ZA200508735B - Improved crystalline form of sucralose, and method for producing it - Google Patents
Improved crystalline form of sucralose, and method for producing it Download PDFInfo
- Publication number
- ZA200508735B ZA200508735B ZA200508735A ZA200508735A ZA200508735B ZA 200508735 B ZA200508735 B ZA 200508735B ZA 200508735 A ZA200508735 A ZA 200508735A ZA 200508735 A ZA200508735 A ZA 200508735A ZA 200508735 B ZA200508735 B ZA 200508735B
- Authority
- ZA
- South Africa
- Prior art keywords
- sucralose
- crystals
- crystal
- composition
- sucralose crystals
- Prior art date
Links
- 235000019408 sucralose Nutrition 0.000 title claims description 123
- 239000004376 Sucralose Substances 0.000 title claims description 121
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 title claims description 121
- 238000004519 manufacturing process Methods 0.000 title description 2
- 239000013078 crystal Substances 0.000 claims description 144
- 238000000034 method Methods 0.000 claims description 32
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 239000000203 mixture Substances 0.000 claims description 15
- 239000002245 particle Substances 0.000 claims description 15
- 238000001816 cooling Methods 0.000 claims description 11
- 238000001035 drying Methods 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 9
- 230000003134 recirculating effect Effects 0.000 claims description 6
- 230000007306 turnover Effects 0.000 claims description 6
- 230000000087 stabilizing effect Effects 0.000 claims 1
- 239000000243 solution Substances 0.000 description 19
- 239000000047 product Substances 0.000 description 10
- 238000002425 crystallisation Methods 0.000 description 8
- 230000015572 biosynthetic process Effects 0.000 description 7
- 230000008025 crystallization Effects 0.000 description 6
- 238000000634 powder X-ray diffraction Methods 0.000 description 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 4
- 230000001965 increasing effect Effects 0.000 description 4
- 230000001276 controlling effect Effects 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 239000012452 mother liquor Substances 0.000 description 3
- 230000000717 retained effect Effects 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- 238000005054 agglomeration Methods 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 239000000428 dust Substances 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 238000009834 vaporization Methods 0.000 description 2
- 230000008016 vaporization Effects 0.000 description 2
- 101150039167 Bex3 gene Proteins 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 229910002483 Cu Ka Inorganic materials 0.000 description 1
- 241001640034 Heteropterys Species 0.000 description 1
- 108010083687 Ion Pumps Proteins 0.000 description 1
- 235000012093 Myrtus ugni Nutrition 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 244000061461 Tema Species 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- -1 but not limited to Chemical class 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000002844 continuous effect Effects 0.000 description 1
