) 2012-04-19
CA2530444C (en) 2012-03-13
US20050009860A1 (en) 2005-01-13
CA2530444A1 (en) 2005-01-13
CN100513407C (zh) 2009-07-15
HK1097532A1 (en) 2007-06-29
NZ572901A (en) 2010-06-25
US20110245291A1 (en) 2011-10-06
NO20060446L (no) 2006-03-27
US7982042B2 (en) 2011-07-19
CN1839135A (zh) 2006-09-27
ZA200600770B (en) 2007-05-30
TW200528105A (en) 2005-09-01
KR20060035645A (ko) 2006-04-26
US7589103B2 (en) 2009-09-15
US8106207B2 (en) 2012-01-31
NO333611B1 (no) 2013-07-22
JP2007516175A (ja) 2007-06-21
KR101132208B1 (ko) 2012-04-12
WO2005003131A1 (en) 2005-01-13
CR8166A (es) 2009-01-16
US20090298867A1 (en) 2009-12-03
EA200501868A1 (ru) 2006-06-30
AU2004253898A1 (en) 2005-01-13
BRPI0411998A (pt) 2006-09-05
JP4810423B2 (ja) 2011-11-09
US8350041B2 (en) 2013-01-08
EA015491B1 (ru) 2011-08-30
EP1644373A1 (en) 2006-04-12

Similar Documents

Publication Publication Date Title
TWI368510B (en) Tricyclic δ-opioid modulators
HK1074622A1 (en) Tricyclic spiropiperidines or spiropyrolidines
EP1735652A4 (en) MODULATORS OF LIGHT
EP1632492A4 (en) TRICYCLIC CONNECTION
IL181120A0 (en) Tricyclic ?? -opioid modulators
EP1751115A4 (en) THERAMUTEINMODULATOREN
GB0329314D0 (en) Substituted arylpyrazoles
EP1666954A4 (en) OPTICAL MODULATOR
EP1646434A4 (en) PROGRESSIVE CAGNOTTES COMMUNICATION TECHNIQUES
AU153882S (en) Ring
GB2422544B (en) Immune modulator
GB0306575D0 (en) Modulators
HK1105634A1 (en) Heteroatoms-containing tricyclic compounds
GB2407131B (en) Modulator
AU2003303520A8 (en) Irs modulators
GB2408811B (en) Optical Modulator
AU158134S (en) Ring
GB0427954D0 (en) Modulator
IL165695A0 (en) Novel tricyclic spiropiperidines or spiropyrrolidines
GB2397449B (en) Modulator
GB0406934D0 (en) Magnet light
SI1521757T1 (sl) Triciklični spiropiperidini ali spiropirolidini
GB0317144D0 (en) Immune modulator
GB0326620D0 (en) Immune modulator
GB0401130D0 (en) Modulators

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees