HUP0303460A2 - IgE-Módosító és sejtburjánzásgátló hatású benzimidazolok és ezeket tartalmazó gyógyszerkészítmények - Google Patents
IgE-Módosító és sejtburjánzásgátló hatású benzimidazolok és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0303460A2 HUP0303460A2 HU0303460A HUP0303460A HUP0303460A2 HU P0303460 A2 HUP0303460 A2 HU P0303460A2 HU 0303460 A HU0303460 A HU 0303460A HU P0303460 A HUP0303460 A HU P0303460A HU P0303460 A2 HUP0303460 A2 HU P0303460A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- independently
- ige
- benzimidazole compounds
- group
- Prior art date
Links
- 125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 title abstract 2
- 230000004663 cell proliferation Effects 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000004176 4-fluorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])* 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 239000013566 allergen Substances 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003367 polycyclic group Chemical group 0.000 abstract 1
- 230000004044 response Effects 0.000 abstract 1
- 150000003384 small molecules Chemical class 0.000 abstract 1
- 125000005415 substituted alkoxy group Chemical group 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A találmány allergénekre adott IgE válasz kismolekulájú inhibitorairavonatkozik, amelyek (I), (II) és (III) általános képletében Rjelentése H, 1-5 szénatomos alkil-, benzil-, p-fluorbenzil- vagydialkilaminoalkil-csoport; R1 és R2 jelentése egymástól függetlenül H,adott esetben szubsztituált alkil-, 3-9 szénatomos cikloalkil-,fenil-, naftil, heteroarilcsoport, policiklusos alifás csoportok; R3és R4 jelentése egymástól függetlenül H, alkil-, aril-,heteroarilcsoport vagy COR'; X és Y jelentése egymástól függetlenül H,halogénatom, adott esetben szubsztituált alkoxi- vagy alkilcsoport,dialkilaminoalkilcsoport, hidroxialkil-csoport, OH, OCH3, COOH, CN,CF3, OCF3, NO2, COOR<, CHO vagy COR<-, amelyek allergia és/vagy asztmavagy bármely egyéb olyan betegség kezelésére alkalmazhatók, amelyet azIgE okoz. A találmány tárgyát képezik sejtproliferáció inhibitorhatású benzimidazolvegyületek is, amelyek rákellenes szerkéntalkalmazhatók. A találmány kiterjed a vegyületeket tartalmazógyógyszerkészítményekre is. Ó
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27526001P | 2001-03-12 | 2001-03-12 | |
US10/090,044 US6759425B2 (en) | 1999-10-21 | 2002-02-27 | Benzimidazole compounds for modulating IgE and inhibiting cellular proliferation |
PCT/US2002/006801 WO2002072090A1 (en) | 2001-03-12 | 2002-02-28 | Benzimidazole compounds for modulating ige and inhibiting cellular proliferation |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0303460A2 true HUP0303460A2 (hu) | 2004-03-01 |
HUP0303460A3 HUP0303460A3 (en) | 2004-07-28 |
Family
ID=34115140
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0303460A HUP0303460A3 (en) | 2001-03-12 | 2002-02-28 | Benzimidazole compounds for modulating ige and inhibiting cellular proliferation and pharmaceutical compositions containing them |
Country Status (20)
Country | Link |
---|---|
US (2) | US7282518B2 (hu) |
EP (1) | EP1368028B1 (hu) |
JP (1) | JP2004528304A (hu) |
CN (1) | CN1496257A (hu) |
AR (1) | AR034023A1 (hu) |
AT (1) | ATE369853T1 (hu) |
