ZA200306792B - Novel amides, preparation and therapeutic use as modulators of CCR-receptor activity. - Google Patents
Novel amides, preparation and therapeutic use as modulators of CCR-receptor activity. Download PDFInfo
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- ZA200306792B ZA200306792B ZA200306792A ZA200306792A ZA200306792B ZA 200306792 B ZA200306792 B ZA 200306792B ZA 200306792 A ZA200306792 A ZA 200306792A ZA 200306792 A ZA200306792 A ZA 200306792A ZA 200306792 B ZA200306792 B ZA 200306792B
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- South Africa
- Prior art keywords
- compound
- formula
- composition
- pharmaceutically acceptable
- solvate
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- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 230000000694 effects Effects 0.000 title claims description 7
- 230000001225 therapeutic effect Effects 0.000 title description 4
- 150000001408 amides Chemical class 0.000 title description 2
- 102000005674 CCR Receptors Human genes 0.000 title 1
- 108010059983 CCR Receptors Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 81
- 238000000034 method Methods 0.000 claims abstract description 36
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- 150000003839 salts Chemical class 0.000 claims description 36
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 35
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 25
- 229920006395 saturated elastomer Polymers 0.000 claims description 25
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A61P19/00—Drugs for skeletal disorders
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
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- Animal Behavior & Ethology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
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| SE0101038A SE0101038D0 (sv) | 2001-03-23 | 2001-03-23 | Novel compounds |
Publications (1)
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| ZA200306792B true ZA200306792B (en) | 2004-11-29 |
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| ZA200306792A ZA200306792B (en) | 2001-03-23 | 2003-08-29 | Novel amides, preparation and therapeutic use as modulators of CCR-receptor activity. |
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| EP (1) | EP1372651B1 (pt) |
| JP (1) | JP2004524345A (pt) |
| KR (1) | KR20030085030A (pt) |
| CN (1) | CN1538844A (pt) |
| AT (1) | ATE355842T1 (pt) |
| BR (1) | BR0208336A (pt) |
| CA (1) | CA2441933A1 (pt) |
| DE (1) | DE60218641T2 (pt) |
| DK (1) | DK1372651T3 (pt) |
| ES (1) | ES2280511T3 (pt) |
| IL (1) | IL157653A0 (pt) |
| MX (1) | MXPA03008443A (pt) |
| NO (1) | NO20034215L (pt) |
| NZ (1) | NZ528296A (pt) |
| PT (1) | PT1372651E (pt) |
| SE (1) | SE0101038D0 (pt) |
| SI (1) | SI1372651T1 (pt) |
| WO (1) | WO2002076457A1 (pt) |
| ZA (1) | ZA200306792B (pt) |
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| CO5300399A1 (es) | 2000-02-25 | 2003-07-31 | Astrazeneca Ab | Heterocicliocs que contienen nitrogeno, proceso para su preparacion y composiciones farmaceuticas que los contienen |
| US7005439B2 (en) * | 2000-06-20 | 2006-02-28 | Astrazeneca Ab | Compounds |
| AR028948A1 (es) * | 2000-06-20 | 2003-05-28 | Astrazeneca Ab | Compuestos novedosos |
| EP1661889A4 (en) * | 2003-09-05 | 2009-08-05 | Ono Pharmaceutical Co | ANTAGONIST OF THE CHEMOKINE RECEPTOR AND ITS USE FOR MEDICAL PURPOSES |
