ZA200308782B - Piperazine oxime derivatives having NK-1 receptor antagonistic activity. - Google Patents

Piperazine oxime derivatives having NK-1 receptor antagonistic activity. Download PDF

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Publication number
ZA200308782B
ZA200308782B ZA200308782A ZA200308782A ZA200308782B ZA 200308782 B ZA200308782 B ZA 200308782B ZA 200308782 A ZA200308782 A ZA 200308782A ZA 200308782 A ZA200308782 A ZA 200308782A ZA 200308782 B ZA200308782 B ZA 200308782B
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disorders
disorder
substance
disease
compound
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ZA200308782A
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Jan H Van Maarseveen
Martinus Th M Tulp
Wouter I Iwema Bakker
Amoldus H J Herremans
Gustaaf J M Van Scharrenburg
Andrew C Mccreary
Hein K A C Coolen
Adrianus Van Den Hoogenband
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Solvay Pharmaceutical B V
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Publication of ZA200308782B publication Critical patent/ZA200308782B/en

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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
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  • Hematology (AREA)
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  • Child & Adolescent Psychology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA200308782A 2001-07-09 2003-11-11 Piperazine oxime derivatives having NK-1 receptor antagonistic activity. ZA200308782B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01202631 2001-07-09

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ZA200308782B true ZA200308782B (en) 2005-02-11

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ZA200308782A ZA200308782B (en) 2001-07-09 2003-11-11 Piperazine oxime derivatives having NK-1 receptor antagonistic activity.

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US (1) US7094779B2 (da)
EP (1) EP1406894B1 (da)
JP (1) JP3765543B2 (da)
KR (1) KR100900889B1 (da)
CN (1) CN1223591C (da)
AR (1) AR034722A1 (da)
AT (1) ATE285407T1 (da)
AU (1) AU2002333229B2 (da)
BR (1) BR0210080A (da)
CA (1) CA2446726A1 (da)
DE (1) DE60202371T2 (da)
DK (1) DK1406894T3 (da)
ES (1) ES2230521T3 (da)
HK (1) HK1067364A1 (da)
HR (1) HRP20030912A2 (da)
HU (1) HUP0401093A3 (da)
IL (2) IL158728A0 (da)
MX (1) MXPA04000230A (da)
NO (1) NO20040065L (da)
PL (1) PL366841A1 (da)
PT (1) PT1406894E (da)
RU (1) RU2273639C2 (da)
SI (1) SI1406894T1 (da)
UA (1) UA75425C2 (da)
WO (1) WO2003006459A1 (da)
ZA (1) ZA200308782B (da)

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AU2004308299B2 (en) 2003-12-19 2011-11-24 Plexxikon, Inc. Compounds and methods for development of Ret modulators
US7498342B2 (en) 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
KR100616099B1 (ko) * 2004-09-20 2006-08-28 한국과학기술연구원 Ｔ-타입 칼슘채널 길항제로 유효한 신규 피페라지닐알킬이소옥사졸 유도체
MX2007014377A (es) 2005-05-17 2008-02-06 Plexxikon Inc Inhibidores de proteina cinasa de derivados de pirrol (2,3-b) piridina.
ATE518860T1 (de) 2005-06-22 2011-08-15 Plexxikon Inc Pyrroloä2,3-büpyridinderivate als proteinkinaseinhibitoren
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
US20100168197A1 (en) * 2007-02-28 2010-07-01 Naresh Kumar Muscarinic receptor antagonists
JP2010533729A (ja) 2007-07-17 2010-10-28 プレキシコン，インコーポレーテッド キナーゼ調節のための化合物と方法、及びそのための適応
TWI404719B (zh) 2009-04-03 2013-08-11 Hoffmann La Roche 組合物及其用途
US20110112127A1 (en) 2009-11-06 2011-05-12 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
EP2672967B1 (en) 2011-02-07 2018-10-17 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
CN104958297A (zh) * 2015-06-03 2015-10-07 周玉梅 一种用于麻醉镇静催眠的药物组合物及其应用
CN110615774B (zh) * 2019-09-19 2022-11-11 安徽中医药大学 具有抗炎活性的苄基哌嗪类化合物、制法及医药用途
JP2022090346A (ja) 2020-12-07 2022-06-17 三星電子株式会社 共重合体、ならびに当該共重合体を用いるエレクトロルミネッセンス素子材料およびエレクトロルミネッセンス素子

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MX9708416A (es) 1995-05-02 1998-02-28 Schering Corp Derivados de piperazino como antagonistas de neuroquininas.
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EP0846116A1 (en) 1995-05-25 1998-06-10 Fujisawa Pharmaceutical Co., Ltd. 1-benzoyl-2-(indolyl-3-alkyl)-piperazine derivatives as neurokinin receptor antagonists
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DE19824865A1 (de) * 1997-08-27 1999-03-04 Solvay Pharm Gmbh Neue Harnstoffderivate
DE69920516T2 (de) 1998-12-23 2005-12-01 Schering Corp. Substituierte oxime und hydrazone als neurokinin antagonisten

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HUP0401093A3 (en) 2004-10-28
HK1067364A1 (en) 2005-04-08
SI1406894T1 (en) 2005-06-30
EP1406894A1 (en) 2004-04-14
KR20040013134A (ko) 2004-02-11
RU2273639C2 (ru) 2006-04-10
JP3765543B2 (ja) 2006-04-12
EP1406894B1 (en) 2004-12-22
US20040176389A1 (en) 2004-09-09
PT1406894E (pt) 2005-05-31
CN1520409A (zh) 2004-08-11
AU2002333229B2 (en) 2006-11-30
IL158728A0 (en) 2004-05-12
KR100900889B1 (ko) 2009-06-03
JP2004536851A (ja) 2004-12-09
IL158728A (en) 2009-09-22
CN1223591C (zh) 2005-10-19
DE60202371T2 (de) 2005-04-14
DE60202371D1 (de) 2005-01-27
WO2003006459A1 (en) 2003-01-23
DK1406894T3 (da) 2005-03-14
ATE285407T1 (de) 2005-01-15
HRP20030912A2 (en) 2005-08-31
BR0210080A (pt) 2004-06-22
US7094779B2 (en) 2006-08-22
HUP0401093A2 (hu) 2004-08-30
RU2003136264A (ru) 2005-04-20
AR034722A1 (es) 2004-03-17
PL366841A1 (en) 2005-02-07
CA2446726A1 (en) 2003-01-23
ES2230521T3 (es) 2005-05-01
MXPA04000230A (es) 2004-05-04
NO20040065L (no) 2004-03-09
UA75425C2 (en) 2006-04-17

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