ZA200600770B - Tricyclic delta opioid modulators - Google Patents
Tricyclic delta opioid modulators Download PDFInfo
- Publication number
- ZA200600770B ZA200600770B ZA200600770A ZA200600770A ZA200600770B ZA 200600770 B ZA200600770 B ZA 200600770B ZA 200600770 A ZA200600770 A ZA 200600770A ZA 200600770 A ZA200600770 A ZA 200600770A ZA 200600770 B ZA200600770 B ZA 200600770B
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- ZA
- South Africa
- Prior art keywords
- ethyl
- compound
- formula
- pain
- neuralgia
- Prior art date
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- 235000019371 penicillin G benzathine Nutrition 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 230000037081 physical activity Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
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- 108020001213 potassium channel Proteins 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
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- 125000004368 propenyl group Chemical group C(=CC)* 0.000 description 1
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- ZVJHJDDKYZXRJI-UHFFFAOYSA-N pyrroline Natural products C1CC=NC1 ZVJHJDDKYZXRJI-UHFFFAOYSA-N 0.000 description 1
- 229940044551 receptor antagonist Drugs 0.000 description 1
- 239000002464 receptor antagonist Substances 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 201000009032 substance abuse Diseases 0.000 description 1
- 231100000736 substance abuse Toxicity 0.000 description 1
- CYFLXLSBHQBMFT-UHFFFAOYSA-N sulfamoxole Chemical group O1C(C)=C(C)N=C1NS(=O)(=O)C1=CC=C(N)C=C1 CYFLXLSBHQBMFT-UHFFFAOYSA-N 0.000 description 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 150000003568 thioethers Chemical class 0.000 description 1
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- 150000003732 xanthenes Chemical class 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
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Classifications
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Landscapes
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- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
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| US48338903P | 2003-06-27 | 2003-06-27 |
Publications (1)
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| CA2530444C (en) | 2003-06-27 | 2012-03-13 | Janssen Pharmaceutica, N.V. | Tricyclic .delta. opioid modulators |
| KR20070083484A (ko) | 2004-07-14 | 2007-08-24 | 피티씨 테라퓨틱스, 인크. | Ｃ형 간염 치료 방법 |
| US7868037B2 (en) | 2004-07-14 | 2011-01-11 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| US7772271B2 (en) | 2004-07-14 | 2010-08-10 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| NZ553329A (en) | 2004-07-22 | 2010-09-30 | Ptc Therapeutics Inc | Thienopyridines for treating hepatitis C |
| CN101039940A (zh) * | 2004-08-05 | 2007-09-19 | 詹森药业有限公司 | 三环δ－阿片样物质调节剂 |
| CA2592462A1 (en) * | 2004-12-22 | 2006-06-29 | Janssen Pharmaceutica N.V. | Tricyclic delta-opioid modulators |
| EA011674B1 (ru) * | 2004-12-22 | 2009-04-28 | Янссен Фармацевтика Н.В. | ТРИЦИКЛИЧЕСКИЕ δ-ОПИОИДНЫЕ МОДУЛЯТОРЫ |
| BRPI0519201A2 (pt) * | 2004-12-22 | 2008-12-30 | Janssen Pharmaceutica Nv | moduladores de delta-opiàide tricÍclico |
| JP2008526878A (ja) | 2005-01-06 | 2008-07-24 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 三環式δ−オピオイド調節剤 |