BR (1) | BR0208010A (hu) |
CA (1) | CA2441177A1 (hu) |
CZ (1) | CZ20032691A3 (hu) |
DE (1) | DE60221804T2 (hu) |
DK (1) | DK1368028T3 (hu) |
ES (1) | ES2291455T3 (hu) |
HU (1) | HUP0303460A3 (hu) |
MX (1) | MXJL03000027A (hu) |
NZ (1) | NZ528835A (hu) |
PL (1) | PL364230A1 (hu) |
PT (1) | PT1368028E (hu) |
RU (1) | RU2003127367A (hu) |
WO (1) | WO2002072090A1 (hu) |
ZA (1) | ZA200307916B (hu) |
Families Citing this family (27)
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US6919366B2 (en) * | 1998-05-22 | 2005-07-19 | Avanir Pharmaceuticals | Benzimidazole derivatives as modulators of IgE |
US6911462B2 (en) * | 1998-05-22 | 2005-06-28 | Avanir Pharmaceuticals | Benzimidazole compounds for regulating IgE |
HUP0303460A3 (en) | 2001-03-12 | 2004-07-28 | Avanir Pharmaceuticals San Die | Benzimidazole compounds for modulating ige and inhibiting cellular proliferation and pharmaceutical compositions containing them |
EA007339B1 (ru) | 2001-07-27 | 2006-08-25 | Кьюэрис, Инк. | Медиаторы путей передачи сигналов генами hedgehog, содержащие их композиции и способы применения указанных веществ |
TW200304820A (en) * | 2002-03-25 | 2003-10-16 | Avanir Pharmaceuticals | Use of benzimidazole analogs in the treatment of cell proliferation |
EP1388535A1 (en) * | 2002-08-07 | 2004-02-11 | Aventis Pharma Deutschland GmbH | Acylated arylcycloalkylamines and their use as pharmaceuticals |
TWI276631B (en) | 2002-09-12 | 2007-03-21 | Avanir Pharmaceuticals | Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation |
WO2004024655A2 (en) | 2002-09-12 | 2004-03-25 | Avanir Pharmaceuticals | Phenyl-indole compounds for modulating ige and inhibiting cellular proliferation |
US20050239844A1 (en) * | 2002-11-02 | 2005-10-27 | Kyung-Lim Lee | Composition fo preventing secretion of immunoglobulin e-dependent histamine releasing factor |
US7132440B2 (en) | 2003-04-17 | 2006-11-07 | Janssen Pharmaceutica, N.V. | Substituted benzimidazoles and imidazo-[4,5]-pyridines |
EP1651198A2 (en) * | 2003-08-08 | 2006-05-03 | Avanir Pharmaceuticals | Selective pharmacologic inhibition of protein trafficking and related methods of treating human diseases |
US7485658B2 (en) * | 2003-08-21 | 2009-02-03 | Osi Pharmaceuticals, Inc. | N-substituted pyrazolyl-amidyl-benzimidazolyl c-Kit inhibitors |
ATE413395T1 (de) | 2003-08-21 | 2008-11-15 | Osi Pharm Inc | N-substituierte pyrazolyl-amidyl-benzimidazolyl-c-kit-inhibitor n |
EP1824832B1 (en) * | 2004-06-30 | 2011-04-27 | Janssen Pharmaceutica NV | Aryl-substituted benzimidazole and imidazopyridine ethers as anti-cancer agents |
UA92180C2 (en) * | 2005-09-06 | 2010-10-11 | Смиткляйн Бичам Корпорейшн | Benzimidazole thiophene compounds as plk inhibitors |
JP2009001495A (ja) * | 2005-10-13 | 2009-01-08 | Taisho Pharmaceutical Co Ltd | 2−アリール−ベンゾイミダゾール−5−カルボキサミド誘導体 |
JP5301999B2 (ja) | 2005-10-31 | 2013-09-25 | メルク・シャープ・アンド・ドーム・コーポレーション | Cetp阻害薬 |
WO2007056155A1 (en) * | 2005-11-03 | 2007-05-18 | Chembridge Research Laboratories, Inc. | Heterocyclic compounds as tyrosine kinase modulators |
GB0606774D0 (en) * | 2006-04-03 | 2006-05-10 | Novartis Ag | Organic compounds |
PE20080888A1 (es) | 2006-10-18 | 2008-08-26 | Novartis Ag | COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE LA ACIL-TRANSFERASA DE ACIL-CoA-DIACIL-GLICEROL 1 (DGAT1) |