| PT1899322E (pt) | 2005-06-28 | 2009-11-09 | Sanofi Aventis | Derivados de isoquinolina como inibidores de rho-cinase |
| RS52241B (en) | 2005-07-26 | 2012-10-31 | Sanofi | CYCLOHEXYLAMINE ISOHINOLONE DERIVATIVES AS RHO-KINASE INHIBITORS |
| BRPI0613861B8 (pt) | 2005-07-26 | 2021-05-25 | Sanofi Aventis | derivados de isoquinolona piperidinil-substituídos como inibidores de rho-cinase |
| TW200738634A (en) * | 2005-08-02 | 2007-10-16 | Astrazeneca Ab | New salt |
| ATE490243T1 (de) | 2006-12-27 | 2010-12-15 | Sanofi Aventis | Cycloalkylaminsubstituierte isochinolin- und isochinolinonderivate |
| MX2009006517A (es) | 2006-12-27 | 2009-06-26 | Sanofi Aventis | Nuevos derivados de isoquinolina e isoquinolinona sustituidos. |
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| CN101616909B (zh) | 2006-12-27 | 2013-09-11 | 塞诺菲-安万特股份有限公司 | 作为Rho-激酶抑制剂的被取代的异喹啉和异喹啉酮衍生物 |
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| CN102131784B (zh) | 2008-06-24 | 2014-08-27 | 赛诺菲-安万特 | 作为rho激酶抑制剂的取代的异喹啉和异喹啉酮 |
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-
2001
- 2001-03-23 SE SE0101038A patent/SE0101038D0/xx unknown
-
2002
- 2002-03-19 MX MXPA03008443A patent/MXPA03008443A/es active IP Right Grant
- 2002-03-19 WO PCT/SE2002/000541 patent/WO2002076457A1/en active IP Right Grant
- 2002-03-19 IL IL15765302A patent/IL157653A0/xx unknown
- 2002-03-19 US US10/472,017 patent/US7345063B2/en not_active Expired - Fee Related
- 2002-03-19 SI SI200230517T patent/SI1372651T1/sl unknown
- 2002-03-19 EP EP02708893A patent/EP1372651B1/en not_active Expired - Lifetime
- 2002-03-19 NZ NZ528296A patent/NZ528296A/en unknown
- 2002-03-19 PT PT02708893T patent/PT1372651E/pt unknown
- 2002-03-19 DE DE60218641T patent/DE60218641T2/de not_active Expired - Fee Related
- 2002-03-19 ES ES02708893T patent/ES2280511T3/es not_active Expired - Lifetime
- 2002-03-19 KR KR10-2003-7012302A patent/KR20030085030A/ko not_active Application Discontinuation
- 2002-03-19 JP JP2002574972A patent/JP2004524345A/ja active Pending
- 2002-03-19 CA CA002441933A patent/CA2441933A1/en not_active Abandoned
- 2002-03-19 AT AT02708893T patent/ATE355842T1/de not_active IP Right Cessation
- 2002-03-19 CN CNA028070968A patent/CN1538844A/zh active Pending
- 2002-03-19 BR BR0208336-1A patent/BR0208336A/pt not_active IP Right Cessation
- 2002-03-19 DK DK02708893T patent/DK1372651T3/da active
-
2003
- 2003-08-29 ZA ZA200306792A patent/ZA200306792B/en unknown
- 2003-09-22 NO NO20034215A patent/NO20034215L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE355842T1 (de) | 2007-03-15 |
| WO2002076457A1 (en) | 2002-10-03 |
| KR20030085030A (ko) | 2003-11-01 |
| BR0208336A (pt) | 2004-03-23 |
| IL157653A0 (en) | 2004-03-28 |
| US7345063B2 (en) | 2008-03-18 |
| PT1372651E (pt) | 2007-05-31 |
| DE60218641T2 (de) | 2007-11-29 |
| SE0101038D0 (sv) | 2001-03-23 |
| MXPA03008443A (es) | 2004-01-29 |
| CA2441933A1 (en) | 2002-10-03 |
| NO20034215D0 (no) | 2003-09-22 |
| ES2280511T3 (es) | 2007-09-16 |
| US20040122020A1 (en) | 2004-06-24 |
| DE60218641D1 (de) | 2007-04-19 |
| JP2004524345A (ja) | 2004-08-12 |
| CN1538844A (zh) | 2004-10-20 |
| EP1372651A1 (en) | 2004-01-02 |
| NO20034215L (no) | 2003-11-24 |
| NZ528296A (en) | 2005-03-24 |
| SI1372651T1 (sl) | 2007-06-30 |
| DK1372651T3 (da) | 2007-05-29 |
| EP1372651B1 (en) | 2007-03-07 |
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