ZA200307916B - Benzimidazole compounds for modulating ige and inhibiting cellular proliferation. - Google Patents
Benzimidazole compounds for modulating ige and inhibiting cellular proliferation. Download PDFInfo
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- ZA200307916B ZA200307916B ZA200307916A ZA200307916A ZA200307916B ZA 200307916 B ZA200307916 B ZA 200307916B ZA 200307916 A ZA200307916 A ZA 200307916A ZA 200307916 A ZA200307916 A ZA 200307916A ZA 200307916 B ZA200307916 B ZA 200307916B
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- South Africa
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- alkyl
- substituted
- group
- heteroaryl
- pharmaceutical composition
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US6919366B2 (en) * | 1998-05-22 | 2005-07-19 | Avanir Pharmaceuticals | Benzimidazole derivatives as modulators of IgE |
| US6911462B2 (en) * | 1998-05-22 | 2005-06-28 | Avanir Pharmaceuticals | Benzimidazole compounds for regulating IgE |
| DE60221804T2 (de) * | 2001-03-12 | 2008-05-15 | Avanir Pharmaceuticals, San Diego | Benzimidazolderivate zur ige-modulierung und zellproliferationshemmung |
| KR20040031782A (ko) * | 2001-07-27 | 2004-04-13 | 쿠리스 인코퍼레이션 | 헤지호그 신호전달 경로의 조절물질, 이를 함유하는조성물 및 이의 용도 |
| TW200304820A (en) * | 2002-03-25 | 2003-10-16 | Avanir Pharmaceuticals | Use of benzimidazole analogs in the treatment of cell proliferation |
| EP1388535A1 (en) * | 2002-08-07 | 2004-02-11 | Aventis Pharma Deutschland GmbH | Acylated arylcycloalkylamines and their use as pharmaceuticals |
| TWI276631B (en) | 2002-09-12 | 2007-03-21 | Avanir Pharmaceuticals | Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation |
| AU2003270426A1 (en) | 2002-09-12 | 2004-04-30 | Avanir Pharmaceuticals | PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION |
| WO2004041280A1 (en) * | 2002-11-02 | 2004-05-21 | Kyung-Lim Lee | Composition for preventing secretion of immunoglobulin e-dependent histamine releasing factor |
| EP1613313B1 (en) * | 2003-04-17 | 2007-06-06 | Janssen Pharmaceutica N.V. | 2-phenyl-benzimidazol and 2-phenyl-imidazo-4,5]-pyridine derivatives as checkpoint kinase cds1 (chk2) inhibitors for the treatment of cancer |
| EP1651198A2 (en) * | 2003-08-08 | 2006-05-03 | Avanir Pharmaceuticals | Selective pharmacologic inhibition of protein trafficking and related methods of treating human diseases |
| AU2004268948A1 (en) | 2003-08-21 | 2005-03-10 | Osi Pharmaceuticals, Inc. | N-substituted pyrazolyl-amidyl-benzimidazolyl c-kit inhibitors |
| US7485658B2 (en) * | 2003-08-21 | 2009-02-03 | Osi Pharmaceuticals, Inc. | N-substituted pyrazolyl-amidyl-benzimidazolyl c-Kit inhibitors |
| US7250427B2 (en) | 2004-06-30 | 2007-07-31 | Janssen Pharmaceutica, N.V. | Aryl-substituted benzimidazole and imidazopyridine ethers |
| UA92180C2 (xx) * | 2005-09-06 | 2010-10-11 | Смиткляйн Бичам Корпорейшн | Сполуки бензімідазолтіофену[соединения бензимидазолтиофена |
| JP2009001495A (ja) * | 2005-10-13 | 2009-01-08 | Taisho Pharmaceutical Co Ltd | ２−アリール−ベンゾイミダゾール−５−カルボキサミド誘導体 |
| CA2627722A1 (en) | 2005-10-31 | 2007-06-21 | Merck & Co., Inc. | Cetp inhibitors |
| EP1960382A1 (en) * | 2005-11-03 | 2008-08-27 | ChemBridge Research Laboratories, Inc. | Heterocyclic compounds as tyrosine kinase modulators |
| GB0606774D0 (en) * | 2006-04-03 | 2006-05-10 | Novartis Ag | Organic compounds |
| AR063311A1 (es) * | 2006-10-18 | 2009-01-21 | Novartis Ag | Compuestos organicos |
| PE20090074A1 (es) * | 2007-04-19 | 2009-03-02 | Novartis Ag | DERIVADOS DE BENCIMIDAZOL COMO MODULADORES DE LOS RECEPTORES DE GLUTAMATO METABOTROPICOS (mGluR) |
| CN101815512B (zh) | 2007-10-04 | 2013-04-24 | 弗·哈夫曼-拉罗切有限公司 | 环丙基芳基酰胺衍生物和其用途 |
| WO2009112445A1 (en) * | 2008-03-10 | 2009-09-17 | Novartis Ag | Method of increasing cellular phosphatidyl choline by dgat1 inhibition |
| CN103288803B (zh) * | 2013-05-17 | 2017-10-31 | 郎恒元 | 苯并咪唑酰胺类化合物及其制备方法和应用 |