- 238000004320 controlled atmosphere Methods 0.000 description 1
- 239000002178 crystalline material Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000010902 jet-milling Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000006911 nucleation Effects 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 238000003921 particle size analysis Methods 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- BAQAVOSOZGMPRM-UHFFFAOYSA-N sucralose Chemical compound OC1C(O)C(Cl)C(CO)OC1OC1(CCl)C(O)C(O)C(CCl)O1 BAQAVOSOZGMPRM-UHFFFAOYSA-N 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Saccharide Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/426,387 US6943248B2 (en) | 2003-04-30 | 2003-04-30 | Crystalline form of sucralose, and method for producing it |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200508735B true ZA200508735B (en) | 2006-07-26 |
Family
ID=33309854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200508735A ZA200508735B (en) | 2003-04-30 | 2005-10-27 | Improved crystalline form of sucralose, and method for producing it |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6943248B2 (es) |
| EP (2) | EP2567962A1 (es) |
| JP (2) | JP4809763B2 (es) |
| KR (1) | KR101088727B1 (es) |
| CN (1) | CN100378115C (es) |
| AR (1) | AR044135A1 (es) |
| AU (1) | AU2004234113B2 (es) |
| BR (1) | BRPI0409905A (es) |
| CA (1) | CA2523806C (es) |
| MX (1) | MXPA05011605A (es) |
| RU (1) | RU2005137179A (es) |
| TW (1) | TWI365881B (es) |
| WO (1) | WO2004096821A1 (es) |
| ZA (1) | ZA200508735B (es) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7750146B2 (en) * | 2005-03-18 | 2010-07-06 | Tate & Lyle Plc | Granular sucralose |
| GB2450040A (en) * | 2006-03-22 | 2008-12-10 | Vb Medicare Pvt Ltd | Novel crystallization methods and novel crystalline and amorphous forms of halo-genated sugars |
| US20070264403A1 (en) * | 2006-05-11 | 2007-11-15 | Nehmer Warren L | Sparkling agglomerated sweetener, and method of making it |
| CN100591684C (zh) * | 2006-12-27 | 2010-02-24 | 盐城捷康三氯蔗糖制造有限公司 | 三氯蔗糖结晶方法 |
| CN101260126B (zh) * | 2007-03-06 | 2010-12-22 | 盐城捷康三氯蔗糖制造有限公司 | 三氯蔗糖的结晶方法 |
| AR070082A1 (es) * | 2008-01-04 | 2010-03-10 | Tate & Lyle Technology Ltd | Metodo para la produccion de sucralosa |
| CN101977664B (zh) * | 2008-03-20 | 2014-02-26 | 塔特和莱利技术有限公司 | 从叔酰胺溶剂中去除酸 |
| US8436157B2 (en) * | 2008-03-26 | 2013-05-07 | Tate & Lyle Technology Limited | Method for the production of sucralose |
| AR071134A1 (es) * | 2008-04-03 | 2010-05-26 | Tate & Lyle Technology Ltd | Cristalizacion de sucralosa a partir de chorros que contienen sucralosa |
| WO2009124113A1 (en) * | 2008-04-03 | 2009-10-08 | Tate & Lyle Technology Ltd. | Extraction of less polar impurities from sucralose containing aqueous feed streams |
| CN101981044B (zh) * | 2008-04-03 | 2014-08-06 | 塔特和莱利技术有限公司 | 碳水化合物浓度对三氯半乳蔗糖萃取效率的影响 |
| US8497367B2 (en) * | 2008-04-03 | 2013-07-30 | Tate & Lyle Technology Limited | Sucralose purification process |
| GB2468936B (en) | 2009-03-27 | 2011-09-07 | Mohamad Rami Radwan Jaber | Chlorination of sucrose-6-esters |
| GB2469157B (en) | 2009-03-30 | 2011-07-06 | John Kerr | Process for removing dimethylamine during sucralose production |