| EP1899351A1 (en) * | 2005-06-09 | 2008-03-19 | Mallinckrodt, Inc. | Method for separation and purification of naltrexone by preparative chromatography |
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| EP2067777B1 (en) | 2006-09-29 | 2013-08-14 | Nippon Zoki Pharmaceutical Co., Ltd. | Oxepin derivative |
| US8715635B2 (en) | 2007-02-06 | 2014-05-06 | Technion Research & Development Foundation Limited | Frictionless molecular rotary motors |
| EP2243778B1 (en) | 2008-01-30 | 2014-10-29 | Nippon Zoki Pharmaceutical Co., Ltd. | Piperidine derivative |
| EP2319840B1 (en) | 2008-08-01 | 2015-12-16 | Nippon Zoki Pharmaceutical Co., Ltd. | Aminopropylidene derivative |
| IT1402691B1 (it) * | 2010-11-10 | 2013-09-13 | Lamberti Spa | Tioxantoni a bassa migrabilita' |
| EP3535243B1 (en) | 2016-11-04 | 2021-12-15 | Auckland Uniservices Limited | Substituted 9h-xanthen-9-one, 9h-thioxanthen-9-one and acridin-9(10h)-one derivatives and related compounds csf-1r inhibitors for the treatment of cancer |
| EP3562819A4 (en) * | 2016-12-28 | 2020-06-03 | Henkel AG & Co. KGaA | THIOXANTHONE DERIVATIVE PHOTOINITIATOR |
| CN110483871A (zh) * | 2019-08-15 | 2019-11-22 | 陈全明 | 一种抗压耐磨的hdpe双壁波纹管 |
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| DE1670118A1 (de) | 1966-07-22 | 1970-11-05 | Boehringer Mannheim Gmbh | Verfahren zur Herstellung neuer Derivate des 6,11-Dihydro-dibenz[b,e]oxepins und ihrer Salze |
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| US4777177A (en) * | 1984-10-19 | 1988-10-11 | Ciba-Geigy Corporation | Pesticidal thioxanthen-9-ylidenepiperidines |
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| AU2001249250A1 (en) | 2000-03-29 | 2001-10-08 | Research Triangle Institute | Selective ligands for the delta opioid receptor |
| SE0001207D0 (sv) * | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
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| EP1306376A1 (en) | 2001-10-25 | 2003-05-02 | Biofrontera Pharmaceuticals AG | Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist |
| US7060711B2 (en) * | 2001-10-25 | 2006-06-13 | Biofrontera Bioscience Gmbh | Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist |
| EP1321169A1 (en) * | 2001-12-18 | 2003-06-25 | Biofrontera Pharmaceuticals AG | Combination of a serotonin receptor antagonist with a histidine decarboxylase inhibitor as a medicament |
| WO2004026030A2 (en) | 2002-09-18 | 2004-04-01 | Fmc Corporation | Insecticidal tricyclic derivatives |
| US20040082612A1 (en) | 2002-10-15 | 2004-04-29 | Baxter Ellen W | Benzyl substituted (piperidin-4-yl)aminobenzamido derivatives |
| WO2004092165A1 (en) | 2003-04-15 | 2004-10-28 | Pfizer Products Inc. | 3-benzhydrylidene-8-aza-bicyclo[3.2.1]octane derivatives with opioid receptor activity |
| CA2530444C (en) | 2003-06-27 | 2012-03-13 | Janssen Pharmaceutica, N.V. | Tricyclic .delta. opioid modulators |
| CN101039940A (zh) * | 2004-08-05 | 2007-09-19 | 詹森药业有限公司 | 三环δ－阿片样物质调节剂 |
| CA2592462A1 (en) * | 2004-12-22 | 2006-06-29 | Janssen Pharmaceutica N.V. | Tricyclic delta-opioid modulators |
| EA011674B1 (ru) * | 2004-12-22 | 2009-04-28 | Янссен Фармацевтика Н.В. | ТРИЦИКЛИЧЕСКИЕ δ-ОПИОИДНЫЕ МОДУЛЯТОРЫ |
| BRPI0519201A2 (pt) * | 2004-12-22 | 2008-12-30 | Janssen Pharmaceutica Nv | moduladores de delta-opiàide tricÍclico |