| CN104208701A (zh) * | 2013-05-29 | 2014-12-17 | 天津金耀集团有限公司 | 含有抗真菌药物的复方吸入制剂 |
| EP3515904B1 (en) * | 2016-09-20 | 2024-01-17 | Centre Léon Bérard | Benzoimidazole derivatives as anticancer agents |
| WO2019231871A1 (en) * | 2018-06-01 | 2019-12-05 | Merck Sharp & Dohme Corp. | Novel [3.3.1] bicyclo compounds as indoleamine 2,3-dioxygenase inhibitors |
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| DE3224512A1 (de) | 1982-07-01 | 1984-01-05 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel |
| US4510158A (en) * | 1984-03-05 | 1985-04-09 | Sterling Drug Inc. | 2-Phenylindole derivatives, their use as complement inhibitors |
| EP0221146B1 (en) | 1985-05-03 | 1991-07-31 | The Foxboro Company | Distillation cut point control |
| US4939133A (en) | 1985-10-01 | 1990-07-03 | Warner-Lambert Company | N-substituted-2-hydroxy-α-oxo-benzeneacetamides and pharmaceutical compositions having activity as modulators of the arachidonic acid cascade |
| LU86258A1 (fr) | 1986-01-21 | 1987-09-03 | Rech Dermatologiques C I R D S | Composes benzamido aromatique,leur procede de preparation et leur utilisation en medecine humaine ou veterinaire et en cosmetique |
| US5206257A (en) * | 1987-03-05 | 1993-04-27 | May & Baker Limited | Pesticidal method using 2-phenylimidazole derivatives |
| JP2630432B2 (ja) * | 1987-08-24 | 1997-07-16 | コニカ株式会社 | 新規なシアンカプラーを含有するハロゲン化銀カラー写真感光材料 |
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-
2002
- 2002-02-28 DE DE60221804T patent/DE60221804T2/de not_active Expired - Fee Related
- 2002-02-28 EP EP02715052A patent/EP1368028B1/en not_active Expired - Lifetime
- 2002-02-28 NZ NZ528835A patent/NZ528835A/en unknown
- 2002-02-28 BR BR0208010-9A patent/BR0208010A/pt not_active IP Right Cessation
- 2002-02-28 PL PL02364230A patent/PL364230A1/xx unknown
- 2002-02-28 CZ CZ20032691A patent/CZ20032691A3/cs unknown
- 2002-02-28 PT PT02715052T patent/PT1368028E/pt unknown
- 2002-02-28 AT AT02715052T patent/ATE369853T1/de not_active IP Right Cessation
- 2002-02-28 ES ES02715052T patent/ES2291455T3/es not_active Expired - Lifetime
- 2002-02-28 JP JP2002571049A patent/JP2004528304A/ja active Pending
- 2002-02-28 CA CA002441177A patent/CA2441177A1/en not_active Abandoned
- 2002-02-28 CN CNA028064860A patent/CN1496257A/zh active Pending
- 2002-02-28 DK DK02715052T patent/DK1368028T3/da active
- 2002-02-28 WO PCT/US2002/006801 patent/WO2002072090A1/en active IP Right Grant
- 2002-02-28 RU RU2003127367/15A patent/RU2003127367A/ru not_active Application Discontinuation
- 2002-02-28 HU HU0303460A patent/HUP0303460A3/hu unknown
- 2002-02-28 MX MXJL03000027A patent/MXJL03000027A/es not_active Application Discontinuation
- 2002-03-11 AR ARP020100869A patent/AR034023A1/es unknown
-
2003
- 2003-10-10 ZA ZA200307916A patent/ZA200307916B/en unknown
-
2004
- 2004-03-05 US US10/795,006 patent/US7282518B2/en not_active Expired - Fee Related
-
2007
- 2007-04-27 US US11/741,702 patent/US20070202133A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ATE369853T1 (de) | 2007-09-15 |
| EP1368028B1 (en) | 2007-08-15 |
| NZ528835A (en) | 2005-05-27 |
| HUP0303460A2 (hu) | 2004-03-01 |
| WO2002072090A1 (en) | 2002-09-19 |
| MXJL03000027A (es) | 2004-04-30 |
| DE60221804D1 (de) | 2007-09-27 |
| US20040214821A1 (en) | 2004-10-28 |
| BR0208010A (pt) | 2004-12-21 |
| JP2004528304A (ja) | 2004-09-16 |
| PT1368028E (pt) | 2007-11-26 |
| CN1496257A (zh) | 2004-05-12 |
| AR034023A1 (es) | 2004-01-21 |
| US7282518B2 (en) | 2007-10-16 |
| US20070202133A1 (en) | 2007-08-30 |
| CA2441177A1 (en) | 2002-09-19 |
| EP1368028A1 (en) | 2003-12-10 |
| CZ20032691A3 (en) | 2004-04-14 |
| DE60221804T2 (de) | 2008-05-15 |
| PL364230A1 (en) | 2004-12-13 |
| DK1368028T3 (da) | 2007-12-27 |
| HUP0303460A3 (en) | 2004-07-28 |
| ES2291455T3 (es) | 2008-03-01 |
| RU2003127367A (ru) | 2005-03-20 |
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