CA2682676A1 (en) * | 2007-04-19 | 2008-10-30 | Novartis Ag | Nicotinic acid derivatives as modulators of metabotropic glutamate receptor-5 |
MX2010003155A (es) | 2007-10-04 | 2010-04-01 | Hoffmann La Roche | Derivados de ciclopropil aril amida y uso de los mismos. |
WO2009112445A1 (en) * | 2008-03-10 | 2009-09-17 | Novartis Ag | Method of increasing cellular phosphatidyl choline by dgat1 inhibition |
CN103288803B (zh) * | 2013-05-17 | 2017-10-31 | 郎恒元 | 苯并咪唑酰胺类化合物及其制备方法和应用 |
CN104208701A (zh) * | 2013-05-29 | 2014-12-17 | 天津金耀集团有限公司 | 含有抗真菌药物的复方吸入制剂 |
JP7278945B2 (ja) * | 2016-09-20 | 2023-05-22 | サントル レオン ベラール | 抗癌剤としてのベンゾイミダゾール誘導体 |
US11267786B2 (en) * | 2018-06-01 | 2022-03-08 | Merck Sharp & Dohme Corp. | [3.3.1] bicyclo compounds as indoleamine 2,3-dioxygenase inhibitors |
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-
2002
- 2002-02-28 HU HU0303460A patent/HUP0303460A3/hu unknown
- 2002-02-28 BR BR0208010-9A patent/BR0208010A/pt not_active IP Right Cessation
- 2002-02-28 NZ NZ528835A patent/NZ528835A/en unknown
- 2002-02-28 EP EP02715052A patent/EP1368028B1/en not_active Expired - Lifetime
- 2002-02-28 CA CA002441177A patent/CA2441177A1/en not_active Abandoned
- 2002-02-28 CZ CZ20032691A patent/CZ20032691A3/cs unknown
- 2002-02-28 DE DE60221804T patent/DE60221804T2/de not_active Expired - Fee Related
- 2002-02-28 CN CNA028064860A patent/CN1496257A/zh active Pending
- 2002-02-28 ES ES02715052T patent/ES2291455T3/es not_active Expired - Lifetime
- 2002-02-28 JP JP2002571049A patent/JP2004528304A/ja active Pending
- 2002-02-28 DK DK02715052T patent/DK1368028T3/da active
- 2002-02-28 AT AT02715052T patent/ATE369853T1/de not_active IP Right Cessation
- 2002-02-28 PL PL02364230A patent/PL364230A1/xx unknown
- 2002-02-28 RU RU2003127367/15A patent/RU2003127367A/ru not_active Application Discontinuation
- 2002-02-28 MX MXJL03000027A patent/MXJL03000027A/es not_active Application Discontinuation
- 2002-02-28 WO PCT/US2002/006801 patent/WO2002072090A1/en active IP Right Grant
- 2002-02-28 PT PT02715052T patent/PT1368028E/pt unknown
- 2002-03-11 AR ARP020100869A patent/AR034023A1/es unknown
-
2003
- 2003-10-10 ZA ZA200307916A patent/ZA200307916B/en unknown
-
2004
- 2004-03-05 US US10/795,006 patent/US7282518B2/en not_active Expired - Fee Related
-
2007
- 2007-04-27 US US11/741,702 patent/US20070202133A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
BR0208010A (pt) | 2004-12-21 |
ZA200307916B (en) | 2004-09-03 |
DK1368028T3 (da) | 2007-12-27 |
US20040214821A1 (en) | 2004-10-28 |
EP1368028A1 (en) | 2003-12-10 |
DE60221804T2 (de) | 2008-05-15 |
PL364230A1 (en) | 2004-12-13 |
RU2003127367A (ru) | 2005-03-20 |
NZ528835A (en) | 2005-05-27 |
WO2002072090A1 (en) | 2002-09-19 |
CN1496257A (zh) | 2004-05-12 |
AR034023A1 (es) | 2004-01-21 |
DE60221804D1 (de) | 2007-09-27 |
PT1368028E (pt) | 2007-11-26 |
MXJL03000027A (es) | 2004-04-30 |
JP2004528304A (ja) | 2004-09-16 |
US20070202133A1 (en) | 2007-08-30 |
ES2291455T3 (es) | 2008-03-01 |
US7282518B2 (en) | 2007-10-16 |
HUP0303460A3 (en) | 2004-07-28 |
CZ20032691A3 (en) | 2004-04-14 |
ATE369853T1 (de) | 2007-09-15 |
EP1368028B1 (en) | 2007-08-15 |
CA2441177A1 (en) | 2002-09-19 |
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