| GB2469158B (en) | 2009-03-31 | 2011-09-28 | Peter J Seaberg | Base-assisted formation of tin-sucrose adducts |
| GB2474311B (en) * | 2009-10-12 | 2012-10-17 | Tate & Lyle Technology Ltd | Low temperature, single solvent process for the production of sucrose-6-ester |
| GB2474310B (en) | 2009-10-12 | 2012-02-29 | Tate & Lyle Technology Ltd | Process for the production of sucrose-6-ester |
| GB201110520D0 (en) | 2011-05-10 | 2011-08-03 | Tate & Lyle Technology Ltd | Extraction of carboxylic acids with tin compounds |
| CN102391319B (zh) * | 2011-10-14 | 2015-01-07 | 山东三和维信生物科技有限公司 | 三氯蔗糖的结晶方法 |
| CN103341339B (zh) * | 2013-07-09 | 2016-01-20 | 盐城捷康三氯蔗糖制造有限公司 | 一种高热稳定性三氯蔗糖及其制备方法 |
| GB2539112B (en) | 2013-12-16 | 2020-11-04 | Tate & Lyle Tech Ltd | Chlorination of sucrose-6-esters |
| CN106573949B (zh) | 2014-08-08 | 2019-03-15 | 塔特和莱利技术有限公司 | 蔗糖-6-酯的氯化 |
| GB2536480B (en) | 2015-03-17 | 2019-09-04 | Tate & Lyle Tech Ltd | DMF Distillation |
| GB2551591B (en) | 2016-06-23 | 2019-08-07 | Tate & Lyle Tech Ltd | Liquid-liquid extraction of DMF |
| CN111138502B (zh) * | 2019-12-31 | 2022-01-11 | 山东三和维信生物科技有限公司 | 大颗粒三氯蔗糖的结晶工艺 |
| CN112543760A (zh) * | 2020-09-30 | 2021-03-23 | 安徽金禾实业股份有限公司 | 三氯蔗糖的纯化方法 |
| CN114989231B (zh) * | 2022-06-20 | 2023-04-25 | 新琪安科技股份有限公司 | 一种三氯蔗糖的结晶方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5654434A (en) * | 1979-10-11 | 1981-05-14 | Kohjin Co Ltd | Radiation and far ultraviolet ray sensitive positive type resist method |
| EP0030804B1 (en) | 1979-12-18 | 1983-10-19 | TATE & LYLE PUBLIC LIMITED COMPANY | Crystalline 4,1',6'-trichloro-4,1',6'-trideoxy-galactosucrose |
| DE3062467D1 (en) | 1979-12-20 | 1983-04-28 | Tate & Lyle Plc | Process for the preparation of 4,1',6'-trichloro-4,1',6'-trideoxy-galactosucrose |
| GB8525954D0 (en) | 1985-10-21 | 1985-11-27 | Mcneilab Inc | Chlorination of carbohydrates &c alcohols |
| GB8525871D0 (en) | 1985-10-21 | 1985-11-27 | Tate & Lyle Plc | Chemical compound |
| GB8525953D0 (en) | 1985-10-21 | 1985-11-27 | Mcneilab Inc | Preparation of galactopyranoside |
| GB8617222D0 (en) * | 1986-07-15 | 1986-08-20 | Tate & Lyle Plc | Sweetener |
| GB8622342D0 (en) | 1986-09-17 | 1986-10-22 | Tate & Lyle Plc | Process |
| JPH0228000A (ja) * | 1988-07-15 | 1990-01-30 | Itochu Seito Kk | 糖液の清浄方法 |
| US4950746A (en) | 1988-07-18 | 1990-08-21 | Noramco, Inc. | Process for synthesizing sucrose derivatives by regioselective reaction |
| GB8818430D0 (en) | 1988-08-03 | 1988-09-07 | Tate & Lyle Plc | Process |
| GB8822674D0 (en) | 1988-09-27 | 1988-11-02 | Tate & Lyle Plc | Preparation of acylated sucrose derivatives |
| FR2648474B1 (fr) * | 1989-06-16 | 1995-01-06 | Roquette Freres | Nouveau procede de fabrication du xylose |
| US4980463A (en) | 1989-07-18 | 1990-12-25 | Noramco, Inc. | Sucrose-6-ester chlorination |
| JPH084520B2 (ja) * | 1989-11-29 | 1996-01-24 | 日本甜菜製糖株式会社 | 蔗糖の回収方法及び回収装置 |
| US5136031A (en) | 1990-07-09 | 1992-08-04 | Tate & Lyle Public Limited Company | Chlorination of sugars |
| US5530106A (en) | 1993-03-12 | 1996-06-25 | Mcneil-Ppc, Inc. | Recovery of sucralose intermediates |