| JP2008526878A (ja) * | 2005-01-06 | 2008-07-24 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 三環式δ−オピオイド調節剤 |
| BRPI0611885A2 (pt) * | 2005-06-16 | 2010-10-05 | Janssen Pharmaceutica Nv | moduladores opióides tricìclicos |
-
2004
- 2004-06-22 CA CA2530444A patent/CA2530444C/en not_active Expired - Fee Related
- 2004-06-22 EP EP04755822A patent/EP1644373A1/en not_active Withdrawn
- 2004-06-22 BR BRPI0411998-3A patent/BRPI0411998A/pt not_active IP Right Cessation
- 2004-06-22 JP JP2006517517A patent/JP4810423B2/ja not_active Expired - Fee Related
- 2004-06-22 CN CNB2004800237098A patent/CN100513407C/zh not_active Expired - Fee Related
- 2004-06-22 US US10/873,527 patent/US7589103B2/en active Active
- 2004-06-22 WO PCT/US2004/019911 patent/WO2005003131A1/en active Application Filing
- 2004-06-22 NZ NZ572901A patent/NZ572901A/en not_active IP Right Cessation
- 2004-06-22 AU AU2004253898A patent/AU2004253898A1/en not_active Abandoned
- 2004-06-22 KR KR1020057025145A patent/KR101132208B1/ko not_active IP Right Cessation
- 2004-06-22 UA UAA200512736A patent/UA86024C2/ru unknown
- 2004-06-22 EA EA200501868A patent/EA015491B1/ru not_active IP Right Cessation
- 2004-06-28 TW TW093118831A patent/TWI368510B/zh not_active IP Right Cessation
- 2004-06-28 AR ARP040102271A patent/AR044940A1/es not_active Application Discontinuation
-
2005
- 2005-12-20 IL IL172713A patent/IL172713A0/en unknown
- 2005-12-27 EC EC2005006256A patent/ECSP056256A/es unknown
-
2006
- 2006-01-02 CR CR8166A patent/CR8166A/es not_active Application Discontinuation
- 2006-01-26 ZA ZA200600770A patent/ZA200600770B/en unknown
- 2006-01-27 NO NO20060446A patent/NO333611B1/no not_active IP Right Cessation
-
2007
- 2007-03-23 HK HK07103171.8A patent/HK1097532A1/xx not_active IP Right Cessation
-
2009
- 2009-08-06 US US12/536,635 patent/US7982042B2/en not_active Expired - Fee Related
-
2011
- 2011-06-10 US US13/157,846 patent/US8106207B2/en not_active Expired - Fee Related
- 2011-12-22 US US13/334,374 patent/US8350041B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2530444A1 (en) | 2005-01-13 |
| JP4810423B2 (ja) | 2011-11-09 |
| AU2004253898A1 (en) | 2005-01-13 |
| US20090298867A1 (en) | 2009-12-03 |
| NZ572901A (en) | 2010-06-25 |
| CN1839135A (zh) | 2006-09-27 |
| NO333611B1 (no) | 2013-07-22 |
| NO20060446L (no) | 2006-03-27 |
| HK1097532A1 (en) | 2007-06-29 |
| UA86024C2 (ru) | 2009-03-25 |
| WO2005003131A1 (en) | 2005-01-13 |
| US8106207B2 (en) | 2012-01-31 |
| CR8166A (es) | 2009-01-16 |
| KR20060035645A (ko) | 2006-04-26 |
| BRPI0411998A (pt) | 2006-09-05 |
| US7982042B2 (en) | 2011-07-19 |
| KR101132208B1 (ko) | 2012-04-12 |
| US7589103B2 (en) | 2009-09-15 |
| EA015491B1 (ru) | 2011-08-30 |
| EP1644373A1 (en) | 2006-04-12 |
| AR044940A1 (es) | 2005-10-12 |
| TWI368510B (en) | 2012-07-21 |
| ECSP056256A (es) | 2006-04-19 |
| IL172713A0 (en) | 2006-04-10 |
| US20050009860A1 (en) | 2005-01-13 |
| TW200528105A (en) | 2005-09-01 |
| CA2530444C (en) | 2012-03-13 |
| US20120095010A1 (en) | 2012-04-19 |
| US20110245291A1 (en) | 2011-10-06 |
| EA200501868A1 (ru) | 2006-06-30 |
| JP2007516175A (ja) | 2007-06-21 |
| US8350041B2 (en) | 2013-01-08 |
| CN100513407C (zh) | 2009-07-15 |
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