| US5498709A (en) * | 1994-10-17 | 1996-03-12 | Mcneil-Ppc, Inc. | Production of sucralose without intermediate isolation of crystalline sucralose-6-ester |
| GB9517281D0 (en) | 1995-08-23 | 1995-10-25 | Tate & Lyle Plc | Solid sucralose |
| JPH11116588A (ja) * | 1997-10-16 | 1999-04-27 | Hayashibara Biochem Lab Inc | トレハロース及び糖アルコールの製造方法 |
| JP2000232900A (ja) * | 1999-02-16 | 2000-08-29 | Showa Sangyo Co Ltd | 無水結晶ぶどう糖の製造方法 |
| JP2001157600A (ja) * | 1999-12-02 | 2001-06-12 | Tsukishima Kikai Co Ltd | 限外ろ過処理およびクロマト分離を含む甘蔗からの直接精糖法 |
| AU2691802A (en) * | 2000-11-17 | 2002-05-27 | Mcneil Ppc Inc | Improved sucralose composition and process for its preparation |
| US6998480B2 (en) * | 2002-03-08 | 2006-02-14 | Tate & Lyle Public Limited Company | Process for improving sucralose purity and yield |
-
2003
- 2003-04-30 US US10/426,387 patent/US6943248B2/en not_active Expired - Lifetime
-
2004
- 2004-04-26 CA CA2523806A patent/CA2523806C/en not_active Expired - Fee Related
- 2004-04-26 RU RU2005137179/04A patent/RU2005137179A/ru not_active Application Discontinuation
- 2004-04-26 JP JP2006506176A patent/JP4809763B2/ja not_active Expired - Fee Related
- 2004-04-26 KR KR1020057020558A patent/KR101088727B1/ko not_active IP Right Cessation
- 2004-04-26 EP EP12185694A patent/EP2567962A1/en not_active Withdrawn
- 2004-04-26 CN CNB2004800110383A patent/CN100378115C/zh not_active Expired - Fee Related
- 2004-04-26 BR BRPI0409905-2A patent/BRPI0409905A/pt not_active IP Right Cessation
- 2004-04-26 MX MXPA05011605A patent/MXPA05011605A/es active IP Right Grant
- 2004-04-26 EP EP04729457A patent/EP1618118B1/en not_active Expired - Lifetime
- 2004-04-26 AU AU2004234113A patent/AU2004234113B2/en not_active Ceased
- 2004-04-26 WO PCT/GB2004/001759 patent/WO2004096821A1/en active Application Filing
- 2004-04-29 TW TW093112005A patent/TWI365881B/zh not_active IP Right Cessation
- 2004-04-29 AR ARP040101469A patent/AR044135A1/es unknown
-
2005
- 2005-05-13 US US11/128,501 patent/US20050203290A1/en not_active Abandoned
- 2005-10-27 ZA ZA200508735A patent/ZA200508735B/en unknown
-
2011
- 2011-06-21 JP JP2011137098A patent/JP2011225591A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20040220398A1 (en) | 2004-11-04 |
| JP2006525295A (ja) | 2006-11-09 |
| JP2011225591A (ja) | 2011-11-10 |
| AU2004234113B2 (en) | 2011-01-20 |
| CA2523806C (en) | 2012-10-02 |
| CN1777617A (zh) | 2006-05-24 |
| JP4809763B2 (ja) | 2011-11-09 |
| CN100378115C (zh) | 2008-04-02 |
| US6943248B2 (en) | 2005-09-13 |
| CA2523806A1 (en) | 2004-11-11 |
| EP2567962A1 (en) | 2013-03-13 |
| BRPI0409905A (pt) | 2006-04-25 |
| KR101088727B1 (ko) | 2011-12-01 |
| TW200510439A (en) | 2005-03-16 |
| TWI365881B (en) | 2012-06-11 |
| US20050203290A1 (en) | 2005-09-15 |
| AU2004234113A1 (en) | 2004-11-11 |
| AR044135A1 (es) | 2005-08-24 |
| EP1618118B1 (en) | 2013-04-03 |
| WO2004096821A1 (en) | 2004-11-11 |
| KR20060008941A (ko) | 2006-01-27 |
| RU2005137179A (ru) | 2006-03-27 |
| MXPA05011605A (es) | 2006-01-23 |
| EP1618118A1 (en) | 2006-01-25 |
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